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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Peripheral Nerve Injuries
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Accession:DOID:9001240 term browser browse the term
Definition:Injuries to the PERIPHERAL NERVES.
Synonyms:exact_synonym: Peripheral Nerve Injury
 primary_id: MESH:D059348;   RDO:0010009
For additional species annotation, visit the Alliance of Genome Resources.


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Peripheral Nerve Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Ank3 ankyrin 3 IEP mRNA:decreased expression:neuron RGD PMID:10915577 RGD:6767305 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Apoa4 apolipoprotein A4 IEP protein:increased expression:sciatic nerve (rat) RGD PMID:2120218 RGD:2311210 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoe apolipoprotein E ISO
IEP
mouse model treated with human peptide
protein:increased expression:sciatic nerve (rat)
RGD PMID:20406857, PMID:2419900 RGD:6906874, RGD:6906875 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Bdnf brain-derived neurotrophic factor IEP
ISO
mRNA,protein:increased expression:fourth lumbar dorsal root ganglion:
mRNA,protein:increased expression:spinal dorsal horn:
RGD PMID:11425916, PMID:23466809 RGD:8657088, RGD:8657102 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Capn2 calpain 2 IEP RGD PMID:25150005 RGD:13792585 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP L5 spinal nerve;proein:increased expression:rostral ventrolateral medulla (rat) RGD PMID:22466130 RGD:8549494 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Chl1 cell adhesion molecule L1-like IEP
IMP
mRNA, protein:increased expression:dorsal root ganglia (rat) RGD PMID:21452236, PMID:21452236 RGD:6483040, RGD:6483040 NCBI chr 4:70,269,414...70,331,313
Ensembl chr 4:70,252,366...70,330,803
JBrowse link
G Dag1 dystroglycan 1 IEP RGD PMID:16254495 RGD:11541065 NCBI chr 8:116,980,501...116,993,182
Ensembl chr 8:116,980,497...116,993,193
JBrowse link
G Gh1 growth hormone 1 treatment ISO RGD PMID:21945950 RGD:10003150 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Hhip Hedgehog-interacting protein IEP RGD PMID:19515211 RGD:11552601 NCBI chr19:31,525,134...31,614,487
Ensembl chr19:31,524,671...31,614,246
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEP mRNA:increased expression RGD PMID:21940431 RGD:5685664 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IEP protein:decreased expression: : RGD PMID:21693130 RGD:6480665 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Il18 interleukin 18 IEP RGD PMID:23000553 RGD:8655963 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta IDA tibial and peroneal nerves RGD PMID:23121415 RGD:7204126 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 IEP RGD PMID:21492407 RGD:10402827 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor IEP RGD PMID:21492407 RGD:10402827 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G L1cam L1 cell adhesion molecule ISO
IDA
RGD PMID:21376041, PMID:17640175 RGD:6483044, RGD:6483092 NCBI chr  X:156,901,244...156,928,064
Ensembl chr  X:156,909,913...156,928,057
JBrowse link
G Mir96 microRNA 96 IEP RNA:altered expression:dorsal root ganglion: RGD PMID:19699278 RGD:11553934 NCBI chr 4:57,463,366...57,463,471
Ensembl chr 4:57,463,366...57,463,471
JBrowse link
G Mmp3 matrix metallopeptidase 3 IEP RGD PMID:17027671 RGD:2325934 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp7 matrix metallopeptidase 7 IEP RGD PMID:17027671 RGD:2325934 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Ngf nerve growth factor IEP mRNA,protein:increased expression:sciatic nerve: RGD PMID:11425916 RGD:8657088 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ngfr nerve growth factor receptor treatment IDA
IEP
RGD PMID:22669154, PMID:22302815 RGD:10413899, RGD:10413905 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nog noggin treatment ISO RGD PMID:17258709 RGD:10428775 NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386
JBrowse link
G Nts neurotensin IEP mRNA,protein:increased expression:neuron: RGD PMID:8866516 RGD:9743915 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Plau plasminogen activator, urokinase IEP Cavernous Nerve Injury; mRNA:increased expression:pelvic ganglion (rat) RGD PMID:22300381 RGD:7241556 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Procr protein C receptor IEP RGD PMID:27771530 RGD:13515125 NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 disease_progression IEP RGD PMID:14576556 RGD:5688234 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP
ISO
protein:increased expression: RGD PMID:14871450, PMID:14871450 RGD:5688227, RGD:5688227 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Reg3b regenerating family member 3 beta IEP mRNA:increased expression:hypoglossal nerve (rat) RGD PMID:15896308 RGD:9831386 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Serpinf1 serpin family F member 1 IEP mRNA:increased expression:pelvic ganglion (rat) RGD PMID:22300381 RGD:7241556 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Shh sonic hedgehog signaling molecule IEP RGD PMID:22994531 RGD:12879407 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Tnf tumor necrosis factor IEP protein:increased expression:dorsal root ganglion:
protein:increased expression:nucleus accumbens
RGD PMID:19543754, PMID:24845379 RGD:7394752, RGD:10450588 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IEP protein:increased expression:dorsal root ganglion: RGD PMID:18514429 RGD:10043379 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    Wounds and Injuries 835
      Nerve Injuries 38
        Peripheral Nerve Injuries 34
Path 2
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      nervous system disease 10897
        Nervous System Trauma 531
          Peripheral Nerve Injuries 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.