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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Peripheral Nerve Injuries
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Accession:DOID:9001240 term browser browse the term
Definition:Injuries to the PERIPHERAL NERVES.
Synonyms:exact_synonym: Peripheral Nerve Injury
 primary_id: MESH:D059348
 xref: EFO:0009510


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Peripheral Nerve Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Ank3 ankyrin 3, epithelial ISO mRNA:decreased expression:neuron RGD PMID:10915577 RGD:6767305 NCBI chr10:69,234,608...69,863,266
Ensembl chr10:69,234,603...69,863,268 		JBrowse link
G Apoa4 apolipoprotein A-IV ISO protein:increased expression:sciatic nerve (rat) RGD PMID:2120218 RGD:2311210 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757 		JBrowse link
G Apoe apolipoprotein E ISO mouse model treated with human peptide
protein:increased expression:sciatic nerve (rat)		 RGD PMID:20406857 PMID:2419900 RGD:6906874, RGD:6906875 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO
IEP		 mRNA,protein:increased expression:fourth lumbar dorsal root ganglion:
mRNA,protein:increased expression:spinal dorsal horn:		 RGD PMID:11425916 PMID:23466809 RGD:8657088, RGD:8657102 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Capn2 calpain 2 ISO RGD PMID:25150005 RGD:13792585 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173 		JBrowse link
G Cbl Casitas B-lineage lymphoma ISO mRNA:increased expression:spinal cord RGD PMID:30021515 RGD:126925240 NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346 		JBrowse link
G Cblb Casitas B-lineage lymphoma b ISO mRNA:increased expression:spinal cord RGD PMID:30021515 RGD:126925240 NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO L5 spinal nerve;proein:increased expression:rostral ventrolateral medulla (rat) RGD PMID:22466130 RGD:8549494 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Chl1 cell adhesion molecule L1-like ISO mRNA, protein:increased expression:dorsal root ganglia (rat) RGD PMID:21452236 RGD:6483040 NCBI chr 6:103,487,372...103,709,999
Ensembl chr 6:103,487,547...103,727,172 		JBrowse link
G Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5 ISO protein:increased expression:spinal nerve RGD PMID:15652389 RGD:150530460 NCBI chr 9:54,888,112...54,918,704
Ensembl chr 9:54,888,164...54,915,063 		JBrowse link
G Dag1 dystroglycan 1 ISO RGD PMID:16254495 RGD:11541065 NCBI chr 9:108,082,060...108,141,176
Ensembl chr 9:108,081,833...108,141,157 		JBrowse link
G Ephb2 Eph receptor B2 ISO mRNA,protein:increased expression:dorsal root ganglion RGD PMID:32149862 RGD:127285658 NCBI chr 4:136,374,850...136,563,637
Ensembl chr 4:136,374,850...136,563,299 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ameliorates ISO RGD PMID:23437108 RGD:405650403 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Gh growth hormone treatment ISO RGD PMID:21945950 RGD:10003150 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691 		JBrowse link
G Hhip Hedgehog-interacting protein ISO RGD PMID:19515211 RGD:11552601 NCBI chr 8:80,692,480...80,784,637
Ensembl chr 8:80,692,480...80,784,635 		JBrowse link
G Hspa5 heat shock protein 5 ISO mRNA:increased expression RGD PMID:21940431 RGD:5685664 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 ISO protein:decreased expression: : RGD PMID:21693130 RGD:6480665 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:23000553 RGD:8655963 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta ISO tibial and peroneal nerves RGD PMID:23121415 RGD:7204126 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:21492407 RGD:10402827 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha ISO RGD PMID:21492407 RGD:10402827 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Irf5 interferon regulatory factor 5 ISO protein:increased expression:spinal dorsal horn RGD PMID:29927790 RGD:40924654 NCBI chr 6:29,526,129...29,541,874
Ensembl chr 6:29,526,624...29,541,870 		JBrowse link
G Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1 ISO protein:decreased expression:tibial nerve, motor neuron, neuronal cell body (rat) RGD PMID:24355600 RGD:126908004 NCBI chr 2:166,937,889...167,032,088
Ensembl chr 2:166,937,889...167,032,075 		JBrowse link
G L1cam L1 cell adhesion molecule IMP
ISO		 RGD PMID:21376041 PMID:17640175 RGD:6483044, RGD:6483092 NCBI chr  X:72,897,384...72,924,843
Ensembl chr  X:72,897,384...72,939,711 		JBrowse link
G Mir96 microRNA 96 ISO RNA:altered expression:dorsal root ganglion: RGD PMID:19699278 RGD:11553934 NCBI chr 6:30,169,445...30,169,550
Ensembl chr 6:30,169,445...30,169,550 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:17027671 RGD:2325934 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mmp7 matrix metallopeptidase 7 ISO RGD PMID:17027671 RGD:2325934 NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,587 		JBrowse link
G Ngf nerve growth factor treatment ISO mRNA,protein:increased expression:sciatic nerve: RGD PMID:11425916 PMID:22669154 PMID:27392124 RGD:8657088, RGD:10413899, RGD:405100230 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) treatment ISO RGD PMID:22669154 PMID:22302815 RGD:10413899, RGD:10413905 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Nog noggin treatment IMP RGD PMID:17258709 RGD:10428775 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158 		JBrowse link
G Nts neurotensin ISO mRNA,protein:increased expression:neuron: RGD PMID:8866516 RGD:9743915 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347 		JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 sexual_dimorphism ISO in male rat; protein:increased expression:microglia RGD PMID:29927790 RGD:40924654 NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801 		JBrowse link
G Plau plasminogen activator, urokinase ISO Cavernous Nerve Injury; mRNA:increased expression:pelvic ganglion (rat) RGD PMID:22300381 RGD:7241556 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Procr protein C receptor, endothelial IEP RGD PMID:27771530 RGD:13515125 NCBI chr 2:155,592,159...155,597,391
Ensembl chr 2:155,593,037...155,597,391 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 disease_progression ISO RGD PMID:14576556 RGD:5688234 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression: RGD PMID:14871450 PMID:14871450 RGD:5688227, RGD:5688227 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Reg3b regenerating islet-derived 3 beta ISO mRNA:increased expression:hypoglossal nerve (rat) RGD PMID:15896308 RGD:9831386 NCBI chr 6:78,347,868...78,350,449
Ensembl chr 6:78,347,640...78,350,449 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 ISO mRNA:increased expression:pelvic ganglion (rat) RGD PMID:22300381 RGD:7241556 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Shh sonic hedgehog ISO RGD PMID:22994531 RGD:12879407 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:dorsal root ganglion:
protein:increased expression:nucleus accumbens		 RGD PMID:19543754 PMID:24845379 RGD:7394752, RGD:10450588 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 ISO protein:increased expression:dorsal root ganglion: RGD PMID:18514429 RGD:10043379 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16193
    Wounds and Injuries 995
      Nerve Injuries 46
        Peripheral Nerve Injuries 42
Path 2
Term Annotations click to browse term
  disease 16193
    disease of anatomical entity 15759
      nervous system disease 13651
        Nervous System Trauma 603
          Peripheral Nerve Injuries 42
paths to the root