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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Experimental Autoimmune Encephalomyelitis
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Accession:DOID:9002763 term browser browse the term
Definition:An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Synonyms:exact_synonym: Allergic Encephalomyelitis;   EAE;   Experimental Allergic Encephalomyelitides;   Experimental Allergic Encephalomyelitis
 primary_id: MESH:D004681
 xref: EFO:0001066


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Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 ISO RGD PMID:15878627 RGD:1559178 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054 		JBrowse link
G ADAM8 ADAM metallopeptidase domain 8 ISO RGD PMID:9670863 RGD:2325244 Ensembl chr10:134,172,724...134,186,227 JBrowse link
G AIF1 allograft inflammatory factor 1 ISO protein:altered expression:spinal cord (rat) RGD PMID:19246105 RGD:2313022 NCBI chr 6:31,276,215...31,278,051
Ensembl chr 6:32,166,301...32,168,125 		JBrowse link
G AKAP12 A-kinase anchoring protein 12 ISO mRNA,protein:increased expression:spinal cord RGD PMID:20155814 RGD:14348972 NCBI chr 6:149,058,350...149,176,710
Ensembl chr 6:153,757,081...153,873,925 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO RGD PMID:15328042 RGD:5509618 NCBI chr17:4,686,339...4,696,877
Ensembl chr17:4,677,125...4,687,669 		JBrowse link
G AMIGO2 adhesion molecule with Ig like domain 2 severity ISO RGD PMID:28119027 RGD:14392778 NCBI chr12:41,652,954...41,656,393
Ensembl chr12:42,525,858...42,527,426 		JBrowse link
G ANXA1 annexin A1 ISO protein:increased expression:brain, astrocyte, macrophage RGD PMID:9472682 RGD:2306942 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G APOE apolipoprotein E ISO RGD PMID:28578430 RGD:13703134 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G AQP4 aquaporin 4 severity
disease_progression		 ISO RGD PMID:19660138 PMID:21056916 PMID:21157915 PMID:23707078 RGD:5148015 RGD:5490116 RGD:5490117 RGD:8696030 NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919 		JBrowse link
G B2M beta-2-microglobulin ISO RGD PMID:15837577 RGD:6482690 NCBI chr15:23,668,108...23,674,791
Ensembl chr15:41,836,345...41,842,991 		JBrowse link
G B4GALT6 beta-1,4-galactosyltransferase 6 ISO mRNA:increased expression:astrocyte RGD PMID:25216636 RGD:14390079 NCBI chr18:24,840,106...24,906,309
Ensembl chr18:28,438,302...28,500,946 		JBrowse link
G BDNF brain derived neurotrophic factor ISO RGD PMID:23212569 RGD:10059360 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G C3 complement C3 ISO protein:increased expression:cerebrospinal fluid RGD PMID:22320401 RGD:7175513 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G C6 complement C6 severity ISO RGD PMID:11970970 RGD:625607 NCBI chr 5:69,174,411...69,245,801
Ensembl chr 5:74,216,244...74,288,588 		JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B ISO RGD PMID:11353727 RGD:1580151 NCBI chr 9:108,989,621...109,256,841 JBrowse link
G CALCA calcitonin related polypeptide alpha no_association ISO RGD PMID:19563774 RGD:5684360 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267 		JBrowse link
G CASP3 caspase 3 ISO protein:increased activity, increased expression:spinal cord RGD PMID:18521931 RGD:2311436 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CASP8 caspase 8 ISO protein:increased activity, increased expression:spinal cord RGD PMID:18521931 RGD:2311436 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G CASP9 caspase 9 ISO protein:increased expression:spinal cord RGD PMID:18521931 RGD:2311436 NCBI chr 1:14,630,659...14,662,865
Ensembl chr 1:15,624,666...15,656,266 		JBrowse link
G CAV3 caveolin 3 onset ISO Protein:increased expression:spinal cord, astrocyte RGD PMID:15925413 RGD:1582168 NCBI chr 3:8,684,829...8,697,731
Ensembl chr 3:8,928,069...8,940,942 		JBrowse link
G CBLB Cbl proto-oncogene B ISO CTD Direct Evidence: marker/mechanism CTD PMID:20453840 NCBI chr 3:102,752,406...102,966,414
Ensembl chr 3:109,690,120...109,905,191 		JBrowse link
G CCL1 C-C motif chemokine ligand 1 ISO mRNA:decreased expression:lymph node RGD PMID:19865101 RGD:4145472 NCBI chr17:22,425,022...22,430,243
Ensembl chr17:22,719,425...22,722,341 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:spinal cord
mRNA:decreased expression:lymph node
mRNA:increased expression:optic chiasma (rat)		 RGD PMID:11241588 PMID:17666800 PMID:19865101 RGD:2307114 RGD:4145472 RGD:8548888 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:spinal cord
protein:increased expression:brain (mouse)		 RGD PMID:15833367 PMID:17666800 RGD:2307114 RGD:4890027 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO RGD PMID:14512166 PMID:14655765 RGD:5688165 RGD:5688167 NCBI chr 3:46,107,526...46,114,229
Ensembl chr 3:47,214,688...47,215,755 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:spinal cord RGD PMID:9655467 RGD:632391 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G CCR3 C-C motif chemokine receptor 3 ISO RGD PMID:15034073 RGD:6893394 NCBI chr 3:46,147,928...46,172,947
Ensembl chr 3:47,253,878...47,278,630 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:spinal cord, macrophage, microglia (rat) RGD PMID:17484785 RGD:4890436 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379 		JBrowse link
G CD28 CD28 molecule ISO RGD PMID:16061730 RGD:2307203 NCBI chr2B:90,938,795...90,971,438
Ensembl chr2B:209,076,388...209,111,213 		JBrowse link
G CD4 CD4 molecule treatment ISO protein:decreased expression:T lymphocyte: RGD PMID:3097071 PMID:9138014 RGD:10058963 RGD:10058968 NCBI chr12:6,920,587...6,951,814
Ensembl chr12:6,834,011...6,864,204 		JBrowse link
G CD80 CD80 molecule ISO RGD PMID:9379015 RGD:6902906 NCBI chr 3:116,646,590...116,683,725
Ensembl chr 3:123,559,559...123,594,870 		JBrowse link
G CD86 CD86 molecule resistance
disease_progression		 ISO protein:increased expression:spinal cord, blood vessel (rat) RGD PMID:10477557 PMID:20451260 RGD:4892207 RGD:4892227 NCBI chr 3:119,151,884...119,217,641
Ensembl chr 3:126,059,008...126,124,339 		JBrowse link
G CIITA class II major histocompatibility complex transactivator ISO RGD PMID:15821736 RGD:1358146 NCBI chr16:9,819,440...9,885,379
Ensembl chr16:11,041,434...11,090,485 		JBrowse link
G CNP 2',3'-cyclic nucleotide 3' phosphodiesterase ISO RGD PMID:7541143 PMID:10650887 PMID:21107918 RGD:6483335 RGD:6483351 RGD:6483353 NCBI chr17:15,338,085...15,349,089
Ensembl chr17:15,560,056...15,568,916 		JBrowse link
G COMT catechol-O-methyltransferase treatment ISO RGD PMID:25242632 RGD:13450949 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G CPB2 carboxypeptidase B2 ISO RGD PMID:22768796 RGD:7243111 NCBI chr13:26,926,788...26,979,767 JBrowse link
G CSPG4 chondroitin sulfate proteoglycan 4 ISO protein:increased expression:spinal cord RGD PMID:20162860 PMID:21679768 RGD:5686852 RGD:5686863 NCBI chr15:54,583,010...54,621,240
Ensembl chr15:74,177,909...74,200,498 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO RGD PMID:9379015 RGD:6902906 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498 		JBrowse link
G CTSC cathepsin C ISO RGD PMID:843913 RGD:1599653 NCBI chr11:83,299,827...83,345,383
Ensembl chr11:86,890,010...86,933,847 		JBrowse link
G CTSS cathepsin S ISO RGD PMID:21439785 RGD:5686915 NCBI chr 1:126,084,249...126,118,221
Ensembl chr 1:129,733,996...129,768,318 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:16053521 RGD:4891973 NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:16053521 PMID:24706865 RGD:4891973 RGD:9491767 NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:19616545 RGD:7257694 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:21038468 RGD:5135506 NCBI chr  X:60,880,759...60,883,355
Ensembl chr  X:70,933,160...70,935,756 		JBrowse link
G DAB2 DAB adaptor protein 2 disease_progression ISO RGD PMID:21890121 RGD:7243155 NCBI chr 5:70,951,198...71,004,836
Ensembl chr 5:76,022,143...76,041,443 		JBrowse link
G DLK1 delta like non-canonical Notch ligand 1 ISO RGD PMID:24676147 RGD:150520045 NCBI chr14:81,348,380...81,356,607
Ensembl chr14:100,654,965...100,668,019 		JBrowse link
G DLL1 delta like canonical Notch ligand 1 ISO RGD PMID:17947672 RGD:6482235 NCBI chr 6:168,440,192...168,449,071
Ensembl chr 6:173,534,292...173,544,759 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 ameliorates ISO RGD PMID:21813770 RGD:155663662 NCBI chr15:19,871,584...19,881,817
Ensembl chr15:38,121,574...38,129,471 		JBrowse link
G DUSP10 dual specificity phosphatase 10 ISO RGD PMID:15306813 RGD:7775013 NCBI chr 1:197,293,039...197,333,828
Ensembl chr 1:202,367,318...202,404,720 		JBrowse link
G ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 disease_progression ISO RGD PMID:19524108 RGD:9685491 NCBI chr10:92,365,267...92,511,852
Ensembl chr10:95,828,094...95,983,257 		JBrowse link
G EPO erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:18382691 NCBI chr 7:92,747,671...92,750,886
Ensembl chr 7:106,148,062...106,150,974 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30661753 NCBI chr17:58,132,889...58,224,012
Ensembl chr17:63,226,949...63,317,825 		JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:21182085 PMID:21565615 RGD:5508732 RGD:5508735 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303 		JBrowse link
G FASLG Fas ligand treatment ISO RGD PMID:10944459 RGD:12903984 NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281 		JBrowse link
G FGF2 fibroblast growth factor 2 ISO mRNA:increased expression:spinal cord RGD PMID:8929896 PMID:9814819 RGD:8655647 RGD:9831448 NCBI chr 4:115,005,136...115,076,369
Ensembl chr 4:126,149,813...126,214,942 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 treatment ISO RGD PMID:18721816 RGD:10402153 NCBI chr13:9,584,850...9,779,542 JBrowse link
G FOXO3 forkhead box O3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27742544 NCBI chr 6:106,360,519...106,485,676
Ensembl chr 6:110,406,266...110,516,272 		JBrowse link
G GHRH growth hormone releasing hormone resistance ISO RGD PMID:21846799 RGD:5687168 NCBI chr20:33,573,001...33,583,699
Ensembl chr20:34,687,587...34,693,240 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide treatment ISO RGD PMID:19620309 RGD:12905041 NCBI chr 3:10,221,829...10,229,229
Ensembl chr 3:10,573,537...10,580,723 		JBrowse link
G GJC2 gap junction protein gamma 2 ISO protein:decreased expression:white matter of spinal cord, gap junction (mouse) RGD PMID:22461072 RGD:13208593 NCBI chr 1:203,551,556...203,561,702 JBrowse link
G GLI1 GLI family zinc finger 1 ISO RGD PMID:18991353 RGD:12801440 NCBI chr12:31,453,759...31,466,194
Ensembl chr12:31,710,057...31,722,473 		JBrowse link
G GLUD1 glutamate dehydrogenase 1 ISO mRNA, protein:decreased expression:spinal cord RGD PMID:9145307 RGD:6484657 NCBI chr10:83,498,338...83,540,730 JBrowse link
G GPX3 glutathione peroxidase 3 ISO RGD PMID:22320401 RGD:7175513 NCBI chr 5:146,447,939...146,456,476 JBrowse link
G HAVCR2 hepatitis A virus cellular receptor 2 ISO mRNA:increased expression:spinal cord: RGD PMID:11823861 PMID:15913792 RGD:9686086 RGD:9686113 NCBI chr 5:152,486,125...152,514,004
Ensembl chr 5:159,108,915...159,131,007 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:14691063 PMID:17085013 RGD:5508469 RGD:5508476 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G IFNB1 interferon beta 1 exacerbates
treatment
ameliorates		 ISO RGD PMID:8955226 PMID:9578846 PMID:18997868 PMID:19380780 RGD:401854237 RGD:401854246 RGD:401854247 RGD:5147399 NCBI chr 9:20,884,742...20,886,317 JBrowse link
G IFNG interferon gamma treatment
disease_progression		 ISO RGD PMID:15661899 PMID:22896638 RGD:10755692 RGD:7987912 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IGF1 insulin like growth factor 1 treatment ISO human protein in a rat model RGD PMID:7541143 RGD:6483353 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:23872438 RGD:7364993 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL10RA interleukin 10 receptor subunit alpha ISO RGD PMID:12620647 RGD:2316323 NCBI chr11:112,820,445...112,835,603
Ensembl chr11:116,752,619...116,767,771 		JBrowse link
G IL12A interleukin 12A ISO RGD PMID:12471147 RGD:724447 NCBI chr 3:157,011,675...157,019,897
Ensembl chr 3:165,061,505...165,068,666 		JBrowse link
G IL12B interleukin 12B ISO mRNA, protein:increased expression:lymph node RGD PMID:19233473 RGD:4831840 NCBI chr 5:154,706,467...154,722,231
Ensembl chr 5:161,325,303...161,335,381 		JBrowse link
G IL13 interleukin 13 severity ISO RGD PMID:7523520 PMID:18250480 RGD:5684366 RGD:5684367 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G IL16 interleukin 16 ISO RGD PMID:17641011 RGD:5024940 NCBI chr15:60,181,827...60,299,406
Ensembl chr15:79,122,988...79,250,861 		JBrowse link
G IL17A interleukin 17A treatment ISO mRNA, protein:increased expression:lymph node RGD PMID:16200068 PMID:16785554 PMID:19233473 PMID:20003332 RGD:4831840 RGD:4888522 RGD:4889113 RGD:9212317 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL18 interleukin 18 ISO mRNA:increased expression:spinal cord RGD PMID:9834127 PMID:9846824 RGD:4889542 RGD:4889543 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL18R1 interleukin 18 receptor 1 ISO mRNA:increased expression:lymph node RGD PMID:19269041 RGD:2311529 NCBI chr2A:99,419,686...99,462,650 JBrowse link
G IL1RN interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:7593560 RGD:8551836 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G IL21 interleukin 21 ISO RGD PMID:18997868 RGD:5147399 NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915 		JBrowse link
G IL21R interleukin 21 receptor no_association
disease_progression		 ISO RGD PMID:18353312 PMID:18546146 RGD:6892939 RGD:6892940 Ensembl chr16:27,774,864...27,821,769 JBrowse link
G IL22 interleukin 22 ISO RGD PMID:19269041 RGD:2311529 NCBI chr12:65,757,069...65,762,418
Ensembl chr12:68,542,076...68,547,421 		JBrowse link
G IL27 interleukin 27 ISO protein:decreased expression:blood serum (mouse) RGD PMID:33403844 RGD:126790527
G IL2RA interleukin 2 receptor subunit alpha ISO RGD PMID:19269041 RGD:2311529 NCBI chr10:6,053,549...6,103,863 JBrowse link
G IL32 interleukin 32 ameliorates ISO human gene in a mouse model RGD PMID:26564962 RGD:150340739 NCBI chr16:2,007,018...2,023,757
Ensembl chr16:3,179,637...3,203,929 		JBrowse link
G IL4 interleukin 4 treatment ISO RGD PMID:1383385 PMID:18239607 RGD:7829778 RGD:8142395 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G IL6 interleukin 6 ISO protein:increased expression:oligodendrocytes (rat) RGD PMID:9358769 PMID:23322593 RGD:12791289 RGD:2307412 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G ITGA4 integrin subunit alpha 4 susceptibility
treatment		 ISO rat bone marrow cells in a mouse model RGD PMID:12626659 PMID:18722022 RGD:9698418 RGD:9698436 NCBI chr2B:68,719,376...68,802,488
Ensembl chr2B:186,530,187...186,612,203 		JBrowse link
G JAG1 jagged canonical Notch ligand 1 ISO RGD PMID:17947672 RGD:6482235 NCBI chr20:10,582,234...10,618,507
Ensembl chr20:10,582,094...10,618,383 		JBrowse link
G JAK2 Janus kinase 2 ISO RGD PMID:22066025 RGD:6483041 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626 		JBrowse link
G JAK3 Janus kinase 3 treatment ISO RGD PMID:25012120 RGD:11533939 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:19233483 RGD:5684404 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase ISO RGD PMID:25972476 RGD:12910744 NCBI chr 4:69,199,543...69,282,323
Ensembl chr 4:75,761,946...75,844,473 		JBrowse link
G LOC100972994 HLA class II histocompatibility antigen, DQ beta 1 chain ISO RGD PMID:9834080 PMID:16194572 PMID:16723470 RGD:5147639 RGD:5147647 RGD:5147666 NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272 		JBrowse link
G LOC100979269 alpha-2-macroglobulin treatment ISO RGD PMID:1710603 RGD:10046021 NCBI chr12:9,154,457...9,202,833
Ensembl chr12:9,385,359...9,433,979 		JBrowse link
G LOC100986475 metallothionein-2 ISO mRNA:increased expression:brain (mouse) RGD PMID:19619133 RGD:6484112 NCBI chr16:36,894,853...36,895,826
Ensembl chr16:56,007,922...56,028,093 		JBrowse link
G LOC100987081 HLA class II histocompatibility antigen, DR alpha chain ISO RGD PMID:8676084 RGD:5490166 NCBI chr 6:32,105,421...32,110,579
Ensembl chr 6:32,982,228...32,987,417 		JBrowse link
G LRP1 LDL receptor related protein 1 ISO protein:increased expression:cerebellum, spinal cord RGD PMID:19299462 RGD:13800552 NCBI chr12:31,713,938...31,799,287
Ensembl chr12:31,966,149...32,051,979 		JBrowse link
G LTA lymphotoxin alpha ISO mRNA:increased expression:spinal cord
mRNA:increased expression:brain		 RGD PMID:7593556 PMID:9184655 RGD:1625038 RGD:4143220 NCBI chr 6:31,233,411...31,235,409
Ensembl chr 6:32,123,353...32,125,375 		JBrowse link
G MAPT microtubule associated protein tau treatment ISO RGD PMID:15494405 RGD:1358431 NCBI chr17:11,373,220...11,506,669
Ensembl chr17:11,458,159...11,523,129 		JBrowse link
G MBP myelin basic protein ISO CTD Direct Evidence: marker/mechanism
human sequence peptide in a rat model; associated with Herpesviridae infections		 CTD
RGD		 PMID:11501064 PMID:12811845 PMID:15159442 PMID:16285900 PMID:17884951 More... RGD:30296670 RGD:7349334 NCBI chr18:70,369,882...70,526,693
Ensembl chr18:73,629,522...73,755,351 		JBrowse link
G MDK midkine ISO RGD PMID:9814819 RGD:9831448 NCBI chr11:46,339,365...46,342,388
Ensembl chr11:46,891,540...46,893,254 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO RGD PMID:19922364 RGD:2325703 NCBI chr16:35,711,866...35,738,881
Ensembl chr16:54,812,694...54,844,279 		JBrowse link
G MMP7 matrix metallopeptidase 7 ISO RGD PMID:9549496 RGD:8547909 NCBI chr11:97,467,037...97,477,305
Ensembl chr11:100,960,032...100,971,099 		JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO protein:increased expression:multiple tissues RGD PMID:9549496 PMID:20810258 PMID:22800566 PMID:24797785 RGD:13204762 RGD:13204801 RGD:8547909 RGD:8547936 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G MOBP myelin associated oligodendrocyte basic protein ISO RGD PMID:10623862 RGD:27226694 NCBI chr 3:39,372,102...39,450,066
Ensembl chr 3:39,688,104...39,699,486 		JBrowse link
G MOG myelin oligodendrocyte glycoprotein ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:10384097 PMID:12799014 PMID:12904460 PMID:14624757 PMID:16931536 More... RGD:9685372 RGD:9685373 RGD:9685375 NCBI chr 6:29,461,174...29,476,362
Ensembl chr 6:30,119,599...30,134,152 		JBrowse link
G MT1X metallothionein 1X ISO mRNA:increased expression:brain (mouse) RGD PMID:19619133 RGD:6484112 NCBI chr16:36,959,854...36,961,632
Ensembl chr16:56,092,218...56,093,976 		JBrowse link
G MT3 metallothionein 3 ISO mRNA:increased expression:brain (mouse) RGD PMID:19619133 RGD:6484112 NCBI chr16:36,875,919...36,877,558
Ensembl chr16:56,007,922...56,028,093 		JBrowse link
G NCAM1 neural cell adhesion molecule 1 ISO protein:decreased expression:hippocampus RGD PMID:17064783 RGD:40924670 NCBI chr11:107,845,507...108,160,441
Ensembl chr11:111,925,677...112,000,401 		JBrowse link
G NEFL neurofilament light chain ISO protein:increased expression:cerebrospinal fluid, spinal cord RGD PMID:16182933 RGD:2299007 NCBI chr 8:24,218,510...24,224,627
Ensembl chr 8:21,134,533...21,140,694 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19910389 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085 		JBrowse link
G NGF nerve growth factor ISO protein, mRNA:increased expression:thalamus and cortex, CNS RGD PMID:8866783 RGD:5508386 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NGFR nerve growth factor receptor severity ISO mRNA:increased expression:central nervous system RGD PMID:8866783 PMID:16519950 RGD:5508312 RGD:5508386 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO RGD PMID:21857957 RGD:5509069 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 ISO RGD PMID:21266776 RGD:6480877 NCBI chr19:47,340,077...47,346,737
Ensembl chr19:56,243,124...56,250,024 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:17322387 RGD:4892331 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO mRNA:increased expression:brain subventricular zone: RGD PMID:15589512 RGD:5684777 Ensembl chr 1:136,007,476...136,047,355 JBrowse link
G OLIG1 oligodendrocyte transcription factor 1 treatment ISO RGD PMID:24941845 RGD:40902822 NCBI chr21:19,432,165...19,434,481 JBrowse link
G OLIG2 oligodendrocyte transcription factor 2 treatment ISO RGD PMID:24941845 PMID:29682587 RGD:40902822 RGD:40902863 NCBI chr21:19,387,860...19,391,291 JBrowse link
G PDCD1 programmed cell death 1 susceptibility ISO RGD PMID:24648472 RGD:40818258 NCBI chr12:130,849,353...130,858,776 JBrowse link
G PDGFB platelet derived growth factor subunit B treatment ISO RGD PMID:16042218 RGD:11080975 NCBI chr22:20,127,223...20,148,407
Ensembl chr22:37,944,018...37,964,883 		JBrowse link
G PDGFRA platelet derived growth factor receptor alpha treatment ISO RGD PMID:16042218 RGD:11080975 NCBI chr 4:69,639,081...69,709,870
Ensembl chr 4:76,199,382...76,271,097 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta treatment ISO RGD PMID:16042218 RGD:11080975 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:20303183 RGD:6482686 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614 		JBrowse link
G PLP1 proteolipid protein 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:21068375 PMID:24941845 RGD:40902822 NCBI chr  X:93,015,098...93,031,193
Ensembl chr  X:103,353,184...103,412,513 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:17261635 Ensembl chr22:45,218,364...45,302,970 JBrowse link
G PRF1 perforin 1 ISO RGD PMID:20708278 RGD:6482806 NCBI chr10:67,071,141...67,078,057
Ensembl chr10:69,597,574...69,603,070 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 severity ISO RGD PMID:19486896 RGD:6484540 NCBI chr 5:69,581,748...69,620,721
Ensembl chr 5:74,627,830...74,666,505 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:cerebral cortex, cerebellum, spinal cord
protein:increased expression:microglia, macrophage,		 RGD PMID:10229132 PMID:21667309 RGD:5688149 RGD:5688250 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:cerebral cortex, cerebellum, spinal cord
protein:increased expression:endothelial cell		 RGD PMID:10229132 PMID:21667309 RGD:5688149 RGD:5688250 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G PTN pleiotrophin ISO mRNA:increased expression:spinal cord (rat) RGD PMID:9814819 RGD:9831448 NCBI chr 7:129,184,786...129,300,815
Ensembl chr 7:141,701,430...141,705,623 		JBrowse link
G QKI QKI, KH domain containing RNA binding ISO RGD PMID:22740327 RGD:10045997 NCBI chr 6:161,361,413...161,523,414 JBrowse link
G RANGRF RAN guanine nucleotide release factor ISO RGD PMID:8557821 RGD:6771380 NCBI chr17:43,369,556...43,371,025
Ensembl chr17:48,101,744...48,103,394 		JBrowse link
G RHOA ras homolog family member A severity ISO protein:increased expression:microglial cell, brain RGD PMID:17983427 RGD:2298887 NCBI chr 3:49,282,009...49,339,887 JBrowse link
G SERPINE1 serpin family E member 1 ISO mRNA,protein:increased expression,increased activity:spinal cord, astrocyte: RGD PMID:11733372 RGD:13208549 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G SHH sonic hedgehog signaling molecule ISO RGD PMID:15892298 PMID:18991353 RGD:12801423 RGD:12801440 NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651 		JBrowse link
G SIGMAR1 sigma non-opioid intracellular receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30661753 NCBI chr 9:34,471,362...34,474,459 JBrowse link
G SIRT1 sirtuin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:23547115 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor treatment ISO RGD PMID:22436018 RGD:9999395 NCBI chr20:41,583,429...41,585,773
Ensembl chr20:42,673,417...42,675,773 		JBrowse link
G SNCB synuclein beta ISO RGD PMID:12496452 RGD:730073 NCBI chr 5:171,918,297...171,928,672
Ensembl chr 5:178,988,439...178,998,800 		JBrowse link
G SRSF9 serine and arginine rich splicing factor 9 treatment ISO RGD PMID:20616573 RGD:11040805 NCBI chr12:118,043,325...118,052,107
Ensembl chr12:121,417,557...121,425,708 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO RGD PMID:22066025 RGD:6483041 NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:17878325 PMID:22066025 RGD:6483041 RGD:6892946 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 ISO RGD PMID:11240014 RGD:7207888 NCBI chr2B:78,331,402...78,549,231
Ensembl chr2B:196,247,881...196,366,011 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO mRNA, protein:increased expression:central nervous system RGD PMID:17204936 RGD:2302088 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TGFB2 transforming growth factor beta 2 ISO mRNA, protein:decreased expression:central nervous system RGD PMID:17204936 RGD:2302088 NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO protein:increased expression:spinal cord RGD PMID:15878627 RGD:1559178 NCBI chr22:13,811,297...13,872,799
Ensembl chr22:31,662,562...31,723,964 		JBrowse link
G TLR2 toll like receptor 2 ISO protein:increased expression:spinal cord RGD PMID:18644848 RGD:2312575 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO protein:increased expression:spinal cord RGD PMID:18644848 RGD:2312575 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor treatment ISO RGD PMID:11421579 RGD:12904661 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO RGD PMID:12196270 RGD:1580348 NCBI chr 1:103,377,815...103,395,118
Ensembl chr 1:102,091,336...102,107,732 		JBrowse link
G VDR vitamin D receptor treatment ISO RGD PMID:21287548 PMID:21318047 RGD:13210791 RGD:8158064 NCBI chr12:40,828,413...40,891,700
Ensembl chr12:41,702,742...41,766,192 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO mRNA,protein:decreased expression:spinal cord:
mRNA:decreased expression:Cerebrospinal Fluid:		 RGD PMID:12387457 PMID:17083617 RGD:634258 RGD:7421596 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353 		JBrowse link
G VIP vasoactive intestinal peptide ISO RGD PMID:20978211 RGD:5685386 NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730 		JBrowse link
G XBP1 X-box binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30661753 NCBI chr22:9,863,479...9,869,491
Ensembl chr22:27,567,041...27,571,943 		JBrowse link
Acute Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAG myelin associated glycoprotein ISO protein:decreased expression:optic nerve RGD PMID:9820787 RGD:9685300 NCBI chr19:32,238,457...32,260,497
Ensembl chr19:40,975,763...40,997,401 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A disease_progression ISO RGD PMID:26320658 RGD:11534569 NCBI chr 1:36,743,341...36,753,261
Ensembl chr 1:38,093,917...38,103,556 		JBrowse link
Chronic Relapsing Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:spinal cord (rat) RGD PMID:12098510 RGD:8655962 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G NEFH neurofilament heavy chain ISO protein:decreased expression:spinal cord: RGD PMID:12742652 RGD:27226817 NCBI chr22:10,525,738...10,536,788 JBrowse link
G PLP1 proteolipid protein 1 ISO human sequence peptide in a mouse model; associated with Herpesviridae infections RGD PMID:12811845 RGD:30296670 NCBI chr  X:93,015,098...93,031,193
Ensembl chr  X:103,353,184...103,412,513 		JBrowse link
G SERPINE1 serpin family E member 1 ISO RGD PMID:17983428 RGD:13208507 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17996
    Animal Diseases 1270
      Animal Disease Models 1226
        Experimental Nervous System Autoimmune Disease 185
          Experimental Autoimmune Encephalomyelitis 158
            Acute Experimental Autoimmune Encephalomyelitis 2
            Chronic Relapsing Experimental Autoimmune Encephalomyelitis 4
Path 2
Term Annotations click to browse term
  disease 17996
    disease of anatomical entity 15260
      Immune & Inflammatory Diseases 5048
        immune system disease 4393
          primary immunodeficiency disease 3796
            autoimmune disease 2024
              autoimmune disease of the nervous system 557
                autoimmune disease of central nervous system 296
                  Demyelinating Autoimmune Diseases, CNS 289
                    Experimental Autoimmune Encephalomyelitis 158
                      Acute Experimental Autoimmune Encephalomyelitis 2
                      Chronic Relapsing Experimental Autoimmune Encephalomyelitis 4
paths to the root