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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Spirochaetales Infections
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Accession:DOID:9002423 term browser browse the term
Definition:Infections with bacteria of the order SPIROCHAETALES.
Synonyms:exact_synonym: Spirochaetales Infection;   Spirochete Infection;   Spirochete Infections
 primary_id: MESH:D013145;   RDO:0005038
 xref: EFO:0009567


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leptospirosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase (Cartwright blood group) ISO RGD PMID:21921108 RGD:5688128 NCBI chrNW_004936543:856,678...862,080
Ensembl chrNW_004936543:856,676...862,109
JBrowse link
G Ada adenosine deaminase ISO RGD PMID:21320715 RGD:5128858 NCBI chrNW_004936530:2,217,713...2,224,070 JBrowse link
G Bche butyrylcholinesterase ISO protein:increased expression:serum RGD PMID:21921108 RGD:5688128 NCBI chrNW_004936707:1,784,338...1,913,401
Ensembl chrNW_004936707:1,854,444...1,913,460
JBrowse link
G F2 coagulation factor II, thrombin severity ISO protein:increased expression:blood plasma (human) RGD PMID:18171258 PMID:20002620 RGD:40818429 RGD:40819859 NCBI chrNW_004936562:2,371,725...2,388,617
Ensembl chrNW_004936562:2,372,044...2,388,650
JBrowse link
G Il1b interleukin 1 beta ISO mRNA, protein:increased expression:kidney (mouse) RGD PMID:22323544 RGD:7175257 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:19635914 RGD:7240557 NCBI chrNW_004936576:522,234...531,660
Ensembl chrNW_004936576:527,434...529,788
JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:16428731 PMID:19635914 RGD:7240557 RGD:7241090 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095
JBrowse link
Lyme disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 ISO protein:increased expression:synovial fluid RGD PMID:23371320 RGD:7488895 NCBI chrNW_004936525:8,238,128...8,240,974
Ensembl chrNW_004936525:8,237,831...8,240,974
JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:21387014 RGD:5508754 NCBI chrNW_004936475:3,708,069...3,742,845
Ensembl chrNW_004936475:3,713,362...3,745,982
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO mRNA:increased expression:skin RGD PMID:19461880 RGD:6483813 NCBI chrNW_004936706:840,968...855,552 JBrowse link
Lyme Neuroborreliosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chrNW_004936514:6,936,915...6,947,246
Ensembl chrNW_004936514:6,936,572...6,947,280
JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chrNW_004936513:10,607,617...10,620,403
Ensembl chrNW_004936513:10,607,617...10,620,403
JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:23134838 RGD:7193053 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165
JBrowse link
G LOC101964975 interleukin-8 treatment ISO RGD PMID:24239846 RGD:39939054 NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353
JBrowse link
Neurosyphilis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101964975 interleukin-8 treatment ISO RGD PMID:27650493 RGD:39939071 NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353
JBrowse link
G Nefl neurofilament light chain disease_progression ISO protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chrNW_004936757:1,642,122...1,646,499
Ensembl chrNW_004936757:1,642,222...1,645,697
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 disease_progression ISO protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940
JBrowse link
syphilis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 treatment ISO RGD PMID:27284313 RGD:38456006 NCBI chrNW_004936721:1,118,376...1,125,282
Ensembl chrNW_004936721:1,118,782...1,132,308
JBrowse link
G Nefl neurofilament light chain ISO associated with age;protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chrNW_004936757:1,642,122...1,646,499
Ensembl chrNW_004936757:1,642,222...1,645,697
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO associated with age;protein:increased expression:CSF (human) RGD PMID:32117023 RGD:127285386 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16465
    disease by infectious agent 1965
      Bacterial Infections and Mycoses 946
        bacterial infectious disease 745
          Spirochaetales Infections 16
            Borrelia Infections + 7
            Treponemal Infections + 4
            leptospirosis + 7
paths to the root