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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Pregnancy-Induced Hypertension
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Accession:DOID:9001650 term browser browse the term
Definition:A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.
Synonyms:exact_synonym: Pregnancy Transient Hypertension;   gestational hypertension
 related_synonym: pregnancy-induced hypertension, susceptibility to
 primary_id: MESH:D046110
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
Pregnancy-Induced Hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IEP RGD PMID:17977916 RGD:8548898 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 IEP RGD PMID:17977916 RGD:8548898 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Agt angiotensinogen IEP RGD PMID:17977916 RGD:8548898 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Edn1 endothelin 1 no_association ISO DNA:transversion:exon:p.K198N rs5370 (human) RGD PMID:19730395 PMID:11593097 RGD:4145063, RGD:4145070 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:21383306 RGD:10755723 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hp haptoglobin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16597321 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Hypertension, pregnancy-induced, susceptibility to		 CTD
ClinVar		 PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More... NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Tfpi tissue factor pathway inhibitor IEP mRNA:decreased expression:aorta: RGD PMID:26104991 RGD:11062065 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Tnf tumor necrosis factor treatment IMP RGD PMID:18981324 RGD:13825265 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
eclampsia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 treatment IDA RGD PMID:27106269 RGD:11062145 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
HELLP syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 ISO protein:decreased activity:plasma (human) RGD PMID:12969811 RGD:10449045 NCBI chr 3:10,299,264...10,338,464
Ensembl chr 3:10,300,028...10,346,687 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:blood platelet (human) RGD PMID:23241952 RGD:11522719 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:9158311 RGD:1580990 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Fas Fas cell surface death receptor susceptibility ISO
IEP		 DNA:SNP:promoter:-670A>G(rs1800682)(human)
protein,mRNA:altered expression:placenta, liver:		 RGD PMID:30066360 PMID:28501275 RGD:14700669, RGD:14700673 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand susceptibility ISO
IEP		 DNA:SNP:intron:124A>G(rs5030772)(human)
protein:altered expression:blood, placenta, liver:		 RGD PMID:30066360 PMID:28501275 RGD:14700669, RGD:14700673 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
pre-eclampsia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme onset ISO CTD Direct Evidence: marker/mechanism
DNA:insertion/deletion:intron 16:		 CTD
RGD		 PMID:17114810 PMID:20044877 RGD:40400703 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Add1 adducin 1 ISO mRNA:increased expression:blood RGD PMID:19731222 RGD:5147993 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182 		JBrowse link
G Agt angiotensinogen ISO DNA:polymorphism: :p.M235T (human)
ClinVar Annotator: match by term: Preeclampsia, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
RGD		 PMID:1394429 PMID:7649545 PMID:7883995 PMID:8348146 PMID:8513325 More... RGD:1300394, RGD:13432363 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 treatment ISO
IEP		 mRNA:decreased expression:blood: RGD PMID:19681734 PMID:25876805 RGD:10053633, RGD:11541124 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alb albumin severity ISO RGD PMID:21923989 RGD:11035264 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alkbh5 alkB homolog 5, RNA demethylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:34995009 NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331 		JBrowse link
G Anxa5 annexin A5 ISO CTD Direct Evidence: therapeutic CTD PMID:19837457 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Apela apelin receptor early endogenous ligand ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr16:24,694,231...24,703,466
Ensembl chr16:24,694,324...24,703,465 		JBrowse link
G Arhgap45 Rho GTPase activating protein 45 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26095815 NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268 		JBrowse link
G Asb4 ankyrin repeat and SOCS box-containing 4 ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 4:33,506,992...33,544,630
Ensembl chr 4:33,506,992...33,544,630 		JBrowse link
G C3 complement C3 treatment IDA RGD PMID:23685261 RGD:7411624 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP protein:increased secretion:serum (rat) RGD PMID:19617880 RGD:2317272 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn3 cellular communication network factor 3 ISO protein:decreased expression:placenta (human) RGD PMID:16675545 RGD:1580971 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019 		JBrowse link
G Cd274 CD274 molecule treatment IEP RGD PMID:27277012 RGD:40886269 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd40 CD40 molecule ISO protein:increased expression:blood, monocyte (human) RGD PMID:19221099 RGD:11520792 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand treatment IMP
ISO		 protein:increased expression:blood platelet (human) RGD PMID:26310940 PMID:23241952 RGD:11056772, RGD:11522719 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cd46 CD46 molecule susceptibility
no_association		 ISO DNA:missense mutation:cds:p.A304V (human) RGD PMID:21445332 PMID:25710174 RGD:6483459, RGD:11352807 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:34398343 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Chi3l1 chitinase 3 like 1 ISO protein:increased secretion:umbilical cord, serum (human) RGD PMID:18054022 RGD:4892664 NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787 		JBrowse link
G Clu clusterin ISO DNA:SNP:exon:866C>T (human) RGD PMID:15925890 RGD:1581195 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cmklr1 chemerin chemokine-like receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34398343 NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129 		JBrowse link
G Comt catechol-O-methyltransferase ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Corin corin, serine peptidase ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503 		JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18679377 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Crebbp CREB binding protein ISO mRNA:decreased expression:placenta (human) RGD PMID:33625689 RGD:153350159 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Cst3 cystatin C ISO protein:increased expression:plasma (human) RGD PMID:18197549 RGD:2314350 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 ISO DNA:missense mutation:cds:p.V386A (human) RGD PMID:15569322 RGD:1576428 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 ISO DNA:missense mutation:cds:p.V386A (human) RGD PMID:15569322 RGD:1576428 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 ISO
IMP		 mRNA:increased expression:placenta, decidua RGD PMID:23155181 PMID:23155181 RGD:7243127, RGD:7243127 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22285683 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511 		JBrowse link
G Ebag9 estrogen receptor binding site associated antigen 9 ISO protein:increased expression:decidua RGD PMID:17845206 RGD:2289846 NCBI chr 7:75,810,950...75,828,902
Ensembl chr 7:75,810,594...75,861,248 		JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25230003 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn2 endothelin 2 ISO RGD PMID:9015697 RGD:1580919 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814 		JBrowse link
G Eif3d eukaryotic translation initiation factor 3, subunit D ISO CTD Direct Evidence: marker/mechanism CTD PMID:34520790 NCBI chr 7:109,539,795...109,552,184
Ensembl chr 7:109,539,356...109,552,206 		JBrowse link
G Eng endoglin severity
treatment		 ISO
IEP
IDA		 protein:increased expression:serum (human)
protein:increased expression:serum (rat)
protein:increased expression:plasma (mouse)		 RGD PMID:23460287 PMID:22763474 PMID:22308016 PMID:20351341 PMID:23357179 RGD:7248767, RGD:7257530, RGD:7257524, RGD:7248777, RGD:7248768 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 ISO protein:decreased expression:abdominal fascia: RGD PMID:17469012 RGD:9685457 NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317 		JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:11159352 RGD:1580974 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Ephx1 epoxide hydrolase 1 ISO DNA:polymorphism
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:11283205 PMID:12173035 PMID:11283205 RGD:1601064 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:9158311 RGD:1580990 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:15894829 RGD:1581016 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F2 coagulation factor II severity ISO DNA:polymorphism: :20210G>A(human) RGD PMID:16246971 RGD:6893628 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor ISO RGD PMID:12161502 RGD:1581033 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G F3 coagulation factor III, tissue factor ISO associated with Fetal Death;protein:increased expression:plasma RGD PMID:19736615 RGD:11340220 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G F5 coagulation factor V severity ISO DNA:mutation: :1691G>A(human) RGD PMID:16246971 RGD:6893628 NCBI chr13:76,513,463...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G Fas Fas cell surface death receptor susceptibility ISO DNA:SNP:promoter:-670A>G (human)
DNA:SNP:promoter:-670A>G(rs1800682)(human)		 RGD PMID:15695771 PMID:30066360 RGD:12903973, RGD:14700669 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand susceptibility ISO DNA:SNP:intron:124A>G(rs5030772)(human) RGD PMID:30066360 RGD:14700669 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18679377 PMID:28628106 PMID:15472115 RGD:1582493 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 susceptibility ISO DNA:missense mutation:cds:p.I105V (human) RGD PMID:11826024 RGD:737707 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:chorionic villus (human) RGD PMID:22840297 RGD:155631283 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22197494 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hp haptoglobin severity ISO protein:increased expression
DNA:polymorphism		 RGD PMID:17220952 PMID:16879055 RGD:1626337, RGD:1626343 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP RGD PMID:21830843 RGD:8547718 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:serum (human) RGD PMID:21126355 RGD:6906962 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Inhba inhibin subunit beta A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17332518 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme ISO mRNA:decreased expression:chorionic villus (human) RGD PMID:22840297 RGD:155631283 NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150 		JBrowse link
G Itga4 integrin subunit alpha 4 IEP protein:increased expression:blood, granulocyte (rat) RGD PMID:10694336 RGD:9698441 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor ISO RGD PMID:16952198 RGD:2292128 NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612 		JBrowse link
G Lcn2 lipocalin 2 ISO protein:increased expression:serum,urine RGD PMID:23957217 RGD:126781721 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lep leptin IEP protein:decreased expression:plasma RGD PMID:16021089 RGD:5128718 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor IEP protein:increased expression:placenta RGD PMID:16021089 RGD:5128718 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Mir126b microRNA 126b ISO miRNA:decreased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr 3:9,415,087...9,415,159 JBrowse link
G Mir144 microRNA 144 ISO miRNA:decreased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430 		JBrowse link
G Mir152 microRNA 152 IEP miRNA:increased expression:placenta RGD PMID:31114978 RGD:21066344 NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020 		JBrowse link
G Mir155 microRNA 155 ISO miRNA:increased expression:blood serum (human) RGD PMID:28700503 RGD:155882490 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir15b microRNA 15b ISO miRNA:decreased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir193a microRNA 193a ISO miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454 		JBrowse link
G Mir204 microRNA 204 ISO miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Mir210 microRNA 210 disease_progression
severity		 ISO miRNA:increased expression:placenta (human)
miRNA:increased expression:blood serum (human)
miRNA:increased expression:chorionic villus (human)
miRNA:increased expression:blood plasma (human)		 RGD PMID:27746364 PMID:25017274 PMID:28700503 PMID:22840297 PMID:21388517 RGD:155260325, RGD:155882496, RGD:155882490, RGD:155631283, RGD:155269044 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mir215 microRNA 215 HEP miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr13:96,851,440...96,851,536 JBrowse link
G Mir25 microRNA 25 ISO miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015 		JBrowse link
G Mir296 microRNA 296 ISO miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr 3:163,051,838...163,051,915
Ensembl chr 3:163,051,838...163,051,915 		JBrowse link
G Mir32 microRNA 32 ISO miRNA:increased expression:blood serum (human) RGD PMID:25017274 RGD:155882496 NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO mRNA, protein:decreased expression:placenta RGD PMID:17083831 RGD:2290399 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA, protein:decreased expression:placenta RGD PMID:17083831 PMID:23776237 RGD:2290399, RGD:13204787 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:29250138 RGD:13504712 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch2 notch receptor 2 ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088 		JBrowse link
G Nsd1 nuclear receptor binding SET domain protein 1 ISO ClinVar Annotator: match by term: Preeclampsia ClinVar PMID:12464997 PMID:12807965 PMID:15942875 PMID:17565729 PMID:18414213 More... NCBI chr17:9,311,963...9,426,373
Ensembl chr17:9,315,237...9,425,358 		JBrowse link
G Pdcd1 programmed cell death 1 treatment ISO
IEP		 protein:increased expression:Treg cell RGD PMID:27277012 PMID:27277012 RGD:40886269, RGD:40886269 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Pde5a phosphodiesterase 5A IMP RGD PMID:18538317 RGD:2314465 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pgf placental growth factor ISO
IEP		 RGD PMID:21756887 PMID:20720407 RGD:6483577, RGD:6483779 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO protein:increased expression:plasma RGD PMID:21722073 RGD:6484119 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Pml PML nuclear body scaffold ISO mRNA:decreased expression:placenta (human) RGD PMID:20228380 RGD:41404689 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:34995009 PMID:15562025 RGD:1580687 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa ISO RGD PMID:9065198 RGD:11564336 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 disease_progression ISO mRNA:decreased expression:placenta (human) RGD PMID:27746364 RGD:155260325 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Rarres2 retinoic acid receptor responder 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34398343 NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556 		JBrowse link
G RT1-Bb RT1 class II, locus Bb susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*04 (human) RGD PMID:10960630 RGD:36174024 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16555725 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181 		JBrowse link
G Serpina1 serpin family A member 1 ISO RGD PMID:1852102 RGD:1643155 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339 		JBrowse link
G Serpine1 serpin family E member 1 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:blood:		 CTD
RGD		 PMID:18679377 PMID:16952198 RGD:2292128 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf2 serpin family F member 2 ISO protein:increased expression:urine RGD PMID:1334334 RGD:1625535 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO mRNA:decreased expression:chorionic villus (human) RGD PMID:22840297 RGD:155631283 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Stox1 storkhead box 1 no_association ISO DNA:missense mutation:cds:p.Y153H (human)
human fetally expressed gene in a mouse model		 RGD PMID:15806103 PMID:23357179 PMID:17617193 RGD:11553888, RGD:7248768, RGD:11553890 NCBI chr20:30,598,656...30,666,371
Ensembl chr20:30,598,168...30,666,939 		JBrowse link
G Tfpi tissue factor pathway inhibitor ISO protein:increased expression:plasma: RGD PMID:10078579 RGD:11060132 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO mRNA, protein:increased expression:placenta RGD PMID:17083831 RGD:2290399 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr3 toll-like receptor 3 IEP protein:increased expression:placenta (rat) RGD PMID:19779466 RGD:5128769 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:16157088 RGD:1580682 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:15901845 RGD:1580314 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO human protein in rat model RGD PMID:21505354 RGD:5131211 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Uts2 urotensin 2 ISO RGD PMID:15866083 RGD:1580806 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA:decreased expression:chorionic villus (human) RGD PMID:16517614 PMID:22840297 RGD:1580566, RGD:155631283 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Preeclampsia/Eclampsia 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos3 nitric oxide synthase 3 ISO OMIM NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
Preeclampsia/Eclampsia 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stox1 storkhead box 1 ISO ClinVar Annotator: match by term: Preeclampsia/eclampsia 4 OMIM
ClinVar		 PMID:15806103 PMID:17325670 PMID:33116287 NCBI chr20:30,598,656...30,666,371
Ensembl chr20:30,598,168...30,666,939 		JBrowse link
Preeclampsia/Eclampsia 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Corin corin, serine peptidase ISO ClinVar Annotator: match by term: Preeclampsia/eclampsia 5 OMIM
ClinVar		 PMID:22437503 PMID:24828501 PMID:25741868 PMID:28492532 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503 		JBrowse link
Preeclamptic Toxemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22534418 RGD:6771230 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Ren renin ISO protein:increased activity:blood plasma (human) RGD PMID:683663 RGD:125097480 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
severe pre-eclampsia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir155 microRNA 155 severity ISO miRNA:increased expression:blood serum (human) RGD PMID:31487655 RGD:155582220 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir210 microRNA 210 severity ISO miRNA:increased expression:blood serum (human)
miRNA:increased expression:blood plasma (human)		 RGD PMID:31487655 PMID:33778218 RGD:155582220, RGD:155582221 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18256
    disease of anatomical entity 17617
      Urogenital Diseases 4763
        Female Urogenital Diseases and Pregnancy Complications 2267
          Pregnancy Complications 686
            Pregnancy-Induced Hypertension 109
              pre-eclampsia + 108
Path 2
Term Annotations click to browse term
  disease 18256
    disease of anatomical entity 17617
      cardiovascular system disease 4908
        vascular disease 3688
          artery disease 2575
            hypertension 1614
              Pregnancy-Induced Hypertension 109
                pre-eclampsia + 108
paths to the root