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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Neointima
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Accession:DOID:9002514 term browser browse the term
Definition:The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.
Synonyms:exact_synonym: Neointima Formation;   Neointimas
 primary_id: MESH:D058426


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Neointima term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor treatment ISO RGD PMID:24132651 RGD:8695998 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129 		JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19258495 PMID:29609002 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO RGD PMID:25751394 RGD:329328927 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193 		JBrowse link
G ANXA2 annexin A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21204247 NCBI chr30:25,176,845...25,210,244
Ensembl chr30:25,115,842...25,218,281 		JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 treatment ISO RGD PMID:23535897 RGD:13782090 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388 		JBrowse link
G ATP7A ATPase copper transporting alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20671235 NCBI chr  X:60,203,336...60,356,525
Ensembl chr  X:60,203,270...60,352,869 		JBrowse link
G AXL AXL receptor tyrosine kinase ISO RGD PMID:9758639 RGD:631894 NCBI chr 1:112,699,679...112,727,434
Ensembl chr 1:112,700,365...112,726,960 		JBrowse link
G BECN1 beclin 1 ISO RGD PMID:25238224 RGD:11558011 NCBI chr 9:20,204,203...20,215,081
Ensembl chr 9:20,204,220...20,214,236 		JBrowse link
G CLU clusterin ISO RGD PMID:19696405 PMID:20032585 RGD:8699512 RGD:9068412 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563 		JBrowse link
G CYBB cytochrome b-245 beta chain treatment ISO RGD PMID:20485380 RGD:11040762 NCBI chr  X:32,533,365...32,568,149
Ensembl chr  X:32,533,320...32,568,217 		JBrowse link
G DRD4 dopamine receptor D4 treatment ISO associated with type 2 diabetes mellitus RGD PMID:24888351 RGD:13506962
G ECE1 endothelin converting enzyme 1 ISO mRNA:increased expression:carotid artery RGD PMID:8575076 RGD:7244170 NCBI chr 2:77,732,645...77,793,950
Ensembl chr 2:77,678,686...77,792,114 		JBrowse link
G ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 treatment ISO RGD PMID:18485080 RGD:9685444 NCBI chr28:9,181,851...9,311,835
Ensembl chr28:9,211,050...9,323,939 		JBrowse link
G EPC1 enhancer of polycomb homolog 1 treatment ISO RGD PMID:22398275 RGD:9587795 NCBI chr 2:14,566,177...14,659,774
Ensembl chr 2:14,565,560...14,659,353 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:17438359 RGD:2289992 NCBI chr37:19,029,647...20,134,576
Ensembl chr37:19,037,217...20,134,426 		JBrowse link
G F3 coagulation factor III, tissue factor treatment ISO RGD PMID:22140576 RGD:11341672 NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607 		JBrowse link
G FGF2 fibroblast growth factor 2 ISO RGD PMID:8808969 RGD:8655643 NCBI chr19:17,403,288...17,463,143
Ensembl chr19:16,994,661...17,463,151 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 ISO RGD PMID:15072997 RGD:10402089 NCBI chr16:27,029,902...27,080,514
Ensembl chr16:27,031,588...27,078,261 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 treatment ISO mRNA,protein:increased expression:smooth muscle cell: RGD PMID:9400373 PMID:22814749 RGD:10402128 RGD:10402146 NCBI chr25:11,231,958...11,410,379
Ensembl chr25:11,231,737...11,407,621 		JBrowse link
G FOXO4 forkhead box O4 ISO protein:increased expression:smooth muscle cell: RGD PMID:16054032 PMID:17242183 RGD:10402361 RGD:10402362 NCBI chr  X:55,469,738...55,477,699
Ensembl chr  X:55,469,382...55,477,699 		JBrowse link
G GAS6 growth arrest specific 6 ISO RGD PMID:9758639 RGD:631894 NCBI chr22:60,975,196...61,005,869
Ensembl chr22:60,974,849...61,005,875 		JBrowse link
G GATA2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr20:2,472,251...2,488,380
Ensembl chr20:2,473,912...2,480,991 		JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:21804207 RGD:10755571 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773 		JBrowse link
G IGF1 insulin like growth factor 1 ISO associated with Hypertension RGD PMID:12791939 RGD:1580477 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794 		JBrowse link
G IQGAP1 IQ motif containing GTPase activating protein 1 ISO associated with Vascular System Injuries RGD PMID:23657573 RGD:11049552 NCBI chr 3:53,683,869...53,791,136
Ensembl chr 3:53,683,791...53,792,186 		JBrowse link
G IRF8 interferon regulatory factor 8 ameliorates ISO associated with Carotid Artery Injuries RGD PMID:24248596 RGD:329902075 NCBI chr 5:66,789,264...66,812,477
Ensembl chr 5:66,791,350...66,842,179 		JBrowse link
G KLF5 KLF transcription factor 5 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:10417400 PMID:16224062 RGD:1581746 NCBI chr22:27,163,179...27,185,241
Ensembl chr22:27,162,397...27,200,871 		JBrowse link
G LGALS3 galectin 3 ISO mRNA:increased expression:thoracic aorta RGD PMID:9688561 RGD:9685205 NCBI chr 8:30,977,438...30,994,711
Ensembl chr 8:30,983,633...30,994,705 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 treatment ISO RGD PMID:14638553 RGD:10412321 NCBI chr 1:29,107,813...29,306,437
Ensembl chr 1:29,108,591...29,306,503 		JBrowse link
G MIR125A microRNA mir-125a treatment ISO RGD PMID:30156956 RGD:26884369 NCBI chr 1:105,400,273...105,400,332
Ensembl chr 1:105,400,270...105,400,337 		JBrowse link
G MMP2 matrix metallopeptidase 2 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:17964422 PMID:23344254 RGD:13207403 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113 		JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:17964422 PMID:23344254 RGD:13207403 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293 		JBrowse link
G MYB MYB proto-oncogene, transcription factor treatment ISO RGD PMID:10438864 RGD:11532744 NCBI chr 1:27,908,309...27,991,984
Ensembl chr 1:27,908,364...27,991,969 		JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 ISO RGD PMID:22508052 RGD:11073699 NCBI chr35:3,294,776...3,315,438
Ensembl chr35:3,294,850...3,312,836 		JBrowse link
G NRG1 neuregulin 1 ISO RGD PMID:17438359 RGD:2289992 NCBI chr16:31,697,958...32,771,888
Ensembl chr16:31,706,851...32,771,932 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 ISO RGD PMID:19359598 PMID:22922962 RGD:10041068 RGD:11533945 NCBI chr21:21,341,530...21,409,535
Ensembl chr21:21,265,484...21,408,416 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO RGD PMID:15044192 RGD:10413907 NCBI chr 7:38,503,072...38,542,556
Ensembl chr 7:38,503,067...38,542,127 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO RGD PMID:8585266 RGD:10449489 NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746 		JBrowse link
G PDGFRA platelet derived growth factor receptor alpha treatment ISO associated with Carotid Artery Injuries RGD PMID:9323080 RGD:11087557 NCBI chr13:46,729,722...46,775,828
Ensembl chr13:46,730,703...46,773,278 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta treatment ISO associated with Carotid Artery Injuries RGD PMID:9323080 RGD:11087557 NCBI chr 4:58,925,922...58,963,639
Ensembl chr 4:58,926,351...58,962,283 		JBrowse link
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:20307651 RGD:8693429 NCBI chr20:51,156,887...51,168,131
Ensembl chr20:51,157,121...51,168,136 		JBrowse link
G PKN1 protein kinase N1 ameliorates ISO RGD PMID:22893700 RGD:243065233 NCBI chr20:48,160,480...48,184,346
Ensembl chr20:48,160,529...48,184,751 		JBrowse link
G POLDIP2 DNA polymerase delta interacting protein 2 ISO RGD PMID:30237457 RGD:124713557 NCBI chr 9:42,597,792...42,607,576
Ensembl chr 9:42,597,792...42,607,576 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta ISO associated with Carotid Artery Injuries RGD PMID:22922962 RGD:10041068 NCBI chr25:30,137,546...30,264,221
Ensembl chr25:30,138,209...30,264,133 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:12377736 RGD:729766 NCBI chr 7:4,155,876...4,282,151
Ensembl chr 7:4,137,728...4,282,124 		JBrowse link
G S1PR1 sphingosine-1-phosphate receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29609002 NCBI chr 6:48,897,320...48,902,206
Ensembl chr 6:48,897,449...48,900,037 		JBrowse link
G SELP selectin P treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:12377736 RGD:729766 NCBI chr 7:28,956,428...28,997,266
Ensembl chr 7:28,958,486...28,996,313 		JBrowse link
G SENP1 SUMO specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr27:6,664,750...6,719,257
Ensembl chr27:6,664,818...6,714,479 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO human protein in rat model
associated with Diabetes Mellitus, Type 2 		RGD PMID:18091579 PMID:19574558 RGD:8547879 RGD:8547913 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301 		JBrowse link
G SPON2 spondin 2 ISO RGD PMID:25751394 RGD:329328927 NCBI chr 3:91,411,245...91,421,245 JBrowse link
G SSH1 slingshot protein phosphatase 1 ISO protein:increased expression:carotid artery RGD PMID:21868701 RGD:11535005 NCBI chr26:18,074,229...18,136,001
Ensembl chr26:18,074,075...18,131,185 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 treatment ISO associated with Carotid Artery Injuries RGD PMID:16118253 RGD:5509614 NCBI chr37:1,566,563...1,685,378
Ensembl chr37:1,566,585...1,829,894 		JBrowse link
G STIM1 stromal interaction molecule 1 ameliorates ISO RGD PMID:19107116 RGD:151893459 NCBI chr21:26,394,592...26,594,764
Ensembl chr21:26,394,811...26,593,375 		JBrowse link
G TFPI tissue factor pathway inhibitor treatment ISO RGD PMID:10521388 PMID:22140576 RGD:11060274 RGD:11341672 NCBI chr36:29,457,131...29,546,455
Ensembl chr36:29,459,371...29,511,310 		JBrowse link
G TIMM44 translocase of inner mitochondrial membrane 44 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:16186389 RGD:13463598 NCBI chr20:52,614,814...52,628,545
Ensembl chr20:52,615,040...52,628,471 		JBrowse link
G YY1 YY1 transcription factor treatment ISO RGD PMID:21030713 RGD:9588268 NCBI chr 8:68,539,511...68,572,796
Ensembl chr 8:68,539,353...68,568,058 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15754
    Pathological Conditions, Signs and Symptoms 12320
      Pathologic Processes 7816
        Neointima 56
Path 2
Term Annotations click to browse term
  disease 15754
    Pathological Conditions, Signs and Symptoms 12320
      Pathologic Processes 7816
        Hyperplasia 123
          Intimal Hyperplasia 72
            Neointima 56
paths to the root