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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Anorexia
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Accession:DOID:9001109 term browser browse the term
Definition:The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.
Synonyms:exact_synonym: Anorexias
 primary_id: MESH:D000855


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Anorexia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IMP RGD PMID:6534893 RGD:10047083 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835 		JBrowse link
G Cck cholecystokinin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22903826 PMID:24385417 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Crh corticotropin releasing hormone IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16420149 PMID:12429558 RGD:704394 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16420149 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17627984 PMID:17050037 RGD:5131264 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Dbh dopamine beta-hydroxylase IMP RGD PMID:20554938 RGD:5129235 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Gcg glucagon ISO CTD Direct Evidence: marker/mechanism CTD PMID:21824258 PMID:28633506 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO RGD PMID:15788704 RGD:1642818 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Gip gastric inhibitory polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:28633506 PMID:28666375 PMID:29689362 NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503 		JBrowse link
G Gpx1 glutathione peroxidase 1 treatment ISO associated with Uremia RGD PMID:12005352 RGD:11352773 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B IEP associated with Sarcoma;protein:increased expression:hypothalamus RGD PMID:15698923 RGD:1626473 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15146954 NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321 		JBrowse link
G Il1a interleukin 1 alpha IEP associated with Sarcoma, Experimental;protein:increased expression:cerebrospinal fluid RGD PMID:8748250 RGD:7794755 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta IEP
ISO		 mRNA:increased expression:hypothalamus
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12077204 PMID:25392278 PMID:22902858 RGD:13825124 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist IEP
ISO		 associated with Adenocarcinoma;mRNA:increased expression:cerebral cortex, hypothalamus (rat)
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:25392278 PMID:9688694 RGD:8551744 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8635092 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Npsr1 neuropeptide S receptor 1 IMP RGD PMID:19821837 RGD:9835045 NCBI chr 8:22,606,946...22,831,558
Ensembl chr 8:22,606,946...22,831,558 		JBrowse link
G Npy neuropeptide Y IEP
ISO		 associated with Neoplasms
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16084549 PMID:16101753 PMID:25825358 PMID:17234300 RGD:10448965 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 IEP associated with Neoplasms;mRNA, protein:decreased expression:hypothalamus RGD PMID:17234300 RGD:10448965 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 treatment IDA RGD PMID:11981590 RGD:9835031 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 treatment IMP RGD PMID:22902858 RGD:13825124 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pyy peptide YY ISO CTD Direct Evidence: marker/mechanism CTD PMID:22903826 PMID:29689362 NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815 		JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30336258 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25392278 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b ISO CTD Direct Evidence: marker/mechanism CTD PMID:19652058 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO CTD Direct Evidence: therapeutic CTD PMID:18801959 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Ucn2 urocortin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17627984 NCBI chr 8:109,637,624...109,639,173
Ensembl chr 8:109,638,285...109,639,172 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    Pathological Conditions, Signs and Symptoms 13331
      Signs and Symptoms 10807
        Digestive Signs and Symptoms 195
          Anorexia 27
            FACES Syndrome 0
paths to the root