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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:alcohol withdrawal syndrome
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Accession:DOID:9002735 term browser browse the term
Definition:The symptoms of this medical condition occur following a reduction in alcohol use after a period of excessive use and ranges from such minor symptoms as insomnia and tremulousness to severe complications such as withdrawal seizures and delirium tremens. Although the history and physical examination usually are sufficient to diagnose alcohol withdrawal syndrome, other conditions may present with similar symptoms.
Synonyms:exact_synonym: AWS


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alcohol withdrawal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmal1 basic helix-loop-helix ARNT like 1 severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Clock clock circadian regulator severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 ISO mRNA:decreased expression:Peripheral blood mononuclear cell (human) RGD PMID:20735373 RGD:401976556 NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 no_association
treatment		 ISO DNA:SNPs::CYP2C19*2 (681G>A,rs4244285), CYP2C19*3 (636G>A, rs4986893),CYP2C19*17 (-806C>T, rs12248560) (human)
DNA:SNP:promoter:CYP2C19*17 (-806C>T,rs12248560)(human)
DNA:SNP:cds:CYP2C19*2 (681G>A,rs4244285)(human)		 RGD PMID:27099220 PMID:30325732 PMID:31957548 RGD:401960863, RGD:401960882, RGD:401960880 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Drd4 dopamine receptor D4 severity ISO DNA:repeats:exon: RGD PMID:20359751 RGD:401959612 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 severity ISO DNA:SNPs,haplotypes:multiple RGD PMID:24603855 RGD:401976481 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IEP protein:altered expression:brain RGD PMID:26727528 PMID:31778691 RGD:405101372, RGD:405255665 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 IEP mRNA, protein:increased expression:hippocampus (rat) RGD PMID:12488536 RGD:402528882 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Ngf nerve growth factor ISO protein:increased expression:plasma RGD PMID:8727238 RGD:401976550 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 IEP mRNA:decreased expression:hippocampus, cerebral cortex (rat) RGD PMID:20028355 RGD:10448926 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Per1 period circadian regulator 1 severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Per2 period circadian regulator 2 severity ISO mRNA:decreased expression:Peripheral blood mononuclear cell (human) RGD PMID:20735373 RGD:401976556 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Prl prolactin treatment ISO RGD PMID:3816539 RGD:401960110 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
Alcohol Withdrawal Delirium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:11841893 RGD:1626329 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Ngf nerve growth factor ISO protein:increased expression:serum RGD PMID:17434673 RGD:401965399 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:16318954 RGD:5688289 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
Alcohol Withdrawal Seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium voltage-gated channel subunit alpha1 D susceptibility IEP mRNA, protein:increased expression:inferior colliculus (rat) RGD PMID:25556199 RGD:152985539 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Drd2 dopamine receptor D2 susceptibility ISO DNA:SNP:exon:A>G(human) RGD PMID:23238469 RGD:401959213 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Pdyn prodynorphin ISO mRNA:increased expression:brain RGD PMID:15869750 RGD:401850576 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21283641 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    Chemically-Induced Disorders 1385
      substance-related disorder 702
        withdrawal disorder 96
          alcohol withdrawal syndrome 21
            Alcohol Withdrawal Delirium 4
            Alcohol Withdrawal Seizures 5
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18212
      nervous system disease 14060
        central nervous system disease 12399
          brain disease 11634
            disease of mental health 8301
              substance-related disorder 702
                Alcohol-Related Disorders 398
                  alcohol withdrawal syndrome 21
                    Alcohol Withdrawal Delirium 4
                    Alcohol Withdrawal Seizures 5
paths to the root