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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Spinal Cord Reperfusion Injury
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Accession:DOID:9002138 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the spinal cord, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: spinal cord ischemia-reperfusion injury


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Spinal Cord Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death treatment IDA RGD PMID:23643992 RGD:10053660 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bdnf brain-derived neurotrophic factor treatment IEP RGD PMID:24361987 RGD:10059358 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 treatment IEP RGD PMID:25374587 RGD:11561952 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 treatment IDA RGD PMID:25301568 RGD:13782374 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 treatment IEP RGD PMID:25301568 RGD:13782374 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IEP RGD PMID:17368520 PMID:29310813 RGD:155226865, RGD:155226868 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 IMP RGD PMID:27760212 RGD:12910551 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 IMP RGD PMID:27760212 RGD:12910551 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase treatment IEP RGD PMID:30195603 RGD:13792615 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 treatment IEP protein:increased expression:spinal cord: RGD PMID:24463125 RGD:11354961 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:10903607 RGD:11100044 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 treatment IEP RGD PMID:30195603 RGD:13792615 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808 		JBrowse link
G Tlr4 toll-like receptor 4 IMP RGD PMID:27760212 RGD:12910551 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    Nutritional and Metabolic Diseases 8237
      disease of metabolism 8237
        acquired metabolic disease 2535
          Reperfusion Injury 816
            Spinal Cord Reperfusion Injury 13
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      nervous system disease 14059
        central nervous system disease 12398
          spinal cord disease 1917
            Spinal Cord Vascular Diseases 16
              Spinal Cord Ischemia 16
                Spinal Cord Reperfusion Injury 13
paths to the root