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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Viral Skin Diseases
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Accession:DOID:9001063 term browser browse the term
Definition:Skin diseases caused by viruses.
Synonyms:exact_synonym: Viral Skin Disease
 primary_id: MESH:D017193;   RDO:0005546


show annotations for term's descendants           Sort by:
anogenital venereal wart term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL20 C-C motif chemokine ligand 20 ISO protein:decreased expression:skin RGD PMID:17545018 RGD:7483603 NCBI chr15:129,172,743...129,176,069 JBrowse link
G CD8A CD8 subunit alpha ISO mRNA:decreased expression:zone of skin (human) RGD PMID:25774455 RGD:36174028 NCBI chr 3:57,999,228...58,029,768
Ensembl chr 3:57,998,891...58,029,760 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103 		JBrowse link
G FOXP3 forkhead box P3 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,785...43,322,968 		JBrowse link
G IL10 interleukin 10 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL12B interleukin 12B treatment ISO protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:16114559 PMID:23754510 RGD:40400714 RGD:7829774 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929 		JBrowse link
G IL2 interleukin 2 ISO protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G IL21 interleukin 21 ISO protein:decreased expression:blood serum (human) RGD PMID:31414711 RGD:127285371 NCBI chr 8:101,532,742...101,540,712
Ensembl chr 8:101,532,531...101,541,713 		JBrowse link
G IL4 interleukin 4 treatment ISO protein:increased expression:peripheral blood mononuclear cells (human) RGD PMID:16114559 PMID:23754510 RGD:40400714 RGD:7829774 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G IL6 interleukin 6 ISO protein:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 ISO mRNA,protein:decreased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 5:61,646,691...61,655,386
Ensembl chr 5:61,647,043...61,656,192 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 treatment ISO mRNA:increased expression:zone of skin (human) RGD PMID:25774455 RGD:36174028 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G NCR1 natural cytotoxicity triggering receptor 1 ISO mRNA,protein:decreased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 6:59,092,258...59,099,992
Ensembl chr 6:59,092,911...59,099,990 		JBrowse link
G PDCD1 programmed cell death 1 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr15:140,337,353...140,347,493
Ensembl chr15:140,336,258...140,347,478 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISO protein:increased expression:foreskin RGD PMID:18543080 RGD:39128248 NCBI chr14:39,202,165...39,292,041
Ensembl chr14:39,202,169...39,292,003 		JBrowse link
G PTPN6 protein tyrosine phosphatase non-receptor type 6 ISO protein:increased expression:foreskin RGD PMID:18543080 RGD:39128248 NCBI chr 5:63,762,109...63,779,086
Ensembl chr 5:63,762,112...63,808,350 		JBrowse link
G SERPINF1 serpin family F member 1 disease_progression ISO mRNA, protein:decreased expression:skin of body (human) RGD PMID:23569025 RGD:27226706 NCBI chr12:47,949,004...47,959,471
Ensembl chr12:47,948,510...47,959,470 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
G TLR2 toll like receptor 2 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TLR3 toll like receptor 3 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,969,006...46,979,291 		JBrowse link
G TLR4 toll like receptor 4 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR7 toll like receptor 7 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:9,573,178...9,576,987 JBrowse link
G TLR8 toll like receptor 8 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr  X:9,551,284...9,616,762
Ensembl chr  X:9,597,604...9,616,757 		JBrowse link
G TLR9 toll like receptor 9 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:peripheral blood mononuclear cells (human) RGD PMID:23754510 RGD:40400714 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G TNFRSF18 TNF receptor superfamily member 18 ISO mRNA,protein:increased expression:multiple (human) RGD PMID:23754510 RGD:40400714 NCBI chr 6:63,516,037...63,519,323
Ensembl chr 6:63,516,045...63,518,405 		JBrowse link
bowenoid papulosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIRC3 baculoviral IAP repeat containing 3 ISO mRNA:increased expression:perianal skin (human) RGD PMID:20346172 RGD:152998971 NCBI chr 9:33,003,570...33,020,252
Ensembl chr 9:33,003,276...33,020,242 		JBrowse link
G LOC100622859 baculoviral IAP repeat-containing protein 2 ISO mRNA:increased expression:perianal skin (human) RGD PMID:20346172 RGD:152998971 NCBI chr 9:33,041,592...33,062,865
Ensembl chr 9:33,041,663...33,062,854 		JBrowse link
eczema herpeticum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDO1 indoleamine 2,3-dioxygenase 1 severity ISO associated with atopic dermatitis; protein:increased activity:serum (human) RGD PMID:26198597 RGD:11528429 NCBI chr17:9,245,283...9,260,140
Ensembl chr17:9,245,196...9,260,473 		JBrowse link
G IFNG interferon gamma susceptibility ISO DNA:haplotype::
mRNA,protein:decreased expression:peripheral mononuclear cell:		 RGD PMID:21458658 RGD:6480259 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
epidermodysplasia verruciformis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TMC6 transmembrane channel like 6 ISO ClinVar Annotator: match by term: Epidermodysplasia verruciformis ClinVar PMID:9536098 PMID:12426567 PMID:15042430 PMID:16199547 PMID:17139267 More... NCBI chr12:3,825,374...3,848,367
Ensembl chr12:3,825,443...3,844,624 		JBrowse link
G TMC8 transmembrane channel like 8 ISO ClinVar Annotator: match by term: Epidermodysplasia verruciformis ClinVar PMID:9536098 PMID:10084299 PMID:12426567 PMID:16045695 PMID:16199547 More... NCBI chr12:3,802,344...3,837,413
Ensembl chr12:3,817,049...3,837,363 		JBrowse link
G TNRC6C trinucleotide repeat containing adaptor 6C ISO ClinVar Annotator: match by term: Epidermodysplasia verruciformis ClinVar PMID:28492532 NCBI chr12:3,847,522...3,939,054
Ensembl chr12:3,847,901...3,935,368 		JBrowse link
Epidermodysplasia Verruciformis 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TMC6 transmembrane channel like 6 susceptibility ISO ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 1 | ClinVar Annotator: match by term: TMC6-related condition ClinVar
OMIM		 PMID:9536098 PMID:12426567 PMID:15042430 PMID:16199547 PMID:17139267 More... NCBI chr12:3,825,374...3,848,367
Ensembl chr12:3,825,443...3,844,624 		JBrowse link
G TMC8 transmembrane channel like 8 ISO ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 1 ClinVar PMID:9536098 PMID:12426567 PMID:17576681 PMID:22158547 PMID:25741868 More... NCBI chr12:3,802,344...3,837,413
Ensembl chr12:3,817,049...3,837,363 		JBrowse link
Epidermodysplasia Verruciformis 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TMC6 transmembrane channel like 6 ISO ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 2 ClinVar PMID:9536098 PMID:17576681 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr12:3,825,374...3,848,367
Ensembl chr12:3,825,443...3,844,624 		JBrowse link
G TMC8 transmembrane channel like 8 susceptibility ISO ClinVar Annotator: match by term: Epidermodysplasia verruciformis 2 | ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 2 ClinVar
OMIM		 PMID:9536098 PMID:10084299 PMID:12426567 PMID:17576681 PMID:22158547 More... NCBI chr12:3,802,344...3,837,413
Ensembl chr12:3,817,049...3,837,363 		JBrowse link
Epidermodysplasia Verruciformis 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CIB1 calcium and integrin binding 1 susceptibility ISO ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 3 ClinVar
OMIM		 PMID:228581 PMID:19702156 PMID:20982046 PMID:21196704 PMID:28492532 More... NCBI chr 7:55,794,834...55,798,666
Ensembl chr 7:55,794,836...55,798,590 		JBrowse link
Epidermodysplasia Verruciformis 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RHOH ras homolog family member H susceptibility ISO ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 4 OMIM
ClinVar		 PMID:22850876 PMID:25741868 PMID:28492532 NCBI chr 8:31,321,005...31,372,366
Ensembl chr 8:31,321,059...31,372,364 		JBrowse link
Epidermodysplasia Verruciformis 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL7 interleukin 7 susceptibility ISO ClinVar Annotator: match by term: Epidermodysplasia verruciformis, susceptibility to, 5 OMIM
ClinVar		 PMID:25981006 NCBI chr 4:57,677,895...57,744,713
Ensembl chr 4:57,684,796...57,744,709 		JBrowse link
genital herpes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 ISO RGD PMID:12502811 RGD:4890015 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 exacerbates ISO RGD PMID:28264883 RGD:125093738 NCBI chr13:196,925,731...196,951,398
Ensembl chr13:196,925,734...196,952,239 		JBrowse link
G IFNG interferon gamma ISO protein:increased expression:vaginal secretion: RGD PMID:10366565 RGD:8158034 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL21 interleukin 21 treatment ISO RGD PMID:24358128 RGD:127285365 NCBI chr 8:101,532,742...101,540,712
Ensembl chr 8:101,532,531...101,541,713 		JBrowse link
G IRF9 interferon regulatory factor 9 exacerbates ISO RGD PMID:28264883 RGD:125093738 NCBI chr 7:75,133,800...75,139,641
Ensembl chr 7:75,126,622...75,139,640 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 ameliorates ISO RGD PMID:31555293 RGD:42722615 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G RNASEL ribonuclease L severity ISO RGD PMID:17157346 RGD:40902623 NCBI chr 9:123,895,045...123,910,386
Ensembl chr 9:123,893,294...123,910,398 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 treatment
severity		 ISO DNA:SNP:intron:rs7572482 (human)
DNA:SNPs, haplotype: :multiple		 RGD PMID:22718836 RGD:8661697 NCBI chr15:95,656,206...95,764,099
Ensembl chr15:95,656,077...95,763,472 		JBrowse link
herpes simplex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E ISO RGD PMID:17101197 RGD:7771596 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G C3 complement C3 ISO RGD PMID:11509581 RGD:7401276 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO mRNA:increased expression:cornea (mouse) RGD PMID:9544579 RGD:8549472 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CD274 CD274 molecule ISO RGD PMID:29669784 RGD:41412169 NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724 		JBrowse link
G CD40LG CD40 ligand ISO RGD PMID:11134274 RGD:8547770 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,709 		JBrowse link
G CD8A CD8 subunit alpha ISO mRNA:increased expression:trigeminal ganglion (mouse) RGD PMID:19151393 RGD:124715454 NCBI chr 3:57,999,228...58,029,768
Ensembl chr 3:57,998,891...58,029,760 		JBrowse link
G DOCK8 dedicator of cytokinesis 8 severity ISO RGD PMID:25776845 RGD:11055046 NCBI chr 1:221,257,771...221,491,889
Ensembl chr 1:221,256,009...221,491,953 		JBrowse link
G IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 ISO RGD PMID:30050136 RGD:40902865 NCBI chr12:25,196,955...25,244,660
Ensembl chr12:25,197,058...25,243,272 		JBrowse link
G IL18 interleukin 18 treatment ISO RGD PMID:9971824 RGD:8655923 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL21 interleukin 21 treatment ISO mRNA:increased expression:spleen (mouse) RGD PMID:16406655 PMID:19233474 RGD:127285367 RGD:127285372 NCBI chr 8:101,532,742...101,540,712
Ensembl chr 8:101,532,531...101,541,713 		JBrowse link
G IL33 interleukin 33 ISO protein:increased expression:skin RGD PMID:26872602 RGD:39939003 NCBI chr 1:215,899,830...215,941,944
Ensembl chr 1:215,899,436...215,941,840 		JBrowse link
G IRF5 interferon regulatory factor 5 susceptibility ISO associated with multiple sclerosis;DNA:SNP: :rs3807306 (human) RGD PMID:20861862 RGD:40924643 NCBI chr18:19,678,377...19,691,154
Ensembl chr18:19,678,687...19,691,243 		JBrowse link
G MBL2 mannose binding lectin 2 disease_progression
susceptibility		 ISO DNA:polymorphism:cds: RGD PMID:15498041 PMID:19480845 RGD:8693725 RGD:8693727 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083 		JBrowse link
G NECTIN1 nectin cell adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10729168 NCBI chr 9:46,823,552...46,891,564
Ensembl chr 9:46,789,726...46,891,304 		JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10729168 PMID:11602758 PMID:30319691 NCBI chr 6:51,317,386...51,358,665 JBrowse link
G PCD1B CD1B antigen exacerbates ISO RGD PMID:18614643 RGD:127345112 NCBI chr 4:92,035,122...92,040,724
Ensembl chr 4:92,031,712...92,040,742 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 exacerbates ISO RGD PMID:25316792 PMID:30050136 RGD:127229943 RGD:40902865 NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251 		JBrowse link
G RPL30 ribosomal protein L30 ISO protein:increased serine phosphorylation:ribosome RGD PMID:7588575 RGD:11039399 NCBI chr 4:38,702,220...38,720,420
Ensembl chr 4:38,701,720...38,720,780 		JBrowse link
Herpes Simplex Encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E susceptibility ISO DNA:polymorphism:exon: RGD PMID:11118260 RGD:7771554 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G AQP4 aquaporin 4 ISO RGD PMID:17454447 RGD:8698664 NCBI chr 6:111,407,632...111,422,169
Ensembl chr 6:111,407,639...111,422,109 		JBrowse link
G CALCB calcitonin-related polypeptide beta treatment ISO RGD PMID:22761571 RGD:7240516 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G CALCR calcitonin receptor treatment ISO RGD PMID:22761571 RGD:7240516 NCBI chr 9:73,279,874...73,403,516
Ensembl chr 9:73,279,879...73,403,436 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:22377584 RGD:8661752 NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,285,012...29,376,343 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO RGD PMID:23391218 RGD:8551839 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:22377584 RGD:8661752 NCBI chr13:23,944,386...23,957,567
Ensembl chr13:23,944,369...23,957,486 		JBrowse link
G GDNF glial cell derived neurotrophic factor ISO mRNA:increased expression:brain: RGD PMID:15950786 RGD:8657070 NCBI chr16:22,936,602...22,965,929
Ensembl chr16:22,936,604...22,966,536 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 severity ISO RGD PMID:26872602 RGD:39939003 NCBI chr 3:51,868,549...51,902,454
Ensembl chr 3:51,846,792...51,951,383 		JBrowse link
G IRF3 interferon regulatory factor 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151 		JBrowse link
G LTA lymphotoxin alpha ISO RGD PMID:11145686 RGD:8548806 NCBI chr 7:23,696,387...23,698,280
Ensembl chr 7:23,696,040...23,698,299 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO protein:increased activity:brain RGD PMID:15364410 RGD:8547868 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982 		JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO protein:increased activity:brain RGD PMID:15364410 PMID:20483026 RGD:8547867 RGD:8547868 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 susceptibility ISO RGD PMID:17266445 RGD:8661706 NCBI chr15:95,656,206...95,764,099
Ensembl chr15:95,656,077...95,763,472 		JBrowse link
G TICAM1 TIR domain containing adaptor molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 2:74,004,566...74,021,100
Ensembl chr 2:74,004,308...74,021,873 		JBrowse link
G TLR2 toll like receptor 2 disease_progression ISO RGD PMID:14739339 PMID:20806060 RGD:5130178 RGD:8553026 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TLR3 toll like receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,969,006...46,979,291 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:20806060 RGD:5130178 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR9 toll like receptor 9 resistance ISO mRNA:increased expression:cheek (rat) RGD PMID:20806060 RGD:5130178 NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673 		JBrowse link
G TRAF3 TNF receptor associated factor 3 ISO CTD Direct Evidence: marker/mechanism CTD
G UNC93B1 unc-93 homolog B1, TLR signaling regulator ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 2:4,898,414...4,909,833
Ensembl chr 2:4,898,409...4,909,856 		JBrowse link
Herpes Simplex Encephalitis 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKRD37 ankyrin repeat domain 37 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,445,789...46,450,046
Ensembl chr15:46,445,881...46,450,097 		JBrowse link
G CCDC110 coiled-coil domain containing 110 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,494,535...46,503,676
Ensembl chr15:46,491,805...46,546,501 		JBrowse link
G CFAP96 cilia and flagella associated protein 96 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,470,680...46,612,173
Ensembl chr15:46,470,765...46,490,006 		JBrowse link
G CFAP97 cilia and flagella associated protein 97 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,207,781...46,257,478
Ensembl chr15:46,207,787...46,267,521 		JBrowse link
G CYP4V2 cytochrome P450 family 4 subfamily V member 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:47,038,078...47,068,315
Ensembl chr15:47,046,269...47,068,304 		JBrowse link
G F11 coagulation factor XI ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr17:9,045,990...9,073,552
Ensembl chr17:9,046,002...9,073,520 		JBrowse link
G FAM149A family with sequence similarity 149 member A ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,995,350...47,037,934
Ensembl chr15:46,995,180...47,038,190 		JBrowse link
G FAT1 FAT atypical cadherin 1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr17:8,466,099...8,580,715
Ensembl chr17:8,457,187...8,580,715 		JBrowse link
G KLKB1 kallikrein B1 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:47,071,581...47,100,272
Ensembl chr15:47,071,556...47,103,622 		JBrowse link
G LRP2BP LRP2 binding protein ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,383,433...46,445,688
Ensembl chr15:46,383,432...46,445,643 		JBrowse link
G MTNR1A melatonin receptor 1A ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr17:8,597,047...8,618,746
Ensembl chr17:8,596,911...8,617,657 		JBrowse link
G PDLIM3 PDZ and LIM domain 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,516,178...46,546,658
Ensembl chr15:46,513,449...46,546,507 		JBrowse link
G SLC25A4 solute carrier family 25 member 4 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,193,498...46,197,989
Ensembl chr15:46,193,746...46,200,987 		JBrowse link
G SNX25 sorting nexin 25 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,306,967...46,388,404
Ensembl chr15:46,266,762...46,388,324 		JBrowse link
G SORBS2 sorbin and SH3 domain containing 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,585,599...46,910,679
Ensembl chr15:46,585,602...46,795,038 		JBrowse link
G TBK1 TANK binding kinase 1 ISO ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 1 ClinVar PMID:25700176 PMID:25741868 PMID:25803835 PMID:26476236 PMID:26581300 More... NCBI chr 5:28,880,210...28,929,964
Ensembl chr 5:28,880,205...28,929,963 		JBrowse link
G TLR3 toll like receptor 3 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis 1 | ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:9536098 PMID:15042513 PMID:16199547 PMID:17434873 PMID:17576681 More... NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,969,006...46,979,291 		JBrowse link
G UFSP2 UFM1 specific peptidase 2 ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 ClinVar PMID:15042513 PMID:25118264 PMID:25629076 PMID:28492532 NCBI chr15:46,448,918...46,470,616
Ensembl chr15:46,448,904...46,470,572 		JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator susceptibility ISO ClinVar Annotator: match by term: Herpes simplex encephalitis 1 | ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 1 OMIM
ClinVar		 PMID:9536098 PMID:16199547 PMID:16973841 PMID:17576681 PMID:24033266 More... NCBI chr 2:4,898,414...4,909,833
Ensembl chr 2:4,898,409...4,909,856 		JBrowse link
Herpes Simplex Encephalitis 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMN amnion associated transmembrane protein ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 ClinVar PMID:28492532
G TRAF3 TNF receptor associated factor 3 susceptibility ISO ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3 | ClinVar Annotator: match by term: TRAF3 haploinsufficiency | ClinVar Annotator: match by term: TRAF3-related condition OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:25741868 PMID:28492532 PMID:31681265 More...
Herpes Simplex Encephalitis 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TICAM1 TIR domain containing adaptor molecule 1 susceptibility ISO ClinVar Annotator: match by term: ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 6 | ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 4 OMIM
ClinVar		 PMID:22105173 PMID:24033266 PMID:25741868 PMID:26513235 PMID:28492532 NCBI chr 2:74,004,566...74,021,100
Ensembl chr 2:74,004,308...74,021,873 		JBrowse link
Herpes Simplex Encephalitis 7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF3 interferon regulatory factor 3 susceptibility ISO ClinVar Annotator: match by term: Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7 OMIM
ClinVar		 PMID:25741868 PMID:26216125 PMID:26513235 PMID:28492532 NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151 		JBrowse link
herpes simplex virus keratitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E treatment ISO RGD PMID:18515564 RGD:7771550 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G ATM ATM serine/threonine kinase ameliorates ISO RGD PMID:24370835 RGD:126781690 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,552 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 severity ISO associated with Herpes Simplex, Type 1 RGD PMID:16997857 RGD:8548890 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 ISO RGD PMID:15287366 RGD:7483593 NCBI chr15:129,172,743...129,176,069 JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO RGD PMID:16476970 PMID:18798077 RGD:8551819 RGD:8551837 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 ISO RGD PMID:15287366 RGD:7483593 NCBI chr 1:2,016,600...2,034,172
Ensembl chr 1:2,018,608...2,019,821 		JBrowse link
G CD274 CD274 molecule ISO RGD PMID:16253242 RGD:41410794 NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:18798077 RGD:8551819 NCBI chr  X:57,592,032...57,595,706
Ensembl chr  X:57,592,038...57,595,692 		JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 treatment ISO RGD PMID:15670795 RGD:40902819 NCBI chr 3:103,041,029...103,096,741
Ensembl chr 3:103,041,221...103,096,738 		JBrowse link
G IFNB1 interferon beta 1 treatment ISO RGD PMID:15670795 RGD:40902819 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495 		JBrowse link
G IFNG interferon gamma ISO RGD PMID:12162877 RGD:8157603 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:22467659 RGD:7364834 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL1RN interleukin 1 receptor antagonist treatment ISO human protein in a mouse model RGD PMID:15258192 RGD:8549793
G IL21 interleukin 21 treatment ISO RGD PMID:21204603 PMID:29370719 RGD:127285376 RGD:127285545 NCBI chr 8:101,532,742...101,540,712
Ensembl chr 8:101,532,531...101,541,713 		JBrowse link
G IL23A interleukin 23 subunit alpha ISO mRNA;increased expression:trigeminal ganglion (mouse) RGD PMID:12162874 RGD:39457946 NCBI chr 5:21,732,416...21,733,981
Ensembl chr 5:21,732,165...21,734,267 		JBrowse link
G KDR kinase insert domain receptor treatment ISO protein:increased expression:cornea: RGD PMID:16951377 RGD:8549742 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
G LOC110258578 interleukin-1 beta-like ISO mRNA:increased expression:cornea RGD PMID:10624423 RGD:7401196
G RNASEL ribonuclease L treatment ISO RGD PMID:15670795 RGD:40902819 NCBI chr 9:123,895,045...123,910,386
Ensembl chr 9:123,893,294...123,910,398 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 susceptibility ISO RGD PMID:17266445 RGD:8661706 NCBI chr15:95,656,206...95,764,099
Ensembl chr15:95,656,077...95,763,472 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:17686871 RGD:7794851 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TLR4 toll like receptor 4 ISO mRNA:increased expression:cornea: RGD PMID:17667620 PMID:17686871 RGD:7794851 RGD:8552970 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR9 toll like receptor 9 ISO RGD PMID:17686871 RGD:7794851 NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673 		JBrowse link
G TNF tumor necrosis factor ISO mRNA:increased expression:cornea RGD PMID:10624423 PMID:12162877 RGD:7401196 RGD:8157603 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
Immunodeficiency 83 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TLR3 toll like receptor 3 susceptibility ISO ClinVar Annotator: match by term: Immunodeficiency 83, susceptibility to viral infections ClinVar
OMIM		 PMID:17872438 PMID:19625408 PMID:20472559 PMID:20855885 PMID:21911422 More... NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,969,006...46,979,291 		JBrowse link
molluscum contagiosum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TLR2 toll like receptor 2 ISO protein:increased expression,altered expression:cytoplasm,membrane, nucleus: RGD PMID:24617037 RGD:8553046 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
skin papilloma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL20 C-C motif chemokine ligand 20 ISO protein:decreased expression:skin RGD PMID:21715145 RGD:7483622 NCBI chr15:129,172,743...129,176,069 JBrowse link
G CLU clusterin ISO RGD PMID:11085517 RGD:8746700 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,595...11,349,764 		JBrowse link
G FGF10 fibroblast growth factor 10 ISO protein:increased expression:skin (mouse) RGD PMID:24582960 RGD:126928134 NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,470...28,777,509 		JBrowse link
G MIR21 microRNA mir-21 ameliorates ISO RGD PMID:21646541 RGD:41404663 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358 		JBrowse link
G NRG1 neuregulin 1 ISO DNA:hypermethylation: RGD PMID:31892232 RGD:39456089 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505 		JBrowse link
G TLR2 toll like receptor 2 ISO protein:increased expression,altered expression:cytoplasm,membrane, nucleus: RGD PMID:24617037 RGD:8553046 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
smallpox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRF1 interferon regulatory factor 1 treatment ISO DNA:SNPs,haplotype: :rs839, rs9282763(human) RGD PMID:18454680 RGD:42722608 NCBI chr 2:134,776,122...134,783,646
Ensembl chr 2:134,776,129...134,783,801 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase treatment ISO DNA:SNP:exon:rs1801133(human) RGD PMID:18454680 RGD:42722608 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
WHIM syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCR4 C-X-C motif chemokine receptor 4 ISO ClinVar Annotator: match by term: CXCR4-related condition | ClinVar Annotator: match by term: WHIM syndrome 1 | ClinVar Annotator: match by term: Warts, hypogammaglobulinemia, infections, and myelokathexis OMIM
ClinVar		 PMID:12692554 PMID:15026312 PMID:15536153 PMID:16275383 PMID:16899028 More... NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,232 		JBrowse link
G DARS1 aspartyl-tRNA synthetase 1 ISO ClinVar Annotator: match by term: Warts, hypogammaglobulinemia, infections, and myelokathexis ClinVar PMID:28492532 NCBI chr15:15,810,497...15,885,706
Ensembl chr15:15,810,618...15,885,706 		JBrowse link
G LOC100625897 lactase-phlorizin hydrolase ISO ClinVar Annotator: match by term: Warts, hypogammaglobulinemia, infections, and myelokathexis ClinVar PMID:28492532 NCBI chr15:16,094,277...16,154,467 JBrowse link
G MCM6 minichromosome maintenance complex component 6 ISO ClinVar Annotator: match by term: Warts, hypogammaglobulinemia, infections, and myelokathexis ClinVar PMID:28492532 NCBI chr15:15,923,638...15,978,587
Ensembl chr15:15,923,681...15,985,405 		JBrowse link
G MIR128-1 microRNA mir-128-1 ISO ClinVar Annotator: match by term: Warts, hypogammaglobulinemia, infections, and myelokathexis ClinVar PMID:28492532 NCBI chr15:16,273,557...16,273,638
Ensembl chr15:16,273,551...16,273,659 		JBrowse link
G R3HDM1 R3H domain containing 1 ISO ClinVar Annotator: match by term: Warts, hypogammaglobulinemia, infections, and myelokathexis ClinVar PMID:28492532 NCBI chr15:16,230,961...16,414,358
Ensembl chr15:16,230,922...16,413,990 		JBrowse link
G RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 ISO ClinVar Annotator: match by term: Warts, hypogammaglobulinemia, infections, and myelokathexis ClinVar PMID:28492532 NCBI chr15:16,756,368...16,893,148
Ensembl chr15:16,763,990...16,816,754 		JBrowse link
G UBXN4 UBX domain protein 4 ISO ClinVar Annotator: match by term: Warts, hypogammaglobulinemia, infections, and myelokathexis ClinVar PMID:28492532 NCBI chr15:16,162,115...16,206,511
Ensembl chr15:16,160,304...16,206,329 		JBrowse link
G ZRANB3 zinc finger RANBP2-type containing 3 ISO ClinVar Annotator: match by term: Warts, hypogammaglobulinemia, infections, and myelokathexis ClinVar PMID:28492532 NCBI chr15:16,414,291...16,727,659
Ensembl chr15:16,414,757...16,727,841 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17415
    disease by infectious agent 2090
      viral infectious disease 1605
        Viral Skin Diseases 116
          exanthema subitum 0
          herpes simplex + 75
          molluscum contagiosum 1
          skin papilloma + 48
          smallpox + 2
Path 2
Term Annotations click to browse term
  disease 17415
    Pathological Conditions, Signs and Symptoms 11801
      Signs and Symptoms 9739
        Neurologic Manifestations 9419
          sensory system disease 6506
            skin disease 3704
              Infectious Skin Diseases 244
                Viral Skin Diseases 116
                  exanthema subitum 0
                  herpes simplex + 75
                  molluscum contagiosum 1
                  skin papilloma + 48
                  smallpox + 2
paths to the root