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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Central Nervous System Protozoal Infections
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Accession:DOID:9002216 term browser browse the term
Definition:Infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. The central nervous system may be the primary or secondary site of protozoal infection. These diseases may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts.
Synonyms:exact_synonym: Amebic Meningoencephalitides;   Amebic Meningoencephalitis;   Cerebral Protozoal Infection;   Cerebral Protozoal Infections;   Infection, Central Nervous System, Protozoal;   Protozoal Meningoencephalitides;   Protozoal Meningoencephalitis
 primary_id: MESH:D020808;   RDO:0000264



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cerebral malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 susceptibility ISO DNA:SNP:intron 1: C>T RGD PMID:20117248 RGD:40818420 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Aqp4 aquaporin 4 disease_progression ISO protein:increased expression:astrocyte: RGD PMID:21904632 RGD:8698661 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Cast calpastatin ISO protein:increased express:brain RGD PMID:16236382 RGD:5509817 NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:3,973,112...4,082,659
JBrowse link
G Cd36 CD36 molecule ISO RGD PMID:17367535 RGD:6893527 NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Clec12a C-type lectin domain family 12, member A ameliorates ISO RGD PMID:31269448 RGD:41412201 NCBI chr 4:164,484,162...164,502,793
Ensembl chr 4:162,798,125...162,816,753
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 treatment ISO RGD PMID:25682948 RGD:40400741 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il33 interleukin 33 treatment ISO protein:increased expression:brain RGD PMID:25659095 PMID:25682948 RGD:39938955, RGD:40400741 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Jak3 Janus kinase 3 ISO RGD PMID:22363534 RGD:11531103 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Lta lymphotoxin alpha ISO RGD PMID:12021316 RGD:10449455 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Nrg1 neuregulin 1 treatment ISO mRNA, protein:increased expression:cerebral cortex (mouse)
human protein in a mouse model
RGD PMID:29636063 PMID:24433482 RGD:39456084, RGD:39456102 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO RGD PMID:25775137 RGD:38599200 NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ISO mRNA:decreased expression:brain (mouse) RGD PMID:29107705 RGD:39456137 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO RGD PMID:12228317 RGD:5131158 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
Cerebral Toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkb1 nuclear factor kappa B subunit 1 severity ISO RGD PMID:20156658 RGD:40902838 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
congenital toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Ba RT1 class II, locus Ba susceptibility ISO DNA:polymorphisms: :HLA-DQA1*01:03, HLA-DQA1*03:02 (human) RGD PMID:26856406 RGD:126928144 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,575,134...4,579,744
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19141
    disease by infectious agent 2253
      parasitic infectious disease 329
        parasitic protozoa infectious disease 177
          Central Nervous System Protozoal Infections 15
            Cerebral Toxoplasmosis 1
            cerebral malaria 13
            congenital toxoplasmosis 1
            primary amebic meningoencephalitis + 0
Path 2
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      nervous system disease 14360
        central nervous system disease 12636
          Central Nervous System Infections 343
            Central Nervous System Parasitic Infections 20
              Central Nervous System Protozoal Infections 15
                Cerebral Toxoplasmosis 1
                cerebral malaria 13
                congenital toxoplasmosis 1
                primary amebic meningoencephalitis + 0
paths to the root