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ONTOLOGY REPORT - ANNOTATIONS


Term:Hyperalgesia
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Accession:DOID:9002211 term browser browse the term
Definition:An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Synonyms:exact_synonym: Allodynia;   Allodynias, Mechanical;   Allodynias, Tactile;   Allodynias, Thermal;   Hyperalgesia, Primary;   Hyperalgesia, Secondary;   Hyperalgesia, Tactile;   Hyperalgesias;   Hyperalgesias, Mechanical;   Hyperalgesias, Primary;   Hyperalgesias, Secondary;   Hyperalgesias, Tactile;   Hyperalgesias, Thermal;   Hyperalgesic Sensations;   Mechanical Allodynia;   Mechanical Hyperalgesia;   Tactile Allodynia;   Thermal Allodynia;   Thermal Hyperalgesia;   pain hypersensitivity
 primary_id: MESH:D006930;   RDO:0005827
For additional species annotation, visit the Alliance of Genome Resources.


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Hyperalgesia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABAT 4-aminobutyrate aminotransferase JBrowse link 16 8,850,010 8,958,420 RGD:9068941
G ADK adenosine kinase JBrowse link 10 73,342,806 73,903,071 RGD:9068941
G ADM adrenomedullin JBrowse link 11 10,165,423 10,167,842 RGD:9068941
G ADORA1 adenosine A1 receptor JBrowse link 1 183,023,466 183,063,760 RGD:9068941
G ADRA1A adrenoceptor alpha 1A JBrowse link 8 22,930,296 23,043,595 RGD:9068941
G ADRA2A adrenoceptor alpha 2A JBrowse link 10 111,119,153 111,122,369 RGD:9068941
G ADRA2C adrenoceptor alpha 2C JBrowse link 4 3,894,575 3,897,018 RGD:9068941
G ADRB1 adrenoceptor beta 1 JBrowse link 10 114,075,628 114,076,596 RGD:9068941
G AGER advanced glycosylation end-product specific receptor JBrowse link 6 32,708,251 32,711,641 RGD:9068941
G AGT angiotensinogen JBrowse link 1 211,279,015 211,291,044 RGD:9068941
G AIF1 allograft inflammatory factor 1 JBrowse link 6 32,166,301 32,168,125 RGD:9068941
G AKR1B1 aldo-keto reductase family 1 member B JBrowse link 7 138,907,448 138,924,317 RGD:9068941
G ALOX12 arachidonate 12-lipoxygenase, 12S type JBrowse link 17 7,014,038 7,029,602 RGD:9068941
G ALOX5 arachidonate 5-lipoxygenase JBrowse link 10 45,639,946 45,710,016 RGD:9068941
G ANO3 anoctamin 3 JBrowse link 11 26,188,895 26,519,646 RGD:9068941
G ANXA1 annexin A1 JBrowse link 9 71,930,148 71,948,779 RGD:9068941
G AQP4 aquaporin 4 JBrowse link 18 23,713,141 23,726,919 RGD:9068941
G BACE1 beta-secretase 1 JBrowse link 11 116,054,303 116,084,813 RGD:9068941
G BDKRB1 bradykinin receptor B1 JBrowse link 14 96,208,312 96,221,049 RGD:9068941
G BDKRB2 bradykinin receptor B2 JBrowse link 14 96,157,122 96,196,253 RGD:9068941
G BDNF brain derived neurotrophic factor JBrowse link 11 27,520,306 27,589,239 RGD:9068941
G BECN1 beclin 1 JBrowse link 17 14,719,781 14,733,286 RGD:9068941
G C3 complement C3 JBrowse link 19 6,629,240 6,674,786 RGD:9068941
G CACNA1B calcium voltage-gated channel subunit alpha1 B JBrowse link 9 137,935,165 138,147,969 RGD:9068941
G CACNA1H calcium voltage-gated channel subunit alpha1 H JBrowse link 16 1,195,991 1,222,917 RGD:9068941
G CACNA1I calcium voltage-gated channel subunit alpha1 I JBrowse link 22 38,325,411 38,412,923 RGD:9068941
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 JBrowse link 7 87,575,054 88,068,480 RGD:9068941
G CALCA calcitonin related polypeptide alpha JBrowse link 11 14,745,588 14,751,267 RGD:9068941
G CAMK2A calcium/calmodulin dependent protein kinase II alpha JBrowse link 5 151,649,062 151,719,373 RGD:9068941
G CAPN2 calpain 2 JBrowse link 1 204,346,476 204,410,137 RGD:9068941
G CARTPT CART prepropeptide JBrowse link 5 44,236,114 44,238,229 RGD:9068941
G CAT catalase JBrowse link 11 34,289,603 34,323,160 RGD:9068941
G CCK cholecystokinin JBrowse link 3 42,431,021 42,439,396 RGD:9068941
G CCKBR cholecystokinin B receptor JBrowse link 11 6,075,816 6,088,145 RGD:9068941
G CCL2 C-C motif chemokine ligand 2 JBrowse link 17 22,821,336 22,823,271 RGD:9068941
G CCL5 C-C motif chemokine ligand 5 JBrowse link 17 21,210,798 21,219,172 RGD:9068941
G CCR2 C-C motif chemokine receptor 2 JBrowse link 3 47,361,118 47,368,312 RGD:9068941
G CCR5 C-C motif chemokine receptor 5 JBrowse link 3 47,377,564 47,383,625 RGD:9068941
G CFL1 cofilin 1 JBrowse link 11 64,544,275 64,548,372 RGD:9068941
G CNR1 cannabinoid receptor 1 JBrowse link 6 89,289,102 89,315,174 RGD:9068941
G CNR2 cannabinoid receptor 2 JBrowse link 1 24,046,009 24,135,236 RGD:9068941
G COMT catechol-O-methyltransferase JBrowse link 22 18,375,434 18,402,387 RGD:9068941
G CRCP CGRP receptor component JBrowse link 7 73,181,115 73,219,243 RGD:9068941
G CRHR1 corticotropin releasing hormone receptor 1 JBrowse link 17 11,650,057 11,701,208 RGD:9068941
G CSF3 colony stimulating factor 3 JBrowse link 17 17,491,272 17,493,729 RGD:9068941
G CSK C-terminal Src kinase JBrowse link 15 73,342,703 73,363,476 RGD:9068941
G CTSS cathepsin S JBrowse link 1 129,733,996 129,768,318 RGD:9068941
G CX3CL1 C-X3-C motif chemokine ligand 1 JBrowse link 16 56,779,065 56,791,760 RGD:9068941
G CX3CR1 C-X3-C motif chemokine receptor 1 JBrowse link 3 39,439,009 39,456,797 RGD:9068941
G CXCL12 C-X-C motif chemokine ligand 12 JBrowse link 10 44,476,962 44,564,231 RGD:9068941
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 4 56,285,026 56,288,308 RGD:9068941
G CXCR2 C-X-C motif chemokine receptor 2 JBrowse link 2B 223,987,556 223,999,511 RGD:9068941
G CXCR4 C-X-C motif chemokine receptor 4 JBrowse link 2B 140,185,803 140,189,626 RGD:9068941
G DLG4 discs large MAGUK scaffold protein 4 JBrowse link 17 7,207,483 7,236,000 RGD:9068941
G DNMT1 DNA methyltransferase 1 JBrowse link 19 10,342,478 10,390,397 RGD:9068941
G DRD3 dopamine receptor D3 JBrowse link 3 118,187,636 118,237,403 RGD:9068941
G DUSP1 dual specificity phosphatase 1 JBrowse link 5 175,032,797 175,035,960 RGD:9068941
G DUSP6 dual specificity phosphatase 6 JBrowse link 12 90,195,482 90,200,321 RGD:9068941
G EDN1 endothelin 1 JBrowse link 6 12,405,538 12,503,545 RGD:9068941
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 JBrowse link 8 118,998,530 119,114,271 RGD:9068941
G EP300 E1A binding protein p300 JBrowse link 22 40,079,214 40,168,936 RGD:9068941
G EPHA4 EPH receptor A4 JBrowse link 2B 227,246,593 227,402,791 RGD:9068941
G EPHX2 epoxide hydrolase 2 JBrowse link 8 23,964,094 24,017,749 RGD:9068941
G ESR1 estrogen receptor 1 JBrowse link 6 154,200,521 154,635,806 RGD:9068941
G ESR2 estrogen receptor 2 JBrowse link 14 63,064,397 63,175,303 RGD:9068941
G F2 coagulation factor II, thrombin JBrowse link 11 47,227,891 47,249,157 RGD:9068941
G F2R coagulation factor II thrombin receptor JBrowse link 5 39,110,170 39,129,688 RGD:9068941
G FOS Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 14 74,676,316 74,679,766 RGD:9068941
G GAL galanin and GMAP prepropeptide JBrowse link 11 67,075,104 67,081,696 RGD:9068941
G GDNF glial cell derived neurotrophic factor JBrowse link 5 77,573,466 77,600,478 RGD:9068941
G GFAP glial fibrillary acidic protein JBrowse link 17 12,579,754 12,589,748 RGD:9068941
G GFRA1 GDNF family receptor alpha 1 JBrowse link 10 116,079,056 116,295,195 RGD:9068941
G GJA1 gap junction protein alpha 1 JBrowse link 6 123,348,744 123,360,887 RGD:9068941
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 9 137,168,543 137,198,297 RGD:9068941
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 16 9,909,406 10,339,147 RGD:9068941
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 12 13,943,936 14,272,195 RGD:9068941
G GRK2 G protein-coupled receptor kinase 2 JBrowse link 11 65,939,169 65,959,066 RGD:9068941
G HIF1A hypoxia inducible factor 1 subunit alpha JBrowse link 14 60,552,374 60,604,885 RGD:9068941
G HMGB1 high mobility group box 1 JBrowse link 13 30,173,875 30,179,527 RGD:9068941
G HOXD1 homeobox D1 JBrowse link 2B 181,176,789 181,179,105 RGD:9068941
G HTR2A 5-hydroxytryptamine receptor 2A JBrowse link 13 46,694,273 46,759,826 RGD:9068941
G HTR7 5-hydroxytryptamine receptor 7 JBrowse link 10 91,008,278 91,125,416 RGD:9068941
G IGF1 insulin like growth factor 1 JBrowse link 12 103,385,911 103,463,264 RGD:9068941
G IL10 interleukin 10 JBrowse link 1 186,648,289 186,653,155 RGD:9068941
G IL13 interleukin 13 JBrowse link 5 134,235,788 134,240,548 RGD:9068941
G IL17A interleukin 17A JBrowse link 6 53,004,820 53,009,074 RGD:9068941
G IL18 interleukin 18 JBrowse link 11 110,867,586 110,888,371 RGD:9068941
G IL1A interleukin 1 alpha JBrowse link 2A 113,784,854 113,795,801 RGD:9068941
G IL1B interleukin 1 beta JBrowse link 2A 113,846,299 113,853,424 RGD:9068941
G IL1R1 interleukin 1 receptor type 1 JBrowse link 2A 103,151,559 103,230,005 RGD:9068941
G IL1RN interleukin 1 receptor antagonist JBrowse link 2A 114,061,182 114,077,048 RGD:9068941
G IL2 interleukin 2 JBrowse link 4 125,782,563 125,787,819 RGD:9068941
G IL6 interleukin 6 JBrowse link 7 23,027,560 23,032,419 RGD:9068941
G IL6R interleukin 6 receptor JBrowse link 1 133,374,078 133,433,089 RGD:9068941
G INSR insulin receptor JBrowse link 19 7,255,444 7,411,916 RGD:9068941
G ITGA1 integrin subunit alpha 1 JBrowse link 5 62,692,673 62,865,771 RGD:9068941
G ITGA2 integrin subunit alpha 2 JBrowse link 5 62,554,387 62,659,641 RGD:9068941
G ITGA3 integrin subunit alpha 3 JBrowse link 17 49,019,889 49,055,245 RGD:9068941
G ITGA5 integrin subunit alpha 5 JBrowse link 12 35,052,994 35,076,860 RGD:9068941
G ITGB1 integrin subunit beta 1 JBrowse link 10 33,608,978 33,662,258 RGD:9068941
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 JBrowse link 3 4,549,775 4,904,811 RGD:9068941
G JAK2 Janus kinase 2 JBrowse link 9 5,006,271 5,156,626 RGD:9068941
G JAK3 Janus kinase 3 JBrowse link 19 18,283,157 18,304,641 RGD:9068941
G KCNC4 potassium voltage-gated channel subfamily C member 4 JBrowse link 1 127,457,895 127,480,954 RGD:9068941
G KCNK2 potassium two pore domain channel subfamily K member 2 JBrowse link 1 195,431,036 195,660,681 RGD:9068941
G KCNQ3 potassium voltage-gated channel subfamily Q member 3 JBrowse link 8 131,747,069 132,110,448 RGD:9068941
G KMO kynurenine 3-monooxygenase JBrowse link 1 222,075,577 222,138,866 RGD:9068941
G KNG1 kininogen 1 JBrowse link 3 192,219,675 192,245,318 RGD:9068941
G LOC100976367 oxytocin-neurophysin 1 JBrowse link 20 2,934,408 2,937,077 RGD:9068941
G LOC100982531 cytochrome b-245 heavy chain JBrowse link X 37,939,744 37,976,116 RGD:9068941
G LOC100990615 metabotropic glutamate receptor 8 JBrowse link 7 131,117,218 131,279,815 RGD:9068941
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha JBrowse link 20 32,018,279 32,020,411 RGD:9068941
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 20,365,480 20,412,561 RGD:9068941
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,489,362 30,498,026 RGD:9068941
G MAPK7 mitogen-activated protein kinase 7 JBrowse link 17 36,894,146 36,899,969 RGD:9068941
G MAPK8 mitogen-activated protein kinase 8 RGD:9068941
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 5 182,748,381 182,801,464 RGD:9068941
G MC4R melanocortin 4 receptor JBrowse link 18 57,069,089 57,070,670 RGD:9068941
G MEN1 menin 1 JBrowse link 11 63,499,954 63,507,164 RGD:9068941
G MFN2 mitofusin 2 JBrowse link 1 11,945,849 11,981,077 RGD:9068941
G MMP3 matrix metallopeptidase 3 JBrowse link 11 101,267,561 101,275,432 RGD:9068941
G MPZ myelin protein zero JBrowse link 1 140,603,609 140,631,273 RGD:9068941
G MTOR mechanistic target of rapamycin kinase JBrowse link 1 11,093,765 11,249,841 RGD:9068941
G NEFH neurofilament heavy JBrowse link 22 28,331,778 28,341,874 RGD:9068941
G NGF nerve growth factor JBrowse link 1 122,272,750 122,325,909 RGD:9068941
G NGFR nerve growth factor receptor JBrowse link 17 8,075,301 8,094,966 RGD:9068941
G NLGN2 neuroligin 2 JBrowse link 17 7,425,927 7,438,504 RGD:9068941
G NOS1 nitric oxide synthase 1 JBrowse link 12 118,163,655 118,314,005 RGD:9068941
G NOS2 nitric oxide synthase 2 JBrowse link 17 29,477,285 29,519,412 RGD:9068941
G NPY neuropeptide Y JBrowse link 7 24,566,963 24,574,657 RGD:9068941
G NRG1 neuregulin 1 JBrowse link 8 29,049,787 29,267,531 RGD:9068941
G NTF3 neurotrophin 3 JBrowse link 12 5,470,093 5,534,300 RGD:9068941
G NTRK2 neurotrophic receptor tyrosine kinase 2 JBrowse link 9 84,022,677 84,378,307 RGD:9068941
G NTSR1 neurotensin receptor 1 JBrowse link 20 60,392,736 60,446,056 RGD:9068941
G OPRK1 opioid receptor kappa 1 JBrowse link 8 47,030,643 47,056,577 RGD:9068941
G OPRL1 opioid related nociceptin receptor 1 JBrowse link 20 62,004,176 62,017,866 RGD:9068941
G OPRM1 opioid receptor mu 1 JBrowse link 6 156,517,666 156,627,758 RGD:9068941
G P2RX2 purinergic receptor P2X 2 JBrowse link 12 134,679,826 134,694,613 RGD:9068941
G P2RX3 purinergic receptor P2X 3 JBrowse link 3 160,070,860 160,104,550 RGD:9068941
G P2RY12 purinergic receptor P2Y12 JBrowse link 3 155,934,333 155,981,818 RGD:9068941
G PAWR pro-apoptotic WT1 regulator JBrowse link 12 79,964,693 80,071,088 RGD:9068941
G PDYN prodynorphin JBrowse link 20 1,856,850 1,872,452 RGD:9068941
G PENK proenkephalin JBrowse link 8 50,234,170 50,239,949 RGD:9068941
G PLA2G4A phospholipase A2 group IVA JBrowse link 1 166,512,870 166,672,114 RGD:9068941
G PNOC prepronociceptin JBrowse link 8 24,796,490 24,822,764 RGD:9068941
G PPP2CA protein phosphatase 2 catalytic subunit alpha JBrowse link 5 135,751,964 135,761,395 RGD:9068941
G PRKCB protein kinase C beta JBrowse link 16 24,091,284 24,466,701 RGD:9068941
G PRKCE protein kinase C epsilon JBrowse link 2A 46,688,109 47,223,421 RGD:9068941
G PRKCG protein kinase C gamma JBrowse link 19 59,671,762 59,696,728 RGD:9068941
G PRKCZ protein kinase C zeta JBrowse link 1 1,918,653 2,046,236 RGD:9068941
G PRKG1 protein kinase cGMP-dependent 1 JBrowse link 10 49,778,821 51,069,314 RGD:9068941
G PROK2 prokineticin 2 JBrowse link 3 73,067,609 73,080,897 RGD:9068941
G PROKR1 prokineticin receptor 1 JBrowse link 2A 69,808,032 69,822,410 RGD:9068941
G PTAFR platelet activating factor receptor JBrowse link 1 28,447,178 28,474,623 RGD:9068941
G PTGER1 prostaglandin E receptor 1 JBrowse link 19 14,879,798 14,881,969 RGD:9068941
G PTGER3 prostaglandin E receptor 3 JBrowse link 1 72,058,998 72,254,063 RGD:9068941
G PTGER4 prostaglandin E receptor 4 JBrowse link 5 74,731,470 74,745,121 RGD:9068941
G PTGES3 prostaglandin E synthase 3 JBrowse link 12 32,475,989 32,503,181 RGD:9068941
G PTGS1 prostaglandin-endoperoxide synthase 1 JBrowse link 9 121,837,095 121,859,283 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 166,355,845 166,364,517 RGD:9068941
G PTHLH parathyroid hormone like hormone JBrowse link 12 60,959,327 60,973,749 RGD:9068941
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 3 12,853,415 12,932,871 RGD:9068941
G RGS4 regulator of G protein signaling 4 JBrowse link 1 142,284,040 142,292,225 RGD:9068941
G SCN10A sodium voltage-gated channel alpha subunit 10 JBrowse link 3 38,876,068 38,972,247 RGD:9068941
G SCN11A sodium voltage-gated channel alpha subunit 11 JBrowse link 3 39,024,090 39,131,293 RGD:9068941
G SIN3A SIN3 transcription regulator family member A JBrowse link 15 73,881,500 73,966,560 RGD:9068941
G SLC12A5 solute carrier family 12 member 5 JBrowse link 20 43,445,193 43,483,132 RGD:9068941
G SLC17A8 solute carrier family 17 member 8 JBrowse link 12 101,342,113 101,405,844 RGD:9068941
G SPARC secreted protein acidic and cysteine rich JBrowse link 5 153,091,160 153,115,745 RGD:9068941
G STAT3 signal transducer and activator of transcription 3 JBrowse link 17 15,152,358 15,227,084 RGD:9068941
G SYN2 synapsin II JBrowse link 3 12,275,084 12,465,806 RGD:9068941
G TAC1 tachykinin precursor 1 JBrowse link 7 103,257,450 103,266,005 RGD:9068941
G TACR1 tachykinin receptor 1 JBrowse link 2A 76,614,478 76,771,018 RGD:9068941
G TGFBR1 transforming growth factor beta receptor 1 JBrowse link 9 98,337,417 98,362,748 RGD:9068941
G THBD thrombomodulin JBrowse link 20 23,343,758 23,347,966 RGD:9068941
G TLR2 toll like receptor 2 JBrowse link 4 157,848,058 157,870,324 RGD:9068941
G TLR4 toll like receptor 4 JBrowse link 9 117,180,250 117,193,510 RGD:9068941
G TNF tumor necrosis factor JBrowse link 6 32,126,618 32,129,389 RGD:9068941
G TNFRSF11B TNF receptor superfamily member 11b JBrowse link 8 118,134,305 118,162,422 RGD:9068941
G TNFRSF1A TNF receptor superfamily member 1A JBrowse link 12 6,374,256 6,387,613 RGD:9068941
G TNFRSF1B TNF receptor superfamily member 1B JBrowse link 1 12,130,663 12,172,646 RGD:9068941
G TRPA1 transient receptor potential cation channel subfamily A member 1 JBrowse link 8 70,208,697 70,262,802 RGD:9068941
G TRPC1 transient receptor potential cation channel subfamily C member 1 JBrowse link 3 147,348,776 147,432,332 RGD:9068941
G TRPC6 transient receptor potential cation channel subfamily C member 6 JBrowse link 11 99,918,382 100,051,110 RGD:9068941
G TRPV1 transient receptor potential cation channel subfamily V member 1 JBrowse link 17 3,609,952 3,655,011 RGD:9068941
G TRPV4 transient receptor potential cation channel subfamily V member 4 JBrowse link 12 110,754,238 110,786,182 RGD:9068941
G VIP vasoactive intestinal peptide JBrowse link 6 155,236,848 155,263,730 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12464
    disease of anatomical entity 12026
      nervous system disease 9779
        Neurologic Manifestations 3667
          Pain 277
            Hyperalgesia 187
Path 2
Term Annotations click to browse term
  disease 12464
    disease of anatomical entity 12026
      nervous system disease 9779
        Neurologic Manifestations 3667
          Sensation Disorders 873
            Somatosensory Disorders 308
              Hyperalgesia 187
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.