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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hyperalgesia
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Accession:DOID:9002211 term browser browse the term
Definition:An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Synonyms:exact_synonym: Allodynia;   Allodynias, Tactile;   Allodynias, Thermal;   Hyperalgesia, Primary;   Hyperalgesia, Secondary;   Hyperalgesias;   Hyperalgesias, Mechanical;   Hyperalgesias, Primary;   Hyperalgesias, Secondary;   Hyperalgesias, Tactile;   Hyperalgesias, Thermal;   Hyperalgesic Sensations;   Mechanical Allodynia;   Mechanical Allodynias;   Mechanical Hyperalgesia;   Tactile Allodynia;   Tactile Hyperalgesia;   Thermal Allodynia;   Thermal Hyperalgesia;   pain hypersensitivity
 primary_id: MESH:D006930


show annotations for term's descendants           Sort by:
Hyperalgesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase treatment IMP RGD PMID:24890317 RGD:9588557 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835 		JBrowse link
G Adk adenosine kinase IMP associated with diabetic neuropathies; RGD PMID:11423084 PMID:9932716 RGD:6482662, RGD:6482666 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510 		JBrowse link
G Adm adrenomedullin IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17043245 PMID:17043245 RGD:1625316 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adora1 adenosine A1 receptor IDA associated with Spinal Cord Injuries RGD PMID:20065990 RGD:5129094 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adra1a adrenoceptor alpha 1A IEP associated with Diabetes Mellitus, Experimental; mRNA:increased expression:dorsal root ganglion RGD PMID:10841349 RGD:5688377 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra2a adrenoceptor alpha 2A IMP RGD PMID:17959985 RGD:6480488 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2c adrenoceptor alpha 2C IMP RGD PMID:20007733 RGD:6893568 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:19283893 RGD:5129125 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment IMP
IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:25014009 PMID:25014009 PMID:24077211 RGD:8695980, RGD:7364865 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:9613798 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aif1 allograft inflammatory factor 1 IEP
ISO		 associated with Alcohol-Induced Disorders, Nervous System; protein:increased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27093858 PMID:17284346 RGD:2313035 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 IDA associated with Hyperglycemia RGD PMID:12505670 RGD:1626082 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12582831 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12582831 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Ano3 anoctamin 3 IMP RGD PMID:23872594 RGD:9681745 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154 		JBrowse link
G Anxa1 annexin A1 IMP
IEP		 protein:increased expression:dorsal root ganglion RGD PMID:9222544 PMID:21990306 RGD:2306950, RGD:7421656 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Aqp4 aquaporin 4 IEP associated with Spinal Cord Injuries;mRNA,protein:increased expression:brain,spinal cord: RGD PMID:16219025 RGD:8695957 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Avp arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:9613798 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bace1 beta-secretase 1 IMP RGD PMID:28012171 RGD:13782150 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bdkrb1 bradykinin receptor B1 IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17989505 PMID:19300402 PMID:19815945 PMID:12927641 PMID:12637034 RGD:1579989, RGD:7241581 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 IMP
ISO		 associated with Diabetic Neuropathy
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17989505 PMID:19300402 PMID:19815945 PMID:10188975 PMID:19300402 RGD:4891040, RGD:2313332 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Bdnf brain-derived neurotrophic factor IMP
ISO
IDA
IEP		 associated with Peripheral Nerve Injuries;
associated with Sciatic Neuropathy;
associated with Pancreatitis, Chronic;
associated with inflammation;protein:increased expression:dorsal root ganglion:		 RGD PMID:11425916 PMID:12470870 PMID:21499209 PMID:21864655 PMID:12435470 More... RGD:8657088, RGD:8657091, RGD:8657093, RGD:8657099, RGD:8657101, RGD:8657114, RGD:8657122 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 IEP RGD PMID:23665054 RGD:11560531 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G C3 complement C3 IEP associated with Sciatic Neuropathy;mRNA, protein:increased expression:spinal cord RGD PMID:23588254 RGD:7401259 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B IDA RGD PMID:17567797 RGD:1626313 NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO CTD Direct Evidence: marker/mechanism CTD PMID:19577366 PMID:30552955 PMID:34286406 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I IMP RGD PMID:17112407 RGD:15003199 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11245671 PMID:17881535 PMID:24133248 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Calca calcitonin-related polypeptide alpha IEP
ISO		 associated with inflammation;protein:increased expression:dorsal root ganglion:
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:12787826 PMID:12855330 PMID:15265675 PMID:27093858 PMID:21958434 RGD:8657122 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20053885 PMID:18042863 RGD:7240711 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Capn2 calpain 2 treatment IMP associated with Peripheral Nerve Injuries RGD PMID:25150005 RGD:13792585 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Cartpt CART prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:21167239 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Cat catalase treatment IEP
IMP		 RGD PMID:23952340 PMID:23658840 RGD:9479063, RGD:9479069 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cck cholecystokinin IDA RGD PMID:15647484 RGD:1626108 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Cckbr cholecystokinin B receptor IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11880531 PMID:15647484 RGD:1626108 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IDA
IMP
ISO
IEP		 protein:increased expression:dorsal root ganglion, spinal cord (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17881535 PMID:18419759 PMID:22531750 PMID:20737477 PMID:21712071 RGD:2307043, RGD:8548845, RGD:8548848, RGD:8548873 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP
IDA		 mRNA:increased expression:dorsal root ganglion (rat) RGD PMID:18076762 PMID:18656466 RGD:4890034, RGD:2303121 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IMP
IEP
ISO		 associated with Bone Neoplasms;protein:increased expression:spinal cord:
protein:increased expression:dorsal horn of spinal cord:
associated with Sciatic Neuropathy;
associated with Demyelinating Diseases;
associated with Intervertebral disc disease;		 RGD PMID:18419759 PMID:23511129 PMID:22721162 PMID:24907405 PMID:18076762 More... RGD:2307043, RGD:8661772, RGD:8548831, RGD:8661781, RGD:4890034, RGD:8661788 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 IEP
IMP
ISO		 mRNA:increased expression:dorsal root ganglion (rat)
associated with Spinal Cord Injuries		 RGD PMID:18076762 PMID:24589480 PMID:23147416 PMID:22033364 RGD:4890034, RGD:8551795, RGD:8551809, RGD:8551820 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cfl1 cofilin 1 IEP protein:increased phosphorylation:dorsal root ganglion (rat) RGD PMID:24962708 RGD:11570412 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit ameliorates IMP RGD PMID:15652389 RGD:150530460 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ameliorates IDA associated with sciatic neuropathy; RGD PMID:20619541 RGD:151708701 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17572696 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:17572696 PMID:18664590 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Comt catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:28195063 PMID:20726980 RGD:8662326 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Crcp CGRP receptor component IEP RGD PMID:12895509 RGD:727768 NCBI chr12:26,623,968...26,659,756
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28434951 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO associated with Sciatic Neuropathy; RGD PMID:24253780 RGD:11039470 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Csk C-terminal Src kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16769263 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Ctss cathepsin S IMP
ISO		 associated with Arthritis, Experimental
associated with Colitis		 RGD PMID:22213084 PMID:21802389 RGD:5686870, RGD:5686873 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 treatment IDA
IEP		 associated with Arthritis, Experimental RGD PMID:19249394 PMID:22647647 RGD:2304251, RGD:9491779 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO
IMP
IEP		 associated with Bone Neoplasms
associated with Sciatic Neuropathy
associated with Inflammation
associated with Arthritis, Experimental;protein:increased expression:lumbar spinal cord		 RGD PMID:20609517 PMID:20736819 PMID:19959384 PMID:20524966 PMID:16324111 More... RGD:4891885, RGD:4892020, RGD:4891942, RGD:9354422, RGD:9387859, RGD:9491779 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 IDA RGD PMID:28638088 RGD:13838657 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 IMP RGD PMID:19283893 RGD:5129125 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 treatment IMP RGD PMID:28638088 PMID:30142543 RGD:13838657, RGD:13838658 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cybb cytochrome b-245 beta chain ISO associated with Spinal Cord Injuries; RGD PMID:20679217 RGD:11040629 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 IDA associated with Diabetic neuropathies; RGD PMID:20531396 RGD:7257680 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20433900 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment IEP
IDA		 associated with Sciatic Neuropathy RGD PMID:22901764 PMID:22540262 RGD:7771531, RGD:7771574 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp6 dual specificity phosphatase 6 treatment IEP associated with Sciatic Neuropathy RGD PMID:22901764 RGD:7771531 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Edn1 endothelin 1 susceptibility ISO mRNA:increased expression:paw skin (mouse)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19429182 PMID:23347081 PMID:15664691 RGD:8661716, RGD:8661735 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 treatment IMP RGD PMID:20392816 RGD:9685429 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Ep300 E1A binding protein p300 IMP RGD PMID:25263804 RGD:9588307 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epha4 Eph receptor A4 IMP associated with spinal cord injuries; RGD PMID:16959251 RGD:5688783 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Ephx2 epoxide hydrolase 2 IMP RGD PMID:16962614 RGD:5688387 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IEP associated with interstitial cystitis; RGD PMID:30989724 RGD:405295490 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:19285805 RGD:8553066 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 IDA
ISO		 RGD PMID:17056036 PMID:19285805 RGD:5508846, RGD:8553066 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F2 coagulation factor II, thrombin ISO associated with Sciatic Neuropathy RGD PMID:16251448 RGD:7387272 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor severity ISO
IDA		 RGD PMID:19674841 PMID:12717003 PMID:11877315 RGD:7387269, RGD:7387270, RGD:7387271 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Fcgr1a Fc gamma receptor 1A ameliorates IMP RGD PMID:32510872 RGD:127338469 NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP
ISO		 protein:increased expression:dorsal horn of spinal cord, neuron
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27093858 PMID:22160634 RGD:9999169 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase treatment ISO associated with Cerebral Hemorrhage RGD PMID:34102854 RGD:329812008 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Gad1 glutamate decarboxylase 1 treatment ISO
IEP		 protein:increased expression:dorsal horn of spinal cord RGD PMID:26752351 PMID:27277808 RGD:405850208, RGD:405850240 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20457222 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfap glial fibrillary acidic protein IEP
ISO		 associated with Spinal Cord Injuries;mRNA,protein:increased expression:brain,spinal cord:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27093858 PMID:16219025 RGD:8695957 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 IDA RGD PMID:16464682 RGD:6218969 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Gja1 gap junction protein, alpha 1 treatment IMP
IEP
ISO		 associated with Sciatic Neuropathy
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:34286406 PMID:24631560 PMID:23374942 RGD:8662447, RGD:8662456 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:25280432 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 treatment ISO RGD PMID:27816787 RGD:405650587 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IDA RGD PMID:29758384 RGD:13792698 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B treatment ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20042082 PMID:24204988 RGD:13210755 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment
severity		 IDA
IMP
IEP		 associated with bone cancer
associated with Complex Regional Pain Syndromes		 RGD PMID:26935064 PMID:26064176 PMID:25466829 PMID:22796071 RGD:13513996, RGD:13514046, RGD:13514049, RGD:13792780 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grm8 glutamate metabotropic receptor 8 ISO RGD PMID:17113112 RGD:6771186 NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP associated with Limb Ischemia;protein:increased expression:foot muscle, plantar RGD PMID:18691814 RGD:9068903 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 treatment IEP
ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:27474498 PMID:24077211 PMID:30142543 RGD:7364865, RGD:13838658 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hoxd1 homeo box D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21151121 NCBI chr 3:59,665,629...59,667,769
Ensembl chr 3:59,665,629...59,667,769 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A IDA
ISO
IMP		 associated with Diabetic neuropathies;
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17888573 PMID:18930597 PMID:20531396 PMID:20039957 PMID:25584948 RGD:7257680, RGD:401901200, RGD:401938625 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP
IDA		 RGD PMID:21693130 PMID:21843960 RGD:6480665, RGD:6482179 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:9452187 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il10 interleukin 10 treatment IEP
IDA
ISO		 associated with Sciatic Neuropathy
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:7582491 PMID:17174526 PMID:23957449 PMID:22820166 PMID:24077211 RGD:7364792, RGD:7364827, RGD:7364865 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 treatment ISO RGD PMID:11399514 RGD:8549555 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il17a interleukin 17A treatment IDA
IMP		 RGD PMID:23192794 PMID:23246025 RGD:9068942, RGD:9222699 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 treatment IMP associated with Peripheral Nerve Injuries RGD PMID:19036970 RGD:8655929 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:12727271 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta IDA
ISO		 associated with Peripheral Nerve Injuries
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:7582491 PMID:10401557 PMID:12727271 PMID:17320857 PMID:20937348 More... RGD:1626676, RGD:6482671, RGD:7175548, RGD:7401209 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 IMP
ISO		 RGD PMID:19022353 PMID:11585580 RGD:8662898, RGD:8662903 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment
severity		 IDA
ISO
IMP		 associated with Arthritis, Experimental; rat model treated with human protein
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:8864563 PMID:15317861 PMID:17174526 PMID:20937348 PMID:23092240 More... RGD:6909165, RGD:6909175, RGD:7401210, RGD:8549800 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 treatment IMP
IEP
IDA		 associated with Sciatic Neuropathy; mRNA,protein:increased expression:spinal cord: RGD PMID:12755376 PMID:22189457 PMID:18423867 RGD:8662973, RGD:8662977, RGD:8662980 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il33 interleukin 33 IMP RGD PMID:29329586 RGD:40400909 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il6 interleukin 6 IEP
ISO		 associated with Foot Injuries; protein:increased expression:serum:
mRNA:increased expression:dorsal root ganglion
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:7582491 PMID:10401557 PMID:18652822 PMID:18988309 PMID:23953943 RGD:8662979, RGD:10402830 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor IEP mRNA:increased expression:dorsal root ganglion RGD PMID:23953943 RGD:10402830 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Insr insulin receptor treatment ISO associated with Diabetic Neuropathies
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18331706 PMID:23511693 RGD:10403050 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Itga1 integrin subunit alpha 1 IMP knock-down using a specific monoclonal antibody or RNAi
PGE2-induced		 RGD PMID:15836982 PMID:14984413 RGD:2302139, RGD:2302389 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Itga2 integrin subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18234883 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itga3 integrin subunit alpha 3 IMP knock-down using a specific monoclonal antibody or RNAi RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itga5 integrin subunit alpha 5 IMP epinephrine-induced
knock-down using a specific monoclonal antibody or RNAi		 RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Itgb1 integrin subunit beta 1 IMP knock-down using a specific monoclonal antibody or RNAi RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 IEP RGD PMID:25972297 RGD:13793383 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Jak2 Janus kinase 2 treatment IMP
ISO		 associated with Diabetic Neuropathies RGD PMID:18636982 PMID:23511693 RGD:6483031, RGD:10403050 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jak3 Janus kinase 3 treatment IEP RGD PMID:21434883 RGD:11533942 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 IMP RGD PMID:17855600 RGD:10411908 NCBI chr 2:195,063,967...195,100,244
Ensembl chr 2:195,071,769...195,099,233 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 ISO RGD PMID:16675954 RGD:9831112 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435 		JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 IEP associated with Bone Neoplasms;protein:decreased expression:dorsal root ganglia (rat) RGD PMID:23352759 RGD:9686417 NCBI chr 7:97,730,219...98,025,652
Ensembl chr 7:97,730,465...98,025,653 		JBrowse link
G Kmo kynurenine 3-monooxygenase treatment IMP RGD PMID:26524415 RGD:13703043 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
G Kng1 kininogen 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2010815 PMID:2128375 PMID:3061568 PMID:7493622 PMID:7582491 More... NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:20868656 RGD:11059894 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29143802 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:23665054 RGD:11560531 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 onset ISO RGD PMID:19427893 RGD:7495807 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12941468 PMID:27093858 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12941468 PMID:27093858 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17237256 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mc1r melanocortin 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19996949 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Mc4r melanocortin 4 receptor IEP protein:increased expression:dorsal root ganglia (rat) RGD PMID:20081244 RGD:6484233 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mecp2 methyl CpG binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33010341 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Men1 menin 1 IEP associated with Sciatic Neuropathy;protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:20369282 RGD:9589142 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871 		JBrowse link
G Mfn2 mitofusin 2 IEP
ISO		 mRNA:decreased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:28587902 PMID:28587902 RGD:12910704 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir15b microRNA 15b IDA RGD PMID:28012171 RGD:13782150 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir17 microRNA 17 severity IMP RGD PMID:26222740 RGD:11074685 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir381 microRNA 381 treatment IDA RGD PMID:30142543 RGD:13838658 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Mir500 microRNA 500 IEP RNA:decreased expression:dorsal horn of spinal cord RGD PMID:27277808 RGD:405850240 NCBI chr  X:15,258,778...15,258,857
Ensembl chr  X:15,258,768...15,258,859 		JBrowse link
G Mir96 microRNA 96 treatment IDA associated with Sciatic Neuropathy RGD PMID:24234845 RGD:11553932 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Mmp3 matrix metallopeptidase 3 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18754875 PMID:22056600 RGD:8693664 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mpz myelin protein zero ISO CTD Direct Evidence: marker/mechanism CTD PMID:16676325 NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:24382350 RGD:10040983 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nectin1 nectin cell adhesion molecule 1 IMP RGD PMID:27394444 RGD:405866373 NCBI chr 8:44,101,776...44,164,863
Ensembl chr 8:44,101,776...44,189,787 		JBrowse link
G Nefh neurofilament heavy chain treatment IEP RGD PMID:21071147 RGD:27226885 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Ngf nerve growth factor treatment ISO
IMP
IDA		 associated with Cystitis
associated with Peripheral Nerve Injuries;
CTD Direct Evidence: marker/mechanism
associated with Osteoarthritis, Experimental		 CTD
RGD		 PMID:20457222 PMID:16203088 PMID:18448607 PMID:22839415 PMID:11425916 More... RGD:7242799, RGD:7242803, RGD:7242849, RGD:8657088, RGD:402463955, RGD:405100717 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor treatment IMP associated with Brachial Plexus Neuropathies RGD PMID:23324933 RGD:10413898 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nlgn2 neuroligin 2 IMP RGD PMID:23891900 RGD:9831150 NCBI chr10:54,544,461...54,557,854
Ensembl chr10:54,544,588...54,558,434 		JBrowse link
G Nos1 nitric oxide synthase 1 IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19300402 PMID:23909597 RGD:7257597 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17989504 PMID:19300402 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npy neuropeptide Y treatment IEP associated with Sciatic Neuropathy RGD PMID:19556004 RGD:10448929 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nrg1 neuregulin 1 IEP associated with Sciatic Neuropathy
associated with interstitial cystitis;		 RGD PMID:22212401 PMID:30989724 RGD:10449019, RGD:405295490 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Ntf3 neurotrophin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:15659614 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IMP RGD PMID:17667845 PMID:20351485 RGD:5144120, RGD:5684352 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO
IEP		 associated with inflammation;protein:increased expression:dorsal root ganglion: RGD PMID:12470870 PMID:21958434 RGD:8657091, RGD:8657122 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Ntsr1 neurotensin receptor 1 IDA RGD PMID:22396077 RGD:9743902 NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377 		JBrowse link
G Oprk1 opioid receptor, kappa 1 treatment IMP associated with Diabetes Mellitus, Experimental; RGD PMID:16924480 RGD:9834947 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IEP associated with Sciatic Neuropathy;mRNA:increased expression:spinal cord lumbar segment,dorsal root ganglion: RGD PMID:12106803 RGD:9835017 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17996026 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G P2rx2 purinergic receptor P2X 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19383439 NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891 		JBrowse link
G P2rx3 purinergic receptor P2X 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19383439 NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178 		JBrowse link
G P2rx4 purinergic receptor P2X 4 treatment IMP associated with Peripheral Nerve Injuries; RGD PMID:29927790 RGD:40924654 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G P2ry12 purinergic receptor P2Y12 ISO
IMP		 RGD PMID:20398327 PMID:20136836 RGD:6480525, RGD:6480526 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361 		JBrowse link
G Pawr pro-apoptotic WT1 regulator treatment IDA RGD PMID:17179954 RGD:9835416 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pdyn prodynorphin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17670969 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:23235561 RGD:10003116 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pla2g4a phospholipase A2 group 4A IMP RGD PMID:16203828 RGD:1642461 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pnoc prepronociceptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12665541 PMID:19231294 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha IMP RGD PMID:26732138 RGD:11572421 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Prkcb protein kinase C, beta IDA associated with inflammation;protein:increased activity:spinal cord RGD PMID:16360284 RGD:1625519 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkce protein kinase C, epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:11738263 PMID:12582831 PMID:20457222 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkcg protein kinase C, gamma treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19955894 PMID:27093858 PMID:12560106 RGD:28867224 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prkcz protein kinase C, zeta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27899695 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 treatment ISO RGD PMID:14973199 RGD:7775058 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Prok2 prokineticin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385 		JBrowse link
G Prokr1 prokineticin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr 4:120,022,301...120,033,367
Ensembl chr 4:120,021,747...120,033,379 		JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP RGD PMID:16925995 RGD:10041052 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Ptger1 prostaglandin E receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11375261 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Ptger3 prostaglandin E receptor 3 IEP protein:increased expression:lumbar spinal cord dorsal horn (rat) RGD PMID:17413918 RGD:5688169 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptger4 prostaglandin E receptor 4 treatment IMP RGD PMID:20423341 RGD:10003041 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptges3 prostaglandin E synthase 3 IMP RGD PMID:16192391 RGD:5688057 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IEP
ISO		 protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17989504 PMID:17413918 RGD:5688169 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17112505 PMID:17989504 PMID:15464832 RGD:5688224 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pthlh parathyroid hormone-like hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:16769263 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18976650 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 treatment IMP associated with lesion of sciatic nerve RGD PMID:27641322 RGD:13524513 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16545521 PMID:19070548 RGD:6484253 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23264124 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044 		JBrowse link
G Sin3a SIN3 transcription regulator family member A IEP associated with Arthritis, Experimental;mRNA:decreased expression:spinal cord, neuron RGD PMID:17553988 RGD:9495916 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192 		JBrowse link
G Slc12a5 solute carrier family 12 member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20086212 NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 IEP protein:increased expression:dorsal horn of spinal cord, neuron RGD PMID:22160634 RGD:9999169 NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079 		JBrowse link
G Sparc secreted protein acidic and cysteine rich ISO CTD Direct Evidence: marker/mechanism CTD PMID:20714283 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IEP protein:increased phosphorylation:spinal cord RGD PMID:27394444 RGD:405866373 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IMP RGD PMID:24098399 RGD:8694290 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Syn2 synapsin II ISO CTD Direct Evidence: marker/mechanism CTD PMID:18701217 NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192 		JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8864563 PMID:9714424 PMID:10499367 PMID:12351280 PMID:12787826 More... NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15964684 PMID:17123731 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33607128 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 IMP associated with Experimental Pancreatitis, Chronic RGD PMID:26645248 RGD:14995470 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Thbd thrombomodulin treatment ISO associated with Inflammation
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:27474498 PMID:24004409 RGD:11038687 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Tlr2 toll-like receptor 2 ISO
IDA		 RGD PMID:17355971 PMID:24204973 RGD:8553059, RGD:8553185 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 IMP
ISO		 RGD PMID:20714435 PMID:15809417 PMID:24204973 RGD:4144070, RGD:7815040, RGD:8553185 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor IMP
IEP
IDA
ISO		 protein:increased expression:lumbar vertebra:
mRNA,protein:increased expression:spinal cord:
associated with Diabetic Neuropathies;
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:7582491 PMID:7881729 PMID:10401557 PMID:12727271 PMID:16472913 More... RGD:7387300, RGD:7387300, RGD:7387302, RGD:7394737, RGD:7394741, RGD:7394757, RGD:7401179 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B ISO CTD Direct Evidence: therapeutic CTD PMID:16769263 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A treatment IMP
ISO
IEP		 associated with Sciatic Neuropathy RGD PMID:12752784 PMID:21145890 PMID:20417692 PMID:24257399 PMID:21712071 More... RGD:5130913, RGD:5130939, RGD:8661726, RGD:8661737, RGD:8548873, RGD:8661750 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO
IMP		 associated with Sciatic Neuropathy RGD PMID:18463260 PMID:22652595 RGD:5130960, RGD:8661750 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IMP
ISO		 associated with Peripheral Nerve Injuries;
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18234885 PMID:21481532 PMID:23523557 PMID:18954467 RGD:10043618 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 IMP associated with Inflammation RGD PMID:19439599 RGD:7247605 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 IMP RGD PMID:19439599 RGD:7247605 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IEP
ISO		 associated with inflammation;protein:increased expression:dorsal root ganglion:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12151517 PMID:18234885 PMID:18774343 PMID:23006841 PMID:21958434 RGD:8657122 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18234883 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517 		JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12787826 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19065
    sensory system disease 7235
      Somatosensory Disorders 327
        Hyperalgesia 209
Path 2
Term Annotations click to browse term
  disease 19065
    Pathological Conditions, Signs and Symptoms 13511
      Signs and Symptoms 11070
        Neurologic Manifestations 10322
          sensory system disease 7235
            Somatosensory Disorders 327
              Hyperalgesia 209
paths to the root