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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Periapical Diseases
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Accession:DOID:9002699 term browser browse the term
Definition:Diseases of the PERIAPICAL TISSUE surrounding the root of the tooth, which is distinguished from DENTAL PULP DISEASES inside the TOOTH ROOT.
Synonyms:exact_synonym: Periapical Disease
 primary_id: MESH:D010483;   RDO:0006316
For additional species annotation, visit the Alliance of Genome Resources.


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Periapical Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:20113782 RGD:8661683 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,744...46,360,940
Ensembl chr 3:46,353,744...46,360,940
Ensembl chr 3:46,353,744...46,360,940
JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:23829599 RGD:9491793 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
JBrowse link
G PDGFB platelet derived growth factor subunit B ISO RGD PMID:17509411 RGD:10449488 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO RGD PMID:21793936 RGD:7205516 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885
JBrowse link
periapical granuloma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL7 C-C motif chemokine ligand 7 IEP protein:increased expression:periodontal ligament RGD PMID:20646081 RGD:6483772 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
JBrowse link
G CCR2 C-C motif chemokine receptor 2 IEP mRNA:increased expression:gingiva: RGD PMID:16101967 RGD:8661719 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,744...46,360,940
Ensembl chr 3:46,353,744...46,360,940
Ensembl chr 3:46,353,744...46,360,940
JBrowse link
G CCR3 C-C motif chemokine receptor 3 IEP RGD PMID:11683586 RGD:6893426 NCBI chr 3:46,210,699...46,266,706
Ensembl chr 3:46,163,604...46,266,706
Ensembl chr 3:46,163,604...46,266,706
JBrowse link
periapical periodontitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:24631631 RGD:8661717 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL7 C-C motif chemokine ligand 7 disease_progression IEP protein:increased expression:periodontal ligament RGD PMID:20646081 RGD:6483772 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:24631631 RGD:8661717 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,744...46,360,940
Ensembl chr 3:46,353,744...46,360,940
Ensembl chr 3:46,353,744...46,360,940
JBrowse link
G CIITA class II major histocompatibility complex transactivator ISO RGD PMID:20478458 RGD:7242892 NCBI chr16:10,866,208...10,941,562
Ensembl chr16:10,866,222...10,943,021
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:22341067 RGD:7257692 NCBI chr 2:218,125,294...218,137,253
Ensembl chr 2:218,125,289...218,137,251
JBrowse link
G FGF2 fibroblast growth factor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16631837 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G IL17A interleukin 17A ISO protein:increased expression:Periapical Tissue RGD PMID:19166776 RGD:4832829 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b treatment ISO Lactobacillus acidophilus RGD PMID:32436602 RGD:42721981 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885
JBrowse link
Radicular Cyst term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL7 C-C motif chemokine ligand 7 IEP protein:increased expression:periodontal ligament RGD PMID:20646081 RGD:6483772 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
JBrowse link
suppurative periapical periodontitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELANE elastase, neutrophil expressed ISO protein:increased expression:neutrophil: RGD PMID:19913217 RGD:10450566 NCBI chr19:850,997...856,250
Ensembl chr19:851,014...856,247
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19905
    Stomatognathic Diseases 1005
      Jaw Diseases 304
        Periapical Diseases 12
          Radicular Cyst 1
          periapical periodontitis + 10
Path 2
Term Annotations click to browse term
  disease 19905
    disease of anatomical entity 18516
      nervous system disease 14515
        sensory system disease 5854
          mouth disease 779
            tooth disease 299
              periodontal disease 115
                Periapical Diseases 12
                  Radicular Cyst 1
                  periapical periodontitis + 10
paths to the root