RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Arterial Injury
Accession: DOID:9002056
browse the term
Definition: Damage to an artery caused by blunt force, penetrating trauma, or iatrogenic manipulation.
Synonyms: exact_synonym: arterial injuries; artery injuries; artery injury
primary_id: RDO:9000059
For additional species annotation, visit the
Alliance of Genome Resources .
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Ccr5
C-C motif chemokine receptor 5
IEP
RGD
PMID:22292067
RGD:8552233
NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
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Map3k5
mitogen-activated protein kinase kinase kinase 5
ISO
RGD
PMID:14638553
RGD:10412321
NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
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Mmp9
matrix metallopeptidase 9
treatment
IDA
RGD
PMID:22552115
RGD:6484736
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Pdcd4
programmed cell death 4
IEP
RGD
PMID:20357187
RGD:9589087
NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
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Rapgef3
Rap guanine nucleotide exchange factor 3
IEP
mRNA:increased expression:femoral artery (rat)
RGD
PMID:18689492
RGD:9835375
NCBI chr 7:139,232,263...139,254,668
Ensembl chr 7:139,232,251...139,254,551
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Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
IEP
RGD
PMID:9188065
RGD:10448925
NCBI chr 1:1,734,863...1,767,759
Ensembl chr 1:1,736,276...1,767,618
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Vwf
von Willebrand factor
IEP
protein:increased expression:endothelial cell:
RGD
PMID:2650559
RGD:11079230
NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
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Ldlr
low density lipoprotein receptor
ISO
ClinVar Annotator: match by term: Carotid artery dissection
ClinVar
PMID:1301956 PMID:2088165 PMID:2318961 PMID:3263645 PMID:8882879 PMID:9157944 PMID:9484998 PMID:10782930 PMID:10978268 PMID:12837857 PMID:16183066 PMID:16250003 PMID:17094996 PMID:17765246 PMID:18677035 PMID:19318025 PMID:20506408 PMID:21310417 PMID:21475731 PMID:21722902 PMID:22390909 PMID:22698793 PMID:23375686 PMID:24033266 PMID:25741868 PMID:27765764 PMID:28492532 PMID:31345425
NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
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Mylk
myosin light chain kinase
ISO
ClinVar Annotator: match by term: Carotid artery dissection
ClinVar
PMID:25326637 PMID:25741868 PMID:28492532
NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158
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Ldlr
low density lipoprotein receptor
ISO
ClinVar Annotator: match by term: Internal carotid artery dissection
ClinVar
PMID:1301956 PMID:2088165 PMID:2318961 PMID:3263645 PMID:8882879 PMID:9157944 PMID:9484998 PMID:10782930 PMID:10978268 PMID:12837857 PMID:16183066 PMID:16250003 PMID:17094996 PMID:17765246 PMID:18677035 PMID:19318025 PMID:20506408 PMID:21310417 PMID:21475731 PMID:21722902 PMID:22390909 PMID:22698793 PMID:23375686 PMID:24033266 PMID:25741868 PMID:27765764 PMID:28492532 PMID:31345425
NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
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Mylk
myosin light chain kinase
ISO
ClinVar Annotator: match by term: Internal carotid artery dissection
ClinVar
PMID:25326637 PMID:25741868 PMID:28492532
NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158
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Ager
advanced glycosylation end product-specific receptor
IMP
RGD
PMID:21680901
RGD:7245963
NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
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Agtr1a
angiotensin II receptor, type 1a
treatment
IEP
mRNA:increased expression:artery:
RGD
PMID:9918604
RGD:10047106
NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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Alox12
arachidonate 12-lipoxygenase, 12S type
IEP
RGD
PMID:16118253
RGD:5509614
NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
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Cbl
Cbl proto-oncogene
IEP
protein:hyperphosphorylation:tyrosine:
RGD
PMID:18663086
RGD:11038825
NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
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Ccl2
C-C motif chemokine ligand 2
treatment
ISO IDA
human gene in rat model
RGD
PMID:12223446 , PMID:15353495
RGD:8549774 , RGD:11526152
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccn2
cellular communication network factor 2
IEP
protein:increased expression:arterial wall (rat)
RGD
PMID:19570811
RGD:2314490
NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
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Ccna2
cyclin A2
IEP
mRNA:increased expression:artery:
RGD
PMID:18667424
RGD:10054494
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
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Cflar
CASP8 and FADD-like apoptosis regulator
disease_progression
IEP
RGD
PMID:10623660
RGD:11341688
NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
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Csf3
colony stimulating factor 3
IEP
protein:increased expression:smooth muscle cell:
RGD
PMID:15385271
RGD:11039423
NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
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Dusp1
dual specificity phosphatase 1
IEP
RGD
PMID:9546380
RGD:7771579
NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
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Foxo3
forkhead box O3
IEP
RGD
PMID:15662024
RGD:10402197
NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
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Gc
GC, vitamin D binding protein
IEP
protein:decreased expression:plasma
RGD
PMID:21416056
RGD:5509868
NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581
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Hdac4
histone deacetylase 4
IEP
protein:increased expression:carotid artery:
RGD
PMID:19389706
RGD:9681448
NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
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Hey1
hes-related family bHLH transcription factor with YRPW motif 1
IEP
RGD
PMID:11971902
RGD:625426
NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
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Hey2
hes-related family bHLH transcription factor with YRPW motif 2
IEP
RGD
PMID:11971902
RGD:625426
NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
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Heyl
hes-related family bHLH transcription factor with YRPW motif-like
IEP
RGD
PMID:11971902
RGD:625426
NCBI chr 5:140,923,914...140,940,905
Ensembl chr 5:140,923,914...140,940,905
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Hp
haptoglobin
IEP
RGD
PMID:19012726
RGD:11041814
NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
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Icam1
intercellular adhesion molecule 1
IEP
mRNA:increased expression:carotid artery (rat)
RGD
PMID:20368503
RGD:4145429
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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Igf1
insulin-like growth factor 1
ISO
protein:increased expression:serum,carotid artery:
RGD
PMID:12490968
RGD:10046051
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
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Igf1r
insulin-like growth factor 1 receptor
treatment
IEP
protein:increased phosphorylation:carotid artery:
RGD
PMID:17606126
RGD:10046006
NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
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Il18
interleukin 18
IMP IEP
protein:increased expression:carotid artery
RGD
PMID:16864728 , PMID:19955748
RGD:4889500 , RGD:4889159
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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Il1rn
interleukin 1 receptor antagonist
ISO
human gene in rat model
RGD
PMID:12754378
RGD:2316108
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
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Itgb3
integrin subunit beta 3
IEP
protein:increased expression:carotid artery
RGD
PMID:17868879
RGD:4892652
NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
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Jag1
jagged canonical Notch ligand 1
IEP
protein:increased expression:carotid artery
RGD
PMID:21330605
RGD:6482230
NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
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Map3k5
mitogen-activated protein kinase kinase kinase 5
IEP
protein:increased activity:carotid artery:
RGD
PMID:14638553
RGD:10412321
NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
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Mir223
microRNA 223
IEP
RNA:increased expression:carotid artery
RGD
PMID:26065992
RGD:25824846
NCBI chr X:65,367,812...65,367,921
Ensembl chr X:65,367,812...65,367,921
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Mmp2
matrix metallopeptidase 2
IEP
RGD
PMID:9327785
RGD:8547910
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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Mmp3
matrix metallopeptidase 3
IEP
RGD
PMID:9327785
RGD:8547910
NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
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Mmp9
matrix metallopeptidase 9
IEP
RGD
PMID:9327785
RGD:8547910
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Myc
MYC proto-oncogene, bHLH transcription factor
treatment
IDA IMP IEP
mRNA:increased expression:carotid artery (rat)
RGD
PMID:23178522 , PMID:8113414 , PMID:22546228
RGD:7207861 , RGD:10059612 , RGD:7240535
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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Myh9
myosin, heavy chain 9
IEP
protein:increased expression:carotid artery:
RGD
PMID:11003588
RGD:11533926
NCBI chr 7:118,740,005...118,792,507
Ensembl chr 7:118,741,110...118,792,625
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Nos3
nitric oxide synthase 3
treatment
IEP
RGD
PMID:29207649
RGD:13504723
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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Notch1
notch receptor 1
IEP
RGD
PMID:11971902
RGD:625426
NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
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Notch2
notch receptor 2
IEP
RGD
PMID:11971902
RGD:625426
NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215
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Notch3
notch receptor 3
IEP
RGD
PMID:11971902
RGD:625426
NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
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Parp1
poly (ADP-ribose) polymerase 1
IEP
protein:increased expression:blood vessel:
RGD
PMID:15044192
RGD:10413907
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pcsk5
proprotein convertase subtilisin/kexin type 5
IEP
mRNA,protein:increased expression:artery:
RGD
PMID:12649739
RGD:11556213
NCBI chr 1:236,031,988...236,313,858
Ensembl chr 1:236,031,988...236,313,858
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Pdgfd
platelet derived growth factor D
IEP
protein:increased expression:carotid artery:
RGD
PMID:18258854
RGD:9854624
NCBI chr 8:4,441,010...4,666,754
Ensembl chr 8:4,440,876...4,669,014
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Plat
plasminogen activator, tissue type
IEP
mRNA, protein:increased expression, increased activity:carotid artery (rat)
RGD
PMID:8343497
RGD:11537479
NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
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Postn
periostin
IEP
mRNA,protein:increased expression:artery:
RGD
PMID:15514205
RGD:10040973
NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
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Pparg
peroxisome proliferator-activated receptor gamma
treatment
ISO
mouse gene in a rat model
RGD
PMID:19339015
RGD:8553019
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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Ppargc1a
PPARG coactivator 1 alpha
treatment
IDA ISO
mouse gene in a rat model
RGD
PMID:22892143 , PMID:19553562
RGD:7242065 , RGD:2311405
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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Ptpn11
protein tyrosine phosphatase, non-receptor type 11
IEP
protein:increased expression:aorta tunica intima, aorta tunica media
RGD
PMID:12117720
RGD:39456082
NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
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Rangap1
RAN GTPase activating protein 1
IEP
protein:increased expression:carotid artery, intima (rat)
RGD
PMID:24988324
RGD:9835414
NCBI chr 7:122,939,266...122,967,178
Ensembl chr 7:122,940,376...122,967,178
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Scgb1a1
secretoglobin family 1A member 1
IDA
RGD
PMID:11107082
RGD:5144055
NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
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Serpine1
serpin family E member 1
IEP
mRNA:increased expression:carotid artery (rat)
RGD
PMID:25617690
RGD:11075082
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Serpinf1
serpin family F member 1
treatment
ISO
human gene in a rat model
RGD
PMID:17525281
RGD:8618841
NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
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Sp1
Sp1 transcription factor
IEP
protein:increased phosphorylation:smooth muscle cell:
RGD
PMID:18258854
RGD:9854624
NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
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Tfpi2
tissue factor pathway inhibitor 2
IEP
mRNA,protein:increased expression:carotid artery:
RGD
PMID:20537494
RGD:11060271
NCBI chr 4:28,947,951...28,953,261
Ensembl chr 4:28,947,965...28,953,067
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