Diabetes Complications - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Diabetes Complications	go back to main search page
Accession:	DOID:9002661	browse the term
Definition:	Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Synonyms:	exact_synonym:	Complications of Diabetes Mellitus; Diabetes Complication; Diabetes Mellitus Complication; Diabetes Mellitus Complications; Diabetes Related Complications; Diabetes-Related Complication; Diabetic Complication; Diabetic Complications
	primary_id:	MESH:D048909; RDO:0001421

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Rat (539) Mouse (525) Human (3562) Chinchilla (455) Bonobo (488) Dog (493) Squirrel (466) Pig (483) Green Monkey (480) Naked Mole-rat (445) All
Genes (525) QTL (6) Strains (8)

Diabetes Complications

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

CTD Direct Evidence: marker/mechanism

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

aldo-keto reductase family 1 member B1

CTD Direct Evidence: marker/mechanism

PMID:25304492 PMID:25541468

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldehyde dehydrogenase 2 family member

CTD Direct Evidence: therapeutic

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

bradykinin receptor B1

RGD

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

RGD

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

caspase 9

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cytochrome P450, subfamily 2, polypeptide 11

RGD

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

Associated with obesity

RGD

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

G

ghrelin and obestatin prepropeptide

protein: decreased expression: serum

RGD

NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621

G

glyoxalase 1

no_association

DNA:SNP: :419C>A (human)

RGD

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

histone deacetylase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

G

hypoxia inducible factor 1 subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

haptoglobin

CTD Direct Evidence: marker/mechanism

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

microRNA 126a

associated with type 1 diabetes mellitus;

RGD

NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180

G

microRNA 140

CTD Direct Evidence: marker/mechanism

NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675

G

microRNA 26a

CTD Direct Evidence: marker/mechanism

NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378

G

mucin 1, cell surface associated

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

nuclear receptor subfamily 0, group B, member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

phospholamban

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:diaphragm

RGD

NCBI chr20:32,629,537...32,639,559

G

paraoxonase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

protein kinase AMP-activated catalytic subunit alpha 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

solute carrier family 10 member 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475

G

solute carrier family 51 member A

CTD Direct Evidence: marker/mechanism

NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485

G

SLC51 subunit beta

CTD Direct Evidence: marker/mechanism

NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145

G

solute carrier family 9 member A1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

background diabetic retinopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

treatment

RGD

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

catalase

associated withDiabetes Mellitus, Type 2; mRNA,protein:decreased expression, decreased activity:blood,l serum:

RGD

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Fms related receptor tyrosine kinase 1

protein:decreased expression:aqueous humor:

RGD

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

mitogen-activated protein kinase kinase kinase 8

protein:increased activity:serum:

RGD

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

platelet derived growth factor subunit B

protein:decreased expression:vitreous:

RGD

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

chromosome 17q11.2 deletion syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ring finger protein 135

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Chromosome 17q11.2 deletion syndrome, 1.4Mb | ClinVar Annotator: match by term: Macrocephaly, macrosomia, facial dysmorphism syndrome

PMID:17632510 PMID:21681106 PMID:25741868 PMID:27535533 PMID:28135719 More...

NCBI chr10:65,170,560...65,189,791
Ensembl chr10:65,170,560...65,262,804

Cleft Palate, Proliferative Retinopathy, and Developmental Delay

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

leucine rich repeat containing 32

ClinVar Annotator: match by term: Cleft palate, proliferative retinopathy, and developmental delay

PMID:25741868 PMID:30976112

NCBI chr 1:152,785,709...152,802,997
Ensembl chr 1:152,786,511...152,798,373

diabetic angiopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 3

PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More...

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

adenylate cyclase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686

G

adenylate cyclase 8

CTD Direct Evidence: marker/mechanism

NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911

G

advanced glycosylation end product-specific receptor

CTD Direct Evidence: marker/mechanism

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

albumin

CTD Direct Evidence: marker/mechanism

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

argininosuccinate synthase 1

CTD Direct Evidence: therapeutic

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

bradykinin receptor B1

RGD

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

caspase 3

CTD Direct Evidence: marker/mechanism

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

C-C motif chemokine ligand 2

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

Cd28 molecule

associated with Diabetes Mellitus, Insulin-Dependent;protein:decreased expression:T cell

RGD

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

CD40 ligand

protein:increased expression:serum

RGD

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

cAMP responsive element modulator

CTD Direct Evidence: marker/mechanism

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

C-X-C motif chemokine ligand 12

susceptibility

associated with Diabetic Foot;DNA:polymorphism:3' utr (human)

RGD

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

erythropoietin

ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 2

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

coagulation factor III, tissue factor

associated with Diabetes Mellitus, Non-Insulin-Dependent
protein:increased expression:plasma

RGD

PMID:16371118 PMID:9285207

RGD:2313861, RGD:2313868

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

Fas cell surface death receptor

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

associated with Diabetes Mellitus, Non-Insulin-Dependent
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25381014 PMID:15803113

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibronectin 1

RGD

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

GTP cyclohydrolase 1

associated with type 2 diabetes mellitus;DNA:SNV: :C59038T (human)

RGD

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

G

glycoprotein Ib platelet subunit alpha

RGD

NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774

G

glutathione peroxidase 1

cardiovascular complications in type 2 diabetics

RGD

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

cardiovascular complications in type 2 diabetics

RGD

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

homeostatic iron regulator

ClinVar Annotator: match by term: MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 7 | ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 7

PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More...

NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502

G

heme oxygenase 1

CTD Direct Evidence: therapeutic

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

haptoglobin

CTD Direct Evidence: marker/mechanism

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

intercellular adhesion molecule 1

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;mRNA:increased expression:aorta

RGD

PMID:18796303 PMID:18093596

RGD:2313473, RGD:2306988

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

insulin-like growth factor binding protein 1

DNA:SNPs

RGD

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

interleukin 1 receptor antagonist

ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 4

PMID:25741868 PMID:28492532

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

integrin subunit alpha M

protein:increased expression:neutrophil (human)

RGD

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

matrix metallopeptidase 14

RGD

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

nitric oxide synthase 2

associated with Diabetes Mellitus, Experimental; protein:increased expression:cochlea

RGD

PMID:19241604 PMID:19587355

RGD:4891384, RGD:2313210

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

treatment

associated with Diabetes Mellitus, Experimental; protein:increased expression:cochlea
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12124201 PMID:19241604 PMID:29329611

RGD:4891384, RGD:13504708

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

platelet and endothelial cell adhesion molecule 1

associated with Diabetes Mellitus, Experimental;protein:increased tyrosine phosphorylation:conceptus

RGD

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

plasminogen activator, tissue type

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

paraoxonase 1

associated with Diabetes Mellitus;DNA:polymorphisms: p.L55M, p.Q192R (human)
ClinVar Annotator: match by term: RETINOPATHY, DIABETIC, SUSCEPTIBILITY TO

PMID:9011577 PMID:9661650 PMID:11335891 PMID:11788650 PMID:11889198 More...

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

protein tyrosine kinase 2 beta

treatment

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282

G

retinol binding protein 4

disease_progression

protein:increased expression:blood serum (human)

RGD

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RT1 class II, locus Db1

susceptibility

associated with Diabetes Mellitus Type 1;DNA:polymorphism: :HLA-DRB1*03:01(human)

RGD

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

serpin family E member 1

susceptibility

associated with Diabetes Mellitus, Type 2;DNA:deletion, haplotype:promoter:g.-676_-674delG (human)

RGD

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serpin family F member 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

superoxide dismutase 1

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

ClinVar Annotator: match by term: SUPEROXIDE DISMUTASE 2 POLYMORPHISM

PMID:8633092 PMID:10425186 PMID:12624725 PMID:15591282 PMID:16538174 More...

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted protein acidic and cysteine rich

associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:mesentery, blood vessel

RGD

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

thrombospondin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thrombospondin 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

tumor necrosis factor

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:c.-308G>A (human)

RGD

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

protein:increased expression:cochlea:
ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 1

OMIM
ClinVar
RGD

PMID:11978667 PMID:19241604

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Diabetic Cardiomyopathies

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

angiotensin I converting enzyme

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acyl-CoA thioesterase 1

associated with type 2 diabetes mellitus

RGD

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

adiponectin, C1Q and collagen domain containing

associated with Diabetes Mellitus, Type2;mRNA, protein:decreased expression:heart, serum

RGD

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adiponectin receptor 1

associated with Diabetes Mellitus, Type2;mRNA, protein:decreased expression:heart, serum

RGD

NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241

G

advanced glycosylation end product-specific receptor

treatment

associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:heart (rat)

RGD

PMID:23251674 PMID:23251674

RGD:7244283, RGD:7244283

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

angiotensinogen

CTD Direct Evidence: marker/mechanism

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 2

CTD Direct Evidence: marker/mechanism

PMID:15587404 PMID:16025228

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

AKT serine/threonine kinase 1

ameliorates

RGD

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

apolipoprotein A1

CTD Direct Evidence: therapeutic

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

activating transcription factor 6

ameliorates

RGD

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16685413 PMID:21441944

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATPase copper transporting alpha

treatment

RGD

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

BCL2-associated agonist of cell death

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

ameliorates

RGD

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

treatment

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:increased phosphorylation:myocardium (mouse)

RGD

PMID:21296063 PMID:21474815

RGD:10053697, RGD:11522727

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 12

treatment

associated with Experimental Diabetes Mellitus

RGD

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

treatment

RGD

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

treatment

RGD

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

treatment

RGD

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calsequestrin 2

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267

G

calcium-sensing receptor

protein:decreased expression:myocardium (rat)

RGD

NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811

G

cofilin 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

catenin beta 1

mRNA,protein:increased expression:heart

RGD

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

DNA-damage inducible transcript 3

ameliorates

RGD

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

erb-b2 receptor tyrosine kinase 2

associated with Diabetes Mellitus, Experimental;mRNA:decreased expresssion:left ventricle myocardium

RGD

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 4

associated with Diabetes Mellitus, Experimental;mRNA:decreased expresssion:left ventricle myocardium

RGD

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

H19 imprinted maternally expressed transcript

ameliorates

RGD

PMID:27796346 PMID:27903964 PMID:36044268

RGD:156430325, RGD:156451660, RGD:156430337

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

heme oxygenase 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

PMID:23853776 PMID:23453443

RGD:9586347, RGD:10412713

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein 90 beta family member 1

ameliorates

RGD

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 5

ameliorates

RGD

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

insulin-like growth factor 1

CTD Direct Evidence: therapeutic

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2 receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

interleukin 10

treatment

RGD

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

insulin 1

CTD Direct Evidence: therapeutic

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

CTD Direct Evidence: therapeutic

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

kallikrein 1

CTD Direct Evidence: therapeutic

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

leptin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

mitogen activated protein kinase kinase kinase 7

associated with type 2 diabetes mellitus;protein:decreased expression:myocardium of ventricle (rat)

RGD

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

mitogen activated protein kinase 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microRNA 140

ameliorates

RGD

PMID:36044268 PMID:31078585

RGD:156430337, RGD:329347833

NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675

G

mechanistic target of rapamycin kinase

ameliorates

RGD

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

myosin light chain kinase 2

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 3:141,376,450...141,388,357
Ensembl chr 3:141,376,691...141,387,728

G

NFE2 like bZIP transcription factor 2

treatment
ameliorates

associated with Diabetes Mellitus, Experimental

RGD

PMID:23453443 PMID:36044268 PMID:23353773

RGD:10412713, RGD:156430337, RGD:10412721

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 3

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 1

treatment

RGD

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

natriuretic peptide A

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

neuregulin 1

treatment

associated with Diabetes Mellitus, Experimental;protein:decreased expresssion:left ventricle myocardium

RGD

PMID:22285193 PMID:32828943

RGD:10449013, RGD:405650202

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

ameliorates

RGD

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phospholamban

associated with Diabetes Mellitus, Experimental;protein:increased expression:heart left ventricle

RGD

NCBI chr20:32,629,537...32,639,559

G

peroxisome proliferator activated receptor alpha

Strain: ZDF

RGD

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

ryanodine receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

G

solute carrier family 25 member 4

CTD Direct Evidence: therapeutic

NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733

G

solute carrier family 8 member A1

treatment

RGD

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

secreted phosphoprotein 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

telomerase reverse transcriptase

treatment

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

xanthine dehydrogenase

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

diabetic cataract

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione-disulfide reductase

RGD

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

Diabetic Cystopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor, mitochondria associated 1

protein:increased expression:nuclei:

RGD

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

BCL2-associated agonist of cell death

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

caspase 12

associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:urinary bladder detrusor smooth muscle

RGD

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

Diabetic Embryopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fas associated via death domain

RGD

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

diabetic encephalopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

advanced glycosylation end product-specific receptor

treatment

associated with Diabetes Mellitus, Experimental

RGD

PMID:23529380 PMID:24291733

RGD:7244255, RGD:8553040

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

amyloid beta precursor protein

treatment

associated with type 2 diabetes mellitus

RGD

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

dual specificity phosphatase 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr10:16,680,478...16,683,275

G

glycogen synthase kinase 3 beta

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

insulin degrading enzyme

associated with type 2 diabetes mellitus

RGD

NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440

G

nerve growth factor

treatment

associated with Diabetes Mellitus, Experimental
associated with Experimental Diabetes Mellitus

RGD

PMID:23528019 PMID:32681844

RGD:7242845, RGD:402463968

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nerve growth factor receptor

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

peroxisome proliferator-activated receptor gamma

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

Diabetic Foot

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

protein:decreased expression:plasma

RGD

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

advanced glycosylation end product-specific receptor

associated with Diabetes Mellitus, Type 2;protein:decreased expression:blood

RGD

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

C-reactive protein

disease_progression

protein:increased expression:blood:

RGD

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

gap junction protein, alpha 1

protein:increased expression:dermis

RGD

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

H19 imprinted maternally expressed transcript

ameliorates

RNA:increased expression:foot (human)

RGD

PMID:33174326 PMID:33174326

RGD:156451663, RGD:156451663

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

hypoxia inducible factor 1 subunit alpha

mRNA,protein:decreased expression:blood serum, foot (human)

RGD

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heat shock protein family A (Hsp70) member 1B

severity

DNA:polymorphism: :1538G>A (human)

RGD

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

insulin-like growth factor 1

protein:decreased expression:fibroblast of dermis,stratum basale of epidermis:

RGD

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 15

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:dermis, endothelial cell

RGD

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

integrin subunit alpha M

protein:increased expression:pes (human)

RGD

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

mannose binding lectin 2

protein:increased expression:serum:

RGD

NCBI chr 1:228,016,439...228,024,736

G

microRNA 17

NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712

G

microRNA 210

miRNA:increased expression:blood serum, foot (human)

RGD

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

G

matrix metallopeptidase 9

severity

RGD

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

notch receptor 1

protein:increased expression:skin, epidermis:

RGD

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

plasminogen activator, tissue type

RGD

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

pentraxin 3

protein:decreased expression:plasma (human)

RGD

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

toll-like receptor 4

susceptibility

DNA:SNPs,haplotype: :rs4986790,rs4986791,rs10759931,rs1927911(human);

RGD

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

diabetic ketoacidosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aquaporin 2

RGD

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

insulin 2

CTD Direct Evidence: therapeutic

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

insulin receptor

RGD

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

paired box 4

ClinVar Annotator: match by term: Diabetes mellitus, ketosis-prone | ClinVar Annotator: match by term: Diabetes mellitus, ketosis-prone, susceptibility to

PMID:9536098 PMID:15509590 PMID:17576681 PMID:18414213 PMID:25741868 More...

NCBI chr 4:57,058,453...57,065,995
Ensembl chr 4:57,058,462...57,063,408

G

serpin family A member 7

protein:decreased expression:serum

RGD

NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040

Diabetic Nephropathies

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

treatment
no_association
susceptibility

CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:insertion/deletion
associated with Diabetes Mellitus, Type 1;DNA:insertion/deletion
associated with Diabetes Mellitus, Type 1;DNA:deletion:intron:IVS16+1464-1751del (human)

CTD
RGD

PMID:7909524 PMID:10099885 PMID:10857950 PMID:23733546 PMID:28468961 More...

RGD:2311449, RGD:11039044, RGD:8548885, RGD:8548872, RGD:7829780, RGD:7829777, RGD:1331525

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

no_association

associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphisms: :multiple (human)
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Diabetes Mellitus, Non-Insulin Dependent;mRNA, protein:decreased expression:kidney
mRNA, protein:altered expression:kidney
associated with Diabetes Mellitus, Experimental

CTD
RGD

PMID:12623933 PMID:17600118 PMID:20844835 PMID:18235039 PMID:19034303 More...

RGD:2313800, RGD:2313797, RGD:2313796, RGD:2313800

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

actinin, alpha 1

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251

G

activin A receptor type 1

associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:kidney

RGD

NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241

G

adiponectin, C1Q and collagen domain containing

disease_progression
no_association

protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum
associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs1501299 (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs2241766 (human)

CTD
RGD

PMID:17942768 PMID:21945031 PMID:17970779 PMID:23260797 PMID:23260797

RGD:5686409, RGD:8694475, RGD:8694443, RGD:8694443

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adenosine A1 receptor

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adrenoceptor alpha 2B

associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism (human)

RGD

NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355

G

adrenoceptor beta 3

associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.W64R rs4994 (human)

RGD

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

advanced glycosylation end product-specific receptor

susceptibility
treatment

associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney cortex, glomerulus
associated with Diabetes Mellitus, Type 2;protein:increased expression:renal cortex (mouse)
associated with Diabetes Mellitus, Type 2;DNA:polymorphism: :1704G>T (human)
associated with Diabetes Mellitus;DNA:polymorphisms, haplotype:cds, intron:p.G82S, g.2184A>G (rs2070600, rs3134940) (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum

RGD

PMID:19142024 PMID:12651605 PMID:14747204 PMID:21533139 PMID:23091285 More...

RGD:2325651, RGD:7243248, RGD:8695982, RGD:7244187, RGD:7244174, RGD:7243852, RGD:7243248

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

angiotensinogen

disease_progression
no_association

CTD Direct Evidence: therapeutic
associated with Diabetes Mellitus, Type 2;DNA:polymorphism: :p.M235T (human)
associated with Diabetes Mellitus, Type 1;DNA:polymorphism: :p.M235T (human)

CTD
RGD

PMID:17890855 PMID:20383342 PMID:15118671 PMID:19014923 PMID:11938025 More...

RGD:1331525, RGD:11039058, RGD:8548885, RGD:8548872, RGD:8548868

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:polymorphism: :1166A>C (human)

RGD

PMID:12172324 PMID:12476891

RGD:6903861, RGD:8548891

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 2

associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:kidney

RGD

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

alpha-2-HS-glycoprotein

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum

RGD

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

aldo-keto reductase family 1 member B1

susceptibility

associated with Diabetes Mellitus, Type 1;DNA:promoter:repeat:g.?(AC)n (human)

RGD

PMID:9215310 PMID:9000706

RGD:734542, RGD:8548641

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

albumin

associated with Metabolic Syndrome X;protein:increased expression:urine
CTD Direct Evidence: therapeutic
associated with Diabetes Mellitus, Experimental;protein:increased expression:urine
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine

CTD
RGD

PMID:16380483 PMID:19424163 PMID:21441310 PMID:19397971 PMID:19246226

RGD:2306882, RGD:5135032, RGD:2306885, RGD:2306886

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

alpha-kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157

G

amine oxidase, copper containing 3

CTD Direct Evidence: marker/mechanism

NCBI chr10:86,272,757...86,280,702

G

apolipoprotein A1

RGD

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein A2

associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:serum

RGD

PMID:11126402 PMID:9829487

RGD:2313958, RGD:2313960

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

apolipoprotein B

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein C1

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:very-low-density lipoprotein particle

RGD

NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375

G

apolipoprotein C3

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-455T>C

RGD

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

apolipoprotein E

susceptibility
no_association

DNA:missense mutations, haplotype:cds:p.C112R, p.R158C (human)
associated with Diabetes Mellitus, type 1;
associated with Diabetes Mellitus, Experimental

RGD

PMID:21127830 PMID:11495633 PMID:22859852

RGD:6903840, RGD:7771553, RGD:6902935

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein H

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum

RGD

NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329

G

aquaporin 2

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased secretion:urine

RGD

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

arginase 2

RGD

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

agouti signaling protein

CTD Direct Evidence: marker/mechanism

NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171

G

ATP synthase F1 subunit beta

treatment

mRNA:decreased expression:renal glomerulus (rat)

RGD

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

Axl receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12644472 PMID:15619028

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

antizyme inhibitor 1

treatment

RGD

NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578

G

bradykinin receptor B2

susceptibility

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

brain-derived neurotrophic factor

RGD

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

protein:increased expression:kidney

RGD

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

associated with Diabetes Mellitus, Type2; protein:increased expression:serum:

RGD

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

bone morphogenetic protein 7

RGD

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

complement C3

associated with Diabetes Mellitus, Type 1; protein:increased expression:kidney:
associated with Diabetes Mellitus, Type 2

RGD

PMID:19200691 PMID:25662584

RGD:7183082, RGD:11040807

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C5

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

calcium voltage-gated channel subunit alpha1 B

treatment

RGD

NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091

G

calpain 10

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494

G

caspase 12

associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney

RGD

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

treatment

associated with Diabetes Mellitus, Experimental;protein:increased activity:kidney
associated with Diabetes Mellitus, Experimental
associated with type 2 diabetes mellitus

RGD

PMID:19601660 PMID:29606028 PMID:28456626

RGD:2311440, RGD:13792586, RGD:13782304

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

treatment

associated with type 2 diabetes mellitus

RGD

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

treatment

associated with type 2 diabetes mellitus
associated with Diabetes Mellitus, Experimental

RGD

PMID:28456626 PMID:29606028

RGD:13782304, RGD:13792586

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

treatment

associated with Diabetes Mellitus, Experimental

RGD

PMID:30038056 PMID:29606028

RGD:13782342, RGD:13792586

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

ISO
IMP
IDA
IEP

rat gene in db/db mice
associated with experimentally induced diabetes

RGD

PMID:22315314 PMID:20299359 PMID:21525431 PMID:21686137

RGD:7205651, RGD:7205676, RGD:7205665, RGD:7205662

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

C-C motif chemokine ligand 11

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 2

susceptibility
disease_progression

associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney
protein:increased expression:urine
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine
associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA:increased expression:kidney

CTD
RGD

PMID:16374426 PMID:17968528 PMID:19369290 PMID:19409809 PMID:19097668 More...

RGD:2306991, RGD:2306980, RGD:2306979, RGD:2306982, RGD:2306989

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 5

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-28C>G
associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:urine

RGD

PMID:12610055 PMID:18326229

RGD:2307107, RGD:2307063

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 2

associated with Diabetes Mellitus, Experimental; protein:increased expression:kidney, glomerulus (rat)
associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:kidney (rat)

RGD

PMID:19895808 PMID:19065061

RGD:2314366, RGD:2314604

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin E1

protein:increased expression:kidney

RGD

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

C-C motif chemokine receptor 2

no_association

associated with Diabetes Mellitus, Insulin-Dependent
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.V64I (human)

RGD

PMID:17631861 PMID:11756347

RGD:2313558, RGD:2313563

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 5

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:59029G>A (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP: :59029G>A (human)

RGD

PMID:12610055 PMID:17428349

RGD:2307107, RGD:8549756

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

CD36 molecule

protein:increased expression:renal proximal tubule, endothelial cell

RGD

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD38 molecule

associated with Diabetes Mellitus, Experimental

RGD

PMID:19073639 PMID:19300526

RGD:2307227, RGD:2307228

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

CD40 ligand

associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:serum

RGD

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

cyclin-dependent kinase inhibitor 1A

CTD Direct Evidence: marker/mechanism

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

mRNA, protein:increased expression:kidney, glomerulus

RGD

PMID:15698433 PMID:16805985

RGD:2293628, RGD:2293619

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cofilin 1

associated with Diabetes Mellitus, Experimental;protein:increased phosphorylation:renal glomerulus (rat)

RGD

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

clusterin

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

carnosine dipeptidase 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17942768 PMID:21393041 PMID:21573905 PMID:21393041

NCBI chr18:77,984,886...78,030,837
Ensembl chr18:77,984,907...78,007,765

G

carnosine dipeptidase 2

CTD Direct Evidence: marker/mechanism

NCBI chr18:78,039,924...78,057,030
Ensembl chr18:78,039,932...78,056,922

G

collagen type I alpha 1 chain

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:renal glomerulus (rat)

RGD

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type IV alpha 1 chain

associated with Diabetes Mellitus, Non-Insulin Dependent;mRNA:increased expression:kidney
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental

CTD
RGD

PMID:18682491 PMID:27997345 PMID:19466391 PMID:17582205

RGD:2311340, RGD:2311342

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type VI alpha 3 chain

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471

G

carboxypeptidase B2

susceptibility

DNA:SNP:cds:1040C>T(human)
protein:increased expression:plasma

RGD

PMID:22932273 PMID:12574207

RGD:7243116, RGD:7243123

NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556

G

cAMP responsive element binding protein 1

susceptibility

RGD

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

C-reactive protein

disease_progression

associated with Diabetes Mellitus, Type 1
associated with Diabetes Mellitus, Type 2;protein:increased expression:urine

RGD

PMID:22885250 PMID:22590912

RGD:6906965, RGD:6906967

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 1 receptor

disease_progression

associated with Diabetes Mellitus, Type 2
mRNA,protein:increased expression:kidney (rat)

RGD

PMID:19466391 PMID:32141565

RGD:2311340, RGD:151665767

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cystatin C

protein:increased expression:plasma (rat)
protein:increased expression:serum (human)

RGD

PMID:18946178 PMID:19132849

RGD:2314297, RGD:2314328

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

G

cytotoxic T-lymphocyte-associated protein 4

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:plasma:

RGD

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

cathepsin D

CTD Direct Evidence: marker/mechanism

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cubilin

RGD

NCBI chr17:76,385,046...76,593,133
Ensembl chr17:76,385,060...76,593,231

G

C-X-C motif chemokine ligand 10

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
associated with Diabetes Mellitus, Insulin-Dependent

RGD

PMID:17425653 PMID:19073786

RGD:2311359, RGD:2311357

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine receptor 2

treatment

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

cytochrome b-245 alpha chain

associated with Diabetes Mellitus, Type 2;DNA:SNP: :242C>T (human)

RGD

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450, family 11, subfamily b, polypeptide 2

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-344C>T (human)

RGD

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 11, subfamily b, polypeptide 3

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-344C>T (human)

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 19, subfamily a, polypeptide 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 2, subfamily j, polypeptide 4

associated with Diabetes Mellitus, Experimental;

RGD

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

decorin

associated with Diabetes Mellitus, Insulin-Dependent
protein:increased expression:plasma, urine
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Insulin-Dependent;mRNA, protein:decreased expression:kidney cortex, glomerulus

RGD

PMID:12187087 PMID:11259366 PMID:17884968 PMID:16868749

RGD:2311415, RGD:2311416, RGD:2311411, RGD:2311412

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

diacylglycerol kinase, eta

CTD Direct Evidence: marker/mechanism

NCBI chr15:53,981,079...54,150,470
Ensembl chr15:53,991,481...54,150,706

G

dickkopf WNT signaling pathway inhibitor 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

endothelin 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased secretion:plasma (human)

RGD

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

epidermal growth factor

RGD

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

engulfment and cell motility 1

CTD Direct Evidence: marker/mechanism

NCBI chr17:44,286,495...44,822,668
Ensembl chr17:44,286,485...44,822,788

G

endoglin

associated with Diabetes Mellitus, Insulin-Dependent; mRNA:increased expression:kidney

RGD

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

glutamyl aminopeptidase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

RGD

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

G

E1A binding protein p300

treatment

associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:kidney (rat)

RGD

PMID:19268536 PMID:19268536

RGD:2311716, RGD:2311716

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

endothelial PAS domain protein 1

treatment

associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental

RGD

PMID:17967803 PMID:17914354

RGD:10395374, RGD:10395377

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

epoxide hydrolase 2

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

erythropoietin

associated with Diabetes Mellitus, Experimental;
DNA:snp:promoter:-1125T>G(rs1617640)(human)

RGD

PMID:19619913 PMID:19356735 PMID:18458324

RGD:2313832, RGD:2313833, RGD:2313838

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

ERBB receptor feedback inhibitor 1

associated with Diabetes Mellitus, Experimental; mRNA:increased expression:kidney:

RGD

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282

G

estrogen receptor 1

associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:snps:introns: multiple(human)

RGD

PMID:16464734 PMID:18305958

RGD:2314020, RGD:2314005

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

coagulation factor II, thrombin

disease_progression

protein:increased expression:plasma (human)
DNA:polymorphism: :20210G>A(human)

RGD

PMID:21955218 PMID:14983223 PMID:21574459

RGD:6893574, RGD:2313643, RGD:6893575

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor III, tissue factor

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma

RGD

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid binding protein 2

RGD

NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089

G

Fas cell surface death receptor

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:kidney
associated with Diabetes Mellitus, Experimental;protein:increased expression:renal distal tubule (rat)
mRNA:increased expression:kidney

RGD

PMID:17851466 PMID:12861046 PMID:18287563

RGD:2315705, RGD:8686421, RGD:2312739

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:kidney

RGD

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibrillin 1

onset

associated with Diabetes Mellitus, Experimental

RGD

PMID:16395273 PMID:16380460

RGD:7365077, RGD:7365080

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

G

F-box and WD repeat domain containing 12

CTD Direct Evidence: marker/mechanism

NCBI chr 8:109,782,315...109,802,086
Ensembl chr 8:109,786,815...109,801,813

G

fibroblast growth factor 2

mRNA:increased expression:kidney

RGD

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 21

protein:increased expression:serum:

RGD

NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454

G

fibroblast growth factor 23

severity

mRNA,protein:increased expression:kidney:

RGD

NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821

G

Fms related receptor tyrosine kinase 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine

RGD

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

fibromodulin

mRNA,protein:increased expression:Kidney Glomerulus
associated with Diabetes Mellitus, Insulin-Dependent;mRNA:decreased expression:kidney cortex

RGD

PMID:11259366 PMID:16868749

RGD:2311416, RGD:2311412

NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133

G

fibronectin 1

treatment

associated with Diabetes Mellitus, Experimental; mRNA:increased expression:kidney
mRNA:increased expression:nephron tubule (human)
CTD Direct Evidence: marker/mechanism
protein:increased expression:kidney cortex:

CTD
RGD

PMID:24413998 PMID:16301823 PMID:35592524 PMID:22736507

RGD:7206843, RGD:401851916, RGD:10402169

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

FTO, alpha-ketoglutarate dependent dioxygenase

susceptibility

associated with diabetes mellitus;DNA:SNP: :rs17817449 (human)
associated with type 2 diabetes mellitus;DNA:SNPs: :rs1121980, rs1421085, rs17817449 (human)
associated with type 2 diabetes mellitus;DNA:SNP: :rs7204609 (human)

RGD

PMID:29154870 PMID:29410390 PMID:34134115

RGD:329813082, RGD:329901856, RGD:329813084

NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083

G

alpha-L-fucosidase 1

associated with Diabetes Mellitus, Insulin-Dependent;protein:decreased activity;urine

RGD

NCBI chr 5:148,152,718...148,169,972
Ensembl chr 5:148,152,700...148,169,972

G

glucose-6-phosphate dehydrogenase

treatment

associated with Hypertension

RGD

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest specific 6

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12644472 PMID:15619028

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

glycine amidinotransferase

RGD

NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129

G

glutamine fructose-6-phosphate transaminase 1

RGD

NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471

G

glutamine-fructose-6-phosphate transaminase 2

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP:3' utr

RGD

NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329

G

growth hormone receptor

susceptibility

associated with Diabetes Mellitus
associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney

RGD

PMID:10541297 PMID:10990443 PMID:10614635 PMID:15066219

RGD:2307370, RGD:2307368, RGD:2307369, RGD:2307364

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

gastric inhibitory polypeptide receptor

RGD

NCBI chr 1:78,804,287...78,814,462
Ensembl chr 1:78,805,593...78,814,462

G

glyoxalase 1

no_association

DNA:SNP:promoter:-7C>T (human)

PMID:21738003 PMID:21738003

RGD:7242569, RGD:7242569

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

glutathione peroxidase 1

treatment

protein:increased expression:glomerulus
associated with Experimental Diabetes Mellitus
associated with Diabetes Mellitus, Type 1

RGD

PMID:17609286 PMID:32592386 PMID:16249459

RGD:2306609, RGD:401827869, RGD:11068479

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 3

treatment

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression:serum (human)
associated with Experimental Diabetes Mellitus

RGD

PMID:17269729 PMID:32592386

RGD:2312635, RGD:401827869

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

G protein-coupled receptor kinase 2

treatment

RGD

NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582

G

G protein-coupled receptor kinase 3

treatment

RGD

NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262

G

G protein-coupled receptor kinase 4

protein:decreased expression:cortex of kidney (rat)

RGD

NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693

G

G protein-coupled receptor kinase 6

treatment

RGD

NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644

G

glycogen synthase kinase 3 beta

treatment

RGD

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

treatment

associated with Diabetes Mellitus, Type 2;protein:decreased activity:kidney
associated with Diabetes Mellitus, Experimental

RGD

PMID:23626958 PMID:24947049

RGD:7257582, RGD:10401899

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

no_association

associated with Diabetes Mellitus, Type 1;DNA:deletion:cds: (human)

RGD

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase theta 1

disease_progression
no_association

associated with Diabetes Mellitus, Type 2;DNA:deletion:cds (human)
associated with Diabetes Mellitus, Type 1;DNA:deletion:cds (human)

RGD

PMID:15927971 PMID:19752172

RGD:2306630, RGD:7495818

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

hyaluronan synthase 2

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:renal medulla

RGD

NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933

G

hepatitis A virus cellular receptor 1

disease_progression

protein:increased expression:plasma
associated with Diabetes mellitus, Type 1;
associated with Diabetes Mellitus,Type 2;protein:increased expression:urine:

RGD

PMID:22997966 PMID:20980978 PMID:22015481

RGD:7245497, RGD:7246890, RGD:7245960

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

histone deacetylase 2

mRNA,protein:increased expression:kidney:

RGD

PMID:24717296 PMID:24717296 PMID:24717296

RGD:9590311, RGD:9590311, RGD:9590311

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

histone deacetylase 4

treatment

mRNA,protein:increased expression:kidney:

RGD

PMID:24717296 PMID:24717296 PMID:24717296 PMID:24717296

RGD:9590311, RGD:9590311, RGD:9590311, RGD:9590311

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

G

histone deacetylase 5

mRNA,protein:increased expression:kidney:

RGD

PMID:24717296 PMID:24717296 PMID:24717296

RGD:9590311, RGD:9590311, RGD:9590311

NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235

G

homeostatic iron regulator

associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.C282Y (human)

RGD

NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502

G

hepatocyte growth factor

RGD

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

hypoxia inducible factor 1 subunit alpha

treatment

associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental

RGD

PMID:17967803 PMID:17914354

RGD:10395374, RGD:10395377

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

mRNA:decreased expression:kidney, liver

RGD

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

hydroxysteroid 11-beta dehydrogenase 1

susceptibility

DNA:SNO:intron: (rs17389016, rs11799643) (human)

RGD

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

heat shock protein family A (Hsp70) member 1A

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

RGD

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 5

associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney

RGD

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

RGD

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 1

mRNA,protein:increased expression:glomerulus:
protein:increased expression:glomerulus, podocyte:

RGD

PMID:21931298 PMID:21931298

RGD:10402764, RGD:10402764

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

5-hydroxytryptamine receptor 2A

associated with Diabetes Mellitus, Experimental;
associated with Diabetes Mellitus Type 2;

RGD

PMID:18175064 PMID:12213354

RGD:7257686, RGD:7257687

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

intercellular adhesion molecule 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Insulin-Dependent;DNA:SNP: :p.K469E (rs5498) (human)
associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney (mouse)

RGD

PMID:18299691 PMID:19246972 PMID:18505543 PMID:20447389

RGD:2312766, RGD:2313470, RGD:2313475, RGD:4145414

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

mRNA, protein:increased expression:kidney, T cell

RGD

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

protein:decreased expression:serum
associated with Diabetes Mellitus, Experimental;protein:decreased expression:serum (rat)

RGD

PMID:17194636 PMID:10444029

RGD:2313764, RGD:12904967

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

mRNA,protein:increased expression:kidney:

RGD

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2

associated with Diabetes Mellitus, Type 2; mRNA:decreased expression:neural tissue, liver:
associates with Diabetes Mellitus; mRNA:decreased expression:brain:

RGD

PMID:9336345 PMID:8764603 PMID:9336345

RGD:5510019, RGD:5510022, RGD:5510019

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor binding protein 1

DNA:SNPs

RGD

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

interleukin 10

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphisms:promoter:g.-1082G>A, g.-819C>T, g.-592C>A (human)

RGD

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental

RGD

PMID:22086159 PMID:19769609

RGD:7175266, RGD:7175519

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

susceptibility
no_association

associated with Diabetes Mellitus, Type 2; DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)

RGD

PMID:16174285 PMID:17286233

RGD:6907371, RGD:6909120

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 6

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)
associated with Diabetes Mellitus, Type1;DNA:polymorphism:promoter:-174G>C(human)
associated with Diabetes Mellitus, Experimental; protein:increased expression:kidney (rat)

RGD

PMID:18716362 PMID:19542902 PMID:19052104

RGD:2307282, RGD:7829816, RGD:2307281

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

resistance

CTD Direct Evidence: marker/mechanism|therapeutic

CTD
RGD

PMID:2143390 PMID:7713310 PMID:7987072 PMID:22068113

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

insulin receptor substrate 2

mRNA:increased expression:kidney tubule

RGD

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

G

integrin subunit alpha 2

severity

associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:mesangial cell (human)

RGD

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

G

integrin subunit beta 2

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

Janus kinase 2

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

potassium calcium-activated channel subfamily N member 4

ameliorates

RGD

PMID:24733189 PMID:29425253

RGD:329955448, RGD:329969879

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

lysine demethylase 6A

associated with Diabetes Mellitus, Type 1;protein:increased expression:kidney (mouse)

RGD

NCBI chr X:4,337,466...4,477,100
Ensembl chr X:4,337,750...4,477,062

G

kinase insert domain receptor

CTD Direct Evidence: marker/mechanism

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

Kelch-like ECH-associated protein 1

RGD

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

Klotho

treatment

protein:decreased expression:kidney:

RGD

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

G

kallikrein 1

CTD Direct Evidence: therapeutic

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

kallikrein 1-related peptidase C12

RGD

NCBI chr 1:94,378,103...94,382,140
Ensembl chr 1:94,378,054...94,382,176

G

kallikrein B1

disease_progression

associated with Diabetes Mellitus, Type 1; protein:increased expression:plasma:

RGD

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

kininogen 1

associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism: :7965C>T (human)

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

kininogen 2

associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism: :7965C>T (human)

RGD

NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971

G

laminin subunit beta 2

RGD

NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549

G

lipocalin 2

protein:increased expression:urine
associated with Diabetes Mellitus,Type 2;protein:increased expression:urine:

RGD

PMID:22997966 PMID:22015481

RGD:7245497, RGD:7245960

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

leptin

RGD

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

CTD Direct Evidence: marker/mechanism
DNA:mutations:cds: : (rat)

CTD
RGD

PMID:28130181 PMID:29988851 PMID:36066211 PMID:28746409

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

lamin A/C

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :1908C>T (human)

RGD

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

leucyl and cystinyl aminopeptidase

RGD

NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544

G

lipoprotein lipase

susceptibility

RGD

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

lymphotoxin alpha

DNA:polymorphism

RGD

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

mitogen activated protein kinase 1

RGD

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased activity:kidney

RGD

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

midkine

CTD Direct Evidence: marker/mechanism

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

mitofusin 2

treatment

associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:27997345 PMID:27997345 PMID:26123583

RGD:12910740, RGD:11053290

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

microRNA 145

CTD Direct Evidence: marker/mechanism

NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727

G

microRNA 146a

exacerbates

RGD

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

microRNA 21

RNA:increased expression:kidney

RGD

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

MLLT3, super elongation complex subunit

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 5:102,259,075...102,515,447
Ensembl chr 5:102,260,011...102,515,361

G

matrix metallopeptidase 12

RGD

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 2

treatment
ameliorates

associated with Diabetes Mellitus, Experimental

RGD

PMID:23384615 PMID:37643020

RGD:13204971, RGD:401827835

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 2; zinc finger nuclease induced mutant 2, Medical College of Wisconsin

ameliorates

RGD

G

matrix metallopeptidase 3

protein: decreased expression: glomerulus

RGD

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

treatment

associated with Diabetes Mellitus, Type 2;DNA:repeat:promoter
associated with Diabetes Mellitus, Experimental

RGD

PMID:11576356 PMID:23384615

RGD:8547866, RGD:13204971

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

methylenetetrahydrofolate reductase

susceptibility
no_association

associated with Diabetes Mellitus, Type 2; DNA:transition:cds:g.677C>T (human)

RGD

PMID:14737040 PMID:18280442

RGD:6893524, RGD:6893576

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

mechanistic target of rapamycin kinase

susceptibility

DNA:SNP,haplotype: :rs7212142(human)
associated with Diabetes Mellitus, Experimental

RGD

PMID:21606597 PMID:28536139 PMID:23827786

RGD:7245564, RGD:13506787, RGD:10003168

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Associated with Diabetes Mellitus, Type 1;DNA:SNP:cds:66A>G, (rs1801394) (human)

RGD

NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425

G

N-acetyltransferase 2

associated with Diabetes Mellitus, Insulin-Dependent

RGD

NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520

G

NADH:ubiquinone oxidoreductase core subunit S3

treatment

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:kidney,glomerulus
associated with Diabetes Mellitus, Experimental

RGD

PMID:22903132 PMID:22591908

RGD:8552684, RGD:13792578

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

G

nuclear factor of activated T-cells 1

protein:increased expression:nucleus

RGD

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 2

treatment

CTD Direct Evidence: therapeutic
associated with Diabetes Mellitus, Experimental

CTD
RGD

PMID:20103708 PMID:21439372 PMID:23064900

RGD:6893386, RGD:10412718

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 1

treatment

associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental

RGD

PMID:23548923 PMID:10966937

RGD:7257655, RGD:13824991

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 3

susceptibility
treatment
no_association

associated with Diabetes Mellitus, Type 2;DNA:duplication:intron:IVS4?-?+27 (human)
associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20042665 PMID:10868974 PMID:29336891 PMID:10741691

RGD:7421530, RGD:13504726, RGD:7421534

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NADPH oxidase 4

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:kidney cortex

RGD

PMID:17511984 PMID:16135519

RGD:2324670, RGD:2324673

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NPHS1 adhesion molecule, nephrin

treatment

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:decreased expression:kidney (mouse)

RGD

PMID:17624267 PMID:21617141 PMID:24173355 PMID:30862474

RGD:38596322, RGD:7241083, RGD:38599008, RGD:38596325

NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078

G

natriuretic peptide A

no_association
disease_progression

DNA:polymorphism:intron
associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma
associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism: :2238T>C (human)
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:blood

RGD

PMID:9681733 PMID:10404802 PMID:15111511 PMID:10381153

RGD:2313593, RGD:7247731, RGD:2313590, RGD:2313592

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma

RGD

PMID:10404802 PMID:16917760

RGD:7247731, RGD:7248603

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

NAD(P)H quinone dehydrogenase 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

neurotrophic receptor tyrosine kinase 2

RGD

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

poly (ADP-ribose) polymerase 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

paired box 2

associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney cortex

RGD

NCBI chr 1:243,616,509...243,697,454
Ensembl chr 1:243,616,606...243,695,321

G

platelet derived growth factor subunit A

associated with Diabetes Mellitus, Non-Insulin Dependent;mRNA, protein:increased expression:kidney

RGD

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

platelet derived growth factor subunit B

associated with Diabetes Mellitus, Non-Insulin Dependent

RGD

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

platelet derived growth factor receptor alpha

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

platelet derived growth factor receptor beta

associated with Diabetes Mellitus, Non-Insulin Dependent

RGD

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

platelet and endothelial cell adhesion molecule 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA:increased expression:glomerulus

RGD

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

placental growth factor

disease_progression

associated with Diabetes Mellitus, Type 1

RGD

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

plasminogen activator, tissue type

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

plasminogen activator, urokinase

mRNA:increased expression:renal glomerulus (rat)

RGD

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

paraoxonase 1

no_association
susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus;DNA:missense mutations:cds:p.L55M, p.Q192R (rs854560, rs662) (human)
associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.Q192R (human)

CTD
RGD

PMID:26884296 PMID:19207863 PMID:24100645 PMID:15270786

RGD:2313266, RGD:8547572, RGD:8547548

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

paraoxonase 2

associated with type 1 diabetes mellitus;DNA:missense mutation:cds:p.C311S (human)
associated with type 2 diabetes mellitus;DNA:polymorphisms:multiple

RGD

PMID:11918623 PMID:11206400

RGD:1580218, RGD:2313492

NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248

G

periostin

mRNA,protein:increased expression:kidney:

RGD

NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099

G

peroxisome proliferator-activated receptor gamma

CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Non-Insulin-Dependent

CTD
RGD

PMID:28182703 PMID:18780770 PMID:18388116

RGD:2301845, RGD:2301862

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

mRNA:decreased expression:kidney (human)
DNA:polymorphism:exon:p.G482S (human)

RGD

PMID:21784897 PMID:19900151

RGD:7242027, RGD:7242045

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein kinase C, beta

associated with hypertension;protein:increased expression:glomerular mesangium
mRNA:increased expression:nephron tubule (human)

RGD

PMID:12540629 PMID:35592524

RGD:729635, RGD:401851916

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

protein arginine methyltransferase 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345

G

protein S

severity
treatment

associated with diabetes mellitus, experimental
associated with diabetes mellitus, experimental;mRNA, protein:increased expression:kidney, glomerulus

RGD

PMID:29511111 PMID:29511111 PMID:29511111 PMID:29511111

RGD:13515131, RGD:13515131, RGD:13515131, RGD:13515131

NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286

G

serine protease 1

protein:increased expression:urine

RGD

NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792

G

protease, serine, 2

protein:increased expression:urine

RGD

NCBI chr 4:70,278,304...70,283,385
Ensembl chr 4:70,278,304...70,283,385

G

phosphatase and tensin homolog

protein:decreased expression:kidney cortex, glomerulus

RGD

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin D2 synthase

susceptibility

RGD

NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833

G

prostaglandin-endoperoxide synthase 2

associated with Diabetes Mellitus, Experimental

RGD

PMID:21441310 PMID:17112505

RGD:5135032, RGD:5688268

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone

DNA:snps:exon, intron:g.350C>A, g.IVS2+56G>A (rs6256, rs6254) (human)

RGD

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

retinol binding protein 4

disease_progression

associated with type 2 diabetes mellitus; protein:increased expression:blood plasma, urine (human)

RGD

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

G

RELA proto-oncogene, NF-kB subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

RGD

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

resistin

RGD

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

ras homolog family member A

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

RT1 class II, locus Da

mRNA:increased expression:nephron tubule (human)

NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455

G

RT1 class II, locus DMa

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432

G

RT1 class II, locus DMb

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340

G

RT1 class II, locus Hb, pseudogene 1

mRNA:increased expression:nephron tubule (human)

NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618

G

selectin P

severity

associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney, serum
associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

PMID:18471420 PMID:18026823

RGD:2312294, RGD:2312302

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

serpin family B member 7

associated with Diabetes Mellitus, Type 1
associated with Diabetes Mellitus, Type 2;DNA:SNP:intron:rs1720843 (human)

RGD

PMID:16443768 PMID:19690890

RGD:7207374, RGD:7207378

NCBI chr13:23,369,830...23,442,205
Ensembl chr13:23,395,671...23,442,205

G

serpin family E member 1

treatment

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:renal glomerulus, mesangial cell (rat)
CTD Direct Evidence: marker/mechanism
associate with Diabetes Mellitus, Type 1;protein:increased expression:plasma (human)

CTD
RGD

PMID:18682491 PMID:15322501 PMID:26712211 PMID:10809802

RGD:1580123, RGD:11073694, RGD:8547711

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serpin family F member 1

treatment

mRNA, protein:decreased expression:renal cortex, renal medulla (rat)
associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma (human)
human protein in a mouse model

RGD

PMID:15616035 PMID:18523656 PMID:23884140

RGD:1359799, RGD:8554896, RGD:8554865

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

solute carrier family 2 member 1

treatment

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:SNP:exon:g.20882C>T (human)

RGD

PMID:15745834 PMID:22707888 PMID:26337659

RGD:2312305, RGD:12879861, RGD:12879466

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

SMAD family member 6

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763

G

suppressor of cytokine signaling 1

treatment

RGD

NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383

G

superoxide dismutase 1

associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphisms: :multiple
human gene in a mouse model
protein:decreased expression:kidney

RGD

PMID:17914031 PMID:11522679 PMID:19470681

RGD:2312365, RGD:8655571, RGD:2312361

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:24819633 PMID:17192491

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

protein:decreased expression:kidney

RGD

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

secreted protein acidic and cysteine rich

associated with Diabetes Mellitus, Experimental;mRNA, protein:decreased expression:kidney

RGD

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

secreted phosphoprotein 1

RGD

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sterol regulatory element binding transcription factor 1

associated with Diabetes Mellitus, Insulin-Dependent;mRNA:increased expression:kidney
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA:increased expression:kidney
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:kidney

RGD

PMID:16936198 PMID:17961514 PMID:17961514 PMID:18613221 PMID:16046298

RGD:2308815, RGD:2308811, RGD:2308811, RGD:2308806, RGD:1581418

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sterol regulatory element binding transcription factor 2

associated with Diabetes Mellitus, Insulin-Dependent;mRNA:increased expression:kidney
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:kidney

RGD

PMID:16936198 PMID:16046298

RGD:2308815, RGD:1581418

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal transducer and activator of transcription 3

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transcription factor 7 like 2

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP (human)

RGD

NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967

G

transferrin

RGD

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transforming growth factor, beta 1

treatment

mRNA:increased expression:glomerulus
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental

CTD
RGD

PMID:18682491 PMID:19960420 PMID:19211686 PMID:24074026

RGD:2306734, RGD:7394855

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta induced

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18682491 PMID:12911551

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

G

transforming growth factor, beta receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

TGFB-induced factor homeobox 1

protein:decreased expression:glomerulus (rat)

RGD

NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802

G

thrombospondin 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

TIMP metallopeptidase inhibitor 2

mRNA:increased expression:kidney

RGD

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

tubulointerstitial nephritis antigen

CTD Direct Evidence: marker/mechanism

NCBI chr 8:77,800,031...77,885,077
Ensembl chr 8:77,800,032...77,885,077

G

toll-like receptor 2

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:increased expression:urine

RGD

PMID:16336586 PMID:12969138 PMID:21441310 PMID:16141456

RGD:1580208, RGD:1580296, RGD:5135032, RGD:1580311

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:63,417,774...63,432,466
Ensembl chr10:63,417,775...63,432,466

G

TNF receptor superfamily member 11B

disease_progression
treatment

associated with Diabetes Mellitus, Type 1
associated with Diabetes Mellitus, Type 2

RGD

PMID:18719882 PMID:20727867

RGD:7205493, RGD:7205514

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 1A

associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Type 1;protein:increased expression:serum

RGD

PMID:22042131 PMID:19073786

RGD:7245547, RGD:2311357

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

onset

associated with Diabetes Mellitus, Type 1
associated with Diabetes Mellitus, Type 1;protein:increased expression:serum
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum

RGD

PMID:22266664 PMID:19073786 PMID:16408124

RGD:7245476, RGD:2311357, RGD:7245529

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

TNF superfamily member 10

protein:increased expression:kidney

RGD

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triggering receptor expressed on myeloid cells 1

treatment

protein:increased expression:kidney interstitium

RGD

PMID:30478987 PMID:29331667 PMID:30478987

RGD:127229931, RGD:127284861, RGD:127229931

NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203

G

thyroid hormone receptor interactor 10

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 9:2,133,085...2,147,795
Ensembl chr 9:2,133,671...2,147,799

G

transient receptor potential cation channel, subfamily C, member 1

mRNA:decreased expression:kidney, liver

RGD

NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276

G

transient receptor potential cation channel, subfamily C, member 6

treatment
induces

associated with Diabetes Mellitus, Experimental

RGD

PMID:22673147 PMID:29923767

RGD:7247584, RGD:149735534

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

G

transient receptor potential cation channel, subfamily C, member 6; CRISPR/Cas9 induced mutant 1, Medical College of Wisconsin

induces

RGD

G

thioredoxin interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

ubiquitin A-52 residue ribosomal protein fusion product 1

associated with Diabetes Mellitus, Type 2;protein:increased expression:urine (human)

RGD

NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807

G

uncoupling protein 1

no_association

DNA:SNP: :-3826A>G (human)

RGD

NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852

G

uncoupling protein 2

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

urotensin 2

disease_progression

mRNA:increased expression:kidney
associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney
associated with Diabetes Mellitus, Type 2;protein:increased expression:urine

RGD

PMID:15492948 PMID:18796544 PMID:15476950

RGD:2306805, RGD:2306786, RGD:2306806

NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237

G

urotensin 2 receptor

mRNA:increased expression:kidney
associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney

RGD

PMID:15492948 PMID:18796544

RGD:2306805, RGD:2306786

NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252

G

vascular cell adhesion molecule 1

protein:increased expression:kidney
associated with Diabetes Mellitus,Type 1;protein:increased expression:plasma:

RGD

PMID:23303408 PMID:20138682

RGD:7240523, RGD:7241237

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

voltage-dependent anion channel 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

voltage-dependent anion channel 2

CTD Direct Evidence: marker/mechanism

NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553

G

vascular endothelial growth factor A

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18630688 PMID:15610240

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vitronectin

associated with Diabetes Mellitus, Experimental;protein:increased expression:glomerulus

RGD

NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810

G

von Willebrand factor

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

G

xanthine dehydrogenase

treatment

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2

RGD

PMID:22302365 PMID:19458127

RGD:7247644, RGD:7247651

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

xylosyltransferase 1

associated with Diabetes Mellitus, Insulin-Dependent;DNA:missense mutation:cds:p.A115S (human)

RGD

NCBI chr 1:171,643,925...171,929,774
Ensembl chr 1:171,643,925...171,926,783

G

YY1 transcription factor

CTD Direct Evidence: marker/mechanism

NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747

diabetic neuropathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 2B

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism (human)

RGD

NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355

G

advanced glycosylation end product-specific receptor

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

aldo-keto reductase family 1 member B1

susceptibility

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 1;DNA:repeat:promoter:g.(CA)n (human)

RGD

PMID:16900242 PMID:9489533

RGD:1626089, RGD:8548642

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldehyde dehydrogenase 2 family member

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

arachidonate 15-lipoxygenase

RGD

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

BCL2-associated agonist of cell death

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

bradykinin receptor B1

RGD

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

brain-derived neurotrophic factor

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

caspase 3

associated with Diabetes Mellitus, Experimental;protein:increased expresssion:sciatic nerve
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12502508 PMID:19555701

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

C-C motif chemokine ligand 5

associated with Diabetes Mellitus;protein:increased expression:serum

RGD

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

Cd63 molecule

associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:platelet

RGD

NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178

G

cholinergic receptor, muscarinic 2

CTD Direct Evidence: therapeutic

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

G

cannabinoid receptor 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

erythropoietin

associated with Diabetes Mellitus, Experimental;

RGD

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

coagulation factor VII

associated with Diabetes Mellitus, Insulin-Dependent; protein:altered expression:plasma (human)

RGD

NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610

G

fibroblast growth factor 2

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

FTO, alpha-ketoglutarate dependent dioxygenase

susceptibility

associated with type 2 diabetes mellitus;DNA:SNP: :rs17817449 (human)

RGD

NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083

G

gamma-glutamyltransferase 1

associated with Diabetes Mellitus,Insulin-Dependent;protein:increased activity:serum

RGD

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

ghrelin and obestatin prepropeptide

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621

G

glutamate metabotropic receptor 5

CTD Direct Evidence: marker/mechanism

NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274

G

hepatocyte growth factor

associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:26000320 PMID:15734864

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

Hedgehog-interacting protein

RGD

NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528

G

interferon gamma

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :874A>T (human)

RGD

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

treatment

associated with Diabetes Mellitus, Experimental
protein:decreased expression:serum

RGD

PMID:19264110 PMID:18545223 PMID:17194636

RGD:2306687, RGD:8549454, RGD:2313764

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 1 beta

treatment

RGD

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

insulin receptor

associated with Diabetes Mellitus, Experimental;protein:decreased phosphorylation:sciatic nerve
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18331706 PMID:18331706

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

leptin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

leucine-rich repeat kinase 2

associated with Diabetes Mellitus, Experimental;protein:increased expression:cerebellum, Purkinje cell

RGD

NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703

G

mitogen activated protein kinase 14

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

myelin basic protein

associated with Diabetes Mellitus, Experimental; protein:decreased expression:sciatic nerve:

RGD

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

microRNA 497

CTD Direct Evidence: therapeutic

NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584

G

membrane metallo-endopeptidase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

CTD Direct Evidence: marker/mechanism

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myelin protein zero

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679

G

nerve growth factor

mRNA,protein:decreased expression:sciatic nerve

RGD

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nerve growth factor receptor

mRNA,protein:decreased expression:dorsal root ganglia (GK/KyoSwe)

RGD

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

nitric oxide synthase 2

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neuregulin 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

neurotrophin 3

CTD Direct Evidence: therapeutic

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

neurotrophic receptor tyrosine kinase 1

mRNA,protein:decreased expression:dorsal root ganglia

RGD

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

poly (ADP-ribose) polymerase 1

RGD

PMID:17976390 PMID:21978940

RGD:5510012, RGD:5683915

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

placental growth factor

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

plasminogen activator, tissue type

RGD

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

prostaglandin-endoperoxide synthase 2

mRNA, protein:increased expression:peripheral nerve

RGD

PMID:17720896 PMID:21951301

RGD:1642588, RGD:5508311

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

resistin

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

serum/glucocorticoid regulated kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

sorbitol dehydrogenase

resistance

RGD

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

sterol regulatory element binding transcription factor 1

associated with Diabetes Mellitus, Insulin-Dependent

RGD

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

transforming growth factor, beta 1

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:dorsal root ganglion
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16696316 PMID:18406405

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:dorsal root ganglion

RGD

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:sciatic nerve

RGD

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

toll-like receptor 4

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphisms: :p.N299G, p.T399I (human)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental;

CTD
RGD

PMID:14693986 PMID:14693986 PMID:22910613

RGD:2312493, RGD:7777098

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

treatment

RGD

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

transient receptor potential cation channel, subfamily A, member 1

RGD

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

uncoupling protein 2

susceptibility

associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism:promoter:-866G>A (rs659366)(human)

RGD

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

uncoupling protein 3

susceptibility

associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism:promoter:-55C>T (human)

RGD

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

ubiquitin specific peptidase 15

CTD Direct Evidence: marker/mechanism

NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721

G

vascular cell adhesion molecule 1

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

treatment

associated with Diabetes Mellitus, Experimental;

RGD

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

diabetic retinopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

susceptibility
no_association

associated with Diabetes Mellitus, Type 2;protein:increased expression:serum (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:exon:g.2350G>A (rs4343) (human)
associated with Diabetes Mellitus, Type 1;DNA:deletion:intron:IVS16+1464-1751del (human)
associated with Diabetes Mellitus, Type 2;DNA:deletion:intron:IVS16+1464-1751del (human)

GAD
RGD

PMID:15118671 PMID:2157294 PMID:23065222 PMID:7729604 PMID:11106834

RGD:1331525, RGD:8142360, RGD:7829794, RGD:7829780, RGD:7829783

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

treatment

associated with Diabetes Mellitus, Experimental
human gene in a mouse model
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:31380462 PMID:21792177 PMID:31380462

RGD:8548900, RGD:40818278

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acid phosphatase 1

associated with Diabetes Mellitus, Insulin-Dependent

RGD

NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021

G

adiponectin, C1Q and collagen domain containing

disease_progression

associated with Diabetes Mellitus, Type 2;DNA:SNP: :g.45T>G (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum

RGD

PMID:24655058 PMID:17970779

RGD:8694412, RGD:8694475

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adrenomedullin

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma

RGD

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adrenoceptor beta 3

associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.W64R rs4994 (human)

RGD

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

advanced glycosylation end product-specific receptor

no_association
treatment
severity
susceptibility

associated with Diabetes Mellitus, Type 2;DNA:polymorphisms: :p.G82S, 1704G>T, 2184A>G (human)
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:SNP: :2245G>A (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-429T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-374T>A, - 429T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-374T>A (human)
associated with Diabetes Mellitus, Type 1;DNA:SNP:promoter:-374T>A (human)
protein:increased expression:retina inner nuclear layer, retinal ganglion cell (rat)
associated with Diabetes Mellitus, Type 2;DNA:polymorphisms:promoter, cds, intron:g.-443T>C, p.G82S, g.1704G>T (rs1800625, rs2070600, rs184003) (human)
associated with Diabetes Mellitus, Type 2;DNA:missense mutation, snp, haplotype:cds, intron:p.G82S, g.1704G>T (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum

GAD
RGD

PMID:15118671 PMID:22427038 PMID:22171162 PMID:22116960 PMID:11375354 More...

RGD:1331525, RGD:8695983, RGD:8695979, RGD:8695967, RGD:8695966, RGD:8695965, RGD:8695958, RGD:8695958, RGD:7244369, RGD:7244248, RGD:7244176, RGD:7244175, RGD:7244174

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

angiotensinogen

treatment

associated with Diabetes Mellitus, Type 1;DNA:polymorphism: :p.M235T (human)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental

CTD
RGD

PMID:15387897 PMID:10862638 PMID:21792177

RGD:8548872, RGD:8548900

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

CTD Direct Evidence: marker/mechanism

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

aldo-keto reductase family 1 member B1

no_association
susceptibility

associated with Diabetes Mellitus, Experimental
protein:increased expression:retinal astrocyte (rat)
associated with Diabetes Mellitus, Type 2;DNA:promoter:repeat:g.-2008(AC)n (rs35839483) (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:promoter:g.-106C>T (human)
associated with Diabetes Mellitus;DNA:repeats, snp:promoter:multiple (human)

RGD

PMID:17003340 PMID:8150024 PMID:21067572 PMID:16701918 PMID:19587357

RGD:1626080, RGD:8548684, RGD:8548676, RGD:8548668, RGD:8548640

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

mRNA, protein:increased expression:retina

RGD

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

angiogenin

associated with Diabetes Mellitus, Type 2;protein:decreased tyrosine phosphorylation:vitreous humor

RGD

NCBI chr15:24,312,711...24,323,361

G

angiopoietin 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

angiopoietin 2

protein:increased expression:retina (rat)

RGD

PMID:16520919 PMID:16520919

RGD:2314216, RGD:2314216

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

amine oxidase, copper containing 3

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma

RGD

NCBI chr10:86,272,757...86,280,702

G

apolipoprotein A4

protein:increased expression:vitreous humor (human)

RGD

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein B

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein C3

severity

protein:increased expression:serum

RGD

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

apolipoprotein E

susceptibility
no_association

associated with Diabetic Mellitus type 2;DNA:polymorphism:exon:

RGD

PMID:16862278 PMID:11495633

RGD:7771557, RGD:7771553

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein H

protein:increased expression:vitreous humor

RGD

NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329

G

aquaporin 4

RGD

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

bradykinin receptor B1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

brain-derived neurotrophic factor

associated with Diabetes Mellitus, Experimental;protein:decreased expression:retina:

RGD

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

caspase 3

associated with Diabetes Mellitus, Experimental;protein:increased expresssion:retina
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Non-Insulin-Dependent

CTD
RGD

PMID:20654064 PMID:19187597 PMID:19013511

RGD:2311444, RGD:2311448

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased activation:retina

RGD

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

protein:decreased expression:retina

RGD

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:retina (rat)

RGD

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

severity

protein:increased expression:serum
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased tyrosine phosphorylation:vitreous humor

RGD

PMID:16249511 PMID:18978347

RGD:2307104, RGD:2307061

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 2

associated with Diabetes Mellitus, Experimental; mRNA:increased expression:retina (rat)

RGD

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

C-C motif chemokine receptor 5

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

CD34 molecule

mRNA, protein:increased expression:retina

RGD

NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832

G

CD59b molecule

protein:decreased expression:retina

RGD

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

CDK5 regulatory subunit associated protein 1-like 1

disease_progression

DNA:SNP:intron: (rs7756992) (human)

RGD

NCBI chr17:34,718,701...35,271,276
Ensembl chr17:34,718,687...35,407,524

G

complement factor B

no_association

associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs1048709 (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs537160, rs4151657, rs2072633 (human)

RGD

PMID:23864767 PMID:23864767

RGD:7365019, RGD:7365019

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

complement factor H

associated with Diabetes Mellitus, Type 2; DNA:SNP: :rs800292(human)
associated with Diabetes Mellitus, Type 1;DNA:SNP: :rs1410996(human)

RGD

PMID:23864767 PMID:23296223

RGD:7365019, RGD:7365023

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

G

claudin 1

treatment

RGD

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

clusterin

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

C-reactive protein

protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20012460 PMID:20012460

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

C-X-C motif chemokine ligand 10

RGD

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

severity

protein:increased expression:vitreous humor

RGD

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome b-245 alpha chain

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

delta like canonical Notch ligand 4

severity

mRNA,protein:increased expression:retina:

RGD

PMID:30787185 PMID:34362349

RGD:155663348, RGD:155663356

NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931

G

endothelin 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:exon:p.K198N (human)
mRNA:increased expression:retina (rat)
associated with Diabetes Mellitus, Insulin-Dependent;protein:increased secretion:plasma

RGD

PMID:18806884 PMID:20628425 PMID:19293263

RGD:2313281, RGD:9068929, RGD:2313279

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor receptor

treatment

protein:increased expression:retina
associated with Diabetes Mellitus, Experimental

RGD

PMID:7947554 PMID:23831329

RGD:1580957, RGD:10059675

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

elastin

RGD

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

endoglin

associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:plasma,vitreous body

RGD

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

E1A binding protein p300

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

erythropoietin

susceptibility

protein:increased expression:serum,vitreous body
associated with Diabetes Mellitus, Experimental
DNA:snp:promoter:-1125T>G(rs1617640)(human)

RGD

PMID:18670462 PMID:24508793 PMID:18235022 PMID:18458324

RGD:2313837, RGD:10400906, RGD:2313890, RGD:2313838

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

coagulation factor XIII A1 chain

protein:increased expression:optic choroid vascular plexus:

RGD

NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700

G

coagulation factor III, tissue factor

protein:increased expression:aqueous humor,serum

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

coagulation factor VII

associated with Diabetes Mellitus, Insulin-Dependent; protein:increased activity:plasma (human)

RGD

NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610

G

fibroblast growth factor 2

associated with Pregnancy in Diabetics
DNA:polymorphism:intron:g.754C>G(human)
DNA:polymorphism:promotor:g.-553T>A(human)
associated with Diabetes Mellitus, Experimental

RGD

PMID:9141532 PMID:17997184 PMID:18279437 PMID:14975211

RGD:2315885, RGD:2315845, RGD:2315844, RGD:2315875

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fms related receptor tyrosine kinase 1

treatment

RGD

PMID:17143550 PMID:18174522

RGD:2313721, RGD:10402119

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

alpha-L-fucosidase 1

associated with Diabetes Mellitus, Experimental;protein:increased activity:retina

RGD

NCBI chr 5:148,152,718...148,169,972
Ensembl chr 5:148,152,700...148,169,972

G

glutamate decarboxylase 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

glyceraldehyde-3-phosphate dehydrogenase

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GC, vitamin D binding protein

protein:increased expression:vitreous body

RGD

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

gamma-glutamyltransferase 1

associated with Diabetes Mellitus,Insulin-Dependent;protein:increased activity:serum

RGD

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

growth hormone 1

RGD

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

glyoxalase 1

no_association

DNA:SNP:promoter:-7C>T (human)

PMID:21738003 PMID:21738003

RGD:7242569, RGD:7242569

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

glutamate-ammonia ligase

treatment

associated with Experimental Diabetes Mellitus

RGD

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glutathione S-transferase mu 1

susceptibility

associated with Diabetes Mellitus, Type 1;DNA:deletion:cds (human)

RGD

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase theta 1

disease_progression
no_association

associated with Diabetes Mellitus, Type 2;DNA:deletion:cds (human)
associated with Diabetes Mellitus, Type 1;DNA:deletion:cds (human)

RGD

PMID:15927971 PMID:19752172

RGD:2306630, RGD:7495818

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

hes family bHLH transcription factor 1

mRNA:increased expression:retina:

RGD

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes-related family bHLH transcription factor with YRPW motif 2

mRNA:increased expression:retina:

RGD

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

G

homeostatic iron regulator

associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.C282Y (human)

RGD

NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502

G

hepatocyte growth factor

disease_progression

associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:serum

RGD

PMID:18335393 PMID:15525877

RGD:2313565, RGD:8548539

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

hypoxia inducible factor 1 subunit alpha

severity
treatment

protein:increased expression:retina, vascular endothelial cell (human)
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:increased expression:retina (rat)

RGD

PMID:17229797 PMID:20515763 PMID:22110070

RGD:8694462, RGD:8696025, RGD:7364887

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

HRas proto-oncogene, GTPase

RGD

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

intercellular adhesion molecule 1

treatment

CTD Direct Evidence: therapeutic
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.K469E (human)

CTD
RGD

PMID:10485912 PMID:18834676 PMID:25066112 PMID:18942221

RGD:2313472, RGD:11354984, RGD:2313471

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

insulin-like growth factor 1

susceptibility

protein:decreased expression:serum

RGD

PMID:16873705 PMID:17194636

RGD:1598424, RGD:2313764

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

disease_progression

mRNA:increased expression:retina:

RGD

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

interleukin 10

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased tyrosine phosphorylation:vitreous humor
associated with Diabetes Mellitus, Type 2

RGD

PMID:18978347 PMID:22105495 PMID:18988929 PMID:16696964

RGD:2307061, RGD:7364856, RGD:2307272, RGD:1598486

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

associated with Diabetes Mellitus, Type 2;protein:increased expression:serum

RGD

PMID:19011009 PMID:16260350

RGD:4889417, RGD:8655907

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased tyrosine phosphorylation:vitreous humor

RGD

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

associated with Diabetes Mellitus, Type 2; protein:decreased tyrosine phosphorylation:vitreous humor
protein:increased expression:serum, vitreous humour

RGD

PMID:18978347 PMID:16284605

RGD:2307061, RGD:7401212

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

susceptibility

associated with Diabetes Mellitus; DNA:polymorphism:promoter:-174G>C (human)
associated with Diabetes Mellitus, Type1;DNA:polymorphism:promoter:-174G>C(human)
associated with Diabetes Mellitus, Typpe 1;protein:increased expression:serum:
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)

RGD

PMID:19140096 PMID:19542902 PMID:17725274 PMID:18988929

RGD:2307267, RGD:7829816, RGD:7829749, RGD:2307272

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:30463601 PMID:22046295

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

insulin receptor

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

integrin subunit alpha 2

severity
no_association
susceptibility

associated with Diabetes Mellitus; DNA:transition:cds:807C>T (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:cds:c.807T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:intron:IVS8-1059T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:intron:IVS7+3160A>G (human)

RGD

PMID:12540964 PMID:21632096 PMID:18806884 PMID:23776381

RGD:2307419, RGD:8686431, RGD:2313281, RGD:7777103

NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481

G

integrin subunit alpha 4

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

integrin subunit alpha M

mRNA, protein:increased expression:retina (rat)

RGD

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 3

protein:increased expression:optic choroid vascular plexus:

RGD

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

jagged canonical Notch ligand 1

mRNA,protein:increased expression:retina:

RGD

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

potassium inwardly-rectifying channel, subfamily J, member 10

treatment

associated with Diabetes Mellitus, Experimental

RGD

PMID:21672350 PMID:22143324

RGD:8662869, RGD:8662907

NCBI chr13:84,802,026...84,835,383
Ensembl chr13:84,802,009...84,835,461

G

lysine demethylase 1A

mRNA, protein:increased expression:retina (rat)
mRNA:increased expression:retina (human)

RGD

PMID:23423566 PMID:23423566 PMID:23423566

RGD:8547881, RGD:8547881, RGD:8547881

NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319

G

Kelch-like ECH-associated protein 1

associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:retina

RGD

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

lymphotoxin alpha

no_association
susceptibility

associated with Diabetes Mellitus, Type 2;DNA:polymorphism:intron, exon:252A>G, 804C>A (human)

RGD

PMID:16979413 PMID:11399938

RGD:8548772, RGD:8548797

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

mesoderm posterior bHLH transcription factor 1

associated with type 2 diabetes mellitus;DNA:increased expression:plasma (human)

RGD

NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875

G

mitofusin 2

associated with Diabetes Mellitus, Experimental;mRNA, protein:decreased expression:retina (rat)

RGD

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

microRNA 126b

ameliorates

RNA:decreased expression:serum,retina

RGD

PMID:33416109 PMID:33416109

RGD:401850543, RGD:401850543

NCBI chr 3:9,415,087...9,415,159

G

microRNA 17

treatment

RGD

NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712

G

microRNA 21

RNA:increased expression:retina

RGD

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 320a

miRNA:decreased expression:blood plasma (human)

RGD

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

G

matrix metallopeptidase 2

protein:increased expression:plasma

RGD

PMID:12714657 PMID:18552985

RGD:1582582, RGD:8547849

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

disease_progression

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2

RGD

PMID:16643893 PMID:21933988 PMID:10374894

RGD:1582616, RGD:8547857, RGD:8547815

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

methylenetetrahydrofolate reductase

susceptibility

associated with Diabetes Mellitus, Type 2; DNA:transition:cds:g.677C>T (human)

RGD

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

myb-like, SWIRM and MPN domains 1

susceptibility

associated with Diabetes Mellitus, Type 2;DNA:snps:introns: IVS1-1269C>T, IVS6+1700G>A (rs2811893, rs12092121) (human)

RGD

NCBI chr 5:109,761,345...109,826,652
Ensembl chr 5:109,776,286...109,819,967

G

NFE2 like bZIP transcription factor 2

associated with Diabetes Mellitus, Experimental;protein:decreased activity:retina

RGD

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nerve growth factor

protein:increased expression:serum
associated with Experimental Diabetes Mellitus

RGD

PMID:18282491 PMID:24030532

RGD:7242804, RGD:405100241

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 1

mRNA, protein:decreased expression:retina

RGD

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 3

no_association
susceptibility
treatment
severity
onset

associated with Diabetes Mellitus, Type 2;DNA:duplication:intron:IVS4?-?+27 (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:exon:c.894G>T (human)
associated with Diabetes Mellitus, Type 2;DNA:snps, duplication, haplotype:promoter, cds, intron:g.-786T>C, p.E298N, IVS4?-?+27 (human)
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:retina (rat)
DNA:snps:promoter, exon:c.-786T>C, c.774C>T (human)
associated with Diabetes Mellitus, Type 1;DNA:duplication:intron:IVS4?-?+27 (human)

RGD

PMID:16581274 PMID:23776381 PMID:22017289 PMID:17558849 PMID:18840783 More...

RGD:7421531, RGD:7777103, RGD:7777101, RGD:7775042, RGD:7771606, RGD:7771569, RGD:7771568, RGD:7771565, RGD:7421533, RGD:7421532

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 1

treatment

RGD

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

natriuretic peptide A

protein:increased expression:vitreous humor

RGD

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide receptor 3

mRNA:decreased expression:retina (rat)

RGD

NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955

G

neuropilin 1

treatment

RGD

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

G

nuclear transport factor 2

treatment

mRNA:decreased expression:peripheral blood:

RGD

PMID:19404486 PMID:19404486

RGD:9831377, RGD:9831377

NCBI chr19:33,752,319...33,773,595
Ensembl chr19:33,752,291...33,773,591

G

occludin

treatment

RGD

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

platelet factor 4

protein:increased expression:retina

RGD

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

placental growth factor

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

mRNA, protein:increased expression:retina

RGD

NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043

G

polo-like kinase 4

treatment

RGD

NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942

G

paraoxonase 1

susceptibility

DNA:polymorphism:promoter:g.-907C>G (human)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus;DNA:missense mutation:cds:p.L55M (rs854560) (human)
associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.Q192R (human)
associated with Diabetes Mellitus, Type 1;protein:decreased activity:serum (human)

CTD
RGD

PMID:9661650 PMID:20012460 PMID:16949520 PMID:24100645 PMID:15270786 More...

RGD:2313272, RGD:8547572, RGD:8547548, RGD:8547537

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

peroxisome proliferator-activated receptor gamma

Retinal Leukostasis;associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

associated with Diabetes Mellitus, Experimental; mRNA:increased expression:retina (rat)

RGD

PMID:20566666 PMID:22003111

RGD:6484532, RGD:5686899

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

phosphatase and tensin homolog

mRNA, protein:decreased expression:retina

RGD

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

retinol binding protein 4

severity

protein:increased expression:blood plasma (human)

RGD

NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399

G

resistin

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

roundabout guidance receptor 1

mRNA,protein:increased expression:retina

RGD

NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203

G

RT1 class II, locus Bb

susceptibility
severity

associated with Diabetes Mellitus, Type 1;DNA:polymorphisms, haplotypes:cds:HLA-DQB1*0201, HLA-DQB1*0501, HLA-DQB1*0504 (human)
DNA:polymorphisms, haplotype:cds:HLA-DQB1*0201, HLA-DQB1*0302 (human)

RGD

PMID:19551681 PMID:8932997

RGD:7421552, RGD:7483573

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RT1 class I, locus CE13

susceptibility

associated with Diabetes Mellitus, Type 1; DNA:polymorphisms:cds:HLA-B*49 (human)

RGD

NCBI chr20:3,314,830...3,318,106

G

RT1 class II, locus Db1

susceptibility

associated with Diabetes Mellitus Type 1;DNA:polymorphism::DRB1*0301,DRB1*0402(human)

RGD

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

serpin family A member 4

protein:decreased expression:vitreous fluid (human)

RGD

NCBI chr 6:122,999,970...123,009,083
Ensembl chr 6:122,999,900...123,009,082

G

serpin family E member 1

susceptibility
no_association

associated with Diabetes Mellitus, Type 2;DNA:deletion:promoter:g.-676_-674delG (human)
associated with Diabetes Mellitus, Type 2;DNA:snp, deletion:promoter:g.-844G>A, g.-676_-674delG (human)
associated with Diabetes Mellitus;repeat, snp:intron, 3' utr:g.7844(CA)1-6, ? (human)
associated with Diabetes Mellitus, Type 1;protein:increased expression:plasma (human)

RGD

PMID:23281898 PMID:19419896 PMID:7974340 PMID:9201602 PMID:12660488

RGD:8547697, RGD:8547741, RGD:8547740, RGD:8547710, RGD:8547699

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serpin family F member 1

severity

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNPs:promoter:g.-5740T>C, g.-5308G>A (rs12150053, rs12948385) (human)
protein:increased expression:vitreous humor
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:vitreous humor
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:retina
associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:serum
protein:alternative form:vitreous humor

RGD

PMID:17658465 PMID:15059706 PMID:18025835 PMID:16054135 PMID:18455830 More...

RGD:2312346, RGD:1580135, RGD:2312344, RGD:2312348, RGD:2312341, RGD:2312337

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

SAGA complex associated factor 29

severity

associated with Diabetes Mellitus, Type 1; DNA:SNP:intron: rs10521145(human)

RGD

NCBI chr 1:181,238,458...181,271,931
Ensembl chr 1:181,238,468...181,274,781

G

sirtuin 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

slit guidance ligand 2

mRNA,protein:increased expression:retina

RGD

NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948

G

superoxide dismutase 1

human gene in a mouse model
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:19074809 PMID:19074809

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249