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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Leukocytosis
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Accession:DOID:9001039 term browser browse the term
Definition:A transient increase in the number of leukocytes in a body fluid.
Synonyms:exact_synonym: Leukocytoses;   Pleocytoses;   Pleocytosis
 primary_id: MESH:D007964

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Leukocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO CTD Direct Evidence: marker/mechanism CTD PMID:27725143 NCBI chrNW_004955418:2,567,804...2,675,062
Ensembl chrNW_004955418:2,566,975...2,674,832 		JBrowse link
G Csf3 colony stimulating factor 3 ISO associated with neoplasms; RGD PMID:18756972 RGD:11039421 NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126 		JBrowse link
G Csf3r colony stimulating factor 3 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19620628 NCBI chrNW_004955452:14,409,484...14,425,818
Ensembl chrNW_004955452:14,411,708...14,422,187 		JBrowse link
G Flt3 fms related receptor tyrosine kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27099147 PMID:27725143 NCBI chrNW_004955497:7,357,533...7,441,215
Ensembl chrNW_004955497:7,357,212...7,461,439 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:1581467 PMID:1884014 PMID:19633061 RGD:10450884 RGD:4142837 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO associated with Meningitis, Listeria; RGD PMID:10085034 RGD:11522759 NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471 		JBrowse link
G Itga4 integrin subunit alpha 4 ISO RGD PMID:12626659 RGD:9698418 NCBI chrNW_004955403:15,726,296...15,807,055
Ensembl chrNW_004955403:15,723,785...15,807,111 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27725143 NCBI chrNW_004955413:20,298,852...20,328,756
Ensembl chrNW_004955413:20,298,824...20,328,758 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 ISO RGD PMID:12417430 RGD:729324 NCBI chrNW_004955403:41,667,632...41,675,619
Ensembl chrNW_004955403:41,667,632...41,675,619 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27725143 NCBI chrNW_004955435:18,001,517...18,009,105
Ensembl chrNW_004955435:18,001,517...18,009,103 		JBrowse link
B-CELL EXPANSION WITH NFKB AND T-CELL ANERGY term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family member 11 ISO ClinVar Annotator: match by term: B-cell expansion with NFKB and T-cell anergy OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:18323416 PMID:23027925 PMID:23129749 More... NCBI chrNW_004955460:12,368,987...12,487,675
Ensembl chrNW_004955460:12,368,918...12,490,041 		JBrowse link
Monoclonal B-Cell Lymphocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amz2 archaelysin family metallopeptidase 2 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chrNW_004955478:4,477,597...4,485,918
Ensembl chrNW_004955478:4,475,646...4,484,820 		JBrowse link
G Apc APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004955418:2,567,804...2,675,062
Ensembl chrNW_004955418:2,566,975...2,674,832 		JBrowse link
G Dazap1 DAZ associated protein 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chrNW_004955495:6,499,553...6,516,227
Ensembl chrNW_004955495:6,497,890...6,524,462 		JBrowse link
G Fcn1 ficolin 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chrNW_004955513:3,690,550...3,697,785
Ensembl chrNW_004955513:3,687,232...3,698,673 		JBrowse link
G Klhl6 kelch like family member 6 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chrNW_004955420:23,813,482...23,877,886 JBrowse link
G Notch2 notch receptor 2 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar PMID:8755249 PMID:21378985 PMID:21378989 PMID:22891273 PMID:22891276 More... NCBI chrNW_004955568:1,660,357...1,812,285
Ensembl chrNW_004955568:1,660,731...1,809,173 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chrNW_004955513:1,224,418...1,328,176
Ensembl chrNW_004955513:1,226,205...1,315,922 		JBrowse link
G Sec14l1 SEC14 like lipid binding 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chrNW_004955506:5,159,090...5,231,827
Ensembl chrNW_004955506:5,158,805...5,232,551 		JBrowse link
G Slc35a5 solute carrier family 35 member A5 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chrNW_004955427:12,906,650...12,940,419
Ensembl chrNW_004955427:12,906,632...12,940,419 		JBrowse link
G Sp4 Sp4 transcription factor ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chrNW_004955410:23,955,408...24,015,667
Ensembl chrNW_004955410:23,955,408...24,015,667 		JBrowse link
G Tmed9 transmembrane p24 trafficking protein 9 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chrNW_004955408:29,830,125...29,834,408
Ensembl chrNW_004955408:29,829,503...29,834,408 		JBrowse link
G Vmp1 vacuole membrane protein 1 ISO ClinVar Annotator: match by term: Monoclonal B-Cell Lymphocytosis ClinVar NCBI chrNW_004955451:3,265,109...3,370,610
Ensembl chrNW_004955451:3,265,109...3,370,610 		JBrowse link
Monocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tet2 tet methylcytosine dioxygenase 2 ISO RGD PMID:24218139 RGD:11038772 NCBI chrNW_004955496:3,885,684...3,963,056
Ensembl chrNW_004955496:3,885,035...3,926,106 		JBrowse link
Neutrophilia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:2475183 RGD:11039032 NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126 		JBrowse link
G Ptafr platelet activating factor receptor treatment ISO associated with Scorpion Stings RGD PMID:10770284 RGD:10043145 NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929 		JBrowse link
Persistent Polyclonal B-Cell Lymphocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family member 11 ISO DNA:missense mutations:cds:p.E127G, p.G116S (human) RGD PMID:23129749 RGD:11100033 NCBI chrNW_004955460:12,368,987...12,487,675
Ensembl chrNW_004955460:12,368,918...12,490,041 		JBrowse link
transient myeloproliferative syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata1 GATA binding protein 1 ISO ClinVar Annotator: match by term: Transient myeloproliferative syndrome ClinVar
OMIM		 PMID:27993330 NCBI chrNW_004955543:334,581...342,042
Ensembl chrNW_004955543:334,061...342,061 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14336
    Pathological Conditions, Signs and Symptoms 11321
      Pathologic Processes 7188
        Leukocytosis 25
          Holoprosencephaly, Recurrent Infections, and Monocytosis 0
          IMMUNODEFICIENCY 100 WITH PULMONARY ALVEOLAR PROTEINOSIS AND HYPOGAMMAGLOBULINEMIA 0
          Leukemoid Reaction + 1
          Lymphocytosis + 13
          Monocytosis 1
          Neutrophilia 2
Path 2
Term Annotations click to browse term
  disease 14336
    disease of anatomical entity 14029
      Hemic and Lymphatic Diseases 3833
        hematopoietic system disease 3384
          leukocyte disease 1175
            Leukocytosis 25
              Holoprosencephaly, Recurrent Infections, and Monocytosis 0
              IMMUNODEFICIENCY 100 WITH PULMONARY ALVEOLAR PROTEINOSIS AND HYPOGAMMAGLOBULINEMIA 0
              Leukemoid Reaction + 1
              Lymphocytosis + 13
              Monocytosis 1
              Neutrophilia 2
paths to the root