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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hyperalgesia
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Accession:DOID:9002211 term browser browse the term
Definition:An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Synonyms:exact_synonym: Allodynia;   Allodynias, Tactile;   Allodynias, Thermal;   Hyperalgesia, Primary;   Hyperalgesia, Secondary;   Hyperalgesias;   Hyperalgesias, Mechanical;   Hyperalgesias, Primary;   Hyperalgesias, Secondary;   Hyperalgesias, Tactile;   Hyperalgesias, Thermal;   Hyperalgesic Sensations;   Mechanical Allodynia;   Mechanical Allodynias;   Mechanical Hyperalgesia;   Tactile Allodynia;   Tactile Hyperalgesia;   Thermal Allodynia;   Thermal Hyperalgesia;   pain hypersensitivity
 primary_id: MESH:D006930


show annotations for term's descendants           Sort by:
Hyperalgesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase treatment ISO RGD PMID:24890317 RGD:9588557 NCBI chr16:8,331,293...8,439,432
Ensembl chr16:8,331,293...8,439,432 		JBrowse link
G Adk adenosine kinase ISO associated with diabetic neuropathies; RGD PMID:11423084 PMID:9932716 RGD:6482662, RGD:6482666 NCBI chr14:21,102,622...21,498,637
Ensembl chr14:21,102,642...21,498,637 		JBrowse link
G Adm adrenomedullin ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17043245 PMID:17043245 RGD:1625316 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027 		JBrowse link
G Adora1 adenosine A1 receptor ISO associated with Spinal Cord Injuries RGD PMID:20065990 RGD:5129094 NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169 		JBrowse link
G Adra1a adrenergic receptor, alpha 1a ISO associated with Diabetes Mellitus, Experimental; mRNA:increased expression:dorsal root ganglion RGD PMID:10841349 RGD:5688377 NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617 		JBrowse link
G Adra2a adrenergic receptor, alpha 2a ISO RGD PMID:17959985 RGD:6480488 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413 		JBrowse link
G Adra2c adrenergic receptor, alpha 2c ISO RGD PMID:20007733 RGD:6893568 NCBI chr 5:35,435,910...35,439,107
Ensembl chr 5:35,435,663...35,439,107 		JBrowse link
G Adrb1 adrenergic receptor, beta 1 ISO RGD PMID:19283893 RGD:5129125 NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:25014009 PMID:25014009 PMID:24077211 RGD:8695980, RGD:7364865 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:9613798 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Aif1 allograft inflammatory factor 1 ISO associated with Alcohol-Induced Disorders, Nervous System; protein:increased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27093858 PMID:17284346 RGD:2313035 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B ISO associated with Hyperglycemia RGD PMID:12505670 RGD:1626082 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12582831 NCBI chr11:70,132,283...70,146,206
Ensembl chr11:70,132,283...70,146,179 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12582831 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Ano3 anoctamin 3 ISO RGD PMID:23872594 RGD:9681745 NCBI chr 2:110,485,546...110,780,854
Ensembl chr 2:110,485,546...110,781,268 		JBrowse link
G Anxa1 annexin A1 ISO protein:increased expression:dorsal root ganglion RGD PMID:9222544 PMID:21990306 RGD:2306950, RGD:7421656 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
G Aqp4 aquaporin 4 ISO associated with Spinal Cord Injuries;mRNA,protein:increased expression:brain,spinal cord: RGD PMID:16219025 RGD:8695957 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039 		JBrowse link
G Avp arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:9613798 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474 		JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 ISO RGD PMID:28012171 RGD:13782150 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697 		JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17989505 PMID:19300402 PMID:19815945 PMID:12927641 PMID:12637034 RGD:1579989, RGD:7241581 NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687 		JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 ISO associated with Diabetic Neuropathy
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17989505 PMID:19300402 PMID:19815945 PMID:10188975 PMID:19300402 RGD:4891040, RGD:2313332 NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO
IMP		 associated with Peripheral Nerve Injuries;
associated with Sciatic Neuropathy;
associated with Pancreatitis, Chronic;
associated with inflammation;protein:increased expression:dorsal root ganglion:		 RGD PMID:11425916 PMID:12470870 PMID:21499209 PMID:21864655 PMID:12435470 More... RGD:8657088, RGD:8657091, RGD:8657093, RGD:8657099, RGD:8657101, RGD:8657114, RGD:8657122 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Becn1 beclin 1, autophagy related ISO RGD PMID:23665054 RGD:11560531 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G C3 complement component 3 ISO associated with Sciatic Neuropathy;mRNA, protein:increased expression:spinal cord RGD PMID:23588254 RGD:7401259 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit ISO RGD PMID:17567797 RGD:1626313 NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164 		JBrowse link
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19577366 PMID:30552955 PMID:34286406 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759 		JBrowse link
G Cacna1i calcium channel, voltage-dependent, alpha 1I subunit ISO RGD PMID:17112407 RGD:15003199 NCBI chr15:80,171,439...80,282,493
Ensembl chr15:80,171,439...80,282,480 		JBrowse link
G Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11245671 PMID:17881535 PMID:24133248 NCBI chr 5:16,139,390...16,579,509
Ensembl chr 5:16,139,786...16,579,502 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha ISO associated with inflammation;protein:increased expression:dorsal root ganglion:
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:12787826 PMID:12855330 PMID:15265675 PMID:27093858 PMID:21958434 RGD:8657122 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20053885 PMID:18042863 RGD:7240711 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Capn2 calpain 2 treatment ISO associated with Peripheral Nerve Injuries RGD PMID:25150005 RGD:13792585 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173 		JBrowse link
G Cartpt CART prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:21167239 NCBI chr13:100,034,991...100,037,191
Ensembl chr13:100,034,997...100,037,599 		JBrowse link
G Cat catalase treatment ISO RGD PMID:23952340 PMID:23658840 RGD:9479063, RGD:9479069 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cck cholecystokinin ISO RGD PMID:15647484 RGD:1626108 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760 		JBrowse link
G Cckbr cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11880531 PMID:15647484 RGD:1626108 NCBI chr 7:105,075,201...105,085,546
Ensembl chr 7:105,074,938...105,120,105 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO
IMP		 protein:increased expression:dorsal root ganglion, spinal cord (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17881535 PMID:18419759 PMID:22531750 PMID:20737477 PMID:21712071 RGD:2307043, RGD:8548845, RGD:8548848, RGD:8548873 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:dorsal root ganglion (rat) RGD PMID:18076762 PMID:18656466 RGD:4890034, RGD:2303121 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO
IMP		 associated with Bone Neoplasms;protein:increased expression:spinal cord:
protein:increased expression:dorsal horn of spinal cord:
associated with Sciatic Neuropathy;
associated with Demyelinating Diseases;
associated with Intervertebral disc disease;		 RGD PMID:18419759 PMID:23511129 PMID:22721162 PMID:24907405 PMID:18076762 More... RGD:2307043, RGD:8661772, RGD:8548831, RGD:8661781, RGD:4890034, RGD:8661788 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO
IMP		 mRNA:increased expression:dorsal root ganglion (rat)
associated with Spinal Cord Injuries		 RGD PMID:18076762 PMID:24589480 PMID:23147416 PMID:22033364 RGD:4890034, RGD:8551795, RGD:8551809, RGD:8551820 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Cfl1 cofilin 1, non-muscle ISO protein:increased phosphorylation:dorsal root ganglion (rat) RGD PMID:24962708 RGD:11570412 NCBI chr19:5,540,483...5,544,059
Ensembl chr19:5,540,483...5,545,229 		JBrowse link
G Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5 ameliorates ISO RGD PMID:15652389 RGD:150530460 NCBI chr 9:54,888,112...54,918,704
Ensembl chr 9:54,888,164...54,915,063 		JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 ameliorates ISO associated with sciatic neuropathy; RGD PMID:20619541 RGD:151708701 NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17572696 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Cnr2 cannabinoid receptor 2 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:17572696 PMID:18664590 NCBI chr 4:135,622,500...135,647,530
Ensembl chr 4:135,622,705...135,647,518 		JBrowse link
G Comt catechol-O-methyltransferase IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:28195063 PMID:20726980 RGD:8662326 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Crcp calcitonin gene-related peptide-receptor component protein ISO RGD PMID:12895509 RGD:727768 NCBI chr 5:130,058,147...130,089,628
Ensembl chr 5:130,058,131...130,089,630 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28434951 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) treatment ISO associated with Sciatic Neuropathy; RGD PMID:24253780 RGD:11039470 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Csk c-src tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16769263 NCBI chr 9:57,533,929...57,560,758
Ensembl chr 9:57,533,929...57,560,914 		JBrowse link
G Ctss cathepsin S ISO
IMP		 associated with Arthritis, Experimental
associated with Colitis		 RGD PMID:22213084 PMID:21802389 RGD:5686870, RGD:5686873 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 treatment ISO associated with Arthritis, Experimental RGD PMID:19249394 PMID:22647647 RGD:2304251, RGD:9491779 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO
IMP		 associated with Sciatic Neuropathy
associated with Bone Neoplasms
associated with Inflammation
associated with Arthritis, Experimental;protein:increased expression:lumbar spinal cord		 RGD PMID:19959384 PMID:20609517 PMID:20736819 PMID:20524966 PMID:16324111 More... RGD:4891942, RGD:4891885, RGD:4892020, RGD:9354422, RGD:9387859, RGD:9491779 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO RGD PMID:28638088 RGD:13838657 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7881729 PMID:10401557 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO RGD PMID:19283893 RGD:5129125 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 treatment ISO RGD PMID:28638088 PMID:30142543 RGD:13838657, RGD:13838658 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide IMP associated with Spinal Cord Injuries; RGD PMID:20679217 RGD:11040629 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 ISO associated with Diabetic Neuropathies: RGD PMID:20531396 RGD:7257680 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348 		JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20433900 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment ISO associated with Sciatic Neuropathy RGD PMID:22901764 PMID:22540262 RGD:7771531, RGD:7771574 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102 		JBrowse link
G Dusp6 dual specificity phosphatase 6 treatment ISO associated with Sciatic Neuropathy RGD PMID:22901764 RGD:7771531 NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351 		JBrowse link
G Edn1 endothelin 1 susceptibility IEP
IMP
ISO		 mRNA:increased expression:paw skin (mouse)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19429182 PMID:23347081 PMID:15664691 RGD:8661716, RGD:8661735 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 treatment ISO RGD PMID:20392816 RGD:9685429 NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288 		JBrowse link
G Ep300 E1A binding protein p300 ISO RGD PMID:25263804 RGD:9588307 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Epha4 Eph receptor A4 ISO associated with spinal cord injuries; RGD PMID:16959251 RGD:5688783 NCBI chr 1:77,343,819...77,491,763
Ensembl chr 1:77,343,822...77,491,725 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic ISO RGD PMID:16962614 RGD:5688387 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO associated with interstitial cystitis; RGD PMID:30989724 RGD:405295490 NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) IMP RGD PMID:19285805 RGD:8553066 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) ISO
IMP		 RGD PMID:17056036 PMID:19285805 RGD:5508846, RGD:8553066 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G F2 coagulation factor II IMP associated with Sciatic Neuropathy RGD PMID:16251448 RGD:7387272 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F2r coagulation factor II thrombin receptor severity IMP
IDA
ISO		 RGD PMID:19674841 PMID:12717003 PMID:11877315 RGD:7387269, RGD:7387270, RGD:7387271 NCBI chr13:95,738,288...95,754,974
Ensembl chr13:95,738,311...95,754,995 		JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I ameliorates ISO RGD PMID:32510872 RGD:127338469 NCBI chr 3:96,190,225...96,201,285
Ensembl chr 3:96,190,225...96,201,285 		JBrowse link
G Fos FBJ osteosarcoma oncogene ISO protein:increased expression:dorsal horn of spinal cord, neuron
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27093858 PMID:22160634 RGD:9999169 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase treatment IMP associated with Cerebral Hemorrhage RGD PMID:34102854 RGD:329812008 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
G Gad1 glutamate decarboxylase 1 treatment ISO protein:increased expression:dorsal horn of spinal cord RGD PMID:26752351 PMID:27277808 RGD:405850208, RGD:405850240 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20457222 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Gfap glial fibrillary acidic protein ISO associated with Spinal Cord Injuries;mRNA,protein:increased expression:brain,spinal cord:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27093858 PMID:16219025 RGD:8695957 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 ISO RGD PMID:16464682 RGD:6218969 NCBI chr19:58,224,013...58,444,387
Ensembl chr19:58,224,036...58,444,341 		JBrowse link
G Gja1 gap junction protein, alpha 1 treatment ISO associated with Sciatic Neuropathy
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:34286406 PMID:24631560 PMID:23374942 RGD:8662447, RGD:8662456 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:25280432 NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555 		JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) treatment IEP RGD PMID:27816787 RGD:405650587 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) ISO RGD PMID:29758384 RGD:13792698 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20042082 PMID:24204988 RGD:13210755 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment
severity		 ISO associated with bone cancer
associated with Complex Regional Pain Syndromes		 RGD PMID:26935064 PMID:26064176 PMID:25466829 PMID:22796071 RGD:13513996, RGD:13514046, RGD:13514049, RGD:13792780 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250 		JBrowse link
G Grm8 glutamate receptor, metabotropic 8 IDA RGD PMID:17113112 RGD:6771186 NCBI chr 6:27,275,120...28,135,094
Ensembl chr 6:27,275,118...28,135,177 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO associated with Limb Ischemia;protein:increased expression:foot muscle, plantar RGD PMID:18691814 RGD:9068903 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:27474498 PMID:24077211 PMID:30142543 RGD:7364865, RGD:13838658 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hoxd1 homeobox D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21151121 NCBI chr 2:74,593,324...74,595,486
Ensembl chr 2:74,593,324...74,595,486 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A ISO associated with Diabetic neuropathies;
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17888573 PMID:18930597 PMID:20531396 PMID:20039957 PMID:25584948 RGD:7257680, RGD:401901200, RGD:401938625 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 ISO RGD PMID:21693130 PMID:21843960 RGD:6480665, RGD:6482179 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:9452187 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il10 interleukin 10 treatment ISO associated with Sciatic Neuropathy
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:7582491 PMID:17174526 PMID:23957449 PMID:22820166 PMID:24077211 RGD:7364792, RGD:7364827, RGD:7364865 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il13 interleukin 13 treatment ISO RGD PMID:11399514 RGD:8549555 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il17a interleukin 17A treatment ISO RGD PMID:23192794 PMID:23246025 RGD:9068942, RGD:9222699 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il18 interleukin 18 treatment ISO associated with Peripheral Nerve Injuries RGD PMID:19036970 RGD:8655929 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:12727271 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta ISO associated with Peripheral Nerve Injuries
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:7582491 PMID:10401557 PMID:12727271 PMID:17320857 PMID:20937348 More... RGD:1626676, RGD:6482671, RGD:7175548, RGD:7401209 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1r1 interleukin 1 receptor, type I ISO
IMP		 RGD PMID:19022353 PMID:11585580 RGD:8662898, RGD:8662903 NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment
severity		 ISO associated with Arthritis, Experimental; rat model treated with human protein
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:8864563 PMID:15317861 PMID:17174526 PMID:20937348 PMID:23092240 More... RGD:6909165, RGD:6909175, RGD:7401210, RGD:8549800 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il2 interleukin 2 treatment ISO associated with Sciatic Neuropathy; mRNA,protein:increased expression:spinal cord: RGD PMID:12755376 PMID:22189457 PMID:18423867 RGD:8662973, RGD:8662977, RGD:8662980 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il33 interleukin 33 ISO RGD PMID:29329586 RGD:40400909 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Il6 interleukin 6 ISO associated with Foot Injuries; protein:increased expression:serum:
mRNA:increased expression:dorsal root ganglion
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:7582491 PMID:10401557 PMID:18652822 PMID:18988309 PMID:23953943 RGD:8662979, RGD:10402830 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha ISO mRNA:increased expression:dorsal root ganglion RGD PMID:23953943 RGD:10402830 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Insr insulin receptor treatment IEP
ISO		 associated with Diabetic Neuropathies
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18331706 PMID:23511693 RGD:10403050 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Itga1 integrin alpha 1 ISO RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr13:115,094,615...115,238,500
Ensembl chr13:115,089,632...115,238,500 		JBrowse link
G Itga2 integrin alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18234883 NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636 		JBrowse link
G Itga3 integrin alpha 3 ISO RGD PMID:15836982 PMID:14984413 RGD:2302139, RGD:2302389 NCBI chr11:94,935,301...94,967,637
Ensembl chr11:94,935,300...94,967,627 		JBrowse link
G Itga5 integrin alpha 5 (fibronectin receptor alpha) ISO RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr15:103,252,713...103,275,218
Ensembl chr15:103,252,713...103,275,190 		JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) ISO RGD PMID:15836982 PMID:14984413 RGD:2302139, RGD:2302389 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 ISO RGD PMID:25972297 RGD:13793383 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070 		JBrowse link
G Jak2 Janus kinase 2 treatment ISO
IMP		 associated with Diabetic Neuropathies RGD PMID:18636982 PMID:23511693 RGD:6483031, RGD:10403050 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Jak3 Janus kinase 3 treatment ISO RGD PMID:21434883 RGD:11533942 NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219 		JBrowse link
G Kcnc4 potassium voltage gated channel, Shaw-related subfamily, member 4 ISO RGD PMID:17855600 RGD:10411908 NCBI chr 3:107,345,614...107,367,617
Ensembl chr 3:107,345,619...107,366,868 		JBrowse link
G Kcnk2 potassium channel, subfamily K, member 2 IMP RGD PMID:16675954 RGD:9831112 NCBI chr 1:188,940,127...189,134,951
Ensembl chr 1:188,940,127...189,134,470 		JBrowse link
G Kcnq3 potassium voltage-gated channel, subfamily Q, member 3 ISO associated with Bone Neoplasms;protein:decreased expression:dorsal root ganglia (rat) RGD PMID:23352759 RGD:9686417 NCBI chr15:65,858,223...66,158,485
Ensembl chr15:65,858,236...66,158,491 		JBrowse link
G Kmo kynurenine 3-monooxygenase treatment ISO RGD PMID:26524415 RGD:13703043 NCBI chr 1:175,459,759...175,488,419
Ensembl chr 1:175,447,947...175,489,682 		JBrowse link
G Kng1 kininogen 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2010815 PMID:2128375 PMID:3061568 PMID:7493622 PMID:7582491 More... NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828 		JBrowse link
G Kng2 kininogen 2 ISO RGD PMID:20868656 RGD:11059894 NCBI chr16:22,804,602...22,847,851
Ensembl chr16:22,804,604...22,848,232 		JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29143802 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha ISO RGD PMID:23665054 RGD:11560531 NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993 		JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 onset IMP RGD PMID:19427893 RGD:7495807 NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12941468 PMID:27093858 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12941468 PMID:27093858 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17237256 NCBI chr11:61,379,638...61,385,101
Ensembl chr11:61,379,638...61,385,232 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mc1r melanocortin 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19996949 NCBI chr 8:124,133,839...124,137,483
Ensembl chr 8:124,133,846...124,137,483 		JBrowse link
G Mc4r melanocortin 4 receptor ISO protein:increased expression:dorsal root ganglia (rat) RGD PMID:20081244 RGD:6484233 NCBI chr18:66,990,776...66,993,558
Ensembl chr18:66,990,775...66,993,577 		JBrowse link
G Mecp2 methyl CpG binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33010341 NCBI chr  X:73,070,198...73,129,296
Ensembl chr  X:73,070,198...73,129,296 		JBrowse link
G Men1 multiple endocrine neoplasia 1 ISO associated with Sciatic Neuropathy;protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:20369282 RGD:9589142 NCBI chr19:6,385,009...6,390,924
Ensembl chr19:6,385,009...6,390,921 		JBrowse link
G Mfn2 mitofusin 2 ISO mRNA:decreased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:28587902 PMID:28587902 RGD:12910704 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mir15b microRNA 15b ISO RGD PMID:28012171 RGD:13782150 NCBI chr 3:68,917,105...68,917,168
Ensembl chr 3:68,917,105...68,917,168 		JBrowse link
G Mir17 microRNA 17 severity ISO RGD PMID:26222740 RGD:11074685 NCBI chr14:115,281,103...115,281,186
Ensembl chr14:115,281,103...115,281,186 		JBrowse link
G Mir381 microRNA 381 treatment ISO RGD PMID:30142543 RGD:13838658 NCBI chr12:109,693,256...109,693,330
Ensembl chr12:109,693,256...109,693,330 		JBrowse link
G Mir500 microRNA 500 ISO RNA:decreased expression:dorsal horn of spinal cord RGD PMID:27277808 RGD:405850240 NCBI chr  X:7,103,922...7,104,013
Ensembl chr  X:7,103,922...7,104,013 		JBrowse link
G Mir96 microRNA 96 treatment ISO associated with Sciatic Neuropathy RGD PMID:24234845 RGD:11553932 NCBI chr 6:30,169,445...30,169,550
Ensembl chr 6:30,169,445...30,169,550 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18754875 PMID:22056600 RGD:8693664 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mpz myelin protein zero ISO CTD Direct Evidence: marker/mechanism CTD PMID:16676325 NCBI chr 1:170,978,282...170,988,699
Ensembl chr 1:170,978,280...170,988,699 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:24382350 RGD:10040983 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Nectin1 nectin cell adhesion molecule 1 ISO RGD PMID:27394444 RGD:405866373 NCBI chr 9:43,655,251...43,718,758
Ensembl chr 9:43,655,281...43,743,955 		JBrowse link
G Nefh neurofilament, heavy polypeptide treatment ISO RGD PMID:21071147 RGD:27226885 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064 		JBrowse link
G Ngf nerve growth factor treatment IMP
ISO		 associated with Cystitis
associated with Peripheral Nerve Injuries;
CTD Direct Evidence: marker/mechanism
associated with Osteoarthritis, Experimental		 CTD
RGD		 PMID:20457222 PMID:16203088 PMID:18448607 PMID:22839415 PMID:11425916 More... RGD:7242799, RGD:7242803, RGD:7242849, RGD:8657088, RGD:402463955, RGD:405100717 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) treatment ISO associated with Brachial Plexus Neuropathies RGD PMID:23324933 RGD:10413898 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Nlgn2 neuroligin 2 ISO RGD PMID:23891900 RGD:9831150 NCBI chr11:69,713,949...69,728,610
Ensembl chr11:69,713,948...69,728,610 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19300402 PMID:23909597 RGD:7257597 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO CTD Direct Evidence: marker/mechanism CTD PMID:17989504 PMID:19300402 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Npy neuropeptide Y treatment ISO associated with Sciatic Neuropathy RGD PMID:19556004 RGD:10448929 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nrg1 neuregulin 1 ISO associated with Sciatic Neuropathy
associated with interstitial cystitis;		 RGD PMID:22212401 PMID:30989724 RGD:10449019, RGD:405295490 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Ntf3 neurotrophin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:15659614 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873 		JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 ISO RGD PMID:17667845 PMID:20351485 RGD:5144120, RGD:5684352 NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 IMP
ISO		 associated with inflammation;protein:increased expression:dorsal root ganglion: RGD PMID:12470870 PMID:21958434 RGD:8657091, RGD:8657122 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Ntsr1 neurotensin receptor 1 ISO RGD PMID:22396077 RGD:9743902 NCBI chr 2:180,141,769...180,186,772
Ensembl chr 2:180,141,769...180,186,773 		JBrowse link
G Oprk1 opioid receptor, kappa 1 treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:16924480 RGD:9834947 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354 		JBrowse link
G Oprl1 opioid receptor-like 1 ISO associated with Sciatic Neuropathy;mRNA:increased expression:spinal cord lumbar segment,dorsal root ganglion: RGD PMID:12106803 RGD:9835017 NCBI chr 2:181,356,585...181,362,778
Ensembl chr 2:181,356,809...181,362,778 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17996026 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198 		JBrowse link
G P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19383439 NCBI chr 5:110,487,678...110,491,186
Ensembl chr 5:110,487,678...110,491,078 		JBrowse link
G P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19383439 NCBI chr 2:84,826,893...84,867,446
Ensembl chr 2:84,828,927...84,867,806 		JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 treatment ISO associated with Peripheral Nerve Injuries; RGD PMID:29927790 RGD:40924654 NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801 		JBrowse link
G P2ry12 purinergic receptor P2Y, G-protein coupled 12 IDA
ISO		 RGD PMID:20398327 PMID:20136836 RGD:6480525, RGD:6480526 NCBI chr 3:59,123,692...59,170,408
Ensembl chr 3:59,123,693...59,170,292 		JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator treatment ISO RGD PMID:17179954 RGD:9835416 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101 		JBrowse link
G Pdyn prodynorphin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17670969 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Penk preproenkephalin treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:23235561 RGD:10003116 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) ISO RGD PMID:16203828 RGD:1642461 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Pnoc prepronociceptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12665541 PMID:19231294 NCBI chr14:65,638,931...65,662,908
Ensembl chr14:65,638,122...65,662,921 		JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform ISO RGD PMID:26732138 RGD:11572421 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605 		JBrowse link
G Prkcb protein kinase C, beta ISO associated with inflammation;protein:increased activity:spinal cord RGD PMID:16360284 RGD:1625519 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625 		JBrowse link
G Prkce protein kinase C, epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:11738263 PMID:12582831 PMID:20457222 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347 		JBrowse link
G Prkcg protein kinase C, gamma treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19955894 PMID:27093858 PMID:12560106 RGD:28867224 NCBI chr 7:3,352,038...3,379,615
Ensembl chr 7:3,337,704...3,379,615 		JBrowse link
G Prkcz protein kinase C, zeta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27899695 NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818 		JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I treatment IMP RGD PMID:14973199 RGD:7775058 NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433 		JBrowse link
G Prok2 prokineticin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr 6:99,687,833...99,703,368
Ensembl chr 6:99,688,260...99,703,353 		JBrowse link
G Prokr1 prokineticin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr 6:87,555,568...87,567,741
Ensembl chr 6:87,555,573...87,567,725 		JBrowse link
G Ptafr platelet-activating factor receptor treatment ISO RGD PMID:16925995 RGD:10041052 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994 		JBrowse link
G Ptger1 prostaglandin E receptor 1 (subtype EP1) ISO CTD Direct Evidence: marker/mechanism CTD PMID:11375261 NCBI chr 8:84,393,171...84,399,385
Ensembl chr 8:84,393,307...84,399,382 		JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) ISO protein:increased expression:lumbar spinal cord dorsal horn (rat) RGD PMID:17413918 RGD:5688169 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525 		JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) treatment ISO RGD PMID:20423341 RGD:10003041 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668 		JBrowse link
G Ptges3 prostaglandin E synthase 3 ISO RGD PMID:16192391 RGD:5688057 NCBI chr10:127,894,851...127,913,123
Ensembl chr10:127,894,823...127,913,141 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17989504 PMID:17413918 RGD:5688169 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17112505 PMID:17989504 PMID:15464832 RGD:5688224 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pthlh parathyroid hormone-like peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:16769263 NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681 		JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18976650 NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 treatment ISO associated with lesion of sciatic nerve RGD PMID:27641322 RGD:13524513 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211 		JBrowse link
G Scn10a sodium channel, voltage-gated, type X, alpha ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16545521 PMID:19070548 RGD:6484253 NCBI chr 9:119,437,522...119,548,388
Ensembl chr 9:119,437,522...119,548,388 		JBrowse link
G Scn11a sodium channel, voltage-gated, type XI, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:23264124 NCBI chr 9:119,582,829...119,654,522
Ensembl chr 9:119,582,825...119,654,522 		JBrowse link
G Sin3a transcriptional regulator, SIN3A (yeast) ISO associated with Arthritis, Experimental;mRNA:decreased expression:spinal cord, neuron RGD PMID:17553988 RGD:9495916 NCBI chr 9:56,979,271...57,035,652
Ensembl chr 9:56,979,324...57,035,650 		JBrowse link
G Slc12a5 solute carrier family 12, member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20086212 NCBI chr 2:164,802,766...164,841,651
Ensembl chr 2:164,802,722...164,841,651 		JBrowse link
G Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 ISO protein:increased expression:dorsal horn of spinal cord, neuron RGD PMID:22160634 RGD:9999169 NCBI chr10:89,409,882...89,457,111
Ensembl chr10:89,409,882...89,457,115 		JBrowse link
G Sparc secreted acidic cysteine rich glycoprotein ISO CTD Direct Evidence: marker/mechanism CTD PMID:20714283 NCBI chr11:55,284,985...55,310,906
Ensembl chr11:55,285,326...55,314,009 		JBrowse link
G Src Rous sarcoma oncogene ISO protein:increased phosphorylation:spinal cord RGD PMID:27394444 RGD:405866373 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment ISO RGD PMID:24098399 RGD:8694290 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Syn2 synapsin II ISO CTD Direct Evidence: marker/mechanism CTD PMID:18701217 NCBI chr 6:115,111,863...115,259,587
Ensembl chr 6:115,111,863...115,258,967 		JBrowse link
G Tac1 tachykinin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8864563 PMID:9714424 PMID:10499367 PMID:12351280 PMID:12787826 More... NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15964684 PMID:17123731 NCBI chr 6:82,378,990...82,537,085
Ensembl chr 6:82,379,315...82,537,085 		JBrowse link
G Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box ISO CTD Direct Evidence: marker/mechanism CTD PMID:33607128 NCBI chr19:55,730,227...55,922,091
Ensembl chr19:55,730,252...55,922,086 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor I ISO associated with Experimental Pancreatitis, Chronic RGD PMID:26645248 RGD:14995470 NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931 		JBrowse link
G Thbd thrombomodulin treatment ISO associated with Inflammation
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:27474498 PMID:24004409 RGD:11038687 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Tlr2 toll-like receptor 2 IMP
ISO		 RGD PMID:17355971 PMID:24204973 RGD:8553059, RGD:8553185 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 ISO
IMP		 RGD PMID:20714435 PMID:15809417 PMID:24204973 RGD:4144070, RGD:7815040, RGD:8553185 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor ISO
IEP
IMP		 protein:increased expression:lumbar vertebra:
mRNA,protein:increased expression:spinal cord:
associated with Diabetic Neuropathies;
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:7582491 PMID:7881729 PMID:10401557 PMID:12727271 PMID:16472913 More... RGD:7387300, RGD:7387302, RGD:7394737, RGD:7394737, RGD:7394741, RGD:7394757, RGD:7401179 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) ISO CTD Direct Evidence: therapeutic CTD PMID:16769263 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a treatment ISO
IMP		 associated with Sciatic Neuropathy RGD PMID:12752784 PMID:21145890 PMID:20417692 PMID:24257399 PMID:21712071 More... RGD:5130913, RGD:5130939, RGD:8661726, RGD:8661737, RGD:8548873, RGD:8661750 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b IMP
ISO		 associated with Sciatic Neuropathy RGD PMID:18463260 PMID:22652595 RGD:5130960, RGD:8661750 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 ISO associated with Peripheral Nerve Injuries;
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18234885 PMID:21481532 PMID:23523557 PMID:18954467 RGD:10043618 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 ISO associated with Inflammation RGD PMID:19439599 RGD:7247605 NCBI chr 9:95,587,125...95,632,438
Ensembl chr 9:95,587,135...95,632,428 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 ISO RGD PMID:19439599 RGD:7247605 NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 ISO associated with inflammation;protein:increased expression:dorsal root ganglion:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12151517 PMID:18234885 PMID:18774343 PMID:23006841 PMID:21958434 RGD:8657122 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18234883 NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482 		JBrowse link
G Vip vasoactive intestinal polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12787826 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16193
    sensory system disease 7036
      Somatosensory Disorders 332
        Hyperalgesia 209
Path 2
Term Annotations click to browse term
  disease 16193
    Pathological Conditions, Signs and Symptoms 12529
      Signs and Symptoms 10387
        Neurologic Manifestations 10062
          sensory system disease 7036
            Somatosensory Disorders 332
              Hyperalgesia 209
paths to the root