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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Alveolar Bone Loss
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Accession:DOID:9000927 term browser browse the term
Definition:Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Synonyms:exact_synonym: Alveolar Bone Atrophies;   Alveolar Bone Atrophy;   Alveolar Bone Losses;   Alveolar Process Atrophies;   Alveolar Process Atrophy;   Alveolar Resorption;   Alveolar Resorptions;   Periodontal Bone Loss;   Periodontal Bone Losses;   Periodontal Resorption;   Periodontal Resorptions
 primary_id: MESH:D016301;   RDO:0006950



show annotations for term's descendants           Sort by:
Alveolar Bone Loss term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007
JBrowse link
G Agtr1a angiotensin II receptor, type 1a treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Agtr2 angiotensin II receptor, type 2 treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403
JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney treatment ISO CTD Direct Evidence: marker/mechanism
associated with hypertension, periodontal disease
CTD
RGD
PMID:20630305 PMID:33364953 RGD:329956421 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IMP associated with Periodontitis; RGD PMID:21241302 RGD:8661687 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
JBrowse link
G Ctsk cathepsin K treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 3:95,406,521...95,416,698
Ensembl chr 3:95,406,567...95,416,673
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
JBrowse link
G Il10 interleukin 10 treatment ISO associated with Diabetes Mellitus, Experimental
associated with periodontal disease
RGD PMID:26270535 PMID:33364953 RGD:11049527, RGD:329956421 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il1b interleukin 1 beta treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Itgav integrin alpha V treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 2:83,554,796...83,637,261
Ensembl chr 2:83,554,741...83,637,260
JBrowse link
G Mas1 MAS1 oncogene treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030
JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Oscar osteoclast associated receptor treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 7:3,612,812...3,619,156
Ensembl chr 7:3,612,812...3,619,156
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 IMP RGD PMID:14630900 RGD:10413909 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma treatment ISO associated with hypertension, periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Tnf tumor necrosis factor treatment ISO associated with Diabetes Mellitus, Experimental
associated with periodontal disease
RGD PMID:26270535 PMID:33364953 RGD:11049527, RGD:329956421 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr 1:105,708,443...105,777,172
Ensembl chr 1:105,708,443...105,775,709
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 treatment ISO CTD Direct Evidence: marker/mechanism
associated with periodontal disease
CTD
RGD
PMID:19249596 PMID:33364953 RGD:329956421 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
JBrowse link
G Vtn vitronectin treatment ISO associated with periodontal disease RGD PMID:33364953 RGD:329956421 NCBI chr11:78,389,946...78,393,151
Ensembl chr11:78,389,917...78,393,150
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18295
    disease of anatomical entity 15588
      musculoskeletal system disease 7882
        bone disease 3866
          bone resorption disease 188
            Alveolar Bone Loss 23
Path 2
Term Annotations click to browse term
  disease 18295
    Pathological Conditions, Signs and Symptoms 12299
      Signs and Symptoms 10077
        Neurologic Manifestations 9730
          sensory system disease 6694
            mouth disease 963
              tooth disease 402
                periodontal disease 135
                  Periodontal Atrophy 24
                    Alveolar Bone Loss 23
paths to the root