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ONTOLOGY REPORT - ANNOTATIONS


Term:Hyperalgesia
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Accession:DOID:9002211 term browser browse the term
Definition:An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Synonyms:exact_synonym: Allodynia;   Allodynias, Mechanical;   Allodynias, Tactile;   Allodynias, Thermal;   Hyperalgesia, Primary;   Hyperalgesia, Secondary;   Hyperalgesia, Tactile;   Hyperalgesias;   Hyperalgesias, Mechanical;   Hyperalgesias, Primary;   Hyperalgesias, Secondary;   Hyperalgesias, Tactile;   Hyperalgesias, Thermal;   Hyperalgesic Sensations;   Mechanical Allodynia;   Mechanical Hyperalgesia;   Tactile Allodynia;   Thermal Allodynia;   Thermal Hyperalgesia;   pain hypersensitivity
 primary_id: MESH:D006930;   RDO:0005827
For additional species annotation, visit the Alliance of Genome Resources.


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Hyperalgesia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABAT 4-aminobutyrate aminotransferase JBrowse link 3 33,913,068 33,960,804 RGD:9068941
G ADK adenosine kinase JBrowse link 14 76,836,072 77,320,586 RGD:9068941
G ADM adrenomedullin JBrowse link 2 49,229,223 49,231,521 RGD:9068941
G ADORA1 adenosine A1 receptor JBrowse link 9 113,835,279 113,875,899 RGD:9068941
G ADRA1A adrenoceptor alpha 1A JBrowse link 14 10,623,391 10,733,378 RGD:9068941
G ADRA2A adrenoceptor alpha 2A JBrowse link 14 121,469,572 121,470,924 RGD:9068941
G ADRA2C adrenoceptor alpha 2C JBrowse link 8 2,320,125 2,322,162 RGD:9068941
G ADRB1 adrenoceptor beta 1 JBrowse link 14 124,400,330 124,401,739 RGD:9068941
G AGER advanced glycosylation end-product specific receptor JBrowse link 7 24,218,116 24,221,162 RGD:9068941
G AGT angiotensinogen JBrowse link 14 59,643,030 59,656,835 RGD:9068941
G AIF1 allograft inflammatory factor 1 JBrowse link 7 23,711,752 23,731,191 RGD:9068941
G AKR1B1 aldo-keto reductase family 1 member B JBrowse link 18 14,593,516 14,752,316 RGD:9068941
G ALOX12 arachidonate 12-lipoxygenase, 12S type JBrowse link 12 52,401,861 52,414,913 RGD:9068941
G ALOX5 arachidonate 5-lipoxygenase JBrowse link 14 90,859,209 90,907,084 RGD:9068941
G ANO3 anoctamin 3 JBrowse link 2 33,618,740 34,048,973 RGD:9068941
G ANXA1 annexin A1 JBrowse link 1 226,414,200 226,431,963 RGD:9068941
G AQP4 aquaporin 4 JBrowse link 6 111,407,632 111,422,169 RGD:9068941
G AVP arginine vasopressin JBrowse link 17 32,581,234 32,583,145 RGD:9068941
G BACE1 beta-secretase 1 JBrowse link 9 44,640,389 44,665,863 RGD:9068941
G BDKRB1 bradykinin receptor B1 JBrowse link 7 117,491,350 117,492,410 RGD:9068941
G BDKRB2 bradykinin receptor B2 JBrowse link 7 117,438,622 117,472,005 RGD:9068941
G BDNF brain derived neurotrophic factor JBrowse link 2 32,623,668 32,679,293 RGD:9068941
G BECN1 beclin 1 JBrowse link 12 20,041,914 20,054,249 RGD:9068941
G C3 complement C3 JBrowse link 2 72,431,470 72,471,622 RGD:9068941
G CACNA1B calcium voltage-gated channel subunit alpha1 B RGD:9068941
G CACNA1H calcium voltage-gated channel subunit alpha1 H JBrowse link 3 40,637,420 40,694,616 RGD:9068941
G CACNA1I calcium voltage-gated channel subunit alpha1 I JBrowse link 5 8,593,014 8,702,734 RGD:9068941
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 JBrowse link 9 97,781,057 98,265,925 RGD:9068941
G CALCB calcitonin-related polypeptide beta JBrowse link 2 44,043,135 44,048,651 RGD:9068941
G CAMK2A calcium/calmodulin dependent protein kinase II alpha JBrowse link 2 151,248,356 151,353,907 RGD:9068941
G CAPN2 calpain 2 JBrowse link 10 19,758,824 19,820,241 RGD:9068941
G CARTPT CART prepropeptide JBrowse link 16 48,043,558 48,045,592 RGD:9068941
G CAT catalase JBrowse link 2 26,493,664 26,533,881 RGD:9068941
G CCK cholecystokinin JBrowse link 13 25,940,674 25,945,879 RGD:9068941
G CCKBR cholecystokinin B receptor JBrowse link 9 3,409,222 3,419,513 RGD:9068941
G CCL2 chemokine (C-C motif) ligand 2 JBrowse link 12 40,798,109 40,800,013 RGD:9068941
G CCL5 C-C motif chemokine ligand 5 JBrowse link 12 39,652,731 39,659,121 RGD:9068941
G CCR2 C-C motif chemokine receptor 2 JBrowse link 13 29,368,735 29,374,564 RGD:9068941
G CCR5 chemokine (C-C motif) receptor 5 JBrowse link 13 29,382,383 29,387,902 RGD:9068941
G CFL1 cofilin 1 JBrowse link 2 6,471,558 6,475,019 RGD:9068941
G CNR1 cannabinoid receptor 1 JBrowse link 1 56,466,022 56,493,275 RGD:9068941
G CNR2 cannabinoid receptor 2 JBrowse link 6 81,659,162 81,692,550 RGD:9068941
G COMT catechol-O-methyltransferase JBrowse link 14 51,384,729 51,403,997 RGD:9068941
G CRCP CGRP receptor component JBrowse link 3 16,528,949 16,622,005 RGD:9068941
G CRHR1 corticotropin releasing hormone receptor 1 JBrowse link 12 17,251,361 17,306,308 RGD:9068941
G CSF3 colony stimulating factor 3 JBrowse link 12 22,333,445 22,335,949 RGD:9068941
G CSK C-terminal Src kinase JBrowse link 7 58,736,473 58,755,034 RGD:9068941
G CTSS cathepsin S JBrowse link 4 98,415,273 98,442,952 RGD:9068941
G CX3CL1 C-X3-C motif chemokine ligand 1 JBrowse link 6 19,312,351 19,324,439 RGD:9068941
G CX3CR1 C-X3-C motif chemokine receptor 1 JBrowse link 13 23,944,386 23,957,567 RGD:9068941
G CXCL12 C-X-C motif chemokine ligand 12 JBrowse link 14 91,516,383 91,543,857 RGD:9068941
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 8 69,932,646 69,935,861 RGD:9068941
G CXCR2 C-X-C motif chemokine receptor 2 JBrowse link 15 120,219,657 120,230,203 RGD:9068941
G CXCR4 C-X-C motif chemokine receptor 4 JBrowse link 15 15,663,652 15,666,706 RGD:9068941
G DLG4 discs large MAGUK scaffold protein 4 JBrowse link 12 52,550,138 52,574,021 RGD:9068941
G DNMT1 DNA methyltransferase 1 JBrowse link 2 68,981,564 69,040,364 RGD:9068941
G DRD3 dopamine receptor D3 JBrowse link 13 145,769,294 145,817,997 RGD:9068941
G DUSP1 dual specificity phosphatase 1 JBrowse link 16 51,457,924 51,461,095 RGD:9068941
G DUSP6 dual specificity phosphatase 6 JBrowse link 5 93,303,058 93,307,510 RGD:9068941
G EDN1 endothelin 1 JBrowse link 7 8,752,018 8,758,354 RGD:9068941
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 JBrowse link 4 19,319,815 19,433,492 RGD:9068941
G EP300 E1A binding protein p300 JBrowse link 5 7,311,165 7,394,515 RGD:9068941
G EPHA4 EPH receptor A4 JBrowse link 15 123,350,867 123,501,872 RGD:9068941
G EPHX2 epoxide hydrolase 2 JBrowse link 14 11,217,125 11,293,018 RGD:9068941
G ESR1 estrogen receptor 1 JBrowse link 1 14,217,032 14,604,906 RGD:9068941
G ESR2 estrogen receptor 2 JBrowse link 1 193,823,666 193,907,330 RGD:9068941
G F2 coagulation factor II, thrombin JBrowse link 2 15,793,257 15,819,151 RGD:9068941
G F2R coagulation factor II thrombin receptor JBrowse link 2 85,642,794 85,659,133 RGD:9068941
G FOS Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 7 98,449,508 98,451,971 RGD:9068941
G GAL galanin and GMAP prepropeptide JBrowse link 2 4,351,113 4,357,167 RGD:9068941
G GDNF glial cell derived neurotrophic factor JBrowse link 16 22,936,602 22,965,929 RGD:9068941
G GFAP glial fibrillary acidic protein JBrowse link 12 18,456,268 18,466,594 RGD:9068941
G GFRA1 GDNF family receptor alpha 1 JBrowse link 14 126,273,558 126,499,957 RGD:9068941
G GJA1 gap junction protein alpha 1 JBrowse link 1 40,988,818 41,002,129 RGD:9068941
G GP91-PHOX NADPH oxidase heavy chain subunit JBrowse link X 33,654,656 33,678,346 RGD:9068941
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 RGD:9068941
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 3 32,749,329 33,149,350 RGD:9068941
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 5 58,477,862 58,948,735 RGD:9068941
G GRK2 G protein-coupled receptor kinase 2 JBrowse link 2 5,209,435 5,227,543 RGD:9068941
G GRM8 glutamate metabotropic receptor 8 JBrowse link 18 20,945,049 21,756,952 RGD:9068941
G HIF1A hypoxia inducible factor 1 subunit alpha JBrowse link 1 190,625,436 190,673,926 RGD:9068941
G HMGB1 high mobility group box 1 JBrowse link 11 7,195,556 7,321,071 RGD:9068941
G HOXD1 homeobox D1 JBrowse link 15 81,987,618 81,990,026 RGD:9068941
G HTR2A 5-hydroxytryptamine receptor 2A JBrowse link 11 20,555,939 20,620,225 RGD:9068941
G HTR7 5-hydroxytryptamine receptor 7 JBrowse link 14 102,443,312 102,548,894 RGD:9068941
G IGF1 insulin like growth factor 1 JBrowse link 5 81,762,027 81,909,253 RGD:9068941
G IL10 interleukin 10 JBrowse link 9 67,400,727 67,405,941 RGD:9068941
G IL13 interleukin 13 JBrowse link 2 134,972,099 134,976,672 RGD:9068941
G IL17A interleukin 17A JBrowse link 7 46,013,584 46,017,161 RGD:9068941
G IL18 interleukin 18 JBrowse link 9 39,839,959 39,861,258 RGD:9068941
G IL1A interleukin 1 alpha JBrowse link 3 43,718,320 43,731,668 RGD:9068941
G IL1R1 interleukin 1 receptor type 1 JBrowse link 3 52,192,912 52,334,734 RGD:9068941
G IL1RN interleukin 1 receptor antagonist RGD:9068941
G IL2 interleukin 2 JBrowse link 8 101,640,938 101,645,683 RGD:9068941
G IL6 interleukin 6 JBrowse link 9 91,506,421 91,510,830 RGD:9068941
G IL6R interleukin 6 receptor JBrowse link 4 95,322,426 95,381,393 RGD:9068941
G INSR insulin receptor JBrowse link 2 71,797,209 71,939,923 RGD:9068941
G ITGA1 integrin subunit alpha 1 JBrowse link 16 32,130,265 32,309,917 RGD:9068941
G ITGA2 integrin subunit alpha 2 JBrowse link 16 32,336,240 32,440,311 RGD:9068941
G ITGA3 integrin subunit alpha 3 JBrowse link 12 26,234,769 26,269,327 RGD:9068941
G ITGA5 integrin subunit alpha 5 JBrowse link 5 19,587,361 19,610,580 RGD:9068941
G ITGB1 integrin subunit beta 1 JBrowse link 10 56,078,393 56,130,608 RGD:9068941
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 JBrowse link 13 61,068,131 61,398,918 RGD:9068941
G JAK2 Janus kinase 2 JBrowse link 1 216,849,744 217,002,310 RGD:9068941
G JAK3 Janus kinase 3 JBrowse link 2 59,905,901 59,926,504 RGD:9068941
G KCNC4 potassium voltage-gated channel subfamily C member 4 JBrowse link 4 109,885,116 109,908,518 RGD:9068941
G KCNK2 potassium two pore domain channel subfamily K member 2 JBrowse link 9 128,429,232 128,659,662 RGD:9068941
G KCNQ3 potassium voltage-gated channel subfamily Q member 3 JBrowse link 4 8,669,969 8,978,656 RGD:9068941
G KMO kynurenine 3-monooxygenase JBrowse link 10 12,442,877 12,489,417 RGD:9068941
G KNG1 kininogen 1 JBrowse link 13 124,521,276 124,557,384 RGD:9068941
G LOC110258578 interleukin-1 beta-like RGD:9068941
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha JBrowse link 17 37,957,830 37,959,505 RGD:9068941
G MAP2K3 mitogen-activated protein kinase kinase 3 JBrowse link 12 61,396,337 61,417,333 RGD:9068941
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 14 50,083,079 50,165,528 RGD:9068941
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 3 18,291,444 18,299,410 RGD:9068941
G MAPK7 mitogen-activated protein kinase 7 JBrowse link 12 60,144,138 60,148,743 RGD:9068941
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 14 88,988,914 89,108,875 RGD:9068941
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 2 78,338,466 78,399,108 RGD:9068941
G MC1R melanocortin 1 receptor JBrowse link 6 181,225 182,187 RGD:9068941
G MC4R melanocortin 4 receptor JBrowse link 1 160,772,013 160,774,124 RGD:9068941
G MEN1 menin 1 JBrowse link 2 7,358,130 7,364,952 RGD:9068941
G MFN2 mitofusin 2 JBrowse link 6 72,026,512 72,056,439 RGD:9068941
G MIR15B microRNA mir-15b JBrowse link 13 100,083,172 100,083,269 RGD:9068941
G MIR381 microRNA mir-381 RGD:9068941
G MIR96 microRNA mir-96 JBrowse link 18 18,982,506 18,982,590 RGD:9068941
G MMP3 matrix metallopeptidase 3 JBrowse link 9 33,446,969 33,453,995 RGD:9068941
G MPZ myelin protein zero JBrowse link 4 89,174,107 89,179,556 RGD:9068941
G MTOR mechanistic target of rapamycin kinase JBrowse link 6 71,286,989 71,412,913 RGD:9068941
G NEFH neurofilament heavy JBrowse link 14 46,559,698 46,568,686 RGD:9068941
G NGF nerve growth factor JBrowse link 4 105,256,691 105,307,843 RGD:9068941
G NGFR nerve growth factor receptor JBrowse link 12 25,699,410 25,720,355 RGD:9068941
G NOS1 nitric oxide synthase 1 JBrowse link 14 35,112,898 35,299,297 RGD:9068941
G NOS2 nitric oxide synthase 2 JBrowse link 12 44,174,944 44,219,875 RGD:9068941
G NPY neuropeptide Y JBrowse link 18 47,985,796 47,993,726 RGD:9068941
G NRG1 neuregulin 1 JBrowse link 15 52,625,550 53,688,003 RGD:9068941
G NTF3 neurotrophin 3 JBrowse link 5 65,052,608 65,122,645 RGD:9068941
G NTRK1 neurotrophic receptor tyrosine kinase 1 JBrowse link 4 93,219,509 93,237,944 RGD:9068941
G NTRK2 neurotrophic receptor tyrosine kinase 2 JBrowse link 10 30,030,050 30,429,938 RGD:9068941
G NTSR1 neurotensin receptor 1 JBrowse link 17 61,989,601 62,038,299 RGD:9068941
G OPRK1 opioid receptor kappa 1 JBrowse link 4 77,399,298 77,429,025 RGD:9068941
G OPRL1 opioid related nociceptin receptor 1 JBrowse link 17 62,905,700 62,913,018 RGD:9068941
G OPRM1 opioid receptor mu 1 JBrowse link 1 12,634,125 12,702,295 RGD:9068941
G P2RX2 purinergic receptor P2X 2 JBrowse link 14 22,854,828 22,858,574 RGD:9068941
G P2RX3 purinergic receptor P2X 3 JBrowse link 2 13,584,913 13,619,652 RGD:9068941
G P2RY12 purinergic receptor P2Y12 JBrowse link 13 91,522,754 91,572,195 RGD:9068941
G PAWR pro-apoptotic WT1 regulator JBrowse link 5 101,693,145 101,797,842 RGD:9068941
G PDYN prodynorphin JBrowse link 17 33,505,075 33,521,534 RGD:9068941
G PENK proenkephalin JBrowse link 4 75,525,497 75,530,403 RGD:9068941
G PLA2G4A phospholipase A2 group IVA JBrowse link 9 127,853,581 128,164,825 RGD:9068941
G PNOC prepronociceptin JBrowse link 14 12,101,223 12,134,174 RGD:9068941
G PPP2CA protein phosphatase 2 catalytic subunit alpha JBrowse link 2 136,497,780 136,522,630 RGD:9068941
G PRKCB protein kinase C beta JBrowse link 3 21,995,227 22,383,628 RGD:9068941
G PRKCE protein kinase C epsilon JBrowse link 3 94,351,277 94,864,549 RGD:9068941
G PRKCG protein kinase C gamma JBrowse link 6 56,213,479 56,235,683 RGD:9068941
G PRKCZ protein kinase C zeta JBrowse link 6 64,073,343 64,159,187 RGD:9068941
G PRKG1 protein kinase cGMP-dependent 1 JBrowse link 14 97,558,531 98,793,080 RGD:9068941
G PROK2 prokineticin 2 JBrowse link 13 53,169,040 53,184,695 RGD:9068941
G PROKR1 prokineticin receptor 1 JBrowse link 3 73,689,583 73,711,410 RGD:9068941
G PTAFR platelet activating factor receptor JBrowse link 6 85,235,390 85,272,360 RGD:9068941
G PTGER1 prostaglandin E receptor 1 JBrowse link 2 64,796,944 64,800,199 RGD:9068941
G PTGER3 prostaglandin E receptor 3 JBrowse link 6 141,958,955 142,160,437 RGD:9068941
G PTGER4 prostaglandin E receptor 4 JBrowse link 16 25,670,832 25,686,556 RGD:9068941
G PTGES3 prostaglandin E synthase 3 JBrowse link 5 22,000,335 22,022,830 RGD:9068941
G PTGS1 prostaglandin-endoperoxide synthase 1 JBrowse link 1 262,456,106 262,482,159 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 9 127,850,164 127,858,866 RGD:9068941
G PTHLH parathyroid hormone like hormone JBrowse link 5 45,750,968 45,763,421 RGD:9068941
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 13 68,581,128 68,657,911 RGD:9068941
G RGS4 regulator of G protein signaling 4 JBrowse link 4 87,383,336 87,390,478 RGD:9068941
G SCN10A sodium voltage-gated channel alpha subunit 10 JBrowse link 13 23,481,537 23,570,454 RGD:9068941
G SCN11A sodium voltage-gated channel alpha subunit 11 JBrowse link 13 23,602,378 23,692,281 RGD:9068941
G SIN3A SIN3 transcription regulator family member A JBrowse link 7 58,171,821 58,246,126 RGD:9068941
G SLC12A5 solute carrier family 12 member 5 JBrowse link 17 48,192,072 48,230,674 RGD:9068941
G SLC17A8 solute carrier family 17 member 8 JBrowse link 5 83,741,641 83,809,472 RGD:9068941
G SPARC secreted protein acidic and cysteine rich JBrowse link 16 71,368,164 71,380,972 RGD:9068941
G STAT3 signal transducer and activator of transcription 3 JBrowse link 12 20,407,316 20,471,091 RGD:9068941
G SYN2 synapsin II JBrowse link 13 68,050,015 68,221,504 RGD:9068941
G TAC1 tachykinin precursor 1 JBrowse link 9 77,197,403 77,206,529 RGD:9068941
G TACR1 tachykinin receptor 1 JBrowse link 3 67,839,367 68,021,733 RGD:9068941
G TGFBR1 transforming growth factor beta receptor 1 JBrowse link 1 240,842,735 240,918,267 RGD:9068941
G THBD thrombomodulin JBrowse link 17 30,219,870 30,223,499 RGD:9068941
G TLR2 toll like receptor 2 JBrowse link 8 75,416,257 75,428,370 RGD:9068941
G TLR4 toll like receptor 4 JBrowse link 1 258,044,610 258,054,641 RGD:9068941
G TNF tumor necrosis factor JBrowse link 7 23,699,635 23,702,393 RGD:9068941
G TNFRSF11B TNF receptor superfamily member 11b JBrowse link 4 19,850,212 19,879,132 RGD:9068941
G TNFRSF1A TNF receptor superfamily member 1A JBrowse link 5 64,319,349 64,331,876 RGD:9068941
G TNFRSF1B TNF receptor superfamily member 1B JBrowse link 6 72,195,420 72,231,146 RGD:9068941
G TRPA1 transient receptor potential cation channel subfamily A member 1 JBrowse link 4 63,493,374 63,558,486 RGD:9068941
G TRPC1 transient receptor potential cation channel subfamily C member 1 JBrowse link 13 83,436,343 83,498,419 RGD:9068941
G TRPC6 transient receptor potential cation channel subfamily C member 6 JBrowse link 9 32,332,768 32,439,184 RGD:9068941
G TRPV1 transient receptor potential cation channel subfamily V member 1 JBrowse link 12 49,676,536 49,709,634 RGD:9068941
G TRPV4 transient receptor potential cation channel subfamily V member 4 JBrowse link 14 41,125,819 41,169,582 RGD:9068941
G VIP vasoactive intestinal peptide JBrowse link 1 13,611,786 13,620,250 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12518
    disease of anatomical entity 12073
      nervous system disease 9798
        Neurologic Manifestations 3674
          Pain 284
            Hyperalgesia 192
Path 2
Term Annotations click to browse term
  disease 12518
    disease of anatomical entity 12073
      nervous system disease 9798
        Neurologic Manifestations 3674
          Sensation Disorders 899
            Somatosensory Disorders 309
              Hyperalgesia 192
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.