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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Experimental Autoimmune Encephalomyelitis
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Accession:DOID:9002763 term browser browse the term
Definition:An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Synonyms:exact_synonym: Allergic Encephalomyelitis;   EAE;   Experimental Allergic Encephalomyelitides;   Experimental Allergic Encephalomyelitis
 primary_id: MESH:D004681
 xref: EFO:0001066



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Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin treatment ISO RGD PMID:1710603 RGD:10046021 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 ISO RGD PMID:15878627 RGD:1559178 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633
JBrowse link
G Adam8 a disintegrin and metallopeptidase domain 8 IMP RGD PMID:9670863 RGD:2325244 NCBI chr 7:139,558,845...139,573,016
Ensembl chr 7:139,558,845...139,572,475
JBrowse link
G Aif1 allograft inflammatory factor 1 ISO protein:altered expression:spinal cord (rat) RGD PMID:19246105 RGD:2313022 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
JBrowse link
G Akap12 A kinase anchor protein 12 ISO mRNA,protein:increased expression:spinal cord RGD PMID:20155814 RGD:14348972 NCBI chr10:4,216,329...4,309,471
Ensembl chr10:4,216,380...4,309,470
JBrowse link
G Alox15 arachidonate 15-lipoxygenase IMP RGD PMID:15328042 RGD:5509618 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 severity IMP RGD PMID:28119027 RGD:14392778 NCBI chr15:97,141,955...97,145,168
Ensembl chr15:97,142,006...97,145,168
JBrowse link
G Anxa1 annexin A1 ISO protein:increased expression:brain, astrocyte, macrophage RGD PMID:9472682 RGD:2306942 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
JBrowse link
G Apoe apolipoprotein E ISO RGD PMID:28578430 RGD:13703134 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113
JBrowse link
G Aqp4 aquaporin 4 disease_progression
severity
IEP
IMP
ISO
IDA
RGD PMID:21056916 PMID:19660138 PMID:21157915 PMID:23707078 RGD:5148015, RGD:5490116, RGD:5490117, RGD:8696030 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039
JBrowse link
G B2m beta-2 microglobulin IMP RGD PMID:15837577 RGD:6482690 NCBI chr 2:121,978,168...121,983,563
Ensembl chr 2:121,978,167...121,983,564
JBrowse link
G B4galt6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 IEP mRNA:increased expression:astrocyte RGD PMID:25216636 RGD:14390079 NCBI chr18:20,817,656...20,879,461
Ensembl chr18:20,817,656...20,879,461
JBrowse link
G Bdnf brain derived neurotrophic factor ISO RGD PMID:23212569 RGD:10059360 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
JBrowse link
G C3 complement component 3 ISO protein:increased expression:cerebrospinal fluid RGD PMID:22320401 RGD:7175513 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G C6 complement component 6 severity ISO RGD PMID:11970970 RGD:625607 NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449
JBrowse link
G Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit ISO RGD PMID:11353727 RGD:1580151 NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha no_association IMP RGD PMID:19563774 RGD:5684360 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G Casp3 caspase 3 ISO protein:increased activity, increased expression:spinal cord RGD PMID:18521931 RGD:2311436 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 ISO protein:increased activity, increased expression:spinal cord RGD PMID:18521931 RGD:2311436 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 ISO protein:increased expression:spinal cord RGD PMID:18521931 RGD:2311436 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cav3 caveolin 3 onset ISO Protein:increased expression:spinal cord, astrocyte RGD PMID:15925413 RGD:1582168 NCBI chr 6:112,436,466...112,449,833
Ensembl chr 6:112,436,466...112,449,833
JBrowse link
G Cblb Casitas B-lineage lymphoma b ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453840 NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 ISO mRNA:decreased expression:lymph node RGD PMID:19865101 RGD:4145472 NCBI chr11:82,067,492...82,070,638
Ensembl chr11:82,067,483...82,196,516
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO mRNA:increased expression:lymph node RGD PMID:19865101 RGD:4145472 NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:spinal cord
mRNA:decreased expression:lymph node
mRNA:increased expression:optic chiasma (rat)
RGD PMID:17666800 PMID:19865101 PMID:11241588 RGD:2307114, RGD:4145472, RGD:8548888 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO mRNA:increased expression:spinal cord RGD PMID:17666800 RGD:2307114 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP
ISO
protein:increased expression:brain (mouse)
mRNA:increased expression:spinal cord
RGD PMID:15833367 PMID:17666800 RGD:4890027, RGD:2307114 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 ISO RGD PMID:14655765 PMID:14512166 RGD:5688165, RGD:5688167 NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:spinal cord RGD PMID:9655467 RGD:632391 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 IDA RGD PMID:15034073 RGD:6893394 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:spinal cord, macrophage, microglia (rat) RGD PMID:17484785 RGD:4890436 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736
JBrowse link
G Cd28 CD28 antigen ISO RGD PMID:16061730 RGD:2307203 NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518
JBrowse link
G Cd4 CD4 antigen treatment ISO protein:decreased expression:T lymphocyte: RGD PMID:9138014 PMID:3097071 RGD:10058963, RGD:10058968 NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184
JBrowse link
G Cd80 CD80 antigen ISO RGD PMID:9379015 RGD:6902906 NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
JBrowse link
G Cd86 CD86 antigen resistance
disease_progression
IMP
ISO
protein:increased expression:spinal cord, blood vessel (rat) RGD PMID:10477557 PMID:20451260 RGD:4892227, RGD:4892207 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Ciita class II transactivator ISO RGD PMID:15821736 RGD:1358146 NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase ISO RGD PMID:21107918 PMID:7541143 PMID:10650887 RGD:6483335, RGD:6483353, RGD:6483351 NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555
JBrowse link
G Comt catechol-O-methyltransferase treatment IMP RGD PMID:25242632 RGD:13450949 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Cpb2 carboxypeptidase B2 ISO RGD PMID:22768796 RGD:7243111 NCBI chr14:75,479,727...75,520,995
Ensembl chr14:75,479,727...75,520,995
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 IEP
ISO
protein:increased expression:spinal cord RGD PMID:21679768 PMID:20162860 RGD:5686852, RGD:5686863 NCBI chr 9:56,772,388...56,807,154
Ensembl chr 9:56,772,317...56,807,154
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO RGD PMID:9379015 RGD:6902906 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
JBrowse link
G Ctsc cathepsin C ISO RGD PMID:843913 RGD:1599653 NCBI chr 7:87,927,233...87,960,083
Ensembl chr 7:87,927,293...87,960,096
JBrowse link
G Ctss cathepsin S IMP RGD PMID:21439785 RGD:5686915 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:16053521 RGD:4891973 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:16053521 PMID:24706865 RGD:4891973, RGD:9491767 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 IMP RGD PMID:19616545 RGD:7257694 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:21038468 RGD:5135506 NCBI chr  X:100,775,141...100,777,753
Ensembl chr  X:100,775,141...100,777,875
JBrowse link
G Dab2 disabled 2, mitogen-responsive phosphoprotein disease_progression ISO RGD PMID:21890121 RGD:7243155 NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193
JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 IDA RGD PMID:24676147 RGD:150520045 NCBI chr12:109,418,411...109,429,262
Ensembl chr12:109,418,749...109,429,262
JBrowse link
G Dll1 delta like canonical Notch ligand 1 IMP RGD PMID:17947672 RGD:6482235 NCBI chr17:15,587,616...15,597,275
Ensembl chr17:15,587,616...15,597,134
JBrowse link
G Dll4 delta like canonical Notch ligand 4 ameliorates IMP RGD PMID:21813770 RGD:155663662 NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443
JBrowse link
G Dusp10 dual specificity phosphatase 10 IMP RGD PMID:15306813 RGD:7775013 NCBI chr 1:183,766,575...183,807,833
Ensembl chr 1:183,745,499...183,807,833
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 disease_progression ISO RGD PMID:19524108 RGD:9685491 NCBI chr19:40,600,810...40,730,046
Ensembl chr19:40,600,810...40,730,046
JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:18382691 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30661753 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678
JBrowse link
G Esr2 estrogen receptor 2 (beta) IMP
IDA
RGD PMID:21565615 PMID:21182085 RGD:5508732, RGD:5508735 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Fasl Fas ligand treatment ISO RGD PMID:10944459 RGD:12903984 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III IMP RGD PMID:12576552 RGD:5508383 NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO mRNA:increased expression:spinal cord RGD PMID:8929896 PMID:9814819 RGD:8655647, RGD:9831448 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 treatment ISO RGD PMID:18721816 RGD:10402153 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821
JBrowse link
G Foxo3 forkhead box O3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27742544 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
JBrowse link
G Ghrh growth hormone releasing hormone resistance IMP RGD PMID:21846799 RGD:5687168 NCBI chr 2:157,171,416...157,190,645
Ensembl chr 2:157,171,417...157,189,426
JBrowse link
G Ghrl ghrelin treatment ISO RGD PMID:19620309 RGD:12905041 NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841
JBrowse link
G Gjc2 gap junction protein, gamma 2 IEP protein:decreased expression:white matter of spinal cord, gap junction (mouse) RGD PMID:22461072 RGD:13208593 NCBI chr11:59,066,390...59,074,039
Ensembl chr11:59,066,394...59,074,039
JBrowse link
G Gli1 GLI-Kruppel family member GLI1 IEP RGD PMID:18991353 RGD:12801440 NCBI chr10:127,165,751...127,177,448
Ensembl chr10:127,165,751...127,177,843
JBrowse link
G Glud1 glutamate dehydrogenase 1 IEP mRNA, protein:decreased expression:spinal cord RGD PMID:9145307 RGD:6484657 NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
JBrowse link
G Gpx3 glutathione peroxidase 3 ISO RGD PMID:22320401 RGD:7175513 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha ISO RGD PMID:18050272 PMID:9834080 PMID:16723470 RGD:5147622, RGD:5147666, RGD:5147639 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 ISO RGD PMID:16723470 PMID:9834080 PMID:16194572 RGD:5147639, RGD:5147666, RGD:5147647 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393
JBrowse link
G H2-Ea histocompatibility 2, class II antigen E alpha ISO RGD PMID:8676084 RGD:5490166 NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta ISO RGD PMID:16194572 RGD:5147647 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648
JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 IMP
ISO
mRNA:increased expression:spinal cord: RGD PMID:11823861 PMID:15913792 RGD:9686086, RGD:9686113 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase IMP
ISO
RGD PMID:17085013 PMID:14691063 RGD:5508469, RGD:5508476 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Ifnb1 interferon beta 1, fibroblast ameliorates
treatment
exacerbates
IDA
ISO
RGD PMID:9578846 PMID:8955226 PMID:19380780 PMID:18997868 RGD:401854237, RGD:401854247, RGD:401854246, RGD:5147399 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
JBrowse link
G Ifng interferon gamma disease_progression
treatment
IMP RGD PMID:15661899 PMID:22896638 RGD:7987912, RGD:10755692 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Igf1 insulin-like growth factor 1 treatment ISO human protein in a rat model RGD PMID:7541143 RGD:6483353 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:23872438 RGD:7364993 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il10ra interleukin 10 receptor, alpha ISO RGD PMID:12620647 RGD:2316323 NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447
JBrowse link
G Il12a interleukin 12a IMP RGD PMID:12471147 RGD:724447 NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
JBrowse link
G Il12b interleukin 12b ISO mRNA, protein:increased expression:lymph node RGD PMID:19233473 RGD:4831840 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
JBrowse link
G Il13 interleukin 13 severity IMP
ISO
RGD PMID:18250480 PMID:7523520 RGD:5684366, RGD:5684367 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il16 interleukin 16 ISO RGD PMID:17641011 RGD:5024940 NCBI chr 7:83,292,027...83,395,479
Ensembl chr 7:83,292,033...83,394,934
JBrowse link
G Il17a interleukin 17A treatment ISO
IMP
IDA
mRNA, protein:increased expression:lymph node RGD PMID:19233473 PMID:16785554 PMID:20003332 PMID:16200068 RGD:4831840, RGD:4889113, RGD:4888522, RGD:9212317 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il18 interleukin 18 ISO mRNA:increased expression:spinal cord RGD PMID:9834127 PMID:9846824 RGD:4889543, RGD:4889542 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il18r1 interleukin 18 receptor 1 ISO mRNA:increased expression:lymph node RGD PMID:19269041 RGD:2311529 NCBI chr 1:40,504,712...40,540,014
Ensembl chr 1:40,504,712...40,540,014
JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:7593560 RGD:8551836 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
JBrowse link
G Il21 interleukin 21 ISO RGD PMID:18997868 RGD:5147399 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785
JBrowse link
G Il21r interleukin 21 receptor no_association
disease_progression
IMP RGD PMID:18546146 PMID:18353312 RGD:6892939, RGD:6892940 NCBI chr 7:125,202,424...125,232,742
Ensembl chr 7:125,202,601...125,232,742
JBrowse link
G Il22 interleukin 22 ISO RGD PMID:19269041 RGD:2311529 NCBI chr10:118,040,456...118,045,952
Ensembl chr10:118,040,847...118,045,952
JBrowse link
G Il27 interleukin 27 IEP protein:decreased expression:blood serum (mouse) RGD PMID:33403844 RGD:126790527 NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain ISO RGD PMID:19269041 RGD:2311529 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004
JBrowse link
G Il4 interleukin 4 treatment IMP
ISO
RGD PMID:18239607 PMID:1383385 RGD:7829778, RGD:8142395 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
JBrowse link
G Il6 interleukin 6 ISO
IMP
protein:increased expression:oligodendrocytes (rat) RGD PMID:9358769 PMID:23322593 RGD:2307412, RGD:12791289 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Itga4 integrin alpha 4 treatment
susceptibility
ISO rat bone marrow cells in a mouse model RGD PMID:12626659 PMID:18722022 RGD:9698418, RGD:9698436 NCBI chr 2:79,084,767...79,163,458
Ensembl chr 2:79,085,770...79,163,467
JBrowse link
G Jag1 jagged 1 IMP RGD PMID:17947672 RGD:6482235 NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564
JBrowse link
G Jak2 Janus kinase 2 IDA RGD PMID:22066025 RGD:6483041 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
JBrowse link
G Jak3 Janus kinase 3 treatment ISO RGD PMID:25012120 RGD:11533939 NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219
JBrowse link
G Kdr kinase insert domain protein receptor IMP RGD PMID:19233483 RGD:5684404 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase IMP RGD PMID:25972476 RGD:12910744 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 IEP protein:increased expression:cerebellum, spinal cord RGD PMID:19299462 RGD:13800552 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
JBrowse link
G Lta lymphotoxin A ISO mRNA:increased expression:spinal cord
mRNA:increased expression:brain
RGD PMID:7593556 PMID:9184655 RGD:1625038, RGD:4143220 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327
JBrowse link
G Mapt microtubule-associated protein tau treatment ISO RGD PMID:15494405 RGD:1358431 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Mbp myelin basic protein ISO CTD Direct Evidence: marker/mechanism
human sequence peptide in a rat model; associated with Herpesviridae infections
CTD
RGD
PMID:11501064 PMID:15159442 PMID:17884951 PMID:24070732 PMID:16285900 More... RGD:7349334, RGD:30296670 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
JBrowse link
G Mdk midkine ISO RGD PMID:9814819 RGD:9831448 NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642
JBrowse link
G Mir146 microRNA 146 IEP mRNA:increased expression:spinal cord (mouse) RGD PMID:22660635 RGD:155663483 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
JBrowse link
G Mir23b microRNA 23b treatment IEP
IMP
mRNA:decreased expression:spinal cord (mouse) RGD PMID:22660635 PMID:22660635 RGD:155663483, RGD:155663483 NCBI chr13:63,448,298...63,448,371
Ensembl chr13:63,448,298...63,448,371
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:19922364 RGD:2325703 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp7 matrix metallopeptidase 7 ISO RGD PMID:9549496 RGD:8547909 NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,587
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO
IEP
protein:increased expression:multiple tissues RGD PMID:9549496 PMID:24797785 PMID:20810258 PMID:22800566 RGD:8547909, RGD:13204801, RGD:13204762, RGD:8547936 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mobp myelin-associated oligodendrocytic basic protein IDA RGD PMID:10623862 RGD:27226694 NCBI chr 9:119,978,740...120,010,554
Ensembl chr 9:119,978,773...120,010,550
JBrowse link
G Mog myelin oligodendrocyte glycoprotein ISO
IMP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:12904460 PMID:16931536 PMID:17654737 PMID:17728465 PMID:18566399 More... RGD:9685372, RGD:9685373, RGD:9685375, RGD:9685375 NCBI chr17:37,321,632...37,334,290
Ensembl chr17:37,321,635...37,334,290
JBrowse link
G Mt1 metallothionein 1 IEP mRNA:increased expression:brain (mouse) RGD PMID:19619133 RGD:6484112 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955
JBrowse link
G Mt2 metallothionein 2 IEP mRNA:increased expression:brain (mouse) RGD PMID:19619133 RGD:6484112 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
JBrowse link
G Mt3 metallothionein 3 IEP mRNA:increased expression:brain (mouse) RGD PMID:19619133 RGD:6484112 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774
JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO protein:decreased expression:hippocampus RGD PMID:17064783 RGD:40924670 NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225
JBrowse link
G Nefl neurofilament, light polypeptide ISO protein:increased expression:cerebrospinal fluid, spinal cord RGD PMID:16182933 RGD:2299007 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19910389 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Ngf nerve growth factor ISO protein, mRNA:increased expression:thalamus and cortex, CNS (rat) RGD PMID:8866783 RGD:5508386 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) severity IMP
ISO
mRNA:increased expression:central nervous system (rat) RGD PMID:16519950 PMID:8866783 RGD:5508312, RGD:5508386 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561
JBrowse link
G Nos2 nitric oxide synthase 2, inducible IMP RGD PMID:21857957 RGD:5509069 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 IMP RGD PMID:21266776 RGD:6480877 NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IMP RGD PMID:17322387 RGD:4892331 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 ISO mRNA:increased expression:brain subventricular zone: RGD PMID:15589512 RGD:5684777 NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469
JBrowse link
G Olig1 oligodendrocyte transcription factor 1 treatment IEP RGD PMID:24941845 RGD:40902822 NCBI chr16:91,066,657...91,068,827
Ensembl chr16:91,066,660...91,068,821
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 treatment IEP
ISO
RGD PMID:24941845 PMID:29682587 RGD:40902822, RGD:40902863 NCBI chr16:91,016,745...91,025,567
Ensembl chr16:91,022,345...91,025,565
JBrowse link
G Pdcd1 programmed cell death 1 susceptibility IMP RGD PMID:24648472 RGD:40818258 NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278
JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide treatment ISO RGD PMID:16042218 RGD:11080975 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178
JBrowse link
G Pdgfra platelet derived growth factor receptor, alpha polypeptide treatment ISO RGD PMID:16042218 RGD:11080975 NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide treatment ISO RGD PMID:16042218 RGD:11080975 NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IMP RGD PMID:20303183 RGD:6482686 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658
JBrowse link
G Plp1 proteolipid protein (myelin) 1 treatment ISO
IEP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:21068375 PMID:24941845 RGD:40902822 NCBI chr  X:135,720,897...135,739,331
Ensembl chr  X:135,723,420...135,740,482
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:17261635 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Prf1 perforin 1 (pore forming protein) IMP RGD PMID:20708278 RGD:6482806 NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit severity IMP RGD PMID:19486896 RGD:6484540 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IEP
ISO
protein:increased expression:cerebral cortex, cerebellum, spinal cord
protein:increased expression:microglia, macrophage,
RGD PMID:21667309 PMID:10229132 RGD:5688149, RGD:5688250 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP
ISO
protein:increased expression:cerebral cortex, cerebellum, spinal cord
protein:increased expression:endothelial cell
RGD PMID:21667309 PMID:10229132 RGD:5688149, RGD:5688250 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Ptn pleiotrophin ISO mRNA:increased expression:spinal cord (rat) RGD PMID:9814819 RGD:9831448 NCBI chr 6:36,691,863...36,787,114
Ensembl chr 6:36,691,864...36,787,155
JBrowse link
G Qki quaking, KH domain containing RNA binding ISO RGD PMID:22740327 RGD:10045997 NCBI chr17:10,425,480...10,538,706
Ensembl chr17:10,421,530...10,538,783
JBrowse link
G Rangrf RAN guanine nucleotide release factor ISO RGD PMID:8557821 RGD:6771380 NCBI chr11:68,863,310...68,866,011
Ensembl chr11:68,863,310...68,866,011
JBrowse link
G Rhoa ras homolog family member A severity ISO protein:increased expression:microglial cell, brain RGD PMID:17983427 RGD:2298887 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 IEP mRNA,protein:increased expression,increased activity:spinal cord, astrocyte: RGD PMID:11733372 RGD:13208549 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Shh sonic hedgehog ISO
IEP
RGD PMID:15892298 PMID:18991353 RGD:12801423, RGD:12801440 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30661753 NCBI chr 4:41,738,493...41,741,359
Ensembl chr 4:41,738,493...41,756,157
JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:23547115 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor treatment IDA RGD PMID:22436018 RGD:9999395 NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
JBrowse link
G Sncb synuclein, beta ISO RGD PMID:12496452 RGD:730073 NCBI chr13:54,906,673...54,914,435
Ensembl chr13:54,906,673...54,914,408
JBrowse link
G Srsf9 serine and arginine-rich splicing factor 9 treatment ISO RGD PMID:20616573 RGD:11040805 NCBI chr 5:115,465,236...115,471,139
Ensembl chr 5:115,465,236...115,471,139
JBrowse link
G Stat1 signal transducer and activator of transcription 1 IDA RGD PMID:22066025 RGD:6483041 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
JBrowse link
G Stat3 signal transducer and activator of transcription 3 IDA
IMP
RGD PMID:22066025 PMID:17878325 RGD:6483041, RGD:6892946 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO RGD PMID:11240014 RGD:7207888 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO mRNA, protein:increased expression:central nervous system RGD PMID:17204936 RGD:2302088 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO mRNA, protein:decreased expression:central nervous system RGD PMID:17204936 RGD:2302088 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 ISO protein:increased expression:spinal cord RGD PMID:15878627 RGD:1559178 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370
JBrowse link
G Tlr2 toll-like receptor 2 treatment ISO protein:increased expression:spinal cord RGD PMID:18644848 PMID:33358978 RGD:2312575, RGD:597538508 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
JBrowse link
G Tlr4 toll-like receptor 4 treatment ISO protein:increased expression:spinal cord RGD PMID:18644848 PMID:33358978 RGD:2312575, RGD:597538508 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:11421579 RGD:12904661 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO RGD PMID:12196270 RGD:1580348 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor treatment IDA
IMP
RGD PMID:21318047 PMID:21287548 RGD:8158064, RGD:13210791 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA:decreased expression:Cerebrospinal Fluid:
mRNA,protein:decreased expression:spinal cord:
RGD PMID:12387457 PMID:17083617 PMID:17083617 RGD:634258, RGD:7421596, RGD:7421596 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vip vasoactive intestinal polypeptide IMP RGD PMID:20978211 RGD:5685386 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617
JBrowse link
G Xbp1 X-box binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30661753 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link
Acute Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mag myelin-associated glycoprotein ISO protein:decreased expression:optic nerve RGD PMID:9820787 RGD:9685300 NCBI chr 7:30,598,600...30,614,347
Ensembl chr 7:30,598,601...30,614,298
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A disease_progression IMP RGD PMID:26320658 RGD:11534569 NCBI chr 4:125,012,207...125,021,674
Ensembl chr 4:125,012,216...125,021,633
JBrowse link
Chronic Relapsing Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:spinal cord (rat) RGD PMID:12098510 RGD:8655962 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Nefh neurofilament, heavy polypeptide IEP protein:decreased expression:spinal cord: RGD PMID:12742652 RGD:27226817 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064
JBrowse link
G Plp1 proteolipid protein (myelin) 1 ISO human sequence peptide in a mouse model; associated with Herpesviridae infections RGD PMID:12811845 RGD:30296670 NCBI chr  X:135,720,897...135,739,331
Ensembl chr  X:135,723,420...135,740,482
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 IMP RGD PMID:17983428 RGD:13208507 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16273
    Animal Diseases 1462
      Animal Disease Models 1413
        Experimental Nervous System Autoimmune Disease 192
          Experimental Autoimmune Encephalomyelitis 164
            Acute Experimental Autoimmune Encephalomyelitis 2
            Chronic Relapsing Experimental Autoimmune Encephalomyelitis 4
Path 2
Term Annotations click to browse term
  disease 16273
    disease of anatomical entity 15866
      Immune & Inflammatory Diseases 5362
        immune system disease 4730
          primary immunodeficiency disease 4151
            autoimmune disease 2121
              autoimmune disease of the nervous system 617
                autoimmune disease of central nervous system 317
                  Demyelinating Autoimmune Diseases, CNS 310
                    Experimental Autoimmune Encephalomyelitis 164
                      Acute Experimental Autoimmune Encephalomyelitis 2
                      Chronic Relapsing Experimental Autoimmune Encephalomyelitis 4
paths to the root