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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Alveolar Bone Loss
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Accession:DOID:9000927 term browser browse the term
Definition:Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Synonyms:exact_synonym: Alveolar Bone Atrophies;   Alveolar Bone Atrophy;   Alveolar Bone Losses;   Alveolar Process Atrophies;   Alveolar Process Atrophy;   Alveolar Resorption;   Alveolar Resorptions;   Periodontal Bone Loss;   Periodontal Bone Losses;   Periodontal Resorption;   Periodontal Resorptions
 primary_id: MESH:D016301;   RDO:0006950



show annotations for term's descendants           Sort by:
Alveolar Bone Loss term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Agtr1a angiotensin II receptor, type 1a treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated treatment ISO
IEP
CTD Direct Evidence: marker/mechanism
associated with hypertension, periodontal disease
CTD
RGD
PMID:20630305 PMID:33364953 RGD:329956421 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO associated with Periodontitis; RGD PMID:21241302 RGD:8661687 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ctsk cathepsin K treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Il10 interleukin 10 treatment IEP associated with Diabetes Mellitus, Experimental
associated with periodontal disease
RGD PMID:26270535 PMID:33364953 RGD:11049527, RGD:329956421 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgav integrin subunit alpha V treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Oscar osteoclast associated Ig-like receptor treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO RGD PMID:14630900 RGD:10413909 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma treatment IEP associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tnf tumor necrosis factor treatment IEP associated with Diabetes Mellitus, Experimental
associated with periodontal disease
RGD PMID:26270535 PMID:33364953 RGD:11049527, RGD:329956421 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 treatment ISO
IEP
CTD Direct Evidence: marker/mechanism
associated with periodontal disease
CTD
RGD
PMID:19249596 PMID:33364953 RGD:329956421 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Vtn vitronectin treatment IEP associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      musculoskeletal system disease 8272
        bone disease 4270
          bone resorption disease 375
            Alveolar Bone Loss 23
Path 2
Term Annotations click to browse term
  disease 21128
    Pathological Conditions, Signs and Symptoms 13331
      Signs and Symptoms 10807
        Neurologic Manifestations 10039
          sensory system disease 6940
            mouth disease 1012
              tooth disease 443
                periodontal disease 134
                  Periodontal Atrophy 24
                    Alveolar Bone Loss 23
paths to the root