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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Central Nervous System Bacterial Infections
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Accession:DOID:9002742 term browser browse the term
Definition:Bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces.
Synonyms:primary_id: MESH:D020806;   RDO:0005051

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bacterial meningitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase (Cartwright blood group) ISO RGD PMID:21303225 RGD:5688130 NCBI chrNW_004955573:79,606...85,799
Ensembl chrNW_004955573:80,298...85,799 		JBrowse link
G Bche butyrylcholinesterase ISO protein:increased expression:blood RGD PMID:21303225 RGD:5688130 NCBI chrNW_004955448:15,327,374...15,396,827
Ensembl chrNW_004955448:15,329,273...15,396,970 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO mRNA:decreased expression:hippocampus,cerebral cortex:
mRNA, protein:increased expression:hippocampus		 RGD PMID:16141791 PMID:22683802 RGD:5684920 RGD:8655554 NCBI chrNW_004955476:6,773,244...6,822,201
Ensembl chrNW_004955476:6,772,088...6,822,588 		JBrowse link
G Cd46 CD46 molecule ISO RGD PMID:16948860 RGD:6483465 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Chi3l1 chitinase 3 like 1 severity ISO protein:increased secretion:cerebrospinal fluid (human) RGD PMID:11986266 RGD:4892662 NCBI chrNW_004955406:39,195,101...39,201,808
Ensembl chrNW_004955406:39,191,073...39,202,020 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:10430840 RGD:8547971 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Ngf nerve growth factor ISO mRNA:decreased expression:hippocampus: RGD PMID:22683802 RGD:8655554 NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO mRNA, protein:increased expression:hippocampus RGD PMID:16141791 RGD:5684920 NCBI chrNW_004955432:2,284,283...2,629,631
Ensembl chrNW_004955432:2,288,898...2,630,878 		JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 susceptibility ISO DNA:snp:cds:p.V762A rs1136410 (human) RGD PMID:21651918 RGD:5683901 NCBI chrNW_004955489:520,875...557,609
Ensembl chrNW_004955489:520,875...557,615 		JBrowse link
G S100b S100 calcium binding protein B ISO protein:increased expression:cerebrospinal fluid RGD PMID:15105355 RGD:5508818 NCBI chrNW_004955407:42,972,584...42,980,510
Ensembl chrNW_004955407:42,972,584...42,980,510 		JBrowse link
Escherichia Coli Meningitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr2 toll like receptor 2 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
G Tlr4 toll like receptor 4 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tlr7 toll like receptor 7 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chrNW_004955544:424,897...443,562
Ensembl chrNW_004955544:424,850...443,564 		JBrowse link
Lyme Neuroborreliosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746 		JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 treatment ISO RGD PMID:24239846 RGD:39939054 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:23134838 RGD:7193053 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
Meningeal Tuberculosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4r interleukin 4 receptor ISO protein:decreased expression:serum RGD PMID:21251883 RGD:5128510 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422 		JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:10318940 RGD:10449456 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
meningococcal meningitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C9 complement C9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9570574 NCBI chrNW_004955426:23,790,792...23,824,117 JBrowse link
G Cd46 CD46 molecule ISO RGD PMID:12869763 RGD:6483466 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Cfp complement factor properdin ISO CTD Direct Evidence: marker/mechanism CTD PMID:8530058 PMID:10909851 NCBI chrNW_004955516:449,993...455,897
Ensembl chrNW_004955516:449,993...456,492 		JBrowse link
G Marco macrophage receptor with collagenous structure ISO protein:increased expression:sub-cortical, meninges, astrocyte RGD PMID:21299846 RGD:41412190 NCBI chrNW_004955459:10,700,645...10,739,222
Ensembl chrNW_004955459:10,698,294...10,739,131 		JBrowse link
G Mmp13 matrix metallopeptidase 13 ISO RGD PMID:10430840 RGD:8547971 NCBI chrNW_004955412:6,106,994...6,118,760
Ensembl chrNW_004955412:6,106,994...6,118,760 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:10430840 RGD:8547971 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 susceptibility ISO DNA:SNP,haplotype: :SNP8(human) RGD PMID:23691182 RGD:7800668 NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16597321 NCBI chrNW_004955453:14,980,562...14,995,118
Ensembl chrNW_004955453:14,980,562...14,995,608 		JBrowse link
G Tlr2 toll like receptor 2 susceptibility ISO DNA:haplotype: :2477G>A(rs5743708)(human) RGD PMID:23691182 RGD:7800668 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
G Tlr4 toll like receptor 4 susceptibility ISO DNA:SNP,haplotype: :896A>G(rs4986790)(human) RGD PMID:23691182 RGD:7800668 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
Neurosyphilis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl8 C-X-C motif chemokine ligand 8 treatment ISO RGD PMID:27650493 RGD:39939071 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643 		JBrowse link
G Nefl neurofilament light chain disease_progression ISO protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chrNW_004955403:47,946,413...47,951,734
Ensembl chrNW_004955403:47,946,353...47,952,026 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 disease_progression ISO protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697 		JBrowse link
Pneumococcal Meningitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 treatment ISO RGD PMID:24491581 RGD:13703038 NCBI chrNW_004955487:5,180,241...5,218,298
Ensembl chrNW_004955487:5,180,252...5,218,216 		JBrowse link
G Aqp4 aquaporin 4 treatment ISO protein:increased expression:brain: RGD PMID:15695511 RGD:8698660 NCBI chrNW_004955772:1,160...10,709
Ensembl chrNW_004955772:1,159...10,709 		JBrowse link
G Atm ATM serine/threonine kinase ameliorates ISO RGD PMID:15529270 RGD:126781748 NCBI chrNW_004955412:10,422,753...10,531,406
Ensembl chrNW_004955412:10,426,135...10,530,545 		JBrowse link
G Camp cathelicidin antimicrobial peptide ISO protein:increased expression:brain, coronal section (rat) RGD PMID:19879657 RGD:2316237 NCBI chrNW_004955420:24,911,920...24,914,698 JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 disease_progression ISO mRNA, protein:increased expression:brain (rat) RGD PMID:31933824 RGD:40903068 NCBI chrNW_004955557:1,667,518...1,702,272 JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 ISO mRNA, protein:increased expression:brain (rat) RGD PMID:31933824 RGD:40903068 NCBI chrNW_004955431:2,203,342...2,282,635
Ensembl chrNW_004955431:2,263,698...2,282,635 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:24844751 RGD:39939118 NCBI chrNW_004955536:2,944,770...2,955,829
Ensembl chrNW_004955536:2,943,611...2,955,829 		JBrowse link
G Il6 interleukin 6 treatment ISO protein:increased expression:brain RGD PMID:8943431 PMID:11581077 PMID:25443778 RGD:11060264 RGD:11062107 RGD:9831197 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Lgals3 galectin 3 ISO mRNA, protein:increased expression:brain RGD PMID:17706429 RGD:9685206 NCBI chrNW_004955409:8,448,120...8,452,437
Ensembl chrNW_004955409:8,447,774...8,452,438 		JBrowse link
G Lgals9 galectin 9 ISO RGD PMID:17706429 RGD:9685206 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
G Marco macrophage receptor with collagenous structure ISO protein:increased expression:meninges, astrocyte RGD PMID:21299846 RGD:41412190 NCBI chrNW_004955459:10,700,645...10,739,222
Ensembl chrNW_004955459:10,698,294...10,739,131 		JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO RGD PMID:24419461 RGD:8657111 NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO protein:increased expression:cerebrospinal fluid RGD PMID:17371820 PMID:24419461 RGD:1642043 RGD:8657111 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 ISO mRNA, protein:increased expression:brain RGD PMID:25443778 RGD:9831197 NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO mRNA:increased expression:brain RGD PMID:21603940 RGD:5684913 NCBI chrNW_004955432:2,284,283...2,629,631
Ensembl chrNW_004955432:2,288,898...2,630,878 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:brain, nucleus RGD PMID:25443778 RGD:9831197 NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516 		JBrowse link
G Serping1 serpin family G member 1 treatment ISO RGD PMID:17538891 RGD:8661645 NCBI chrNW_004955511:2,545,337...2,557,850
Ensembl chrNW_004955511:2,545,285...2,557,982 		JBrowse link
G Tlr2 toll like receptor 2 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
G Tlr4 toll like receptor 4 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tlr9 toll like receptor 9 ISO mRNA:increased expression: : RGD PMID:12781911 RGD:7794740 NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582 		JBrowse link
G Tnf tumor necrosis factor disease_progression ISO protein:increased expression:brain
mRNA:increased expression:brain (rat)		 RGD PMID:25443778 PMID:31933824 RGD:40903068 RGD:9831197 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
streptococcal meningitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Poldip2 DNA polymerase delta interacting protein 2 treatment ISO RGD PMID:32790044 RGD:124713556 NCBI chrNW_004955481:4,776,721...4,785,817
Ensembl chrNW_004955481:4,776,721...4,785,817 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease by infectious agent 1919
      Bacterial Infections and Mycoses 925
        bacterial infectious disease 733
          Central Nervous System Bacterial Infections 42
            Lyme Neuroborreliosis 4
            Neurosyphilis + 3
            bacterial meningitis + 36
            central nervous system tuberculosis + 2
Path 2
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13820
      nervous system disease 12088
        central nervous system disease 10855
          Central Nervous System Infections 246
            Central Nervous System Bacterial Infections 42
              Lyme Neuroborreliosis 4
              Neurosyphilis + 3
              bacterial meningitis + 36
              central nervous system tuberculosis + 2
paths to the root