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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Diabetic Nephropathies
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Accession:DOID:9002165 term browser browse the term
Definition:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Synonyms:exact_synonym: Diabetic Kidney Disease;   Diabetic Kidney Diseases;   Diabetic Nephropathy;   Intracapillary Glomerulosclerosis;   Kimmelstiel Wilson disease;   Kimmelstiel Wilson syndrome;   diabetic glomerulosclerosis;   nodular glomerulosclerosis
 narrow_synonym: type 1 diabetes nephropathy;   type 2 diabetes nephropathy
 related_synonym: diabetic nephropathy, susceptibility to
 primary_id: MESH:D003928
 xref: EFO:0000401;   EFO:0004996;   EFO:0004997


show annotations for term's descendants           Sort by:
Diabetic Nephropathies term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme susceptibility
no_association
treatment		 IMP
ISO
IDA		 associated with Diabetes Mellitus, Type 1;DNA:deletion:intron:IVS16+1464-1751del (human)
associated with Diabetes Mellitus, Type 1;DNA:insertion/deletion
associated with Diabetes Mellitus, Type 2;DNA:insertion/deletion
associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:7909524 PMID:10099885 PMID:10857950 PMID:23733546 PMID:28468961 More... RGD:2311449, RGD:1331525, RGD:7829777, RGD:7829780, RGD:8548872, RGD:8548885, RGD:11039044 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 no_association ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphisms: :multiple (human)
associated with Diabetes Mellitus, Experimental
mRNA, protein:altered expression:kidney
associated with Diabetes Mellitus, Non-Insulin Dependent;mRNA, protein:decreased expression:kidney
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:12623933 PMID:17600118 PMID:20844835 PMID:18235039 PMID:18235039 More... RGD:2313800, RGD:2313800, RGD:2313796, RGD:2313797 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acvr1 activin A receptor type 1 IEP associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:kidney RGD PMID:11675415 RGD:2313802 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing no_association
disease_progression		 ISO protein:increased expression:plasma
associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs2241766 (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs1501299 (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17942768 PMID:21945031 PMID:23260797 PMID:23260797 PMID:17970779 RGD:5686409, RGD:8694443, RGD:8694443, RGD:8694475 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adora1 adenosine A1 receptor IMP associated with Diabetes Mellitus, Experimental RGD PMID:19552053 RGD:2313803 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adra2b adrenoceptor alpha 2B ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism (human) RGD PMID:15660746 RGD:2313545 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Adrb3 adrenoceptor beta 3 ISO associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.W64R rs4994 (human) RGD PMID:9867224 RGD:5684403 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment
susceptibility		 IEP
ISO
IDA		 associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney cortex, glomerulus
associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum
associated with Diabetes Mellitus;DNA:polymorphisms, haplotype:cds, intron:p.G82S, g.2184A>G (rs2070600, rs3134940) (human)
associated with Diabetes Mellitus, Type 2;DNA:polymorphism: :1704G>T (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:renal cortex (mouse)		 RGD PMID:19142024 PMID:12651605 PMID:21856399 PMID:23091285 PMID:21533139 More... RGD:2325651, RGD:7243248, RGD:7243852, RGD:7244174, RGD:7244187, RGD:8695982, RGD:7243248 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen no_association
disease_progression		 ISO associated with Diabetes Mellitus, Type 1;DNA:polymorphism: :p.M235T (human)
associated with Diabetes Mellitus, Type 2;DNA:polymorphism: :p.M235T (human)
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:17890855 PMID:20383342 PMID:15118671 PMID:8772723 PMID:10862638 More... RGD:1331525, RGD:8548868, RGD:8548872, RGD:8548885, RGD:11039058 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP
ISO		 associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:polymorphism: :1166A>C (human)		 RGD PMID:12172324 PMID:12476891 RGD:6903861, RGD:8548891 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IEP associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:kidney RGD PMID:18565281 RGD:6903847 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Ahsg alpha-2-HS-glycoprotein ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum RGD PMID:15698447 RGD:2313813 NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 susceptibility ISO associated with Diabetes Mellitus, Type 1;DNA:promoter:repeat:g.?(AC)n (human) RGD PMID:9215310 PMID:9000706 RGD:734542, RGD:8548641 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Alb albumin IEP
ISO		 associated with Metabolic Syndrome X;protein:increased expression:urine
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:increased expression:urine
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:16380483 PMID:19424163 PMID:19246226 PMID:19397971 PMID:21441310 RGD:2306882, RGD:2306886, RGD:2306885, RGD:5135032 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alpk1 alpha-kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27542954 NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157 		JBrowse link
G Aoc3 amine oxidase, copper containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14977883 NCBI chr10:86,272,757...86,280,702 JBrowse link
G Apoa1 apolipoprotein A1 ISO RGD PMID:9829487 RGD:2313960 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 ISO associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:serum RGD PMID:11126402 PMID:9829487 RGD:2313958, RGD:2313960 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apob apolipoprotein B ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:19324028 RGD:2313979 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc1 apolipoprotein C1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:very-low-density lipoprotein particle RGD PMID:12753304 RGD:2313950 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375 		JBrowse link
G Apoc3 apolipoprotein C3 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-455T>C RGD PMID:16813599 RGD:2306755 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Apoe apolipoprotein E susceptibility
no_association		 ISO DNA:missense mutations, haplotype:cds:p.C112R, p.R158C (human)
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, type 1;		 RGD PMID:21127830 PMID:22859852 PMID:11495633 RGD:6903840, RGD:6902935, RGD:7771553 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Apoh apolipoprotein H ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum RGD PMID:11302005 RGD:2313989 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G Aqp2 aquaporin 2 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased secretion:urine RGD PMID:12218327 RGD:2314343 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468 		JBrowse link
G Arg2 arginase 2 ISO RGD PMID:21926276 RGD:6902923 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta treatment IDA mRNA:decreased expression:renal glomerulus (rat) RGD PMID:22591908 RGD:13792578 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Axl Axl receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12644472 PMID:15619028 RGD:1579938 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Azin1 antizyme inhibitor 1 treatment IEP RGD PMID:26751697 RGD:14700801 NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578 		JBrowse link
G Bdkrb2 bradykinin receptor B2 susceptibility ISO associated with Diabetes Mellitus, Experimental RGD PMID:17596525 RGD:2313335 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Bdnf brain-derived neurotrophic factor IMP RGD PMID:20557422 RGD:4891134 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 IEP protein:increased expression:kidney RGD PMID:21866636 RGD:6483069 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO associated with Diabetes Mellitus, Type2; protein:increased expression:serum: RGD PMID:9347246 RGD:7207424 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bmp7 bone morphogenetic protein 7 IEP RGD PMID:17437042 RGD:2289036 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G C3 complement C3 ISO
IEP		 associated with Diabetes Mellitus, Type 1; protein:increased expression:kidney:
associated with Diabetes Mellitus, Type 2		 RGD PMID:19200691 PMID:25662584 RGD:7183082, RGD:11040807 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C5 complement C5 IEP associated with Diabetes Mellitus, Type 2 RGD PMID:25662584 RGD:11040807 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B treatment ISO RGD PMID:27273361 RGD:13506726 NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091 		JBrowse link
G Capn10 calpain 10 IEP associated with Diabetes Mellitus, Experimental RGD PMID:22012129 RGD:7247733 NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494 		JBrowse link
G Casp12 caspase 12 IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney RGD PMID:19301230 RGD:2311449 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 treatment IEP associated with Diabetes Mellitus, Experimental;protein:increased activity:kidney
associated with type 2 diabetes mellitus
associated with Diabetes Mellitus, Experimental 		RGD PMID:19601660 PMID:28456626 PMID:29606028 RGD:2311440, RGD:13782304, RGD:13792586 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 treatment IEP associated with type 2 diabetes mellitus RGD PMID:28456626 RGD:13782304 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 treatment IEP associated with type 2 diabetes mellitus
associated with Diabetes Mellitus, Experimental 		RGD PMID:28456626 PMID:29606028 RGD:13782304, RGD:13792586 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:30038056 PMID:29606028 RGD:13782342, RGD:13792586 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase ISO
IEP
IDA
IMP		 associated with experimentally induced diabetes
rat gene in db/db mice		 RGD PMID:22315314 PMID:21686137 PMID:21525431 PMID:20299359 RGD:7205651, RGD:7205662, RGD:7205665, RGD:7205676 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21113841 RGD:5683918 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 susceptibility
disease_progression		 ISO
IEP		 associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA:increased expression:kidney
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine
associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16374426 PMID:17968528 PMID:18031723 PMID:19097668 PMID:19409809 More... RGD:2306991, RGD:2306989, RGD:2306982, RGD:2306979, RGD:2306980 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 IEP associated with Diabetes Mellitus, Experimental RGD PMID:17664181 RGD:7483629 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-28C>G
associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:urine		 RGD PMID:12610055 PMID:18326229 RGD:2307107, RGD:2307063 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn2 cellular communication network factor 2 IEP associated with Diabetes Mellitus, Experimental; protein:increased expression:kidney, glomerulus (rat)
associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:kidney (rat)		 RGD PMID:19895808 PMID:19065061 RGD:2314366, RGD:2314604 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccne1 cyclin E1 IEP protein:increased expression:kidney RGD PMID:17825795 RGD:2289273 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 no_association ISO associated with Diabetes Mellitus, Insulin-Dependent
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.V64I (human)		 RGD PMID:17631861 PMID:11756347 RGD:2313558, RGD:2313563 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:59029G>A (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP: :59029G>A (human)		 RGD PMID:12610055 PMID:17428349 RGD:2307107, RGD:8549756 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd36 CD36 molecule IEP protein:increased expression:renal proximal tubule, endothelial cell RGD PMID:15737001 RGD:2307215 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd38 CD38 molecule IMP
ISO		 associated with Diabetes Mellitus, Experimental RGD PMID:19073639 PMID:19300526 RGD:2307227, RGD:2307228 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd40lg CD40 ligand ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:serum RGD PMID:18756582 RGD:2314208 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:27652271 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEP mRNA, protein:increased expression:kidney, glomerulus RGD PMID:15698433 PMID:16805985 RGD:2293628, RGD:2293619 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cfl1 cofilin 1 IEP associated with Diabetes Mellitus, Experimental;protein:increased phosphorylation:renal glomerulus (rat) RGD PMID:24726496 RGD:11570419 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Clu clusterin treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:18949565 RGD:9068414 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cndp1 carnosine dipeptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17942768 PMID:21393041 PMID:21573905 PMID:21393041 RGD:7207213 NCBI chr18:77,984,886...78,030,837
Ensembl chr18:77,984,907...78,007,765 		JBrowse link
G Cndp2 carnosine dipeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21573905 NCBI chr18:78,039,924...78,057,030
Ensembl chr18:78,039,932...78,056,922 		JBrowse link
G Col1a1 collagen type I alpha 1 chain IEP associated with Diabetes Mellitus, Experimental;mRNA:increased expression:renal glomerulus (rat) RGD PMID:22903132 RGD:8552684 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain ISO associated with Diabetes Mellitus, Non-Insulin Dependent;mRNA:increased expression:kidney
associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18682491 PMID:27997345 PMID:19466391 PMID:17582205 RGD:2311340, RGD:2311342 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cpb2 carboxypeptidase B2 susceptibility ISO DNA:SNP:cds:1040C>T(human)
protein:increased expression:plasma		 RGD PMID:22932273 PMID:12574207 RGD:7243116, RGD:7243123 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 susceptibility IEP RGD PMID:15862029 RGD:10059365 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crp C-reactive protein disease_progression ISO associated with Diabetes Mellitus, Type 1
associated with Diabetes Mellitus, Type 2;protein:increased expression:urine		 RGD PMID:22885250 PMID:22590912 RGD:6906965, RGD:6906967 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf1r colony stimulating factor 1 receptor disease_progression ISO
IEP		 associated with Diabetes Mellitus, Type 2
mRNA,protein:increased expression:kidney (rat)		 RGD PMID:19466391 PMID:32141565 RGD:2311340, RGD:151665767 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Cst3 cystatin C IEP
ISO		 protein:increased expression:plasma (rat)
protein:increased expression:serum (human)		 RGD PMID:18946178 PMID:19132849 RGD:2314297, RGD:2314328 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:plasma: RGD PMID:18026823 RGD:2312302 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963 		JBrowse link
G Ctsd cathepsin D ISO CTD Direct Evidence: marker/mechanism CTD PMID:28468961 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Cubn cubilin IEP RGD PMID:17037740 RGD:1599655 NCBI chr17:76,385,046...76,593,133
Ensembl chr17:76,385,060...76,593,231 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
associated with Diabetes Mellitus, Insulin-Dependent		 RGD PMID:17425653 PMID:19073786 RGD:2311359, RGD:2311357 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:22791342 RGD:7257674 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cyba cytochrome b-245 alpha chain ISO associated with Diabetes Mellitus, Type 2;DNA:SNP: :242C>T (human) RGD PMID:14747204 RGD:8695982 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-344C>T (human) RGD PMID:16672053 RGD:2307295 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-344C>T (human) RGD PMID:16672053 RGD:2307295 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 treatment IMP associated with Diabetes Mellitus, Experimental RGD PMID:22301628 RGD:7257708 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 ISO associated with Diabetes Mellitus, Experimental; RGD PMID:21742052 RGD:7243153 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Dcn decorin ISO associated with Diabetes Mellitus, Insulin-Dependent
associated with Diabetes Mellitus, Insulin-Dependent;mRNA, protein:decreased expression:kidney cortex, glomerulus
associated with Diabetes Mellitus, Experimental
protein:increased expression:plasma, urine		 RGD PMID:12187087 PMID:16868749 PMID:17884968 PMID:11259366 RGD:2311415, RGD:2311412, RGD:2311411, RGD:2311416 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Dgkh diacylglycerol kinase, eta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20665664 NCBI chr15:53,981,079...54,150,470
Ensembl chr15:53,991,481...54,150,706 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 IMP associated with Diabetes Mellitus, Experimental RGD PMID:20019166 RGD:6907383 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Edn1 endothelin 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased secretion:plasma (human) RGD PMID:18346810 RGD:2313284 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A IMP associated with Diabetes Mellitus, Experimental RGD PMID:21191784 RGD:4892326 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Egf epidermal growth factor ISO RGD PMID:17475821 RGD:6906912 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Elmo1 engulfment and cell motility 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17942768 NCBI chr17:44,286,495...44,822,668
Ensembl chr17:44,286,485...44,822,788 		JBrowse link
G Eng endoglin ISO associated with Diabetes Mellitus, Insulin-Dependent; mRNA:increased expression:kidney RGD PMID:19395281 RGD:2313795 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Enpep glutamyl aminopeptidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:28468961 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO RGD PMID:19506043 RGD:6906926 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Ep300 E1A binding protein p300 treatment IEP
IDA		 associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:kidney (rat) RGD PMID:19268536 PMID:19268536 RGD:2311716, RGD:2311716 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epas1 endothelial PAS domain protein 1 treatment IDA
IEP		 associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental		 RGD PMID:17967803 PMID:17914354 RGD:10395374, RGD:10395377 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:21832210 RGD:5688728 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Epo erythropoietin ISO DNA:snp:promoter:-1125T>G(rs1617640)(human)
associated with Diabetes Mellitus, Experimental;		 RGD PMID:19619913 PMID:18458324 PMID:19356735 RGD:2313832, RGD:2313838, RGD:2313833 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IEP associated with Diabetes Mellitus, Experimental; mRNA:increased expression:kidney: RGD PMID:10749885 RGD:9685546 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Esr1 estrogen receptor 1 IEP
ISO		 associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:snps:introns: multiple(human)		 RGD PMID:16464734 PMID:18305958 RGD:2314020, RGD:2314005 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G F2 coagulation factor II, thrombin disease_progression ISO DNA:polymorphism: :20210G>A(human)
protein:increased expression:plasma (human)		 RGD PMID:21955218 PMID:21574459 PMID:14983223 RGD:6893574, RGD:6893575, RGD:2313643 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F3 coagulation factor III, tissue factor ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:15004866 RGD:2313863 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fabp2 fatty acid binding protein 2 ISO RGD PMID:16249461 RGD:1578457 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089 		JBrowse link
G Fas Fas cell surface death receptor ISO
IEP		 associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:kidney
mRNA:increased expression:kidney
associated with Diabetes Mellitus, Experimental;protein:increased expression:renal distal tubule (rat)		 RGD PMID:17851466 PMID:18287563 PMID:12861046 RGD:2315705, RGD:2312739, RGD:8686421 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand ISO associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:kidney RGD PMID:17851466 RGD:2315705 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fbn1 fibrillin 1 onset ISO associated with Diabetes Mellitus, Experimental RGD PMID:16395273 PMID:16380460 RGD:7365077, RGD:7365080 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Fbxw12 F-box and WD repeat domain containing 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36073553 NCBI chr 8:109,782,315...109,802,086
Ensembl chr 8:109,786,815...109,801,813 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO mRNA:increased expression:kidney RGD PMID:19279131 RGD:2315842 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgf21 fibroblast growth factor 21 ISO protein:increased expression:serum: RGD PMID:25625802 RGD:10401920 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Fgf23 fibroblast growth factor 23 severity IEP mRNA,protein:increased expression:kidney: RGD PMID:23967103 RGD:10044235 NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine RGD PMID:15610240 RGD:2313731 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fmod fibromodulin ISO mRNA,protein:increased expression:Kidney Glomerulus
associated with Diabetes Mellitus, Insulin-Dependent;mRNA:decreased expression:kidney cortex		 RGD PMID:11259366 PMID:16868749 RGD:2311416, RGD:2311412 NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133 		JBrowse link
G Fn1 fibronectin 1 treatment ISO
IEP		 associated with Diabetes Mellitus, Experimental; mRNA:increased expression:kidney
protein:increased expression:kidney cortex:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:24413998 PMID:16301823 PMID:22736507 RGD:7206843, RGD:10402169 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase susceptibility ISO associated with diabetes mellitus;DNA:SNP: :rs17817449 (human)
associated with type 2 diabetes mellitus;DNA:SNP: :rs7204609 (human)
associated with type 2 diabetes mellitus;DNA:SNPs: :rs1121980, rs1421085, rs17817449 (human)		 RGD PMID:29154870 PMID:34134115 PMID:29410390 RGD:329813082, RGD:329813084, RGD:329901856 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Fuca1 alpha-L-fucosidase 1 ISO associated with Diabetes Mellitus, Insulin-Dependent;protein:decreased activity;urine RGD PMID:8343614 RGD:2315943 NCBI chr 5:148,152,718...148,169,972
Ensembl chr 5:148,152,700...148,169,972 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment IEP associated with Hypertension RGD PMID:21987533 RGD:10449128 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gas6 growth arrest specific 6 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12644472 PMID:15619028 RGD:1579938 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gatm glycine amidinotransferase HEP RGD PMID:26364511 RGD:329961310 NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129 		JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 ISO RGD PMID:9519709 RGD:2313353 NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471 		JBrowse link
G Gfpt2 glutamine-fructose-6-phosphate transaminase 2 susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP:3' utr RGD PMID:14764791 RGD:2307362 NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329 		JBrowse link
G Ghr growth hormone receptor susceptibility ISO
IMP
IEP		 associated with Diabetes Mellitus
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney		 RGD PMID:10541297 PMID:15066219 PMID:10614635 PMID:10990443 RGD:2307370, RGD:2307364, RGD:2307369, RGD:2307368 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Gipr gastric inhibitory polypeptide receptor ISO RGD PMID:19211686 RGD:2306734 NCBI chr 1:78,804,287...78,814,462
Ensembl chr 1:78,805,593...78,814,462 		JBrowse link
G Glo1 glyoxalase 1 no_association ISO DNA:SNP:promoter:-7C>T (human) RGD PMID:21738003 PMID:21738003 RGD:7242569, RGD:7242569 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO protein:increased expression:glomerulus
associated with Diabetes Mellitus, Type 1		 RGD PMID:17609286 PMID:16249459 RGD:2306609, RGD:11068479 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression:serum (human) RGD PMID:17269729 RGD:2312635 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment IEP RGD PMID:23196710 RGD:13792785 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 treatment IEP RGD PMID:23196710 RGD:13792785 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IEP protein:decreased expression:cortex of kidney (rat) RGD PMID:23196710 RGD:13792785 NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 treatment IEP RGD PMID:23196710 RGD:13792785 NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment IMP RGD PMID:26888388 RGD:13792773 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase treatment ISO
IEP		 associated with Diabetes Mellitus, Type 2;protein:decreased activity:kidney
associated with Diabetes Mellitus, Experimental		 RGD PMID:23626958 PMID:24947049 RGD:7257582, RGD:10401899 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 no_association ISO associated with Diabetes Mellitus, Type 1;DNA:deletion:cds: (human) RGD PMID:19752172 RGD:7495818 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 disease_progression
no_association		 ISO associated with Diabetes Mellitus, Type 2;DNA:deletion:cds (human)
associated with Diabetes Mellitus, Type 1;DNA:deletion:cds (human)		 RGD PMID:15927971 PMID:19752172 RGD:2306630, RGD:7495818 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Has2 hyaluronan synthase 2 IEP associated with Diabetes Mellitus, Experimental;mRNA:increased expression:renal medulla RGD PMID:18441392 RGD:9588630 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 disease_progression IEP
ISO		 protein:increased expression:plasma
associated with Diabetes Mellitus,Type 2;protein:increased expression:urine:
associated with Diabetes mellitus, Type 1;		 RGD PMID:22997966 PMID:22015481 PMID:20980978 RGD:7245497, RGD:7245960, RGD:7246890 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hdac2 histone deacetylase 2 IEP
ISO		 mRNA,protein:increased expression:kidney: RGD PMID:24717296 PMID:24717296 PMID:24717296 RGD:9590311, RGD:9590311, RGD:9590311 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hdac4 histone deacetylase 4 treatment IEP
ISO
IMP		 mRNA,protein:increased expression:kidney: RGD PMID:24717296 PMID:24717296 PMID:24717296 PMID:24717296 RGD:9590311, RGD:9590311, RGD:9590311, RGD:9590311 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 IEP
ISO		 mRNA,protein:increased expression:kidney: RGD PMID:24717296 PMID:24717296 PMID:24717296 RGD:9590311, RGD:9590311, RGD:9590311 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hfe homeostatic iron regulator ISO associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.C282Y (human) RGD PMID:15347835 RGD:8694362 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Hgf hepatocyte growth factor ISO RGD PMID:16340242 RGD:2313567 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment IDA
IEP		 associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental		 RGD PMID:17967803 PMID:17914354 RGD:10395374, RGD:10395377 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:21849637 RGD:10755581 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha IEP mRNA:decreased expression:kidney, liver RGD PMID:18184923 RGD:2301838 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 susceptibility ISO DNA:SNO:intron: (rs17389016, rs11799643) (human) RGD PMID:32453474 RGD:329902062 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO RGD PMID:18518860 RGD:7242747 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO associated with Diabetes Mellitus, Type 2 RGD PMID:18518860 RGD:7242747 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney RGD PMID:19301230 RGD:2311449 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 ISO RGD PMID:17330940 RGD:7242762 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IEP
ISO		 mRNA,protein:increased expression:glomerulus:
protein:increased expression:glomerulus, podocyte:		 RGD PMID:21931298 PMID:21931298 RGD:10402764, RGD:10402764 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A IMP
ISO		 associated with Diabetes Mellitus, Experimental;
associated with Diabetes Mellitus Type 2; 		RGD PMID:18175064 PMID:12213354 RGD:7257686, RGD:7257687 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO
IDA		 associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney (mouse)
associated with Diabetes Mellitus, Insulin-Dependent;DNA:SNP: :p.K469E (rs5498) (human)		 RGD PMID:18299691 PMID:20447389 PMID:18505543 PMID:19246972 RGD:2312766, RGD:4145414, RGD:2313475, RGD:2313470 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma ISO mRNA, protein:increased expression:kidney, T cell RGD PMID:22286547 RGD:6893364 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO
IEP		 protein:decreased expression:serum
associated with Diabetes Mellitus, Experimental;protein:decreased expression:serum (rat)		 RGD PMID:17194636 PMID:10444029 RGD:2313764, RGD:12904967 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEP mRNA,protein:increased expression:kidney: RGD PMID:19008912 RGD:10046022 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igf2 insulin-like growth factor 2 IEP
ISO		 associated with Diabetes Mellitus, Type 2; mRNA:decreased expression:neural tissue, liver:
associates with Diabetes Mellitus; mRNA:decreased expression:brain:		 RGD PMID:9336345 PMID:9336345 PMID:8764603 RGD:5510019, RGD:5510019, RGD:5510022 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 ISO DNA:SNPs RGD PMID:16306374 RGD:1625238 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Il10 interleukin 10 susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphisms:promoter:g.-1082G>A, g.-819C>T, g.-592C>A (human) RGD PMID:19031431 RGD:2308943 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta ISO
IDA		 associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental		 RGD PMID:22086159 PMID:19769609 RGD:7175266, RGD:7175519 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility
no_association		 ISO associated with Diabetes Mellitus, Type 2; DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human) RGD PMID:16174285 PMID:17286233 RGD:6907371, RGD:6909120 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il6 interleukin 6 susceptibility ISO
IDA		 associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)
associated with Diabetes Mellitus, Experimental; protein:increased expression:kidney (rat)
associated with Diabetes Mellitus, Type1;DNA:polymorphism:promoter:-174G>C(human)		 RGD PMID:18716362 PMID:19052104 PMID:19542902 RGD:2307282, RGD:2307281, RGD:7829816 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 resistance IDA
ISO		 CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:2143390 PMID:7713310 PMID:7987072 PMID:22068113 RGD:6902908 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Irs2 insulin receptor substrate 2 ISO mRNA:increased expression:kidney tubule RGD PMID:23617393 RGD:7257702 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Itga2 integrin subunit alpha 2 severity ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:mesangial cell (human) RGD PMID:8989742 RGD:2307420 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Jak2 Janus kinase 2 treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:22745068 RGD:10403082 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ameliorates ISO RGD PMID:24733189 PMID:29425253 RGD:329955448, RGD:329969879 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Kdm6a lysine demethylase 6A ISO associated with Diabetes Mellitus, Type 1;protein:increased expression:kidney (mouse) RGD PMID:23508046 RGD:9587808 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Kdr kinase insert domain receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18630688 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 IDA RGD PMID:21439372 RGD:6893386 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Kl Klotho treatment IEP protein:decreased expression:kidney: RGD PMID:24136780 RGD:10403079 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Klk1 kallikrein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19516248 NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Klk1c12 kallikrein 1-related peptidase C12 ISO RGD PMID:17272402 RGD:1641794 NCBI chr 1:94,378,103...94,382,140
Ensembl chr 1:94,378,054...94,382,176 		JBrowse link
G Klkb1 kallikrein B1 disease_progression ISO associated with Diabetes Mellitus, Type 1; protein:increased expression:plasma: RGD PMID:12716755 RGD:7327151 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Kng2 kininogen 2 ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism: :7965C>T (human) RGD PMID:17065357 RGD:2311541 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Lamb2 laminin subunit beta 2 IEP RGD PMID:19864299 RGD:7207449 NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549 		JBrowse link
G Lcn2 lipocalin 2 IEP
ISO		 protein:increased expression:urine
associated with Diabetes Mellitus,Type 2;protein:increased expression:urine:		 RGD PMID:22997966 PMID:22015481 RGD:7245497, RGD:7245960 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lep leptin ISO RGD PMID:22773754 RGD:6907074 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:28130181 PMID:29988851 PMID:36066211 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lmna lamin A/C ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :1908C>T (human) RGD PMID:16117820 RGD:2306095 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase ISO RGD PMID:1789335 RGD:2311543 NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544 		JBrowse link
G Lpl lipoprotein lipase susceptibility ISO RGD PMID:16813599 RGD:2306755 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Lta lymphotoxin alpha ISO DNA:polymorphism RGD PMID:18575614 RGD:2313255 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO RGD PMID:19923143 RGD:7243957 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased activity:kidney RGD PMID:19066844 RGD:2311566 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mdk midkine ISO CTD Direct Evidence: marker/mechanism CTD PMID:17607302 NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Mfn2 mitofusin 2 treatment IMP
IEP
ISO		 associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27997345 PMID:27997345 PMID:26123583 RGD:12910740, RGD:11053290 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir145 microRNA 145 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24223694 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir146a microRNA 146a exacerbates ISO RGD PMID:26647423 RGD:126925142 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir21 microRNA 21 IEP RNA:increased expression:kidney RGD PMID:30847937 RGD:41410820 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mllt3 MLLT3, super elongation complex subunit treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:23077601 RGD:9686143 NCBI chr 5:102,259,075...102,515,447
Ensembl chr 5:102,260,011...102,515,361 		JBrowse link
G Mmp12 matrix metallopeptidase 12 ISO RGD PMID:21277817 RGD:7241216 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:23384615 RGD:13204971 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO protein: decreased expression: glomerulus RGD PMID:9211353 RGD:7241249 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO
IEP		 associated with Diabetes Mellitus, Type 2;DNA:repeat:promoter
associated with Diabetes Mellitus, Experimental		 RGD PMID:11576356 PMID:23384615 RGD:8547866, RGD:13204971 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility
no_association		 ISO associated with Diabetes Mellitus, Type 2; DNA:transition:cds:g.677C>T (human) RGD PMID:14737040 PMID:18280442 RGD:6893524, RGD:6893576 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtor mechanistic target of rapamycin kinase susceptibility ISO
IDA		 associated with Diabetes Mellitus, Experimental
DNA:SNP,haplotype: :rs7212142(human)		 RGD PMID:21606597 PMID:23827786 PMID:28536139 RGD:7245564, RGD:10003168, RGD:13506787 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO Associated with Diabetes Mellitus, Type 1;DNA:SNP:cds:66A>G, (rs1801394) (human) RGD PMID:18774994 RGD:6893652 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Nat2 N-acetyltransferase 2 ISO associated with Diabetes Mellitus, Insulin-Dependent RGD PMID:10591543 RGD:2311598 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 treatment IEP associated with Diabetes Mellitus, Experimental;mRNA:increased expression:kidney,glomerulus
associated with Diabetes Mellitus, Experimental 		RGD PMID:22903132 PMID:22591908 RGD:8552684, RGD:13792578 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 IEP protein:increased expression:nucleus RGD PMID:26481166 RGD:329337345 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IDA
IEP
ISO		 associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:20103708 PMID:21439372 PMID:23064900 RGD:6893386, RGD:10412718 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos1 nitric oxide synthase 1 treatment IDA
IMP		 associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental		 RGD PMID:23548923 PMID:10966937 RGD:7257655, RGD:13824991 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos3 nitric oxide synthase 3 susceptibility
no_association
treatment		 ISO
IEP		 associated with Diabetes Mellitus, Type 2;DNA:duplication:intron:IVS4?-?+27 (human)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental		 CTD
RGD		 PMID:20042665 PMID:10868974 PMID:10741691 PMID:29336891 RGD:7421530, RGD:7421534, RGD:13504726 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox4 NADPH oxidase 4 IEP
IMP		 associated with Diabetes Mellitus, Experimental;mRNA:increased expression:kidney cortex RGD PMID:17511984 PMID:16135519 RGD:2324670, RGD:2324673 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin treatment IEP
ISO		 associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:decreased expression:kidney (mouse)		 RGD PMID:17624267 PMID:30862474 PMID:24173355 PMID:21617141 RGD:38596322, RGD:38596325, RGD:38599008, RGD:7241083 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nppa natriuretic peptide A no_association
disease_progression		 ISO
IEP		 DNA:polymorphism:intron
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:blood
associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism: :2238T>C (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma		 RGD PMID:9681733 PMID:10381153 PMID:15111511 PMID:10404802 RGD:2313593, RGD:2313592, RGD:2313590, RGD:7247731 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma RGD PMID:10404802 PMID:16917760 RGD:7247731, RGD:7248603 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:21457706 RGD:11035226 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IMP RGD PMID:20557422 RGD:4891134 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:20621183 RGD:11073737 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pax2 paired box 2 IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney cortex RGD PMID:15149326 RGD:2316747 NCBI chr 1:243,616,509...243,697,454
Ensembl chr 1:243,616,606...243,695,321 		JBrowse link
G Pdgfa platelet derived growth factor subunit A ISO associated with Diabetes Mellitus, Non-Insulin Dependent;mRNA, protein:increased expression:kidney RGD PMID:12808179 RGD:2311649 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO associated with Diabetes Mellitus, Non-Insulin Dependent RGD PMID:15067514 RGD:2311646 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO associated with Diabetes Mellitus, Non-Insulin Dependent RGD PMID:15067514 RGD:2311646 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA:increased expression:glomerulus RGD PMID:15042541 RGD:2311655 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pgf placental growth factor disease_progression ISO associated with Diabetes Mellitus, Type 1 RGD PMID:21988672 RGD:6483606 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Plat plasminogen activator, tissue type ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:16598198 RGD:2311671 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase IEP mRNA:increased expression:renal glomerulus (rat) RGD PMID:15322501 RGD:1580123 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pon1 paraoxonase 1 susceptibility
no_association		 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent
associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.Q192R (human)
associated with Diabetes Mellitus;DNA:missense mutations:cds:p.L55M, p.Q192R (rs854560, rs662) (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:26884296 PMID:19207863 PMID:15270786 PMID:24100645 RGD:2313266, RGD:8547548, RGD:8547572 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon2 paraoxonase 2 ISO associated with type 1 diabetes mellitus;DNA:missense mutation:cds:p.C311S (human)
associated with type 2 diabetes mellitus;DNA:polymorphisms:multiple		 RGD PMID:11918623 PMID:11206400 RGD:1580218, RGD:2313492 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
G Postn periostin ISO mRNA,protein:increased expression:kidney: RGD PMID:22167593 RGD:10040972 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO
IMP		 associated with Diabetes Mellitus, Non-Insulin-Dependent
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:28182703 PMID:18780770 PMID:18388116 RGD:2301845, RGD:2301862 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO mRNA:decreased expression:kidney (human)
DNA:polymorphism:exon:p.G482S (human)		 RGD PMID:21784897 PMID:19900151 RGD:7242027, RGD:7242045 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkcb protein kinase C, beta IDA associated with hypertension;protein:increased expression:glomerular mesangium RGD PMID:12540629 RGD:729635 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkce protein kinase C, epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:20665664 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:23159951 RGD:9491822 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Pros1 protein S severity
treatment		 ISO
IEP		 associated with diabetes mellitus, experimental
protein:increased expression:kidney, glomerulus
associated with diabetes mellitus, experimental;mRNA, protein:increased expression:kidney, glomerulus		 RGD PMID:29511111 PMID:29511111 PMID:29511111 PMID:29511111 RGD:13515131, RGD:13515131, RGD:13515131, RGD:13515131 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286 		JBrowse link
G Prss1 serine protease 1 ISO protein:increased expression:urine RGD PMID:18428024 RGD:2324899 NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792 		JBrowse link
G Prss2 protease, serine, 2 ISO protein:increased expression:urine RGD PMID:18428024 RGD:2324899 NCBI chr 4:70,278,304...70,283,385
Ensembl chr 4:70,278,304...70,283,385 		JBrowse link
G Pten phosphatase and tensin homolog IEP protein:decreased expression:kidney cortex, glomerulus RGD PMID:16804083 RGD:2292546 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgds prostaglandin D2 synthase susceptibility ISO RGD PMID:15970590 RGD:1642581 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP associated with Diabetes Mellitus, Experimental RGD PMID:21441310 PMID:17112505 RGD:5135032, RGD:5688268 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pth parathyroid hormone ISO DNA:snps:exon, intron:g.350C>A, g.IVS2+56G>A (rs6256, rs6254) (human) RGD PMID:22777106 RGD:7242744 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Rbp4 retinol binding protein 4 disease_progression ISO associated with type 2 diabetes mellitus; protein:increased expression:blood plasma, urine (human) RGD PMID:17568782 RGD:329845581 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17900838 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin IDA RGD PMID:15489960 RGD:1579795 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Retn resistin ISO RGD PMID:21425555 RGD:7207159 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Selp selectin P severity IEP
ISO		 associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney, serum
associated with Diabetes Mellitus, Non-Insulin-Dependent		 RGD PMID:18471420 PMID:18026823 RGD:2312294, RGD:2312302 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Serpinb7 serpin family B member 7 ISO associated with Diabetes Mellitus, Type 1
associated with Diabetes Mellitus, Type 2;DNA:SNP:intron:rs1720843 (human)		 RGD PMID:16443768 PMID:19690890 RGD:7207374, RGD:7207378 NCBI chr13:23,369,830...23,442,205
Ensembl chr13:23,395,671...23,442,205 		JBrowse link
G Serpine1 serpin family E member 1 treatment IEP
ISO
IDA		 associated with Diabetes Mellitus, Experimental;mRNA:increased expression:renal glomerulus, mesangial cell (rat)
associate with Diabetes Mellitus, Type 1;protein:increased expression:plasma (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18682491 PMID:15322501 PMID:10809802 PMID:26712211 RGD:1580123, RGD:8547711, RGD:11073694 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf1 serpin family F member 1 treatment IEP
ISO		 mRNA, protein:decreased expression:renal cortex, renal medulla (rat)
human protein in a mouse model
associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma (human)		 RGD PMID:15616035 PMID:23884140 PMID:18523656 RGD:1359799, RGD:8554865, RGD:8554896 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 treatment ISO
IEP		 associated with Diabetes Mellitus, Type 2;DNA:SNP:exon:g.20882C>T (human)
associated with Diabetes Mellitus, Experimental		 RGD PMID:15745834 PMID:26337659 PMID:22707888 RGD:2312305, RGD:12879466, RGD:12879861 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Smad6 SMAD family member 6 IEP associated with Diabetes Mellitus, Experimental RGD PMID:17437042 RGD:2289036 NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 treatment IDA RGD PMID:31599432 RGD:151347182 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Sod1 superoxide dismutase 1 ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphisms: :multiple
protein:decreased expression:kidney
human gene in a mouse model		 RGD PMID:17914031 PMID:19470681 PMID:11522679 RGD:2312365, RGD:2312361, RGD:8655571 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:24819633 PMID:17192491 RGD:7175540 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 ISO protein:decreased expression:kidney RGD PMID:19470681 RGD:2312361 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sparc secreted protein acidic and cysteine rich IEP associated with Diabetes Mellitus, Experimental;mRNA, protein:decreased expression:kidney RGD PMID:8569083 RGD:2300072 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
G Spp1 secreted phosphoprotein 1 IDA RGD PMID:12032186 RGD:1581328 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO
IEP		 associated with Diabetes Mellitus, Insulin-Dependent;mRNA:increased expression:kidney
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:kidney
associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA:increased expression:kidney
associated with Diabetes Mellitus, Experimental		 RGD PMID:16936198 PMID:16046298 PMID:18613221 PMID:17961514 PMID:17961514 RGD:2308815, RGD:1581418, RGD:2308806, RGD:2308811, RGD:2308811 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO associated with Diabetes Mellitus, Insulin-Dependent;mRNA:increased expression:kidney
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:kidney		 RGD PMID:16936198 PMID:16046298 RGD:2308815, RGD:1581418 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:22745068 RGD:10403082 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP (human) RGD PMID:19506043 RGD:6906926 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tf transferrin IDA RGD PMID:23468095 RGD:7244196 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment ISO
IEP		 mRNA:increased expression:glomerulus
associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18682491 PMID:19960420 PMID:19211686 PMID:24074026 RGD:2306734, RGD:7394855 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbi transforming growth factor, beta induced IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18682491 PMID:12911551 RGD:1304421 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15496156 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 IEP protein:decreased expression:glomerulus (rat) RGD PMID:15153551 RGD:1599409 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802 		JBrowse link
G Thbs1 thrombospondin 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:17878288 RGD:2317941 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 IEP mRNA:increased expression:kidney RGD PMID:17491697 RGD:2290407 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tinag tubulointerstitial nephritis antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19634143 NCBI chr 8:77,800,031...77,885,077
Ensembl chr 8:77,800,032...77,885,077 		JBrowse link
G Tlr2 toll-like receptor 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:21617141 RGD:7241083 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO associated with Diabetes Mellitus, Experimental RGD PMID:22021706 RGD:7207902 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor IDA
ISO
IEP		 associated with Diabetes Mellitus, Experimental;protein:increased expression:urine RGD PMID:16336586 PMID:16141456 PMID:21441310 PMID:12969138 RGD:1580208, RGD:1580311, RGD:5135032, RGD:1580296 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip1 TNF alpha induced protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20665664 NCBI chr10:63,417,774...63,432,466
Ensembl chr10:63,417,775...63,432,466 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B disease_progression
treatment		 ISO associated with Diabetes Mellitus, Type 1
associated with Diabetes Mellitus, Type 2		 RGD PMID:18719882 PMID:20727867 RGD:7205493, RGD:7205514 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Type 1;protein:increased expression:serum		 RGD PMID:22042131 PMID:19073786 RGD:7245547, RGD:2311357 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B onset ISO associated with Diabetes Mellitus, Type 1
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum
associated with Diabetes Mellitus, Type 1;protein:increased expression:serum		 RGD PMID:22266664 PMID:16408124 PMID:19073786 RGD:7245476, RGD:7245529, RGD:2311357 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tnfsf10 TNF superfamily member 10 ISO protein:increased expression:kidney RGD PMID:18287563 RGD:2312739 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 IEP associated with Diabetes Mellitus, Experimental RGD PMID:17901943 RGD:2290561 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 treatment ISO
IEP		 protein:increased expression:kidney interstitium RGD PMID:30478987 PMID:30478987 PMID:29331667 RGD:127229931, RGD:127229931, RGD:127284861 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203 		JBrowse link
G Trip10 thyroid hormone receptor interactor 10 treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:26097534 RGD:11535148 NCBI chr 9:2,133,085...2,147,795
Ensembl chr 9:2,133,671...2,147,799 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 IEP mRNA:decreased expression:kidney, liver RGD PMID:18184923 RGD:2301838 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 treatment
induces		 IDA
IAGP		 associated with Diabetes Mellitus, Experimental RGD PMID:22673147 PMID:29923767 RGD:7247584, RGD:149735534 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Trpc6em1Mcwi transient receptor potential cation channel, subfamily C, member 6; CRISPR/Cas9 induced mutant 1, Medical College of Wisconsin induces IAGP RGD PMID:29923767 RGD:149735534
G Txnip thioredoxin interacting protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:17582205 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:urine (human) RGD PMID:17634209 RGD:2311211 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807 		JBrowse link
G Ucp1 uncoupling protein 1 no_association ISO DNA:SNP: :-3826A>G (human) RGD PMID:15120704 RGD:7247625 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Ucp2 uncoupling protein 2 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:22848482 RGD:7175295 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Uts2 urotensin 2 disease_progression ISO
IEP		 mRNA:increased expression:kidney
associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney
associated with Diabetes Mellitus, Type 2;protein:increased expression:urine		 RGD PMID:15492948 PMID:18796544 PMID:15476950 RGD:2306805, RGD:2306786, RGD:2306806 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237 		JBrowse link
G Uts2r urotensin 2 receptor ISO
IEP		 mRNA:increased expression:kidney
associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney 		RGD PMID:15492948 PMID:18796544 RGD:2306805, RGD:2306786 NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 IEP
ISO		 protein:increased expression:kidney
associated with Diabetes Mellitus,Type 1;protein:increased expression:plasma:		 RGD PMID:23303408 PMID:20138682 RGD:7240523, RGD:7241237 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19634143 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19634143 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18630688 PMID:15610240 RGD:2313731 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vtn vitronectin IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:glomerulus RGD PMID:11728964 RGD:10003096 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810 		JBrowse link
G Xdh xanthine dehydrogenase treatment IDA
ISO		 associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2		 RGD PMID:22302365 PMID:19458127 RGD:7247644, RGD:7247651 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
G Xylt1 xylosyltransferase 1 ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:missense mutation:cds:p.A115S (human) RGD PMID:17003309 RGD:2313138 NCBI chr 1:171,643,925...171,929,774
Ensembl chr 1:171,643,925...171,926,783 		JBrowse link
G Yy1 YY1 transcription factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:35445903 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21112
    disease of anatomical entity 18151
      Urogenital Diseases 5117
        urinary system disease 2750
          kidney disease 2522
            Diabetic Nephropathies 291
Path 2
Term Annotations click to browse term
  disease 21112
    Developmental Disease 18434
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 18288
        genetic disease 18231
          inherited metabolic disorder 6169
            carbohydrate metabolic disorder 3227
              glucose metabolism disease 2028
                diabetes mellitus 1618
                  Diabetes Complications 512
                    Diabetic Nephropathies 291
paths to the root