Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hemorrhagic Shock
go back to main search page
Accession:DOID:9001708 term browser browse the term
Definition:Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
Synonyms:primary_id: MESH:D012771


show annotations for term's descendants           Sort by:
Hemorrhagic Shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin treatment ISO RGD PMID:15973109 PMID:18403050 RGD:7364987 RGD:7364990 NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866 		JBrowse link
G ANGPT1 angiopoietin 1 ISO RGD PMID:18344375 RGD:2316067 NCBI chr 4:29,925,203...30,233,434
Ensembl chr 4:29,933,135...30,233,960 		JBrowse link
G ARG2 arginase 2 ISO protein:increased expression:aorta (rat) RGD PMID:20699748 RGD:4143274 NCBI chr 7:91,343,987...91,385,911
Ensembl chr 7:91,343,988...91,385,909 		JBrowse link
G BAD BCL2 associated agonist of cell death ISO protein:decreased serine phosphorylation:lung RGD PMID:15345971 RGD:2292699 NCBI chr 2:7,831,192...7,842,864
Ensembl chr 2:7,830,920...7,842,863 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO mRNA:increased expression:intestine RGD PMID:17693937 RGD:2293072 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G BCL2L1 BCL2 like 1 ISO protein:increased expression:liver, mitochondrion RGD PMID:17224795 RGD:1643525 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G CASP3 caspase 3 ISO associated with Brain Injuries, Traumatic RGD PMID:29061477 RGD:13782298 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CASP8 caspase 8 ISO associated with Brain Injuries, Traumatic RGD PMID:29061477 RGD:13782298 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468 		JBrowse link
G CFH complement factor H treatment ISO RGD PMID:15973109 PMID:18403050 PMID:18496585 RGD:11041173 RGD:7364987 RGD:7364990
G CNR1 cannabinoid receptor 1 ISO mRNA, protein:increased expression:aorta, mesenteric artery RGD PMID:19493421 RGD:2314664 NCBI chr 1:56,466,022...56,493,275
Ensembl chr 1:56,467,835...56,492,602 		JBrowse link
G CUL5 cullin 5 ISO mRNA:altered expression:brain RGD PMID:12635525 RGD:2301433 NCBI chr 9:36,419,806...36,507,681
Ensembl chr 9:36,419,881...36,507,667 		JBrowse link
G CXCL2 chemokine (C-X-C motif) ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21192278 NCBI chr 8:70,157,253...70,159,145
Ensembl chr 8:70,157,214...70,159,138 		JBrowse link
G EPO erythropoietin treatment ISO RGD PMID:20539178 RGD:10401059 NCBI chr 3:8,620,508...8,622,936
Ensembl chr 3:8,620,508...8,622,936 		JBrowse link
G ESR1 estrogen receptor 1 severity ISO RGD PMID:20195535 RGD:4892252 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:16859701 RGD:8694176 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565 		JBrowse link
G F2 coagulation factor II, thrombin ISO protein:decreased activity:blood (rat) RGD PMID:21550061 RGD:5132267 NCBI chr 2:15,793,257...15,819,151
Ensembl chr 2:15,791,455...15,819,137 		JBrowse link
G F8 coagulation factor VIII ISO protein:decreased expression:plasma RGD PMID:15748447 RGD:10450768 NCBI chr  X:125,265,330...125,350,853
Ensembl chr  X:125,229,450...125,350,853 		JBrowse link
G GFER growth factor, augmenter of liver regeneration ISO RGD PMID:23073658 RGD:9685733 NCBI chr 3:39,981,938...39,984,451
Ensembl chr 3:39,981,940...39,984,991 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO RGD PMID:19077877 RGD:7207423 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GJA5 gap junction protein alpha 5 ISO RGD PMID:19077877 RGD:7207423 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
G GLUL glutamate-ammonia ligase treatment ISO RGD PMID:12766648 RGD:401794596 NCBI chr 9:123,751,551...123,762,575
Ensembl chr 9:123,751,548...123,762,547 		JBrowse link
G GPT glutamic--pyruvic transaminase treatment ISO RGD PMID:16141011 RGD:401717565 NCBI chr 4:297,747...302,498
Ensembl chr 4:297,748...320,056 		JBrowse link
G HMOX1 heme oxygenase 1 severity ISO RGD PMID:20514418 PMID:20819606 RGD:10755719 RGD:10755727
G HP haptoglobin ISO RGD PMID:20016403 RGD:5147418 NCBI chr 6:14,980,382...14,985,245 JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:lung (mouse)		 CTD
RGD		 PMID:19828841 PMID:21192278 RGD:4145497 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G IFNG interferon gamma ISO protein:increased expression:plasma RGD PMID:19439114 RGD:2311495 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL10 interleukin 10 ISO protein:increased expression:serum, lymph RGD PMID:19160132 RGD:2311060 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL18 interleukin 18 ISO protein:increased expression:plasma RGD PMID:23589298 RGD:14695541 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL1A interleukin 1 alpha ISO mRNA:increased expression:lung RGD PMID:15580020 RGD:2311100 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119 		JBrowse link
G IL4 interleukin 4 treatment ISO RGD PMID:24986445 RGD:10402801 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma		 CTD
RGD		 PMID:21168948 PMID:21192278 RGD:5128673 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G LOC110258578 interleukin-1 beta-like severity ISO mRNA:increased expression:lung
protein:increased expression:kidney, serum (rat)		 RGD PMID:15580020 PMID:17545943 PMID:21336199 RGD:1626655 RGD:2311100 RGD:7175325
G MAPK1 mitogen-activated protein kinase 1 ISO protein: increased expression: lung and liver RGD PMID:22392145 RGD:7244173 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO RGD PMID:16141011 RGD:401717565 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788 		JBrowse link
G MPO myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21192278 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G MTOR mechanistic target of rapamycin kinase treatment ISO RGD PMID:24204984 RGD:10041042 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor treatment ISO RGD PMID:22113495 RGD:7240568 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078 		JBrowse link
G NFKBIA NFKB inhibitor alpha treatment ISO RGD PMID:11557243 RGD:127285020 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO mRNA, protein:increased expression:multiple RGD PMID:15854664 RGD:1580937 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO mRNA:increased expression: :multiple RGD PMID:15854664 PMID:29122552 RGD:13450929 RGD:1580937 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G OTC ornithine transcarbamylase ISO protein:increased activity:serum (rat) RGD PMID:17224795 RGD:1643525 NCBI chr  X:34,322,398...34,391,711
Ensembl chr  X:34,322,298...34,391,821 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO protein:increased phosphorylation:nucleus, liver
protein:increased phosphorylation, altered location:nucleus, endothelial cell, lung		 RGD PMID:17950078 PMID:17950083 PMID:18469645 RGD:2298781 RGD:2298841 RGD:2298842 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G SIRT1 sirtuin 1 treatment ISO protein:decreased expression:heart left ventricle RGD PMID:21554952 PMID:22113495 RGD:7240568 RGD:9585770 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297 		JBrowse link
G SLC9A1 solute carrier family 9 member A1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17724433 PMID:19384202 RGD:6771334 NCBI chr 6:84,373,921...84,426,447
Ensembl chr 6:84,372,649...84,426,997 		JBrowse link
G SOD2 superoxide dismutase 2 treatment ISO RGD PMID:26073907 RGD:26923954 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G TFAM transcription factor A, mitochondrial ISO RGD PMID:22469910 RGD:6767567 NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,731 		JBrowse link
G TGFB1 transforming growth factor beta 1 treatment ISO RGD PMID:16141011 RGD:401717565 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 treatment ISO RGD PMID:16141011 RGD:401717565 NCBI chr  X:42,103,251...42,106,289
Ensembl chr  X:42,102,172...42,106,296 		JBrowse link
G TLR4 toll like receptor 4 severity ISO RGD PMID:25049041 RGD:14697700 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TNF tumor necrosis factor treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:21192278 PMID:24315526 RGD:10450602 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 ameliorates ISO RGD PMID:19333144 RGD:127284838 NCBI chr 7:36,510,253...36,531,796
Ensembl chr 7:36,510,253...36,531,796 		JBrowse link
G VWF von Willebrand factor ISO protein:decreased expression:plasma RGD PMID:15748447 RGD:10450768 NCBI chr 5:64,516,627...64,655,938
Ensembl chr 5:64,519,186...65,002,452 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17412
    Pathological Conditions, Signs and Symptoms 11799
      Pathologic Processes 7349
        Hemorrhage 276
          Hemorrhagic Shock 52
            Hemorrhagic Shock and Encephalopathy Syndrome 0
paths to the root