RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Central Nervous System Protozoal Infections
Accession: DOID:9002216
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Definition: Infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. The central nervous system may be the primary or secondary site of protozoal infection. These diseases may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.
Synonyms: exact_synonym: Amebic Meningoencephalitides; Amebic Meningoencephalitis; Cerebral Protozoal Infection; Cerebral Protozoal Infections; Infection, Central Nervous System, Protozoal; Protozoal Meningoencephalitides; Protozoal Meningoencephalitis
primary_id: MESH:D020808 ; RDO:0000264
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Ace2
angiotensin converting enzyme 2
susceptibility
ISO
DNA:SNP:intron 1: C>T
RGD
PMID:20117248
RGD:40818420
NCBI chr X:33,925,458...33,972,851
Ensembl chr X:30,293,589...30,340,977
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Aqp4
aquaporin 4
disease_progression
ISO
protein:increased expression:astrocyte:
RGD
PMID:21904632
RGD:8698661
NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856
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Cast
calpastatin
ISO
protein:increased express:brain
RGD
PMID:16236382
RGD:5509817
NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:3,973,112...4,082,659
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Cd36
CD36 molecule
ISO
RGD
PMID:17367535
RGD:6893527
NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
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Clec12a
C-type lectin domain family 12, member A
ameliorates
ISO
RGD
PMID:31269448
RGD:41412201
NCBI chr 4:164,484,162...164,502,793
Ensembl chr 4:162,798,125...162,816,753
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Il1rl1
interleukin 1 receptor-like 1
treatment
ISO
RGD
PMID:25682948
RGD:40400741
NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:42,697,192...42,727,256
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Il33
interleukin 33
treatment
ISO
protein:increased expression:brain
RGD
PMID:25659095 PMID:25682948
RGD:39938955 , RGD:40400741
NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373
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Jak3
Janus kinase 3
ISO
RGD
PMID:22363534
RGD:11531103
NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536
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Lta
lymphotoxin alpha
ISO
RGD
PMID:12021316
RGD:10449455
NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,618,853...3,620,859
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Nrg1
neuregulin 1
treatment
ISO
mRNA, protein:increased expression:cerebral cortex (mouse) human protein in a mouse model
RGD
PMID:29636063 PMID:24433482
RGD:39456084 , RGD:39456102
NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ISO
RGD
PMID:25775137
RGD:38599200
NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043
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Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
ISO
mRNA:decreased expression:brain (mouse)
RGD
PMID:29107705
RGD:39456137
NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543
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Tnfrsf1b
TNF receptor superfamily member 1B
ISO
RGD
PMID:12228317
RGD:5131158
NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
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Nfkb1
nuclear factor kappa B subunit 1
severity
ISO
RGD
PMID:20156658
RGD:40902838
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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RT1-Ba
RT1 class II, locus Ba
susceptibility
ISO
DNA:polymorphisms: :HLA-DQA1*01:03, HLA-DQA1*03:02 (human)
RGD
PMID:26856406
RGD:126928144
NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,575,134...4,579,744
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