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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Pregnancy-Induced Hypertension
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Accession:DOID:9001650 term browser browse the term
Definition:A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.
Synonyms:exact_synonym: PIH;   Pregnancy Transient Hypertension;   gestational hypertension
 related_synonym: pregnancy-induced hypertension, susceptibility to
 xref: MESH:D046110;   MONDO:0024664


show annotations for term's descendants           Sort by:
Pregnancy-Induced Hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IEP RGD PMID:17977916 RGD:8548898 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ace2 angiotensin converting enzyme 2 IEP RGD PMID:17977916 RGD:8548898 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Agt angiotensinogen IEP RGD PMID:17977916 RGD:8548898 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Edn1 endothelin 1 no_association ISO DNA:transversion:exon:p.K198N rs5370 (human) RGD PMID:19730395 PMID:11593097 RGD:4145063, RGD:4145070 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:increased expression:plasma RGD PMID:8244188 RGD:401827853 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:21383306 RGD:10755723 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hp haptoglobin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16597321 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Hypertension, pregnancy-induced, susceptibility to 		CTD
ClinVar		 PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More... NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Rbp4 retinol binding protein 4 ISO protein:increased expression, decreased expression:blood serum, umbilical cord blood (human) RGD PMID:19708176 RGD:329849109 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:245,306,349...245,313,898 		JBrowse link
G Tfpi tissue factor pathway inhibitor IEP mRNA:decreased expression:aorta: RGD PMID:26104991 RGD:11062065 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742 		JBrowse link
G Tnf tumor necrosis factor treatment IMP RGD PMID:18981324 RGD:13825265 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
eclampsia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 treatment IDA RGD PMID:27106269 RGD:11062145 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
HELLP syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 ISO protein:decreased activity:plasma (human) RGD PMID:12969811 RGD:10449045 NCBI chr 3:30,697,354...30,736,539
Ensembl chr 3:30,697,942...30,736,540 		JBrowse link
G Ahsp alpha hemoglobin stabilizing protein ISO mRNA:decreased expression:placenta (human) RGD PMID:18347943 RGD:329956422 NCBI chr 1:192,310,306...192,315,943
Ensembl chr 1:192,310,244...192,315,942 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:blood platelet (human) RGD PMID:23241952 RGD:11522719 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:9158311 RGD:1580990 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Fas Fas cell surface death receptor susceptibility ISO
IEP 		DNA:SNP:promoter:-670A>G(rs1800682)(human)
protein,mRNA:altered expression:placenta, liver: 		RGD PMID:30066360 PMID:28501275 RGD:14700669, RGD:14700673 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand susceptibility ISO
IEP 		DNA:SNP:intron:124A>G(rs5030772)(human)
protein:altered expression:blood, placenta, liver: 		RGD PMID:30066360 PMID:28501275 RGD:14700669, RGD:14700673 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
mild pre-eclampsia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpx3 glutathione peroxidase 3 ISO protein:increased expression:plasma RGD PMID:8476834 RGD:401827852 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
pre-eclampsia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme onset ISO CTD Direct Evidence: marker/mechanism
DNA:insertion/deletion:intron 16: 		CTD
RGD		 PMID:17114810 PMID:20044877 RGD:40400703 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Acvr2b activin A receptor type 2B ISO protein:increased expression:placenta (human) RGD PMID:27176145 RGD:329853749 NCBI chr 8:128,016,589...128,056,193
Ensembl chr 8:128,016,526...128,048,171 		JBrowse link
G Add1 adducin 1 ISO mRNA:increased expression:blood RGD PMID:19731222 RGD:5147993 NCBI chr14:80,333,242...80,401,641
Ensembl chr14:80,333,244...80,391,732 		JBrowse link
G Agt angiotensinogen ISO DNA:polymorphism: :p.M235T (human)
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:8513325 PMID:8513325 PMID:20530295 RGD:1300394, RGD:13432363 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 treatment ISO
IEP 		mRNA:decreased expression:blood: RGD PMID:19681734 PMID:25876805 RGD:10053633, RGD:11541124 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438 		JBrowse link
G Alb albumin severity ISO RGD PMID:21923989 RGD:11035264 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Alkbh5 alkB homolog 5, RNA demethylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:34995009 NCBI chr10:45,844,411...45,865,853
Ensembl chr10:45,843,656...45,869,658 		JBrowse link
G Anxa5 annexin A5 ISO CTD Direct Evidence: therapeutic CTD PMID:19837457 NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400 		JBrowse link
G Apela apelin receptor early endogenous ligand ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr16:29,460,855...29,469,962
Ensembl chr16:29,460,812...29,469,955 		JBrowse link
G Arhgap45 Rho GTPase activating protein 45 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26095815 NCBI chr 7:10,325,515...10,340,955
Ensembl chr 7:10,325,539...10,341,890 		JBrowse link
G Arid1a AT-rich interaction domain 1A disease_progression ISO associated with Fetal Growth Retardation; protein:increased expression:placenta, nucleus (human) RGD PMID:32529396 RGD:243065143 NCBI chr 5:151,192,014...151,269,291
Ensembl chr 5:151,192,014...151,265,386 		JBrowse link
G Asb4 ankyrin repeat and SOCS box-containing 4 ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 4:34,473,527...34,511,163
Ensembl chr 4:34,473,408...34,512,888 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr 7:35,622,267...35,731,904
Ensembl chr 7:35,622,461...35,731,904 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr 4:148,450,207...148,763,653
Ensembl chr 4:148,450,207...148,696,239 		JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr  X:156,367,582...156,464,085
Ensembl chr  X:156,367,852...156,438,153 		JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr13:47,708,157...47,807,389
Ensembl chr13:47,711,121...47,758,876 		JBrowse link
G C3 complement C3 treatment IDA RGD PMID:23685261 RGD:7411624 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G Calb1 calbindin 1 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:34,172,664...34,200,160 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP protein:increased secretion:serum (rat) RGD PMID:19617880 RGD:2317272 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccn3 cellular communication network factor 3 ISO protein:decreased expression:placenta (human) RGD PMID:16675545 RGD:1580971 NCBI chr 7:87,983,788...87,990,810
Ensembl chr 7:87,982,216...87,994,581 		JBrowse link
G Cd274 CD274 molecule treatment IEP RGD PMID:27277012 RGD:40886269 NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951 		JBrowse link
G Cd40 CD40 molecule ISO protein:increased expression:blood, monocyte (human) RGD PMID:19221099 RGD:11520792 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847 		JBrowse link
G Cd40lg CD40 ligand treatment IMP
ISO 		protein:increased expression:blood platelet (human) RGD PMID:26310940 PMID:23241952 RGD:11056772, RGD:11522719 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:140,164,302...140,176,475 		JBrowse link
G Cd46 CD46 molecule susceptibility
no_association 		ISO DNA:missense mutation:cds:p.A304V (human) RGD PMID:21445332 PMID:25710174 RGD:6483459, RGD:11352807 NCBI chr13:109,104,122...109,134,903 JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:208,084,787...208,087,498 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:34398343 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Chi3l1 chitinase 3 like 1 ISO protein:increased secretion:umbilical cord, serum (human) RGD PMID:18054022 RGD:4892664 NCBI chr13:48,193,839...48,201,822
Ensembl chr13:48,193,800...48,201,825 		JBrowse link
G Clu clusterin ISO DNA:SNP:exon:866C>T (human) RGD PMID:15925890 RGD:1581195 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Cmklr1 chemerin chemokine-like receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34398343 NCBI chr12:48,634,929...48,687,833
Ensembl chr12:48,634,003...48,691,458 		JBrowse link
G Comt catechol-O-methyltransferase ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533 		JBrowse link
G Corin corin, serine peptidase ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr14:36,034,613...36,264,671
Ensembl chr14:36,034,993...36,264,649 		JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18679377 NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087 		JBrowse link
G Crebbp CREB binding protein ISO mRNA:decreased expression:placenta (human) RGD PMID:33625689 RGD:153350159 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266 		JBrowse link
G Cst3 cystatin C ISO protein:increased expression:plasma (human) RGD PMID:18197549 RGD:2314350 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937 		JBrowse link
G Cubn cubilin ISO associated with late term delivery; mRNA:decreased expression:placenta (human) RGD PMID:32682061 RGD:401901078 NCBI chr17:81,293,619...81,501,694
Ensembl chr17:81,293,619...81,501,694 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 ISO DNA:missense mutation:cds:p.V386A (human) RGD PMID:15569322 RGD:1576428 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 ISO DNA:missense mutation:cds:p.V386A (human) RGD PMID:15569322 RGD:1576428 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 ISO associated with hypoxia; protein:increased expression:placenta (human)
mRNA:increased expression:placenta (human) 		RGD PMID:22871339 PMID:36477942 RGD:401901075, RGD:401901174 NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 ISO associated with hypoxia; protein:increased expression:placenta (human)
mRNA:increased expression:placenta (human) 		RGD PMID:22871339 PMID:36477942 RGD:401901075, RGD:401901174 NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:64,756,626...64,761,570 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 ISO
IMP 		mRNA:increased expression:placenta, decidua RGD PMID:23155181 PMID:23155181 RGD:7243127, RGD:7243127 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042 		JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 ISO associated with hypoxia; protein:decreased expression:placenta (human)
mRNA:decreased expression:placenta (human) 		RGD PMID:22871339 PMID:36477942 PMID:32682061 RGD:401901075, RGD:401901174, RGD:401901078 NCBI chr 1:178,166,984...178,232,191
Ensembl chr 1:178,219,704...178,232,423 		JBrowse link
G Dab2ip DAB2 interacting protein ISO mRNA, protein:decreased expression:placenta (human) RGD PMID:25604087 RGD:11553571 NCBI chr 3:39,312,745...39,483,730
Ensembl chr 3:39,312,745...39,483,730 		JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent ISO CTD Direct Evidence: marker/mechanism CTD PMID:22285683 NCBI chr20:3,766,115...3,769,161
Ensembl chr20:3,766,120...3,769,183 		JBrowse link
G Dnah8 dynein, axonemal, heavy chain 8 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr20:8,694,371...8,948,849
Ensembl chr20:8,694,398...8,948,849 		JBrowse link
G Ebag9 estrogen receptor binding site associated antigen 9 ISO protein:increased expression:decidua RGD PMID:17845206 RGD:2289846 NCBI chr 7:77,695,213...77,713,565
Ensembl chr 7:77,695,072...77,713,557 		JBrowse link
G Ebi3 Epstein-Barr virus induced 3 ameliorates IEP RGD PMID:31203154 RGD:213230155 NCBI chr 9:861,441...874,731
Ensembl chr 9:870,792...874,973 		JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25230003 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Edn2 endothelin 2 ISO RGD PMID:9015697 RGD:1580919 NCBI chr 5:139,036,576...139,042,074
Ensembl chr 5:139,036,492...139,043,070 		JBrowse link
G Eif3d eukaryotic translation initiation factor 3, subunit D ISO CTD Direct Evidence: marker/mechanism CTD PMID:34520790 NCBI chr 7:111,420,351...111,432,761
Ensembl chr 7:111,420,351...111,432,740 		JBrowse link
G Eng endoglin severity
treatment 		ISO
IEP
IDA 		protein:increased expression:serum (human)
protein:increased expression:serum (rat)
protein:increased expression:plasma (mouse) 		RGD PMID:23460287 PMID:22763474 PMID:22308016 PMID:20351341 PMID:23357179 RGD:7248767, RGD:7257530, RGD:7257524, RGD:7248777, RGD:7248768 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 ISO protein:decreased expression:abdominal fascia: RGD PMID:17469012 RGD:9685457 NCBI chr 1:249,374,810...249,502,310
Ensembl chr 1:249,374,836...249,502,317 		JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:11159352 RGD:1580974 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729 		JBrowse link
G Ephx1 epoxide hydrolase 1 ISO DNA:polymorphism
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:11283205 PMID:12173035 PMID:11283205 RGD:1601064 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:9158311 RGD:1580990 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:15894829 RGD:1581016 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G F2 coagulation factor II, thrombin severity ISO DNA:polymorphism: :20210G>A(human) RGD PMID:16246971 RGD:6893628 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246 		JBrowse link
G F2r coagulation factor II (thrombin) receptor ISO RGD PMID:12161502 RGD:1581033 NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:28,604,066...28,620,579 		JBrowse link
G F3 coagulation factor III, tissue factor ISO associated with Fetal Death;protein:increased expression:plasma RGD PMID:19736615 RGD:11340220 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G F5 coagulation factor V severity ISO DNA:mutation: :1691G>A(human) RGD PMID:16246971 RGD:6893628 NCBI chr13:79,046,657...79,116,247
Ensembl chr13:79,046,448...79,116,247 		JBrowse link
G Fabp4 fatty acid binding protein 4 ISO protein:increased expression:blood serum (human) RGD PMID:19573524 RGD:329845853 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fas Fas cell surface death receptor susceptibility ISO DNA:SNP:promoter:-670A>G (human)
DNA:SNP:promoter:-670A>G(rs1800682)(human) 		RGD PMID:15695771 PMID:30066360 RGD:12903973, RGD:14700669 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand susceptibility ISO DNA:SNP:intron:124A>G(rs5030772)(human) RGD PMID:30066360 RGD:14700669 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO mRNA,protein:increased expression:placenta
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:18679377 PMID:28628106 PMID:15472115 PMID:22262697 RGD:1582493, RGD:243048428 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase ISO mRNA:increased expression:placenta RGD PMID:31991880 RGD:329961300 NCBI chr 7:10,099,267...10,102,083
Ensembl chr 7:10,098,571...10,102,083 		JBrowse link
G Gata2 GATA binding protein 2 onset ISO RGD PMID:30659233 RGD:401850546 NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055 		JBrowse link
G Gatm glycine amidinotransferase ISO mRNA:increased expression:placenta RGD PMID:31991880 RGD:329961300 NCBI chr 3:130,112,508...130,137,664
Ensembl chr 3:130,112,509...130,129,355 		JBrowse link
G Gc GC, vitamin D binding protein ISO mRNA:decreased expression:placenta (human) RGD PMID:32682061 RGD:401901078 NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,916,246...18,951,673 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO protein:decreased expression:placenta
mRNA:decreased expression:placenta 		RGD PMID:20303587 PMID:18852388 PMID:28705740 RGD:401827170, RGD:401827849, RGD:401827825 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:decreased expression:placenta
mRNA:decreased expression:placenta 		RGD PMID:20303587 PMID:18852388 PMID:28705740 RGD:401827170, RGD:401827849, RGD:401827825 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Gpx4 glutathione peroxidase 4 ISO protein:decreased expression:placenta
mRNA:decreased expression:placenta 		RGD PMID:20303587 PMID:18852388 RGD:401827170, RGD:401827849 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Gsn gelsolin disease_progression ISO protein:decreased expression:blood plasma (human) RGD PMID:24239294 RGD:329337339 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 susceptibility ISO DNA:missense mutation:cds:p.I105V (human) RGD PMID:11826024 RGD:737707 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G H19 H19 imprinted maternally expressed transcript ameliorates IEP
ISO 		RNA:increased expression:placenta (human) RGD PMID:31203154 PMID:29522949 RGD:213230155, RGD:242905198 NCBI chr 1:207,160,175...207,162,851 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:chorionic villus (human) RGD PMID:22840297 RGD:155631283 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22197494 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hnf1a HNF1 homeobox A susceptibility ISO associated with gestational diabetes;DNA:SNP:cd: p.I27L (rs1169288) (human) RGD PMID:31825269 RGD:329901812 NCBI chr12:47,299,171...47,333,457
Ensembl chr12:47,306,245...47,332,755 		JBrowse link
G Hp haptoglobin severity ISO protein:increased expression
DNA:polymorphism 		RGD PMID:17220952 PMID:16879055 RGD:1626337, RGD:1626343 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 susceptibility ISO DNA:SNPs,haplotype: (rs2235543,rs846910) (human) RGD PMID:23659736 RGD:329901926 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP RGD PMID:21830843 RGD:8547718 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:serum (human) RGD PMID:21126355 RGD:6906962 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il6 interleukin 6 ameliorates IEP RGD PMID:31203154 RGD:213230155 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Inhba inhibin subunit beta A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17332518 NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme ISO mRNA:decreased expression:chorionic villus (human) RGD PMID:22840297 RGD:155631283 NCBI chr12:48,512,852...48,518,696
Ensembl chr12:48,512,852...48,518,696 		JBrowse link
G Itga4 integrin subunit alpha 4 IEP protein:increased expression:blood, granulocyte (rat) RGD PMID:10694336 RGD:9698441 NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039 		JBrowse link
G Itgam integrin subunit alpha M ISO DNA:missense mutations:CDS:p.M441K (rs1143680), p.T1000N (rs41321249) (human)
protein:increased expression:neutrophil (human)
associated with Fetal Growth Retardation;mRNA:decreased expression:placenta (human) 		RGD PMID:33539617 PMID:18437152 PMID:32014817 RGD:329853770, RGD:329901825, RGD:329901659 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr 4:180,759,325...181,165,361
Ensembl chr 4:180,760,442...181,164,763 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr20:5,138,553...5,204,189
Ensembl chr20:5,118,834...5,204,184 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ISO protein:decreased expression:umbilical artery,umbilical vein (human) RGD PMID:23261940 RGD:329955574 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:89,086,814...89,102,275 		JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor ISO RGD PMID:16952198 RGD:2292128 NCBI chr13:47,327,159...47,332,759
Ensembl chr13:47,327,004...47,332,906 		JBrowse link
G Lcn2 lipocalin 2 ISO protein:increased expression:serum,urine RGD PMID:23957217 RGD:126781721 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Lep leptin IEP protein:decreased expression:plasma RGD PMID:16021089 RGD:5128718 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lepr leptin receptor IEP protein:increased expression:placenta RGD PMID:16021089 RGD:5128718 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Mir126a microRNA 126a ISO RNA:decreased expression:blood RGD PMID:30659233 RGD:401850546 NCBI chr 3:29,813,150...29,813,267 JBrowse link
G Mir144 microRNA 144 ISO miRNA:decreased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr10:63,459,397...63,459,479
Ensembl chr10:63,459,397...63,459,479 		JBrowse link
G Mir148a microRNA 148a ameliorates IEP RGD PMID:31203154 RGD:213230155 NCBI chr 4:81,664,431...81,664,527 JBrowse link
G Mir152 microRNA 152 IEP miRNA:increased expression:placenta RGD PMID:31114978 RGD:21066344 NCBI chr10:82,329,383...82,329,467
Ensembl chr10:82,329,383...82,329,467 		JBrowse link
G Mir155 microRNA 155 ISO miRNA:increased expression:blood serum (human) RGD PMID:28700503 RGD:155882490 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178 		JBrowse link
G Mir15b microRNA 15b ISO miRNA:decreased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:155,555,178...155,555,275 		JBrowse link
G Mir193a microRNA 193a ISO miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr10:65,170,306...65,170,417 JBrowse link
G Mir204 microRNA 204 ISO miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr 1:229,743,461...229,743,570
Ensembl chr 1:229,743,461...229,743,570 		JBrowse link
G Mir210 microRNA 210 disease_progression
severity 		ISO miRNA:increased expression:placenta (human)
miRNA:increased expression:blood serum (human)
miRNA:increased expression:chorionic villus (human)
miRNA:increased expression:blood plasma (human) 		RGD PMID:27746364 PMID:25017274 PMID:28700503 PMID:22840297 PMID:21388517 RGD:155260325, RGD:155882496, RGD:155882490, RGD:155631283, RGD:155269044 NCBI chr 1:205,755,923...205,756,032
Ensembl chr 1:205,755,917...205,756,034 		JBrowse link
G Mir215 microRNA 215 HEP miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr13:99,382,990...99,383,086 JBrowse link
G Mir216a microRNA 216a ameliorates IEP RGD PMID:31203154 RGD:213230155 NCBI chr14:106,725,077...106,725,182
Ensembl chr14:106,725,077...106,725,182 		JBrowse link
G Mir25 microRNA 25 ISO miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr12:22,156,641...22,156,724 JBrowse link
G Mir296 microRNA 296 ISO miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr 3:183,470,069...183,470,146 JBrowse link
G Mir32 microRNA 32 ISO miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr 5:76,391,285...76,391,354 JBrowse link
G Mir423 microRNA 423 ISO miRNA:increased expression:plasma RGD PMID:30587375 RGD:158014896 NCBI chr10:62,412,272...62,412,350 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO mRNA, protein:decreased expression:placenta RGD PMID:17083831 RGD:2290399 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA, protein:decreased expression:placenta RGD PMID:17083831 PMID:23776237 RGD:2290399, RGD:13204787 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:29250138 RGD:13504712 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Notch2 notch receptor 2 ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 exacerbates ISO mRNA, protein:increased expression:placenta (human)
mRNA:altered expression:placenta, adipose tissue (human) 		RGD PMID:28352810 PMID:20655109 RGD:401842369, RGD:401850787 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532 		JBrowse link
G Nsd1 nuclear receptor binding SET domain protein 1 ISO ClinVar Annotator: match by term: Preeclampsia ClinVar PMID:12464997 PMID:12807965 PMID:15942875 PMID:17565729 PMID:18414213 More... NCBI chr17:9,317,085...9,431,528
Ensembl chr17:9,317,085...9,452,250 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO mRNA:increased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604 		JBrowse link
G Pdcd1 programmed cell death 1 treatment ISO
IEP 		protein:increased expression:Treg cell RGD PMID:27277012 PMID:27277012 RGD:40886269, RGD:40886269 NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:101,866,126...101,879,270 		JBrowse link
G Pde5a phosphodiesterase 5A IMP RGD PMID:18538317 RGD:2314465 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298 		JBrowse link
G Peg10 paternally expressed 10 onset ISO mRNA, protein:decreased expression:placenta (human)
mRNA, protein:increased expression:placenta (human) 		RGD PMID:37464405 PMID:25526181 PMID:22137777 RGD:401851069, RGD:401851074, RGD:401851073 NCBI chr 4:33,809,026...33,822,224
Ensembl chr 4:33,817,190...33,819,166
Ensembl chr 4:33,817,190...33,819,166 		JBrowse link
G Pgf placental growth factor ISO
IEP 		RGD PMID:21756887 PMID:20720407 RGD:6483577, RGD:6483779 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO protein:increased expression:plasma RGD PMID:21722073 RGD:6484119 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130 		JBrowse link
G Pml PML nuclear body scaffold ISO mRNA:decreased expression:placenta (human) RGD PMID:20228380 RGD:41404689 NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:67,523,164...67,576,083 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:34995009 PMID:15562025 RGD:1580687 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa ISO RGD PMID:9065198 RGD:11564336 NCBI chr18:24,038,596...24,049,061
Ensembl chr18:24,038,597...24,048,964 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 disease_progression ISO mRNA:decreased expression:placenta (human) RGD PMID:27746364 RGD:155260325 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481 		JBrowse link
G Rarres2 retinoic acid receptor responder 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34398343 NCBI chr 4:78,853,450...78,856,652
Ensembl chr 4:78,853,453...78,856,457 		JBrowse link
G Rbp4 retinol binding protein 4 disease_progression ISO protein:increased expression:blood serum (human)
protein:decreased expression:umbilical cord,blood serum (human) 		RGD PMID:21173508 PMID:21299359 RGD:329845578, RGD:329845866 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:245,306,349...245,313,898 		JBrowse link
G Robo1 roundabout guidance receptor 1 ISO mRNA,protein:increased expression:placenta RGD PMID:22262697 RGD:243048428 NCBI chr11:24,067,869...25,108,694
Ensembl chr11:24,067,878...25,108,694 		JBrowse link
G Robo4 roundabout guidance receptor 4 ISO mRNA,protein:increased expression:placenta RGD PMID:22262697 RGD:243048428 NCBI chr 8:45,308,739...45,322,522
Ensembl chr 8:45,308,739...45,322,531 		JBrowse link
G RT1-Bb RT1 class II, locus Bb susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*04 (human) RGD PMID:10960630 RGD:36174024 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G RT1-CE16 RT1 class I, locus CE16 susceptibility ISO DNA:SNPs::multiple
DNA:polymorphism::HLA-A24:02(human) 		RGD PMID:19727231 PMID:33126849 RGD:401827097 RGD:401827098 NCBI chr20:3,261,656...3,265,548 JBrowse link
G Ryr1 ryanodine receptor 1 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:93,420,078...93,551,305 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705 		JBrowse link
G Ryr3 ryanodine receptor 3 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr 3:119,886,129...120,433,465
Ensembl chr 3:119,885,878...120,433,677 		JBrowse link
G S100g S100 calcium binding protein G ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr  X:35,337,636...35,340,205
Ensembl chr  X:35,337,675...35,340,205 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16555725 NCBI chr 4:159,809,187...159,832,409
Ensembl chr 4:159,809,170...159,832,405 		JBrowse link
G Serpina1 serpin family A member 1 ISO RGD PMID:1852102 RGD:1643155 NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:128,619,382...128,660,703 		JBrowse link
G Serpine1 serpin family E member 1 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:blood: 		CTD
RGD		 PMID:18679377 PMID:16952198 RGD:2292128 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Serpinf2 serpin family F member 2 ISO protein:increased expression:urine RGD PMID:1334334 RGD:1625535 NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,770,698...60,778,996 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO mRNA:decreased expression:chorionic villus (human) RGD PMID:22840297 RGD:155631283 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Stox1 storkhead box 1 no_association ISO DNA:missense mutation:cds:p.Y153H (human)
human fetally expressed gene in a mouse model 		RGD PMID:15806103 PMID:23357179 PMID:17617193 RGD:11553888, RGD:7248768, RGD:11553890 NCBI chr20:31,140,993...31,209,126
Ensembl chr20:31,140,993...31,208,877 		JBrowse link
G Tfpi tissue factor pathway inhibitor ISO protein:increased expression:plasma: RGD PMID:10078579 RGD:11060132 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO mRNA, protein:increased expression:placenta RGD PMID:17083831 RGD:2290399 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tlr3 toll-like receptor 3 IEP protein:increased expression:placenta (rat) RGD PMID:19779466 RGD:5128769 NCBI chr16:53,554,916...53,572,321
Ensembl chr16:53,555,131...53,568,385 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:16157088 RGD:1580682 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor ameliorates ISO
IEP 		RGD PMID:15901845 PMID:31203154 RGD:1580314, RGD:213230155 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO human protein in rat model RGD PMID:21505354 RGD:5131211 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411 		JBrowse link
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr 4:71,503,085...71,531,134
Ensembl chr 4:71,503,093...71,529,384 		JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 ISO mRNA:decreased expression:placenta (human) RGD PMID:36477942 RGD:401901174 NCBI chr 4:71,474,006...71,489,667
Ensembl chr 4:71,474,007...71,489,671 		JBrowse link
G Uts2 urotensin 2 ISO RGD PMID:15866083 RGD:1580806 NCBI chr 5:166,725,471...166,739,063
Ensembl chr 5:166,733,671...166,739,059 		JBrowse link
G Vdr vitamin D receptor ISO protein:decreased expression:placenta (human)
mRNA:decreased expression:placenta (human)
associated with Premature Birth; mRNA:increased expression:placenta (human) 		RGD PMID:22871339 PMID:36477942 PMID:32682061 RGD:401901075, RGD:401901174, RGD:401901078 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA:decreased expression:chorionic villus (human) RGD PMID:16517614 PMID:22840297 RGD:1580566, RGD:155631283 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Preeclampsia/Eclampsia 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stox1 storkhead box 1 ISO ClinVar Annotator: match by term: Preeclampsia/eclampsia 4 | ClinVar Annotator: match by term: STOX1-related condition
CTD Direct Evidence: marker/mechanism 		OMIM
ClinVar
CTD		 PMID:15806103 PMID:17325670 PMID:25741868 PMID:33116287 NCBI chr20:31,140,993...31,209,126
Ensembl chr20:31,140,993...31,208,877 		JBrowse link
Preeclampsia/Eclampsia 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Corin corin, serine peptidase ISO ClinVar Annotator: match by term: Preeclampsia/eclampsia 5 OMIM
ClinVar		 PMID:22437503 PMID:24828501 PMID:25741868 PMID:28492532 NCBI chr14:36,034,613...36,264,671
Ensembl chr14:36,034,993...36,264,649 		JBrowse link
Preeclamptic Toxemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22534418 RGD:6771230 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Ren renin ISO protein:increased activity:blood plasma (human) RGD PMID:683663 RGD:125097480 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
severe pre-eclampsia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 severity ISO mRNA:increased expression:decidua basalis (human) RGD PMID:24331737 RGD:329845529 NCBI chr 3:63,387,378...63,506,980
Ensembl chr 3:63,387,381...63,477,884 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 susceptibility ISO DNA:polymorphism::p.D148E (human) RGD PMID:24619222 RGD:401850778 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
G Col4a2 collagen type IV alpha 2 chain severity ISO mRNA:increased expression:decidua basalis (human) RGD PMID:24331737 RGD:329845529 NCBI chr16:84,749,672...84,885,520
Ensembl chr16:84,749,672...84,885,520 		JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 severity ISO mRNA:increased expression:decidua basalis (human) RGD PMID:24331737 RGD:329845529 NCBI chr 2:5,666,337...5,705,256
Ensembl chr 2:5,666,436...5,740,056 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:increased expression:plasma RGD PMID:8476834 RGD:401827852 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G H19 H19 imprinted maternally expressed transcript severity ISO DNA:promoter:exon 1:hypermethylation RGD PMID:24969494 RGD:156430323 NCBI chr 1:207,160,175...207,162,851 JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase severity ISO mRNA:increased expression:decidua basalis (human) RGD PMID:24331737 RGD:329845529 NCBI chr 1:66,931,712...67,027,610
Ensembl chr 1:66,931,712...67,027,610 		JBrowse link
G Mir155 microRNA 155 severity ISO miRNA:increased expression:blood serum (human) RGD PMID:31487655 RGD:155582220 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178 		JBrowse link
G Mir210 microRNA 210 severity ISO miRNA:increased expression:blood serum (human)
miRNA:increased expression:blood plasma (human) 		RGD PMID:31487655 PMID:33778218 RGD:155582220, RGD:155582221 NCBI chr 1:205,755,923...205,756,032
Ensembl chr 1:205,755,917...205,756,034 		JBrowse link
G Rbp4 retinol binding protein 4 severity ISO protein:decreased expression:blood serum (human)
protein:increased expression:blood serum (human) 		RGD PMID:31949674 PMID:27279411 PMID:19573524 RGD:329845847, RGD:329845859, RGD:329845853 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:245,306,349...245,313,898 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19150
    disease of anatomical entity 18459
      Urogenital Diseases 5416
        Female Urogenital Diseases and Pregnancy Complications 2689
          Pregnancy Complications 821
            Pregnancy-Induced Hypertension 163
              pre-eclampsia + 162
Path 2
Term Annotations click to browse term
  disease 19150
    disease of anatomical entity 18459
      cardiovascular system disease 5554
        vascular disease 4039
          artery disease 2866
            hypertension 1632
              Pregnancy-Induced Hypertension 163
                pre-eclampsia + 162
paths to the root