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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Experimental Liver Neoplasms
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Accession:DOID:9001586 term browser browse the term
Definition:Experimentally induced tumors of the LIVER.
Synonyms:exact_synonym: Experimental Hepatomas;   Experimental Liver Neoplasm;   Morris Hepatoma;   Novikoff hepatoma;   experimental hepatoma
 primary_id: MESH:D008114
 alt_id: RDO:0006023
For additional species annotation, visit the Alliance of Genome Resources.



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Experimental Liver Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 ISO RGD PMID:15853769 RGD:1598580 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ADSL adenylosuccinate lyase ISO protein:increased activity:liver (rat) RGD PMID:2937404 RGD:1598766 NCBI chr22:40,346,500...40,387,527
Ensembl chr22:40,346,461...40,390,463
JBrowse link
G AFP alpha fetoprotein EXP CTD Direct Evidence: marker/mechanism CTD PMID:24012840 PMID:32961231 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AGPS alkylglycerone phosphate synthase ISO RGD PMID:7407223 RGD:1598794 NCBI chr 2:177,392,773...177,543,834
Ensembl chr 2:177,392,746...177,567,024
JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977
JBrowse link
G APOA4 apolipoprotein A4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
JBrowse link
G APOC2 apolipoprotein C2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr19:44,946,051...44,949,565
Ensembl chr19:44,946,035...44,949,565
JBrowse link
G ARID1A AT-rich interaction domain 1A disease_progression ISO RGD PMID:26569409 RGD:11344640 NCBI chr 1:26,696,015...26,782,104
Ensembl chr 1:26,693,236...26,782,104
JBrowse link
G ARRB2 arrestin beta 2 ISO mRNA, protein:increased expression:liver (rat) RGD PMID:21167192 RGD:5509890 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G ATP7A ATPase copper transporting alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:23792645 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,690...78,050,395
JBrowse link
G ATP7B ATPase copper transporting beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:23792645 NCBI chr13:51,932,669...52,012,132
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G BAK1 BCL2 antagonist/killer 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BBC3 BCL2 binding component 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2 BCL2 apoptosis regulator EXP CTD Direct Evidence: marker/mechanism CTD PMID:10426811 PMID:28100771 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 ISO
EXP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:10426811 PMID:28100771 PMID:22414765 RGD:11353865 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ISO mRNA, protein:increased expression:liver RGD PMID:18246794 RGD:2293125 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CA3 carbonic anhydrase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
JBrowse link
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase ISO protein:increased activity:liver (rat) RGD PMID:13618893 RGD:5132586 NCBI chr 2:27,217,369...27,243,943
Ensembl chr 2:27,217,369...27,243,943
JBrowse link
G CCL20 C-C motif chemokine ligand 20 EXP CTD Direct Evidence: marker/mechanism CTD PMID:30603057 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
JBrowse link
G CCNB1 cyclin B1 ISO mRNA:increased expression:liver RGD PMID:17342310 RGD:2315991 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 ISO
EXP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:28100771 PMID:17055752 RGD:2289139 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNDBP1 cyclin D1 binding protein 1 EXP CTD Direct Evidence: therapeutic CTD PMID:16501603 NCBI chr15:43,185,403...43,197,177
Ensembl chr15:43,185,118...43,197,177
JBrowse link
G CCNG1 cyclin G1 ISO RGD PMID:27982046 RGD:151361200 NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,446,151
JBrowse link
G CCNG2 cyclin G2 ISO RGD PMID:27982046 RGD:151361200 NCBI chr 4:77,157,207...77,170,060
Ensembl chr 4:77,157,207...77,433,388
JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:19035311 RGD:5491179 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
JBrowse link
G CD63 CD63 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr12:55,725,323...55,729,673
Ensembl chr12:55,725,323...55,729,707
JBrowse link
G CDH1 cadherin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20118494 PMID:25319454 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO protein:decreased expression:liver: RGD PMID:8640740 RGD:8662309 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B disease_progression ISO mRNA:increased expression:liver (rat) RGD PMID:19533683 RGD:2315050 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G CDKN1C cyclin dependent kinase inhibitor 1C disease_progression ISO protein:decreased expression:liver (rat)
mRNA:increased expression:liver (rat)
protein:increased expression:liver (rat)
RGD PMID:26606000 PMID:19533683 PMID:3965145 RGD:11354707, RGD:2315050, RGD:152998958 NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775
JBrowse link
G COPS5 COP9 signalosome subunit 5 ISO protein:increased expression:liver (rat) RGD PMID:26606000 RGD:11354707 NCBI chr 8:67,043,079...67,062,133
Ensembl chr 8:67,043,079...67,083,783
JBrowse link
G CP ceruloplasmin EXP CTD Direct Evidence: marker/mechanism CTD PMID:23792645 NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 severity ISO mRNA:decreased expression:liver RGD PMID:3387993 RGD:2303406 NCBI chr 2:210,477,685...210,679,107
Ensembl chr 2:210,477,682...210,679,107
JBrowse link
G CTNNB1 catenin beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11280770 PMID:20118494 PMID:21147764 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO mRNA:increased expression:liver RGD PMID:22687991 RGD:7296954 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11376689 PMID:21147764 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2A7 cytochrome P450 family 2 subfamily A member 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr19:40,875,439...40,882,231
Ensembl chr19:40,875,439...40,882,752
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18056438 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP2F1 cytochrome P450 family 2 subfamily F member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr19:41,114,432...41,128,381
Ensembl chr19:41,114,432...41,128,381
JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) ISO protein:increased activity:liver (rat) RGD PMID:6331524 RGD:5132618 NCBI chr16:72,008,744...72,027,659
Ensembl chr16:72,008,588...72,027,664
JBrowse link
G DTYMK deoxythymidylate kinase ISO protein:increased activity:tumor (rat) RGD PMID:6244089 RGD:5133686 NCBI chr 2:241,675,747...241,686,815
Ensembl chr 2:241,675,747...241,686,944
JBrowse link
G ENO2 enolase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:2910524 NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,698
JBrowse link
G EPHX1 epoxide hydrolase 1 ISO RGD PMID:7260898 RGD:11252158 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563
JBrowse link
G ESR1 estrogen receptor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:35044086 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G F12 coagulation factor XII EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 5:177,402,141...177,409,564
Ensembl chr 5:177,402,133...177,416,583
JBrowse link
G FAS Fas cell surface death receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:30737368 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FOXM1 forkhead box M1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15082532 NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,680...2,877,174
JBrowse link
G FOXP4-AS1 FOXP4 antisense RNA 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:34545456 NCBI chr 6:41,523,895...41,548,621
Ensembl chr 6:41,452,889...41,548,621
JBrowse link
G GJB1 gap junction protein beta 1 ISO
EXP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:18308698 PMID:1336494 RGD:7349398 NCBI chr  X:71,215,239...71,225,516
Ensembl chr  X:71,212,811...71,225,516
JBrowse link
G GJB2 gap junction protein beta 2 ISO RGD PMID:1336494 RGD:7349398 NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938
JBrowse link
G GLUL glutamate-ammonia ligase EXP CTD Direct Evidence: marker/mechanism CTD PMID:20118494 PMID:21147764 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206
JBrowse link
G GRP gastrin releasing peptide EXP CTD Direct Evidence: marker/mechanism CTD PMID:2910524 NCBI chr18:59,219,189...59,230,771
Ensembl chr18:59,220,158...59,230,774
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO
EXP
CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (rat)
CTD
RGD
PMID:2563599 PMID:3124819 PMID:7585603 PMID:20188851 PMID:12016164 More... RGD:2317823, RGD:152998958 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G H19 H19 imprinted maternally expressed transcript ISO
EXP
DNA:hypomethylation:promoter
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:11420682 PMID:15352122 RGD:1342455 NCBI chr11:1,995,176...2,001,466
Ensembl chr11:1,995,166...2,001,470
JBrowse link
G HAT1 histone acetyltransferase 1 ISO protein:increased expression:liver RGD PMID:17182829 RGD:2316578 NCBI chr 2:171,922,461...171,983,686
Ensembl chr 2:171,922,448...171,983,686
JBrowse link
G HGF hepatocyte growth factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:11896611 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G HRAS HRas proto-oncogene, GTPase EXP CTD Direct Evidence: marker/mechanism CTD PMID:7955063 PMID:20118494 PMID:21147764 PMID:27517622 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321
JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO protein:increased expression:brainstem, cerebral cortex RGD PMID:17258772 RGD:1624998 NCBI chr  X:114,584,086...114,910,061
Ensembl chr  X:114,584,078...114,910,061
JBrowse link
G IGF2 insulin like growth factor 2 treatment ISO RGD PMID:22425635 RGD:10402567 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391
JBrowse link
G IGF2R insulin like growth factor 2 receptor ISO RGD PMID:15057872 PMID:9652747 RGD:2311623, RGD:2311630 NCBI chr 6:159,969,082...160,111,504
Ensembl chr 6:159,969,082...160,113,507
JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma EXP CTD Direct Evidence: marker/mechanism CTD PMID:30737368 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046
JBrowse link
G IL6 interleukin 6 disease_progression EXP
ISO
CTD Direct Evidence: marker/mechanism
protein:increased expression:blood serum (mouse)
CTD
RGD
PMID:26297436 PMID:26569409 RGD:11344640 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INSR insulin receptor disease_progression ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:cytoplasm,liver (rat) RGD PMID:15520221 RGD:2306052 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G JAK2 Janus kinase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948
JBrowse link
G KAT6A lysine acetyltransferase 6A ISO protein:increased expression:liver (rat) RGD PMID:17083329 RGD:2312274 NCBI chr 8:41,929,479...42,051,987
Ensembl chr 8:41,929,479...42,051,994
JBrowse link
G KDR kinase insert domain receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:11956651 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
JBrowse link
G KRAS KRAS proto-oncogene, GTPase disease_progression EXP
ISO
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (rat)
CTD
RGD
PMID:8603461 PMID:19533683 RGD:2315050 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:liver RGD PMID:15520221 RGD:2306052 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase EXP CTD Direct Evidence: marker/mechanism CTD PMID:11956651 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377
JBrowse link
G MFGE8 milk fat globule EGF and factor V/VIII domain containing EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr15:88,898,683...88,913,379
Ensembl chr15:88,898,683...88,913,468
JBrowse link
G MIR10A microRNA 10a EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr17:48,579,838...48,579,947
Ensembl chr17:48,579,838...48,579,947
JBrowse link
G MIR125A microRNA 125a EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339
JBrowse link
G MIR145 microRNA 145 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 5:149,430,646...149,430,733
Ensembl chr 5:149,430,646...149,430,733
JBrowse link
G MIR151A microRNA 151a ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 8:140,732,564...140,732,653
Ensembl chr 8:140,732,564...140,732,653
JBrowse link
G MIR181C microRNA 181c EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr19:13,874,699...13,874,808
Ensembl chr19:13,874,699...13,874,808
JBrowse link
G MIR181D microRNA 181d EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr19:13,874,875...13,875,011
Ensembl chr19:13,874,875...13,875,011
JBrowse link
G MIR183 microRNA 183 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:129,774,905...129,775,014
Ensembl chr 7:129,774,905...129,775,014
JBrowse link
G MIR186 microRNA 186 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:71,067,631...71,067,716
Ensembl chr 1:71,067,631...71,067,716
JBrowse link
G MIR18A microRNA 18a EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr13:91,350,751...91,350,821
Ensembl chr13:91,350,751...91,350,821
JBrowse link
G MIR193A microRNA 193a ISO miRNA:decreased expression:liver (mouse) RGD PMID:30165047 RGD:153323340 NCBI chr17:31,559,996...31,560,083
Ensembl chr17:31,559,996...31,560,083
JBrowse link
G MIR195 microRNA 195 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr17:7,017,615...7,017,701
Ensembl chr17:7,017,615...7,017,701
JBrowse link
G MIR196B microRNA 196b EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:27,169,480...27,169,563
Ensembl chr 7:27,169,480...27,169,563
JBrowse link
G MIR200B microRNA 200b EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:1,167,104...1,167,198
Ensembl chr 1:1,167,104...1,167,198
JBrowse link
G MIR206 microRNA 206 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 6:52,144,349...52,144,434
Ensembl chr 6:52,144,349...52,144,434
JBrowse link
G MIR212 microRNA 212 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr17:2,050,271...2,050,380
Ensembl chr17:2,050,271...2,050,380
JBrowse link
G MIR221 microRNA 221 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr  X:45,746,157...45,746,266
Ensembl chr  X:45,746,157...45,746,266
JBrowse link
G MIR26A1 microRNA 26a-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 3:37,969,404...37,969,480
Ensembl chr 3:37,969,404...37,969,480
JBrowse link
G MIR26B microRNA 26b EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 2:218,402,646...218,402,722
Ensembl chr 2:218,402,646...218,402,722
JBrowse link
G MIR300 microRNA 300 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr14:101,041,363...101,041,445
Ensembl chr14:101,041,363...101,041,445
JBrowse link
G MIR301A microRNA 301a EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr17:59,151,136...59,151,221
Ensembl chr17:59,151,136...59,151,221
JBrowse link
G MIR30A microRNA 30a EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 6:71,403,551...71,403,621
Ensembl chr 6:71,403,551...71,403,621
JBrowse link
G MIR30B microRNA 30b EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 8:134,800,520...134,800,607
Ensembl chr 8:134,800,520...134,800,607
JBrowse link
G MIR30D microRNA 30d EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 8:134,804,876...134,804,945
Ensembl chr 8:134,804,876...134,804,945
JBrowse link
G MIR30E microRNA 30e EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:40,754,355...40,754,446
Ensembl chr 1:40,754,355...40,754,446
JBrowse link
G MIR324 microRNA 324 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr17:7,223,297...7,223,379
Ensembl chr17:7,223,297...7,223,379
JBrowse link
G MIR331 microRNA 331 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr12:95,308,420...95,308,513
Ensembl chr12:95,308,420...95,308,513
JBrowse link
G MIR335 microRNA 335 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:130,496,111...130,496,204
Ensembl chr 7:130,496,111...130,496,204
JBrowse link
G MIR338 microRNA 338 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr17:81,125,883...81,125,949
Ensembl chr17:81,125,883...81,125,949
JBrowse link
G MIR339 microRNA 339 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:1,022,933...1,023,026
Ensembl chr 7:1,022,933...1,023,026
JBrowse link
G MIR340 microRNA 340 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 5:180,015,303...180,015,397
Ensembl chr 5:180,015,303...180,015,397
JBrowse link
G MIR34A microRNA 34a EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:9,151,668...9,151,777
Ensembl chr 1:9,151,668...9,151,777
JBrowse link
G MIR383 microRNA 383 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 8:14,853,438...14,853,510
Ensembl chr 8:14,853,438...14,853,510
JBrowse link
G MIR409 microRNA 409 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr14:101,065,300...101,065,378
Ensembl chr14:101,065,300...101,065,378
JBrowse link
G MIR429 microRNA 429 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:1,169,005...1,169,087
Ensembl chr 1:1,169,005...1,169,087
JBrowse link
G MIR483 microRNA 483 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr11:2,134,134...2,134,209
Ensembl chr11:2,134,134...2,134,209
JBrowse link
G MIR505 microRNA 505 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr  X:139,924,148...139,924,231
Ensembl chr  X:139,924,148...139,924,231
JBrowse link
G MIR539 microRNA 539 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr14:101,047,321...101,047,398
Ensembl chr14:101,047,321...101,047,398
JBrowse link
G MIR598 microRNA 598 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 8:11,035,206...11,035,302
Ensembl chr 8:11,035,206...11,035,302
JBrowse link
G MIR652 microRNA 652 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr  X:110,055,329...110,055,426
Ensembl chr  X:110,055,329...110,055,426
JBrowse link
G MIR671 microRNA 671 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 7:151,238,421...151,238,538
Ensembl chr 7:151,238,421...151,238,538
JBrowse link
G MIR708 microRNA 708 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr11:79,402,022...79,402,109
Ensembl chr11:79,402,022...79,402,109
JBrowse link
G MIR760 microRNA 760 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:93,846,832...93,846,911
Ensembl chr 1:93,846,832...93,846,911
JBrowse link
G MIR92B microRNA 92b EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 1:155,195,177...155,195,272
Ensembl chr 1:155,195,177...155,195,272
JBrowse link
G MIR98 microRNA 98 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr  X:53,556,223...53,556,341
Ensembl chr  X:53,556,223...53,556,341
JBrowse link
G MIR99B microRNA 99b EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr19:51,692,612...51,692,681
Ensembl chr19:51,692,612...51,692,681
JBrowse link
G MIRLET7B microRNA let-7b EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr22:46,113,686...46,113,768
Ensembl chr22:46,113,686...46,113,768
JBrowse link
G MIRLET7D microRNA let-7d EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr 9:94,178,834...94,178,920
Ensembl chr 9:94,178,834...94,178,920
JBrowse link
G MIRLET7E microRNA let-7e EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr19:51,692,786...51,692,864
Ensembl chr19:51,692,786...51,692,864
JBrowse link
G MIRLET7I microRNA let-7i EXP CTD Direct Evidence: marker/mechanism CTD PMID:21035526 NCBI chr12:62,603,686...62,603,769
Ensembl chr12:62,603,686...62,603,769
JBrowse link
G MMP2 matrix metallopeptidase 2 ISO
EXP
mRNA, protein:increased expression, increased activity:liver
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:30603057 PMID:19528495 PMID:19539802 RGD:2325736, RGD:2325734 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:liver RGD PMID:19528495 PMID:19539802 RGD:2325736, RGD:2325734 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPEG1 macrophage expressed 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr11:59,208,510...59,212,927
Ensembl chr11:59,208,510...59,212,927
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISO
EXP
mRNA:increased expression:liver (rat)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:9079223 PMID:11280770 PMID:18560566 PMID:3335218 RGD:10059623 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NOS2 nitric oxide synthase 2 ISO protein:increased expression:liver RGD PMID:10383909 RGD:2325277 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOTCH1 notch receptor 1 ISO protein:increased expression:liver RGD PMID:18942116 RGD:2325310 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO mRNA, protein:increased expression:liver (rat) RGD PMID:27867096 RGD:13442478 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 susceptibility ISO RGD PMID:17283114 RGD:14701032 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17172636 PMID:24769335 PMID:25656644 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
JBrowse link
G NRAS NRAS proto-oncogene, GTPase IMP human gene in mouse model RGD PMID:16286660 RGD:14975105 NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771
JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase ISO protein:decreased expression:liver RGD PMID:7929120 RGD:1642378 NCBI chr17:17,505,563...17,592,142
Ensembl chr17:17,505,563...17,591,708
JBrowse link
G PLCL1 phospholipase C like 1 (inactive) disease_progression ISO mRNA:increased expression:liver (rat) RGD PMID:19533683 RGD:2315050 NCBI chr 2:197,804,593...198,149,863
Ensembl chr 2:197,804,593...198,572,581
JBrowse link
G PML PML nuclear body scaffold EXP CTD Direct Evidence: therapeutic CTD PMID:20377131 NCBI chr15:73,994,716...74,047,827
Ensembl chr15:73,994,673...74,047,827
JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase EXP CTD Direct Evidence: marker/mechanism CTD PMID:761203 NCBI chr 4:56,393,362...56,435,615
Ensembl chr 4:56,393,362...56,435,615
JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha ISO mRNA:increased expression:liver (rat) RGD PMID:2562181 RGD:8693574 NCBI chr 5:134,194,332...134,226,073
Ensembl chr 5:134,194,035...134,226,073
JBrowse link
G PRDX1 peroxiredoxin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27517622 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732
JBrowse link
G PTGR1 prostaglandin reductase 1 ISO protein:increased expression:liver RGD PMID:24853774 RGD:14401713 NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G RAD51 RAD51 recombinase ISO protein:decreased expression:liver RGD PMID:17219426 RGD:2292638 NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340
JBrowse link
G RB1 RB transcriptional corepressor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17854601 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RGN regucalcin EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr  X:47,078,443...47,093,313
Ensembl chr  X:47,078,355...47,093,314
JBrowse link
G RIDA reactive intermediate imine deaminase A homolog ISO protein:increased expression:liver (rat) RGD PMID:12939504 RGD:9685719 NCBI chr 8:98,102,344...98,117,171
Ensembl chr 8:98,102,344...98,117,171
JBrowse link
G RRAS2 RAS related 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21147764 NCBI chr11:14,277,920...14,364,506
Ensembl chr11:14,277,922...14,364,506
JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO RGD PMID:15224347 RGD:2316863 NCBI chr11:4,094,685...4,138,932
Ensembl chr11:4,094,707...4,138,932
JBrowse link
G RXRA retinoid X receptor alpha ISO mRNA, protein:decreased expression:liver RGD PMID:17786350 RGD:1643105 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G SERPINA1 serpin family A member 1 ISO RGD PMID:10569800 RGD:1626391 NCBI chr14:94,376,747...94,390,635
Ensembl chr14:94,376,747...94,390,693
JBrowse link
G SLC31A1 solute carrier family 31 member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23792645 NCBI chr 9:113,221,544...113,264,492
Ensembl chr 9:113,221,544...113,264,492
JBrowse link
G SLC7A5 solute carrier family 7 member 5 ISO mRNA:increased expression:liver RGD PMID:17498859 RGD:151357003 NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507
JBrowse link
G SOCS1 suppressor of cytokine signaling 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15197228 NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204
JBrowse link
G SOX4 SRY-box transcription factor 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21147764 NCBI chr 6:21,593,751...21,598,619
Ensembl chr 6:21,593,751...21,598,619
JBrowse link
G SPP1 secreted phosphoprotein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
JBrowse link
G SQLE squalene epoxidase EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr 8:124,998,505...125,022,283
Ensembl chr 8:124,998,497...125,022,283
JBrowse link
G STAT3 signal transducer and activator of transcription 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26297436 PMID:28100771 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,540
JBrowse link
G TEK TEK receptor tyrosine kinase EXP CTD Direct Evidence: marker/mechanism CTD PMID:11956651 NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174
JBrowse link
G TGFA transforming growth factor alpha ISO
EXP
protein:increased expression:liver
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:9079223 PMID:16734725 RGD:2317490 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
JBrowse link
G TGFB1 transforming growth factor beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28100771 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TK1 thymidine kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11420682 NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233
JBrowse link
G TNF tumor necrosis factor treatment
disease_progression
EXP
IMP
ISO
CTD Direct Evidence: marker/mechanism
Morris hepatoma
protein:increased expression:blood serum (mouse)
CTD
RGD
PMID:28100771 PMID:9063767 PMID:26569409 RGD:14696818, RGD:11344640 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b EXP CTD Direct Evidence: therapeutic CTD PMID:18079962 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031
JBrowse link
G TP53 tumor protein p53 ISO
EXP
CTD Direct Evidence: marker/mechanism CTD PMID:10626228 PMID:28100771 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TSC22D1 TSC22 domain family member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15833021 PMID:17533171 NCBI chr13:44,432,143...44,577,344
Ensembl chr13:44,432,143...44,577,147
JBrowse link
G VIM vimentin ISO RGD PMID:19199359 RGD:6480440 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G XDH xanthine dehydrogenase ISO protein:decreased expression:liver RGD PMID:3460692 RGD:13210515 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 22115
    disease of cellular proliferation 8476
      Experimental Neoplasms 521
        Experimental Liver Neoplasms 165
Path 2
Term Annotations click to browse term
  disease 22115
    disease of anatomical entity 20683
      gastrointestinal system disease 6871
        hepatobiliary disease 2843
          liver disease 2725
            Liver Neoplasms 1190
              Experimental Liver Neoplasms 165
paths to the root