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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Anorexia
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Accession:DOID:9001109 term browser browse the term
Definition:The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.
Synonyms:exact_synonym: Anorexias
 primary_id: MESH:D000855


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Anorexia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IMP RGD PMID:6534893 RGD:10047083 NCBI chr10:7,503,351...7,599,474
Ensembl chr10:7,492,022...7,599,474 		JBrowse link
G Cck cholecystokinin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22903826 PMID:24385417 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686 		JBrowse link
G Crh corticotropin releasing hormone induces IDA
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16420149 PMID:12429558 PMID:11981590 RGD:704394, RGD:9835031 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16420149 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,540,192...89,583,466 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IDA
ISO 		CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17627984 PMID:17050037 RGD:5131264 NCBI chr 4:85,553,163...85,596,203
Ensembl chr 4:85,554,268...85,596,318 		JBrowse link
G Dbh dopamine beta-hydroxylase IMP RGD PMID:20554938 RGD:5129235 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:30,886,328...30,903,316 		JBrowse link
G Gcg glucagon ISO CTD Direct Evidence: marker/mechanism CTD PMID:21824258 PMID:28633506 NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:67,522,489...67,531,533 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO RGD PMID:15788704 RGD:1642818 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969 		JBrowse link
G Gip gastric inhibitory polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:28633506 PMID:28666375 PMID:29689362 NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216 		JBrowse link
G Gpx1 glutathione peroxidase 1 treatment ISO associated with Uremia RGD PMID:12005352 RGD:11352773 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B IEP associated with Sarcoma;protein:increased expression:hypothalamus RGD PMID:15698923 RGD:1626473 NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:91,052,432...91,418,583 		JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15146954 NCBI chr18:58,036,277...58,221,327
Ensembl chr18:58,036,277...58,219,622 		JBrowse link
G Il1a interleukin 1 alpha IEP associated with Sarcoma, Experimental;protein:increased expression:cerebrospinal fluid RGD PMID:8748250 RGD:7794755 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta IEP
ISO 		mRNA:increased expression:hypothalamus
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:12077204 PMID:25392278 PMID:22902858 RGD:13825124 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist IEP
ISO 		associated with Adenocarcinoma;mRNA:increased expression:cerebral cortex, hypothalamus (rat)
CTD Direct Evidence: therapeutic 		CTD
RGD		 PMID:25392278 PMID:9688694 RGD:8551744 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il2 interleukin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8635092 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Npsr1 neuropeptide S receptor 1 IMP RGD PMID:19821837 RGD:9835045 NCBI chr 8:30,882,830...31,107,425
Ensembl chr 8:30,882,830...31,107,425 		JBrowse link
G Npy neuropeptide Y IEP
ISO 		associated with Neoplasms
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:16084549 PMID:16101753 PMID:25825358 PMID:17234300 RGD:10448965 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 IEP associated with Neoplasms;mRNA, protein:decreased expression:hypothalamus RGD PMID:17234300 RGD:10448965 NCBI chr16:27,804,416...27,814,070
Ensembl chr16:27,804,416...27,813,387 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 treatment IDA RGD PMID:11981590 RGD:9835031 NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:189,212,175...189,217,426 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 treatment IMP RGD PMID:22902858 RGD:13825124 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Pyy peptide YY ISO CTD Direct Evidence: marker/mechanism CTD PMID:22903826 PMID:29689362 NCBI chr10:87,561,347...87,562,470
Ensembl chr10:87,561,353...87,562,206 		JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30336258 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25392278 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b ISO CTD Direct Evidence: marker/mechanism CTD PMID:19652058 NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO CTD Direct Evidence: therapeutic CTD PMID:18801959 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Ucn2 urocortin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17627984 NCBI chr 8:118,516,111...118,517,660
Ensembl chr 8:118,483,364...118,517,439 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    Pathological Conditions, Signs and Symptoms 13667
      Signs and Symptoms 11198
        Digestive Signs and Symptoms 202
          Anorexia 27
            FACES Syndrome 0
paths to the root