RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
This is adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to one or more limbs, including swelling; hemorrhage; necrosis; and damage from free radicals. A limb is a paired appendage that is evolved from a paired fin.