RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Experimental Autoimmune Encephalomyelitis
Accession: DOID:9002763
browse the term
Definition: An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Synonyms: exact_synonym: Allergic Encephalomyelitis; EAE; Experimental Allergic Encephalomyelitides; Experimental Allergic Encephalomyelitis
primary_id: MESH:D004681
xref: EFO:0001066
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A2m
alpha-2-macroglobulin
treatment
ISO
RGD
PMID:1710603
RGD:10046021
NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
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Adam17
a disintegrin and metallopeptidase domain 17
ISO
RGD
PMID:15878627
RGD:1559178
NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633
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Adam8
a disintegrin and metallopeptidase domain 8
IMP
RGD
PMID:9670863
RGD:2325244
NCBI chr 7:139,558,845...139,573,016
Ensembl chr 7:139,558,845...139,572,475
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Aif1
allograft inflammatory factor 1
ISO
protein:altered expression:spinal cord (rat)
RGD
PMID:19246105
RGD:2313022
NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
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Akap12
A kinase anchor protein 12
ISO
mRNA,protein:increased expression:spinal cord
RGD
PMID:20155814
RGD:14348972
NCBI chr10:4,216,329...4,309,471
Ensembl chr10:4,216,380...4,309,470
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Alox15
arachidonate 15-lipoxygenase
IMP
RGD
PMID:15328042
RGD:5509618
NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857
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Amigo2
adhesion molecule with Ig like domain 2
severity
IMP
RGD
PMID:28119027
RGD:14392778
NCBI chr15:97,141,955...97,145,168
Ensembl chr15:97,142,006...97,145,168
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Anxa1
annexin A1
ISO
protein:increased expression:brain, astrocyte, macrophage
RGD
PMID:9472682
RGD:2306942
NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
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Apoe
apolipoprotein E
ISO
RGD
PMID:28578430
RGD:13703134
NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
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Aqp4
aquaporin 4
disease_progression severity
IEP IMP ISO IDA
RGD
PMID:21056916 PMID:19660138 PMID:21157915 PMID:23707078
RGD:5148015 , RGD:5490116 , RGD:5490117 , RGD:8696030
NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039
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B2m
beta-2 microglobulin
IMP
RGD
PMID:15837577
RGD:6482690
NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564
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B4galt6
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
IEP
mRNA:increased expression:astrocyte
RGD
PMID:25216636
RGD:14390079
NCBI chr18:20,817,656...20,879,461
Ensembl chr18:20,817,656...20,879,461
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Bdnf
brain derived neurotrophic factor
ISO
RGD
PMID:23212569
RGD:10059360
NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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C3
complement component 3
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:22320401
RGD:7175513
NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
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C6
complement component 6
severity
ISO
RGD
PMID:11970970
RGD:625607
NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449
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Cacna1b
calcium channel, voltage-dependent, N type, alpha 1B subunit
ISO
RGD
PMID:11353727
RGD:1580151
NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164
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Calca
calcitonin/calcitonin-related polypeptide, alpha
no_association
IMP
RGD
PMID:19563774
RGD:5684360
NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
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Casp3
caspase 3
ISO
protein:increased activity, increased expression:spinal cord
RGD
PMID:18521931
RGD:2311436
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Casp8
caspase 8
ISO
protein:increased activity, increased expression:spinal cord
RGD
PMID:18521931
RGD:2311436
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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Casp9
caspase 9
ISO
protein:increased expression:spinal cord
RGD
PMID:18521931
RGD:2311436
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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Cav3
caveolin 3
onset
ISO
Protein:increased expression:spinal cord, astrocyte
RGD
PMID:15925413
RGD:1582168
NCBI chr 6:112,436,466...112,449,833
Ensembl chr 6:112,436,466...112,449,833
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Cblb
Casitas B-lineage lymphoma b
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20453840
NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411
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Ccl1
C-C motif chemokine ligand 1
ISO
mRNA:decreased expression:lymph node
RGD
PMID:19865101
RGD:4145472
NCBI chr11:82,067,492...82,070,638
Ensembl chr11:82,067,483...82,196,516
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Ccl11
C-C motif chemokine ligand 11
ISO
mRNA:increased expression:lymph node
RGD
PMID:19865101
RGD:4145472
NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781
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Ccl2
C-C motif chemokine ligand 2
ISO
mRNA:increased expression:spinal cord mRNA:decreased expression:lymph node mRNA:increased expression:optic chiasma (rat)
RGD
PMID:17666800 PMID:19865101 PMID:11241588
RGD:2307114 , RGD:4145472 , RGD:8548888
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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Ccl3
C-C motif chemokine ligand 3
ISO
mRNA:increased expression:spinal cord
RGD
PMID:17666800
RGD:2307114
NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
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Ccl5
C-C motif chemokine ligand 5
IEP ISO
protein:increased expression:brain (mouse) mRNA:increased expression:spinal cord
RGD
PMID:15833367 PMID:17666800
RGD:4890027 , RGD:2307114
NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
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Ccr1
C-C motif chemokine receptor 1
ISO
RGD
PMID:14655765 PMID:14512166
RGD:5688165 , RGD:5688167
NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729
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Ccr2
C-C motif chemokine receptor 2
ISO
mRNA:increased expression:spinal cord
RGD
PMID:9655467
RGD:632391
NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
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Ccr3
C-C motif chemokine receptor 3
IDA
RGD
PMID:15034073
RGD:6893394
NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726
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Ccr5
C-C motif chemokine receptor 5
ISO
mRNA:increased expression:spinal cord, macrophage, microglia (rat)
RGD
PMID:17484785
RGD:4890436
NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736
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Cd28
CD28 antigen
ISO
RGD
PMID:16061730
RGD:2307203
NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518
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Cd4
CD4 antigen
treatment
ISO
protein:decreased expression:T lymphocyte:
RGD
PMID:9138014 PMID:3097071
RGD:10058963 , RGD:10058968
NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184
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Cd80
CD80 antigen
ISO
RGD
PMID:9379015
RGD:6902906
NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
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Cd86
CD86 antigen
resistance disease_progression
IMP ISO
protein:increased expression:spinal cord, blood vessel (rat)
RGD
PMID:10477557 PMID:20451260
RGD:4892227 , RGD:4892207
NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
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Ciita
class II transactivator
ISO
RGD
PMID:15821736
RGD:1358146
NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
ISO
RGD
PMID:21107918 PMID:7541143 PMID:10650887
RGD:6483335 , RGD:6483353 , RGD:6483351
NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555
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Comt
catechol-O-methyltransferase
treatment
IMP
RGD
PMID:25242632
RGD:13450949
NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
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Cpb2
carboxypeptidase B2
ISO
RGD
PMID:22768796
RGD:7243111
NCBI chr14:75,479,727...75,520,995
Ensembl chr14:75,479,727...75,520,995
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Cspg4
chondroitin sulfate proteoglycan 4
IEP ISO
protein:increased expression:spinal cord
RGD
PMID:21679768 PMID:20162860
RGD:5686852 , RGD:5686863
NCBI chr 9:56,772,388...56,807,154
Ensembl chr 9:56,772,317...56,807,154
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
ISO
RGD
PMID:9379015
RGD:6902906
NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
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Ctsc
cathepsin C
ISO
RGD
PMID:843913
RGD:1599653
NCBI chr 7:87,927,233...87,960,083
Ensembl chr 7:87,927,293...87,960,096
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Ctss
cathepsin S
IMP
RGD
PMID:21439785
RGD:5686915
NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714
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Cx3cl1
C-X3-C motif chemokine ligand 1
ISO
RGD
PMID:16053521
RGD:4891973
NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055
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Cx3cr1
C-X3-C motif chemokine receptor 1
ISO
RGD
PMID:16053521 PMID:24706865
RGD:4891973 , RGD:9491767
NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945
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Cxcr2
C-X-C motif chemokine receptor 2
IMP
RGD
PMID:19616545
RGD:7257694
NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:21038468
RGD:5135506
NCBI chr X:100,775,141...100,777,753
Ensembl chr X:100,775,141...100,777,875
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Dab2
disabled 2, mitogen-responsive phosphoprotein
disease_progression
ISO
RGD
PMID:21890121
RGD:7243155
NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193
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Dlk1
delta like non-canonical Notch ligand 1
IDA
RGD
PMID:24676147
RGD:150520045
NCBI chr12:109,418,411...109,429,262
Ensembl chr12:109,418,749...109,429,262
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Dll1
delta like canonical Notch ligand 1
IMP
RGD
PMID:17947672
RGD:6482235
NCBI chr17:15,587,616...15,597,275
Ensembl chr17:15,587,616...15,597,134
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Dll4
delta like canonical Notch ligand 4
ameliorates
IMP
RGD
PMID:21813770
RGD:155663662
NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443
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Dusp10
dual specificity phosphatase 10
IMP
RGD
PMID:15306813
RGD:7775013
NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833
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Entpd1
ectonucleoside triphosphate diphosphohydrolase 1
disease_progression
ISO
RGD
PMID:19524108
RGD:9685491
NCBI chr19:40,600,810...40,730,046
Ensembl chr19:40,600,810...40,730,046
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Epo
erythropoietin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18382691
NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504
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Ern1
endoplasmic reticulum to nucleus signalling 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30661753
NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678
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Esr2
estrogen receptor 2 (beta)
IMP IDA
RGD
PMID:21565615 PMID:21182085
RGD:5508732 , RGD:5508735
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
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Fasl
Fas ligand
treatment
ISO
RGD
PMID:10944459
RGD:12903984
NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
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Fcgr3
Fc receptor, IgG, low affinity III
IMP
RGD
PMID:12576552
RGD:5508383
NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504
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Fgf2
fibroblast growth factor 2
ISO
mRNA:increased expression:spinal cord
RGD
PMID:8929896 PMID:9814819
RGD:8655647 , RGD:9831448
NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
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Flt1
FMS-like tyrosine kinase 1
treatment
ISO
RGD
PMID:18721816
RGD:10402153
NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821
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Foxo3
forkhead box O3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27742544
NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
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Ghrh
growth hormone releasing hormone
resistance
IMP
RGD
PMID:21846799
RGD:5687168
NCBI chr 2:157,171,416...157,190,645
Ensembl chr 2:157,171,417...157,189,426
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Ghrl
ghrelin
treatment
ISO
RGD
PMID:19620309
RGD:12905041
NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841
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Gjc2
gap junction protein, gamma 2
IEP
protein:decreased expression:white matter of spinal cord, gap junction (mouse)
RGD
PMID:22461072
RGD:13208593
NCBI chr11:59,066,390...59,074,039
Ensembl chr11:59,066,394...59,074,039
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Gli1
GLI-Kruppel family member GLI1
IEP
RGD
PMID:18991353
RGD:12801440
NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843
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Glud1
glutamate dehydrogenase 1
IEP
mRNA, protein:decreased expression:spinal cord
RGD
PMID:9145307
RGD:6484657
NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
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Gpx3
glutathione peroxidase 3
ISO
RGD
PMID:22320401
RGD:7175513
NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203
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H2-Aa
histocompatibility 2, class II antigen A, alpha
ISO
RGD
PMID:18050272 PMID:9834080 PMID:16723470
RGD:5147622 , RGD:5147666 , RGD:5147639
NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
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H2-Ab1
histocompatibility 2, class II antigen A, beta 1
ISO
RGD
PMID:16723470 PMID:9834080 PMID:16194572
RGD:5147639 , RGD:5147666 , RGD:5147647
NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393
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H2-Ea
histocompatibility 2, class II antigen E alpha
ISO
RGD
PMID:8676084
RGD:5490166
NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618
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H2-Eb1
histocompatibility 2, class II antigen E beta
ISO
RGD
PMID:16194572
RGD:5147647
NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648
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Havcr2
hepatitis A virus cellular receptor 2
IMP ISO
mRNA:increased expression:spinal cord:
RGD
PMID:11823861 PMID:15913792
RGD:9686086 , RGD:9686113
NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082
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Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
IMP ISO
RGD
PMID:17085013 PMID:14691063
RGD:5508469 , RGD:5508476
NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
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Ifnb1
interferon beta 1, fibroblast
ameliorates treatment exacerbates
IDA ISO
RGD
PMID:9578846 PMID:8955226 PMID:19380780 PMID:18997868
RGD:401854237 , RGD:401854247 , RGD:401854246 , RGD:5147399
NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
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Ifng
interferon gamma
disease_progression treatment
IMP
RGD
PMID:15661899 PMID:22896638
RGD:7987912 , RGD:10755692
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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Igf1
insulin-like growth factor 1
treatment
ISO
human protein in a rat model
RGD
PMID:7541143
RGD:6483353
NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
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Il10
interleukin 10
treatment
ISO
RGD
PMID:23872438
RGD:7364993
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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Il10ra
interleukin 10 receptor, alpha
ISO
RGD
PMID:12620647
RGD:2316323
NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447
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Il12a
interleukin 12a
IMP
RGD
PMID:12471147
RGD:724447
NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
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Il12b
interleukin 12b
ISO
mRNA, protein:increased expression:lymph node
RGD
PMID:19233473
RGD:4831840
NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
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Il13
interleukin 13
severity
IMP ISO
RGD
PMID:18250480 PMID:7523520
RGD:5684366 , RGD:5684367
NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
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Il16
interleukin 16
ISO
RGD
PMID:17641011
RGD:5024940
NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934
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Il17a
interleukin 17A
treatment
ISO IMP IDA
mRNA, protein:increased expression:lymph node
RGD
PMID:19233473 PMID:16785554 PMID:20003332 PMID:16200068
RGD:4831840 , RGD:4889113 , RGD:4888522 , RGD:9212317
NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
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Il18
interleukin 18
ISO
mRNA:increased expression:spinal cord
RGD
PMID:9834127 PMID:9846824
RGD:4889543 , RGD:4889542
NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
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Il18r1
interleukin 18 receptor 1
ISO
mRNA:increased expression:lymph node
RGD
PMID:19269041
RGD:2311529
NCBI chr 1:40,504,712...40,540,014
Ensembl chr 1:40,504,712...40,540,014
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Il1rn
interleukin 1 receptor antagonist
treatment
ISO
human protein in a rat model
RGD
PMID:7593560
RGD:8551836
NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
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Il21
interleukin 21
ISO
RGD
PMID:18997868
RGD:5147399
NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785
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Il21r
interleukin 21 receptor
no_association disease_progression
IMP
RGD
PMID:18546146 PMID:18353312
RGD:6892939 , RGD:6892940
NCBI chr 7:125,202,424...125,232,742
Ensembl chr 7:125,202,601...125,232,742
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Il22
interleukin 22
ISO
RGD
PMID:19269041
RGD:2311529
NCBI chr10:118,040,456...118,045,952
Ensembl chr10:118,040,847...118,045,952
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Il27
interleukin 27
IEP
protein:decreased expression:blood serum (mouse)
RGD
PMID:33403844
RGD:126790527
NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113
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Il2ra
interleukin 2 receptor, alpha chain
ISO
RGD
PMID:19269041
RGD:2311529
NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004
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Il4
interleukin 4
treatment
IMP ISO
RGD
PMID:18239607 PMID:1383385
RGD:7829778 , RGD:8142395
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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Il6
interleukin 6
ISO IMP
protein:increased expression:oligodendrocytes (rat)
RGD
PMID:9358769 PMID:23322593
RGD:2307412 , RGD:12791289
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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Itga4
integrin alpha 4
treatment susceptibility
ISO
rat bone marrow cells in a mouse model
RGD
PMID:12626659 PMID:18722022
RGD:9698418 , RGD:9698436
NCBI chr 2:79,084,767...79,163,458
Ensembl chr 2:79,085,770...79,163,467
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Jag1
jagged 1
IMP
RGD
PMID:17947672
RGD:6482235
NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564
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Jak2
Janus kinase 2
IDA
RGD
PMID:22066025
RGD:6483041
NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
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Jak3
Janus kinase 3
treatment
ISO
RGD
PMID:25012120
RGD:11533939
NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219
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Kdr
kinase insert domain protein receptor
IMP
RGD
PMID:19233483
RGD:5684404
NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
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Kit
KIT proto-oncogene receptor tyrosine kinase
IMP
RGD
PMID:25972476
RGD:12910744
NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
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Lrp1
low density lipoprotein receptor-related protein 1
IEP
protein:increased expression:cerebellum, spinal cord
RGD
PMID:19299462
RGD:13800552
NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
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Lta
lymphotoxin A
ISO
mRNA:increased expression:spinal cord mRNA:increased expression:brain
RGD
PMID:7593556 PMID:9184655
RGD:1625038 , RGD:4143220
NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327
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Mapt
microtubule-associated protein tau
treatment
ISO
RGD
PMID:15494405
RGD:1358431
NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
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Mbp
myelin basic protein
ISO
CTD Direct Evidence: marker/mechanism human sequence peptide in a rat model; associated with Herpesviridae infections
CTD RGD
PMID:11501064 PMID:15159442 PMID:17884951 PMID:24070732 PMID:16285900 PMID:12811845 More...
RGD:7349334 , RGD:30296670
NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
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Mdk
midkine
ISO
RGD
PMID:9814819
RGD:9831448
NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642
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Mir146
microRNA 146
IEP
mRNA:increased expression:spinal cord (mouse)
RGD
PMID:22660635
RGD:155663483
NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
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Mir23b
microRNA 23b
treatment
IEP IMP
mRNA:decreased expression:spinal cord (mouse)
RGD
PMID:22660635 PMID:22660635
RGD:155663483 , RGD:155663483
NCBI chr13:63,448,298...63,448,371
Ensembl chr13:63,448,298...63,448,371
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Mmp2
matrix metallopeptidase 2
ISO
RGD
PMID:19922364
RGD:2325703
NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
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Mmp7
matrix metallopeptidase 7
ISO
RGD
PMID:9549496
RGD:8547909
NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,587
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Mmp9
matrix metallopeptidase 9
treatment
ISO IEP
protein:increased expression:multiple tissues
RGD
PMID:9549496 PMID:24797785 PMID:20810258 PMID:22800566
RGD:8547909 , RGD:13204801 , RGD:13204762 , RGD:8547936
NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
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Mobp
myelin-associated oligodendrocytic basic protein
IDA
RGD
PMID:10623862
RGD:27226694
NCBI chr 9:119,978,740...120,010,554
Ensembl chr 9:119,978,773...120,010,550
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Mog
myelin oligodendrocyte glycoprotein
ISO IMP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12904460 PMID:16931536 PMID:17654737 PMID:17728465 PMID:18566399 PMID:18667803 PMID:21068375 PMID:21317386 PMID:21341682 PMID:23360710 PMID:23547115 PMID:23639249 PMID:30661753 PMID:10384097 PMID:12799014 PMID:14624757 PMID:14624757 More...
RGD:9685372 , RGD:9685373 , RGD:9685375 , RGD:9685375
NCBI chr17:37,321,632...37,334,290
Ensembl chr17:37,321,635...37,334,290
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Mt1
metallothionein 1
IEP
mRNA:increased expression:brain (mouse)
RGD
PMID:19619133
RGD:6484112
NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
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Mt2
metallothionein 2
IEP
mRNA:increased expression:brain (mouse)
RGD
PMID:19619133
RGD:6484112
NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
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Mt3
metallothionein 3
IEP
mRNA:increased expression:brain (mouse)
RGD
PMID:19619133
RGD:6484112
NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774
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Ncam1
neural cell adhesion molecule 1
ISO
protein:decreased expression:hippocampus
RGD
PMID:17064783
RGD:40924670
NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225
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Nefl
neurofilament, light polypeptide
ISO
protein:increased expression:cerebrospinal fluid, spinal cord
RGD
PMID:16182933
RGD:2299007
NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
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Nfe2l2
nuclear factor, erythroid derived 2, like 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19910389
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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Ngf
nerve growth factor
ISO
protein, mRNA:increased expression:thalamus and cortex, CNS (rat)
RGD
PMID:8866783
RGD:5508386
NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
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Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
severity
IMP ISO
mRNA:increased expression:central nervous system (rat)
RGD
PMID:16519950 PMID:8866783
RGD:5508312 , RGD:5508386
NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561
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Nos2
nitric oxide synthase 2, inducible
IMP
RGD
PMID:21857957
RGD:5509069
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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Nr1h2
nuclear receptor subfamily 1, group H, member 2
IMP
RGD
PMID:21266776
RGD:6480877
NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
IMP
RGD
PMID:17322387
RGD:4892331
NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
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Ntrk1
neurotrophic tyrosine kinase, receptor, type 1
ISO
mRNA:increased expression:brain subventricular zone:
RGD
PMID:15589512
RGD:5684777
NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469
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Olig1
oligodendrocyte transcription factor 1
treatment
IEP
RGD
PMID:24941845
RGD:40902822
NCBI chr16:91,066,657...91,068,827
Ensembl chr16:91,066,660...91,068,821
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Olig2
oligodendrocyte transcription factor 2
treatment
IEP ISO
RGD
PMID:24941845 PMID:29682587
RGD:40902822 , RGD:40902863
NCBI chr16:91,016,745...91,025,567
Ensembl chr16:91,022,345...91,025,565
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Pdcd1
programmed cell death 1
susceptibility
IMP
RGD
PMID:24648472
RGD:40818258
NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278
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Pdgfb
platelet derived growth factor, B polypeptide
treatment
ISO
RGD
PMID:16042218
RGD:11080975
NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178
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Pdgfra
platelet derived growth factor receptor, alpha polypeptide
treatment
ISO
RGD
PMID:16042218
RGD:11080975
NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876
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Pdgfrb
platelet derived growth factor receptor, beta polypeptide
treatment
ISO
RGD
PMID:16042218
RGD:11080975
NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
IMP
RGD
PMID:20303183
RGD:6482686
NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658
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Plp1
proteolipid protein (myelin) 1
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21068375 PMID:24941845
RGD:40902822
NCBI chr X:135,720,897...135,739,331
Ensembl chr X:135,723,420...135,740,482
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Ppara
peroxisome proliferator activated receptor alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17261635
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
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Prf1
perforin 1 (pore forming protein)
IMP
RGD
PMID:20708278
RGD:6482806
NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459
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Prkaa1
protein kinase, AMP-activated, alpha 1 catalytic subunit
severity
IMP
RGD
PMID:19486896
RGD:6484540
NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
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Ptgs1
prostaglandin-endoperoxide synthase 1
IEP ISO
protein:increased expression:cerebral cortex, cerebellum, spinal cord protein:increased expression:microglia, macrophage,
RGD
PMID:21667309 PMID:10229132
RGD:5688149 , RGD:5688250
NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
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Ptgs2
prostaglandin-endoperoxide synthase 2
IEP ISO
protein:increased expression:cerebral cortex, cerebellum, spinal cord protein:increased expression:endothelial cell
RGD
PMID:21667309 PMID:10229132
RGD:5688149 , RGD:5688250
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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Ptn
pleiotrophin
ISO
mRNA:increased expression:spinal cord (rat)
RGD
PMID:9814819
RGD:9831448
NCBI chr 6:36,691,863...36,787,114
Ensembl chr 6:36,691,864...36,787,155
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Qki
quaking, KH domain containing RNA binding
ISO
RGD
PMID:22740327
RGD:10045997
NCBI chr17:10,425,480...10,538,706
Ensembl chr17:10,421,530...10,538,783
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Rangrf
RAN guanine nucleotide release factor
ISO
RGD
PMID:8557821
RGD:6771380
NCBI chr11:68,863,310...68,866,011
Ensembl chr11:68,863,310...68,866,011
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Rhoa
ras homolog family member A
severity
ISO
protein:increased expression:microglial cell, brain
RGD
PMID:17983427
RGD:2298887
NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
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Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
IEP
mRNA,protein:increased expression,increased activity:spinal cord, astrocyte:
RGD
PMID:11733372
RGD:13208549
NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
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Shh
sonic hedgehog
ISO IEP
RGD
PMID:15892298 PMID:18991353
RGD:12801423 , RGD:12801440
NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254
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Sigmar1
sigma non-opioid intracellular receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30661753
NCBI chr 4:41,738,493...41,741,359
Ensembl chr 4:41,738,493...41,756,157
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Sirt1
sirtuin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23547115
NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
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Slpi
secretory leukocyte peptidase inhibitor
treatment
IDA
RGD
PMID:22436018
RGD:9999395
NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
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Sncb
synuclein, beta
ISO
RGD
PMID:12496452
RGD:730073
NCBI chr13:54,906,673...54,914,435
Ensembl chr13:54,906,673...54,914,408
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Srsf9
serine and arginine-rich splicing factor 9
treatment
ISO
RGD
PMID:20616573
RGD:11040805
NCBI chr 5:115,465,236...115,471,139
Ensembl chr 5:115,465,236...115,471,139
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Stat1
signal transducer and activator of transcription 1
IDA
RGD
PMID:22066025
RGD:6483041
NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
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Stat3
signal transducer and activator of transcription 3
IDA IMP
RGD
PMID:22066025 PMID:17878325
RGD:6483041 , RGD:6892946
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
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Stat4
signal transducer and activator of transcription 4
ISO
RGD
PMID:11240014
RGD:7207888
NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348
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Tgfb1
transforming growth factor, beta 1
ISO
mRNA, protein:increased expression:central nervous system
RGD
PMID:17204936
RGD:2302088
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
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Tgfb2
transforming growth factor, beta 2
ISO
mRNA, protein:decreased expression:central nervous system
RGD
PMID:17204936
RGD:2302088
NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
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Timp3
tissue inhibitor of metalloproteinase 3
ISO
protein:increased expression:spinal cord
RGD
PMID:15878627
RGD:1559178
NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370
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Tlr2
toll-like receptor 2
treatment
ISO
protein:increased expression:spinal cord
RGD
PMID:18644848 PMID:33358978
RGD:2312575 , RGD:597538508
NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
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Tlr4
toll-like receptor 4
treatment
ISO
protein:increased expression:spinal cord
RGD
PMID:18644848 PMID:33358978
RGD:2312575 , RGD:597538508
NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
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Tnf
tumor necrosis factor
treatment
ISO
RGD
PMID:11421579
RGD:12904661
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Vcam1
vascular cell adhesion molecule 1
ISO
RGD
PMID:12196270
RGD:1580348
NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
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Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor
treatment
IDA IMP
RGD
PMID:21318047 PMID:21287548
RGD:8158064 , RGD:13210791
NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
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Vegfa
vascular endothelial growth factor A
ISO
mRNA:decreased expression:Cerebrospinal Fluid: mRNA,protein:decreased expression:spinal cord:
RGD
PMID:12387457 PMID:17083617 PMID:17083617
RGD:634258 , RGD:7421596 , RGD:7421596
NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
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Vip
vasoactive intestinal polypeptide
IMP
RGD
PMID:20978211
RGD:5685386
NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617
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Xbp1
X-box binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30661753
NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
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Mag
myelin-associated glycoprotein
ISO
protein:decreased expression:optic nerve
RGD
PMID:9820787
RGD:9685300
NCBI chr 7:30,598,600...30,614,347
Ensembl chr 7:30,598,601...30,614,298
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Zc3h12a
zinc finger CCCH type containing 12A
disease_progression
IMP
RGD
PMID:26320658
RGD:11534569
NCBI chr 4:125,012,207...125,021,674
Ensembl chr 4:125,012,216...125,021,633
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Ccl2
C-C motif chemokine ligand 2
ISO
mRNA:increased expression:spinal cord (rat)
RGD
PMID:12098510
RGD:8655962
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
G
Nefh
neurofilament, heavy polypeptide
IEP
protein:decreased expression:spinal cord:
RGD
PMID:12742652
RGD:27226817
NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064
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Plp1
proteolipid protein (myelin) 1
ISO
human sequence peptide in a mouse model; associated with Herpesviridae infections
RGD
PMID:12811845
RGD:30296670
NCBI chr X:135,720,897...135,739,331
Ensembl chr X:135,723,420...135,740,482
G
Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
IMP
RGD
PMID:17983428
RGD:13208507
NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
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