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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Tick-Borne Diseases
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Accession:DOID:9002098 term browser browse the term
Definition:Bacterial, viral, or parasitic diseases transmitted to humans and animals by the bite of infected ticks. The families Ixodidae and Argasidae contain many bloodsucking species that are important pests of man and domestic birds and mammals and probably exceed all other arthropods in the number and variety of disease agents they transmit. Many of the tick-borne diseases are zoonotic.
Synonyms:exact_synonym: Tick Borne Infections;   Tick-Borne Disease;   Tick-Borne Infection
 primary_id: MESH:D017282


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Tick-Borne Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAPGEF3 Rap guanine nucleotide exchange factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24218580 NCBI chr12:40,974,756...40,999,471
Ensembl chr12:41,848,785...41,873,252 		JBrowse link
babesiosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO protein:decreased expression:serum (human) RGD PMID:25539588 RGD:11541121 NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067 		JBrowse link
boutonneuse fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 ISO protein:increased expression:serum RGD PMID:3361150 RGD:11041575 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CFB complement factor B ISO protein:increased expression:serum RGD PMID:3361150 RGD:11041575 NCBI chr 6:31,606,716...31,612,782 JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:14507644 RGD:5135450 NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO RGD PMID:14507644 RGD:5135450 NCBI chr 4:48,198,478...48,204,658
Ensembl chr 4:54,036,342...54,042,502 		JBrowse link
Lyme disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL20 C-C motif chemokine ligand 20 ISO protein:increased expression:synovial fluid RGD PMID:23371320 RGD:7488895 NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 severity ISO RGD PMID:12847259 RGD:7257681 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:21387014 RGD:5508754 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO mRNA:increased expression:skin RGD PMID:19461880 RGD:6483813 NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561 		JBrowse link
Lyme Neuroborreliosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:serum (human) RGD PMID:16358960 RGD:11528571 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CD40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 treatment ISO RGD PMID:24239846 RGD:39939054 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G IL1B interleukin 1 beta ISO RGD PMID:23134838 RGD:7193053 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
tick-borne encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr20:42,455,711...42,467,139
Ensembl chr20:43,541,619...43,552,994 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17996
    disease by infectious agent 2104
      parasitic infectious disease 295
        parasitic protozoa infectious disease 148
          Tick-Borne Diseases 15
            African Swine Fever 0
            Anaplasmosis 0
            Colorado tick fever 0
            Crimean-Congo hemorrhagic fever 0
            Kyasanur forest disease + 0
            Lyme disease + 9
            Nairobi Sheep Disease 0
            Omsk hemorrhagic fever 0
            babesiosis 1
            ehrlichiosis + 0
            relapsing fever + 0
            spotted fever + 4
            theileriasis 0
            tick-borne encephalitis + 2
Path 2
Term Annotations click to browse term
  disease 17996
    disease by infectious agent 2104
      Bacterial Infections and Mycoses 1011
        bacterial infectious disease 802
          Gram-Negative Bacterial Infections 188
            Tick-Borne Diseases 15
              African Swine Fever 0
              Anaplasmosis 0
              Colorado tick fever 0
              Crimean-Congo hemorrhagic fever 0
              Kyasanur forest disease + 0
              Lyme disease + 9
              Nairobi Sheep Disease 0
              Omsk hemorrhagic fever 0
              babesiosis 1
              ehrlichiosis + 0
              relapsing fever + 0
              spotted fever + 4
              theileriasis 0
              tick-borne encephalitis + 2
paths to the root