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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Periapical Diseases
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Accession:DOID:9002699 term browser browse the term
Definition:Diseases of the PERIAPICAL TISSUE surrounding the root of the tooth, which is distinguished from DENTAL PULP DISEASES inside the TOOTH ROOT.
Synonyms:exact_synonym: Periapical Disease
 primary_id: MESH:D010483;   RDO:0006316
For additional species annotation, visit the Alliance of Genome Resources.


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Periapical Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 ISO RGD PMID:20113782 RGD:8661683 NCBI chrNW_004955420:25,641,184...25,664,413 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:23829599 RGD:9491793 NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711
JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO RGD PMID:17509411 RGD:10449488 NCBI chrNW_004955413:25,150,702...25,166,987
Ensembl chrNW_004955413:25,148,062...25,166,987
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11b ISO RGD PMID:21793936 RGD:7205516 NCBI chrNW_004955417:24,804,708...24,831,338
Ensembl chrNW_004955417:24,804,664...24,831,894
JBrowse link
periapical granuloma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:gingiva: RGD PMID:16101967 RGD:8661719 NCBI chrNW_004955420:25,641,184...25,664,413 JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO RGD PMID:11683586 RGD:6893426 NCBI chrNW_004955420:25,702,917...25,723,269
Ensembl chrNW_004955420:25,701,407...25,723,353
JBrowse link
periapical periodontitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 ISO RGD PMID:24631631 RGD:8661717 NCBI chrNW_004955420:25,641,184...25,664,413 JBrowse link
G Ciita class II major histocompatibility complex transactivator ISO RGD PMID:20478458 RGD:7242892 NCBI chrNW_004955442:7,600,903...7,647,619
Ensembl chrNW_004955442:7,603,893...7,647,624
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16631837 NCBI chrNW_004955428:17,840,554...17,894,779
Ensembl chrNW_004955428:17,840,628...17,894,773
JBrowse link
G Il17a interleukin 17A ISO protein:increased expression:Periapical Tissue RGD PMID:19166776 RGD:4832829 NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11b treatment ISO Lactobacillus acidophilus RGD PMID:32436602 RGD:42721981 NCBI chrNW_004955417:24,804,708...24,831,338
Ensembl chrNW_004955417:24,804,664...24,831,894
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12565
    Stomatognathic Diseases 876
      Jaw Diseases 270
        Periapical Diseases 8
          Radicular Cyst 0
          periapical periodontitis + 6
Path 2
Term Annotations click to browse term
  disease 12565
    disease of anatomical entity 12245
      nervous system disease 10176
        sensory system disease 4694
          mouth disease 669
            tooth disease 260
              periodontal disease 97
                Periapical Diseases 8
                  Radicular Cyst 0
                  periapical periodontitis + 6
paths to the root