RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Pregnancy-Induced Hypertension
Accession: DOID:9001650
browse the term
Definition: A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.
Synonyms: exact_synonym: Pregnancy Transient Hypertension; gestational hypertension
related_synonym: pregnancy-induced hypertension, susceptibility to
primary_id: MESH:D046110
For additional species annotation, visit the
Alliance of Genome Resources .
G
Ace
angiotensin I converting enzyme
IEP
RGD
PMID:17977916
RGD:8548898
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ace2
angiotensin I converting enzyme 2
IEP
RGD
PMID:17977916
RGD:8548898
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Agt
angiotensinogen
IEP
RGD
PMID:17977916
RGD:8548898
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Edn1
endothelin 1
no_association
ISO
DNA:transversion:exon:p.K198N rs5370 (human)
RGD
PMID:19730395 PMID:11593097
RGD:4145063 , RGD:4145070
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Hmox1
heme oxygenase 1
treatment
IEP
RGD
PMID:21383306
RGD:10755723
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hp
haptoglobin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16597321
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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Nos3
nitric oxide synthase 3
ISO
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Hypertension, pregnancy-induced, susceptibility to
CTD ClinVar
PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 PMID:11026457 PMID:11354626 PMID:11394896 PMID:11745998 PMID:15007011 PMID:16059745 PMID:16813604 PMID:17165044 PMID:24033266 PMID:25741868 More...
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Tfpi
tissue factor pathway inhibitor
IEP
mRNA:decreased expression:aorta:
RGD
PMID:26104991
RGD:11062065
NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
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Tnf
tumor necrosis factor
treatment
IMP
RGD
PMID:18981324
RGD:13825265
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Il6
interleukin 6
treatment
IDA
RGD
PMID:27106269
RGD:11062145
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
ISO
protein:decreased activity:plasma (human)
RGD
PMID:12969811
RGD:10449045
NCBI chr 3:10,299,264...10,338,464
Ensembl chr 3:10,300,028...10,346,687
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Cd40lg
CD40 ligand
ISO
protein:increased expression:blood platelet (human)
RGD
PMID:23241952
RGD:11522719
NCBI chr X:135,127,119...135,138,302
Ensembl chr X:135,126,969...135,138,306
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Erbb2
erb-b2 receptor tyrosine kinase 2
ISO
RGD
PMID:9158311
RGD:1580990
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Fas
Fas cell surface death receptor
susceptibility
ISO IEP
DNA:SNP:promoter:-670A>G(rs1800682)(human) protein,mRNA:altered expression:placenta, liver:
RGD
PMID:30066360 PMID:28501275
RGD:14700669 , RGD:14700673
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
susceptibility
ISO IEP
DNA:SNP:intron:124A>G(rs5030772)(human) protein:altered expression:blood, placenta, liver:
RGD
PMID:30066360 PMID:28501275
RGD:14700669 , RGD:14700673
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Ace
angiotensin I converting enzyme
onset
ISO
CTD Direct Evidence: marker/mechanism DNA:insertion/deletion:intron 16:
CTD RGD
PMID:17114810 PMID:20044877
RGD:40400703
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Add1
adducin 1
ISO
mRNA:increased expression:blood
RGD
PMID:19731222
RGD:5147993
NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182
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Agt
angiotensinogen
ISO
DNA:polymorphism: :p.M235T (human) ClinVar Annotator: match by term: Preeclampsia, susceptibility to CTD Direct Evidence: marker/mechanism
ClinVar CTD RGD
PMID:1394429 PMID:7649545 PMID:7883995 PMID:8348146 PMID:8513325 PMID:8518804 PMID:9259580 PMID:9421481 PMID:9831339 PMID:16059745 PMID:25741868 PMID:28492532 PMID:8513325 PMID:20530295 More...
RGD:1300394 , RGD:13432363
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Akr1c3
aldo-keto reductase family 1, member C3
treatment
ISO IEP
mRNA:decreased expression:blood:
RGD
PMID:19681734 PMID:25876805
RGD:10053633 , RGD:11541124
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Alb
albumin
severity
ISO
RGD
PMID:21923989
RGD:11035264
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Alkbh5
alkB homolog 5, RNA demethylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34995009
NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331
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Anxa5
annexin A5
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19837457
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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Apela
apelin receptor early endogenous ligand
ISS
OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592
MouseDO
NCBI chr16:24,694,231...24,703,466
Ensembl chr16:24,694,324...24,703,465
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Arhgap45
Rho GTPase activating protein 45
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26095815
NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268
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Asb4
ankyrin repeat and SOCS box-containing 4
ISS
OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592
MouseDO
NCBI chr 4:33,506,992...33,544,630
Ensembl chr 4:33,506,992...33,544,630
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C3
complement C3
treatment
IDA
RGD
PMID:23685261
RGD:7411624
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Ccl5
C-C motif chemokine ligand 5
IEP
protein:increased secretion:serum (rat)
RGD
PMID:19617880
RGD:2317272
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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Ccn3
cellular communication network factor 3
ISO
protein:decreased expression:placenta (human)
RGD
PMID:16675545
RGD:1580971
NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
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Cd274
CD274 molecule
treatment
IEP
RGD
PMID:27277012
RGD:40886269
NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd40
CD40 molecule
ISO
protein:increased expression:blood, monocyte (human)
RGD
PMID:19221099
RGD:11520792
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Cd40lg
CD40 ligand
treatment
IMP ISO
protein:increased expression:blood platelet (human)
RGD
PMID:26310940 PMID:23241952
RGD:11056772 , RGD:11522719
NCBI chr X:135,127,119...135,138,302
Ensembl chr X:135,126,969...135,138,306
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Cd46
CD46 molecule
susceptibility no_association
ISO
DNA:missense mutation:cds:p.A304V (human)
RGD
PMID:21445332 PMID:25710174
RGD:6483459 , RGD:11352807
NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
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Cdkn1c
cyclin-dependent kinase inhibitor 1C
ISS
OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592
MouseDO
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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Cebpa
CCAAT/enhancer binding protein alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34398343
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Chi3l1
chitinase 3 like 1
ISO
protein:increased secretion:umbilical cord, serum (human)
RGD
PMID:18054022
RGD:4892664
NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787
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Clu
clusterin
ISO
DNA:SNP:exon:866C>T (human)
RGD
PMID:15925890
RGD:1581195
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Cmklr1
chemerin chemokine-like receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34398343
NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129
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Comt
catechol-O-methyltransferase
ISS
OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592
MouseDO
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Corin
corin, serine peptidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
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Cp
ceruloplasmin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18679377
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Crebbp
CREB binding protein
ISO
mRNA:decreased expression:placenta (human)
RGD
PMID:33625689
RGD:153350159
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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Cst3
cystatin C
ISO
protein:increased expression:plasma (human)
RGD
PMID:18197549
RGD:2314350
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
ISO
DNA:missense mutation:cds:p.V386A (human)
RGD
PMID:15569322
RGD:1576428
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
ISO
DNA:missense mutation:cds:p.V386A (human)
RGD
PMID:15569322
RGD:1576428
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
ISO IMP
mRNA:increased expression:placenta, decidua
RGD
PMID:23155181 PMID:23155181
RGD:7243127 , RGD:7243127
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Ddah2
dimethylarginine dimethylaminohydrolase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22285683
NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
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Ebag9
estrogen receptor binding site associated antigen 9
ISO
protein:increased expression:decidua
RGD
PMID:17845206
RGD:2289846
NCBI chr 7:75,810,950...75,828,902
Ensembl chr 7:75,810,594...75,861,248
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Edn1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25230003
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Edn2
endothelin 2
ISO
RGD
PMID:9015697
RGD:1580919
NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
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Eif3d
eukaryotic translation initiation factor 3, subunit D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34520790
NCBI chr 7:109,539,795...109,552,184
Ensembl chr 7:109,539,356...109,552,206
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Eng
endoglin
severity treatment
ISO IEP IDA
protein:increased expression:serum (human) protein:increased expression:serum (rat) protein:increased expression:plasma (mouse)
RGD
PMID:23460287 PMID:22763474 PMID:22308016 PMID:20351341 PMID:23357179
RGD:7248767 , RGD:7257530 , RGD:7257524 , RGD:7248777 , RGD:7248768
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
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Entpd1
ectonucleoside triphosphate diphosphohydrolase 1
ISO
protein:decreased expression:abdominal fascia:
RGD
PMID:17469012
RGD:9685457
NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317
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Epas1
endothelial PAS domain protein 1
ISO
RGD
PMID:11159352
RGD:1580974
NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
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Ephx1
epoxide hydrolase 1
ISO
DNA:polymorphism CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:11283205 PMID:12173035 PMID:11283205
RGD:1601064
NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
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Erbb2
erb-b2 receptor tyrosine kinase 2
ISO
RGD
PMID:9158311
RGD:1580990
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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Esr2
estrogen receptor 2
ISO
RGD
PMID:15894829
RGD:1581016
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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F2
coagulation factor II
severity
ISO
DNA:polymorphism: :20210G>A(human)
RGD
PMID:16246971
RGD:6893628
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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F2r
coagulation factor II (thrombin) receptor
ISO
RGD
PMID:12161502
RGD:1581033
NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
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F3
coagulation factor III, tissue factor
ISO
associated with Fetal Death;protein:increased expression:plasma
RGD
PMID:19736615
RGD:11340220
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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F5
coagulation factor V
severity
ISO
DNA:mutation: :1691G>A(human)
RGD
PMID:16246971
RGD:6893628
NCBI chr13:76,513,463...76,583,106
Ensembl chr13:76,513,255...76,582,317
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Fas
Fas cell surface death receptor
susceptibility
ISO
DNA:SNP:promoter:-670A>G (human) DNA:SNP:promoter:-670A>G(rs1800682)(human)
RGD
PMID:15695771 PMID:30066360
RGD:12903973 , RGD:14700669
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
susceptibility
ISO
DNA:SNP:intron:124A>G(rs5030772)(human)
RGD
PMID:30066360
RGD:14700669
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Flt1
Fms related receptor tyrosine kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:18679377 PMID:28628106 PMID:15472115
RGD:1582493
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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Gstp1
glutathione S-transferase pi 1
susceptibility
ISO
DNA:missense mutation:cds:p.I105V (human)
RGD
PMID:11826024
RGD:737707
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Hif1a
hypoxia inducible factor 1 subunit alpha
ISO
protein:increased expression:chorionic villus (human)
RGD
PMID:22840297
RGD:155631283
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hmox1
heme oxygenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22197494
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hp
haptoglobin
severity
ISO
protein:increased expression DNA:polymorphism
RGD
PMID:17220952 PMID:16879055
RGD:1626337 , RGD:1626343
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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Icam1
intercellular adhesion molecule 1
treatment
IMP
RGD
PMID:21830843
RGD:8547718
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ido1
indoleamine 2,3-dioxygenase 1
ISS
OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592
MouseDO
NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
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Il1rn
interleukin 1 receptor antagonist
ISO
protein:increased expression:serum (human)
RGD
PMID:21126355
RGD:6906962
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Inhba
inhibin subunit beta A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17332518
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Iscu
iron-sulfur cluster assembly enzyme
ISO
mRNA:decreased expression:chorionic villus (human)
RGD
PMID:22840297
RGD:155631283
NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150
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Itga4
integrin subunit alpha 4
IEP
protein:increased expression:blood, granulocyte (rat)
RGD
PMID:10694336
RGD:9698441
NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
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Kiss1
KiSS-1 metastasis-suppressor
ISO
RGD
PMID:16952198
RGD:2292128
NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612
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Lcn2
lipocalin 2
ISO
protein:increased expression:serum,urine
RGD
PMID:23957217
RGD:126781721
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Lep
leptin
IEP
protein:decreased expression:plasma
RGD
PMID:16021089
RGD:5128718
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lepr
leptin receptor
IEP
protein:increased expression:placenta
RGD
PMID:16021089
RGD:5128718
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Mir126b
microRNA 126b
ISO
miRNA:decreased expression:blood serum (human)
RGD
PMID:25017274
RGD:155882496
NCBI chr 3:9,415,087...9,415,159
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Mir144
microRNA 144
ISO
miRNA:decreased expression:blood serum (human)
RGD
PMID:25017274
RGD:155882496
NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430
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Mir152
microRNA 152
IEP
miRNA:increased expression:placenta
RGD
PMID:31114978
RGD:21066344
NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020
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Mir155
microRNA 155
ISO
miRNA:increased expression:blood serum (human)
RGD
PMID:28700503
RGD:155882490
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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Mir15b
microRNA 15b
ISO
miRNA:decreased expression:blood serum (human)
RGD
PMID:25017274
RGD:155882496
NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
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Mir193a
microRNA 193a
ISO
miRNA:increased expression:blood serum (human)
RGD
PMID:25017274
RGD:155882496
NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454
G
Mir204
microRNA 204
ISO
miRNA:increased expression:blood serum (human)
RGD
PMID:25017274
RGD:155882496
NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040
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Mir210
microRNA 210
disease_progression severity
ISO
miRNA:increased expression:placenta (human) miRNA:increased expression:blood serum (human) miRNA:increased expression:chorionic villus (human) miRNA:increased expression:blood plasma (human)
RGD
PMID:27746364 PMID:25017274 PMID:28700503 PMID:22840297 PMID:21388517
RGD:155260325 , RGD:155882496 , RGD:155882490 , RGD:155631283 , RGD:155269044
NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
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Mir215
microRNA 215
HEP
miRNA:increased expression:blood serum (human)
RGD
PMID:25017274
RGD:155882496
NCBI chr13:96,851,440...96,851,536
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Mir25
microRNA 25
ISO
miRNA:increased expression:blood serum (human)
RGD
PMID:25017274
RGD:155882496
NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015
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Mir296
microRNA 296
ISO
miRNA:increased expression:blood serum (human)
RGD
PMID:25017274
RGD:155882496
NCBI chr 3:163,051,838...163,051,915
Ensembl chr 3:163,051,838...163,051,915
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Mir32
microRNA 32
ISO
miRNA:increased expression:blood serum (human)
RGD
PMID:25017274
RGD:155882496
NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152
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Mmp2
matrix metallopeptidase 2
ISO
mRNA, protein:decreased expression:placenta
RGD
PMID:17083831
RGD:2290399
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
ISO
mRNA, protein:decreased expression:placenta
RGD
PMID:17083831 PMID:23776237
RGD:2290399 , RGD:13204787
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Nos3
nitric oxide synthase 3
treatment
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:29250138
RGD:13504712
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Notch2
notch receptor 2
ISS
OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592
MouseDO
NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
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Nsd1
nuclear receptor binding SET domain protein 1
ISO
ClinVar Annotator: match by term: Preeclampsia
ClinVar
PMID:12464997 PMID:12807965 PMID:15942875 PMID:17565729 PMID:18414213 PMID:21196496 PMID:24412544 PMID:25741868 PMID:26690673 PMID:27834868 PMID:28492532 PMID:30719864 More...
NCBI chr17:9,311,963...9,426,373
Ensembl chr17:9,315,237...9,425,358
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Pdcd1
programmed cell death 1
treatment
ISO IEP
protein:increased expression:Treg cell
RGD
PMID:27277012 PMID:27277012
RGD:40886269 , RGD:40886269
NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
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Pde5a
phosphodiesterase 5A
IMP
RGD
PMID:18538317
RGD:2314465
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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Pgf
placental growth factor
ISO IEP
RGD
PMID:21756887 PMID:20720407
RGD:6483577 , RGD:6483779
NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
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Plaur
plasminogen activator, urokinase receptor
ISO
protein:increased expression:plasma
RGD
PMID:21722073
RGD:6484119
NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Pml
PML nuclear body scaffold
ISO
mRNA:decreased expression:placenta (human)
RGD
PMID:20228380
RGD:41404689
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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Pparg
peroxisome proliferator-activated receptor gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:34995009 PMID:15562025
RGD:1580687
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
ISO
RGD
PMID:9065198
RGD:11564336
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Ptgs1
prostaglandin-endoperoxide synthase 1
ISS
OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592
MouseDO
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptpn2
protein tyrosine phosphatase, non-receptor type 2
disease_progression
ISO
mRNA:decreased expression:placenta (human)
RGD
PMID:27746364
RGD:155260325
NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
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Rarres2
retinoic acid receptor responder 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34398343
NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
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RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
DNA:polymorphism:cds:HLA-DQB1*04 (human)
RGD
PMID:10960630
RGD:36174024
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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Scnn1a
sodium channel epithelial 1 subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16555725
NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
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Serpina1
serpin family A member 1
ISO
RGD
PMID:1852102
RGD:1643155
NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
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Serpine1
serpin family E member 1
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:blood:
CTD RGD
PMID:18679377 PMID:16952198
RGD:2292128
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serpinf2
serpin family F member 2
ISO
protein:increased expression:urine
RGD
PMID:1334334
RGD:1625535
NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
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Slc2a1
solute carrier family 2 member 1
ISO
mRNA:decreased expression:chorionic villus (human)
RGD
PMID:22840297
RGD:155631283
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Stox1
storkhead box 1
no_association
ISO
DNA:missense mutation:cds:p.Y153H (human) human fetally expressed gene in a mouse model
RGD
PMID:15806103 PMID:23357179 PMID:17617193
RGD:11553888 , RGD:7248768 , RGD:11553890
NCBI chr20:30,598,656...30,666,371
Ensembl chr20:30,598,168...30,666,939
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Tfpi
tissue factor pathway inhibitor
ISO
protein:increased expression:plasma:
RGD
PMID:10078579
RGD:11060132
NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
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Timp1
TIMP metallopeptidase inhibitor 1
ISO
mRNA, protein:increased expression:placenta
RGD
PMID:17083831
RGD:2290399
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tlr3
toll-like receptor 3
IEP
protein:increased expression:placenta (rat)
RGD
PMID:19779466
RGD:5128769
NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
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Tlr4
toll-like receptor 4
ISO
RGD
PMID:16157088
RGD:1580682
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnf
tumor necrosis factor
ISO
RGD
PMID:15901845
RGD:1580314
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf1b
TNF receptor superfamily member 1B
ISO
human protein in rat model
RGD
PMID:21505354
RGD:5131211
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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Uts2
urotensin 2
ISO
RGD
PMID:15866083
RGD:1580806
NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237
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Vegfa
vascular endothelial growth factor A
ISO
mRNA:decreased expression:chorionic villus (human)
RGD
PMID:16517614 PMID:22840297
RGD:1580566 , RGD:155631283
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Nos3
nitric oxide synthase 3
ISO
OMIM
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Stox1
storkhead box 1
ISO
ClinVar Annotator: match by term: Preeclampsia/eclampsia 4
OMIM ClinVar
PMID:15806103 PMID:17325670 PMID:33116287
NCBI chr20:30,598,656...30,666,371
Ensembl chr20:30,598,168...30,666,939
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Corin
corin, serine peptidase
ISO
ClinVar Annotator: match by term: Preeclampsia/eclampsia 5
OMIM ClinVar
PMID:22437503 PMID:24828501 PMID:25741868 PMID:28492532
NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
RGD
PMID:22534418
RGD:6771230
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Ren
renin
ISO
protein:increased activity:blood plasma (human)
RGD
PMID:683663
RGD:125097480
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Mir155
microRNA 155
severity
ISO
miRNA:increased expression:blood serum (human)
RGD
PMID:31487655
RGD:155582220
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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Mir210
microRNA 210
severity
ISO
miRNA:increased expression:blood serum (human) miRNA:increased expression:blood plasma (human)
RGD
PMID:31487655 PMID:33778218
RGD:155582220 , RGD:155582221
NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
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