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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Syncope
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Accession:DOID:9000727 term browser browse the term
Definition:A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
Synonyms:exact_synonym: Cardiogenic Syncope;   Cardiogenic Syncopes;   Carotid Sinus Syncope;   Carotid Sinus Syncopes;   Convulsive Syncope;   Convulsive Syncopes;   Deglutitional Syncope;   Deglutitional Syncopes;   Drop Attack;   Drop Attacks;   Effort Syncope;   Effort Syncopes;   Fainting;   Hyperventilation Syncope;   Hyperventilation Syncopes;   Micturition Syncope;   Micturition Syncopes;   Postural Syncope;   Postural Syncopes;   Presyncope;   Presyncopes;   Situational Syncope;   Situational Syncopes;   Stokes-Adams Syncope;   Stokes-Adams Syncopes;   Syncopal Episode;   Syncopal Episodes;   Syncopal Vertigo;   Syncopes;   Tussive Syncope;   Tussive Syncopes;   Vertigos, Syncopal
 primary_id: MESH:D013575


show annotations for term's descendants           Sort by:
Syncope term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actl6a actin-like 6A ISO ClinVar Annotator: match by term: fainting ClinVar PMID:19215055 PMID:25741868 PMID:28649782 PMID:31994175 NCBI chr 2:117,413,206...117,436,758
Ensembl chr 2:117,418,601...117,436,754 		JBrowse link
G Actn2 actinin alpha 2 ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:23861362 PMID:24033266 PMID:25741868 PMID:26498160 PMID:26899768 More... NCBI chr17:62,835,055...62,902,331
Ensembl chr17:62,812,988...62,903,552 		JBrowse link
G Mefv MEFV innate immunity regulator, pyrin ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:9668175 PMID:10090880 PMID:10612841 PMID:10787450 PMID:10842288 More... NCBI chr10:12,288,514...12,303,337
Ensembl chr10:12,293,782...12,303,333 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO ClinVar Annotator: match by term: Syncope ClinVar NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:25741868 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Ttn titin ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:24033266 PMID:25741868 NCBI chr 3:82,059,648...82,332,130
Ensembl chr 3:82,059,648...82,332,171 		JBrowse link
Vasovagal Syncope term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppb natriuretic peptide B ISO associated with Syncope;protein:increased expression:serum: RGD PMID:23373852 RGD:7247623 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14566
    disease of anatomical entity 13676
      nervous system disease 8528
        Neurologic Manifestations 5934
          Neurobehavioral Manifestations 1646
            Consciousness Disorders 21
              Unconsciousness 21
                Syncope 7
                  Stoll Alembik Dott Syndrome 0
                  Vasovagal Syncope + 1
Path 2
Term Annotations click to browse term
  disease 14566
    disease of anatomical entity 13676
      nervous system disease 8528
        central nervous system disease 6393
          brain disease 5852
            disease of mental health 3944
              cognitive disorder 1355
                Consciousness Disorders 21
                  Unconsciousness 21
                    Syncope 7
                      Stoll Alembik Dott Syndrome 0
                      Vasovagal Syncope + 1
paths to the root