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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Pain
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Accession:DOID:9000641 term browser browse the term
Definition:An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Synonyms:exact_synonym: Ache;   Burning Pain;   Crushing Pain;   Crushing Pains;   Migratory Pain;   Migratory Pains;   Physical Suffering;   Physical Sufferings;   Radiating Pain;   Radiating Pains;   aches;   burning pains;   splitting pain;   splitting pains
 primary_id: MESH:D010146
 xref: EFO:0003843


show annotations for term's descendants           Sort by:
Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO CTD Direct Evidence: therapeutic CTD PMID:28193520 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ace angiotensin I converting enzyme IMP RGD PMID:18555989 RGD:2325233 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Adm adrenomedullin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17043245 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Aif1 allograft inflammatory factor 1 IEP associated with Diabetes Mellitus, Experimental; protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:18186080 RGD:2313034 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17084039 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin ISO CTD Direct Evidence: therapeutic CTD PMID:4126124 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase IMP RGD PMID:19580807 RGD:2317533 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Aqp1 aquaporin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20018876 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Avp arginine vasopressin ISO CTD Direct Evidence: therapeutic CTD PMID:2271928 PMID:6094376 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20152050 PMID:17988733 RGD:5129214 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20152050 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Bdnf brain-derived neurotrophic factor IEP RGD PMID:20452292 RGD:4891137 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17088553 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Casp1 caspase 1 IMP RGD PMID:19853379 RGD:2315887 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cck cholecystokinin IDA RGD PMID:17157334 RGD:2313635 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Cckbr cholecystokinin B receptor IMP associated with Diabetes Mellitus, Experimental RGD PMID:16527403 RGD:2311323 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IDA RGD PMID:18419759 RGD:2307043 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 IMP RGD PMID:11438578 RGD:2306307 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IMP RGD PMID:11438578 RGD:2306307 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IMP
ISO		 associated with Osteoarthritis, Knee; RGD PMID:18419759 PMID:23185004 RGD:2307043, RGD:8661785 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Clcn7 chloride voltage-gated channel 7 IEP mRNA:increased expression:spinal cord dorsal horn RGD PMID:11846422 RGD:1600865 NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130 		JBrowse link
G Cnr1 cannabinoid receptor 1 IMP
ISO		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:19193902 PMID:19661434 RGD:2314649 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 IMP RGD PMID:19409856 RGD:2316193 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Comt catechol-O-methyltransferase severity IMP
ISO		 associated with Multiple Sclerosis;DNA:polymorphism:cds:rs4680(p.V158M)(human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20561508 PMID:17084978 PMID:24290452 RGD:2289747, RGD:13450948 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Crh corticotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:16495007 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Csf2 colony stimulating factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8622042 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf3 colony stimulating factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7541186 PMID:8622042 PMID:10864982 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IMP associated with Bone Neoplasms RGD PMID:20736819 RGD:4892020 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 IMP RGD PMID:11438578 RGD:2306307 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Disc1 DISC1 scaffold protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:20561508 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778 		JBrowse link
G Drd2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15996639 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19429182 PMID:20042899 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19081190 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gjb1 gap junction protein, beta 1 ISO ClinVar Annotator: match by term: Pain ClinVar PMID:16096811 PMID:21291455 PMID:22243284 PMID:25388846 PMID:25741868 More... NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gla galactosidase, alpha treatment IMP Allyl isothiocyanate (XCO:0000608)
compared to wild type		 RGD PMID:29563343 PMID:29563343 RGD:150429980, RGD:150429980 NCBI chr  X:97,769,227...97,780,646
Ensembl chr  X:97,768,996...97,780,664 		JBrowse link
G Glaem2Mcwi galactosidase, alpha; CRISPR/Cas9 system induced mutant 2, Medical College of Wisconsin IMP compared to wild type RGD PMID:29563343 RGD:150429980
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18155693 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Hcrt hypocretin neuropeptide precursor ISO CTD Direct Evidence: therapeutic CTD PMID:16202530 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Hfe homeostatic iron regulator ISO ClinVar Annotator: match by term: Pain ClinVar PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Hgf hepatocyte growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:26000320 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hoxd1 homeo box D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21151121 NCBI chr 3:59,665,629...59,667,769
Ensembl chr 3:59,665,629...59,667,769 		JBrowse link
G Hrh1 histamine receptor H 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12128009 PMID:14569158 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:12595749 PMID:21945716 RGD:5683627 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B IDA RGD PMID:16165284 RGD:1626470 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C IDA RGD PMID:17451674 RGD:1624996 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B ISO CTD Direct Evidence: marker/mechanism CTD PMID:17600820 NCBI chr 8:49,279,291...49,308,444
Ensembl chr 8:49,279,173...49,308,444 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17600820 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Il18 interleukin 18 IDA RGD PMID:19853379 RGD:2315887 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: therapeutic CTD PMID:15317861 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 ISO CTD Direct Evidence: therapeutic CTD PMID:12421473 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer ISO RGD PMID:20626857 RGD:5509945 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Kng1 kininogen 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1281941 PMID:3951883 PMID:10445233 PMID:10543429 PMID:16076651 More... NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 ISO ClinVar Annotator: match by term: Pain ClinVar PMID:25741868 PMID:28492532 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Ngf nerve growth factor treatment IMP
ISO		 associated with Cystitis, Interstitial RGD PMID:19103210 PMID:17905097 RGD:2303798, RGD:7242806 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor IMP associated with Inflammation RGD PMID:20060234 RGD:5144063 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nos3 nitric oxide synthase 3 IMP RGD PMID:18079061 RGD:2292111 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A ISO CTD Direct Evidence: therapeutic CTD PMID:13679232 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B ISO CTD Direct Evidence: therapeutic CTD PMID:27687165 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Npr1 natriuretic peptide receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27687165 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505 		JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20561508 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Ntsr1 neurotensin receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:20727387 NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377 		JBrowse link
G Oprd1 opioid receptor, delta 1 IDA RGD PMID:12710986 RGD:2316589 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9463367 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 IDA RGD PMID:12710986 RGD:2316589 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IMP
ISO		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:6094376 PMID:17420069 PMID:17664006 RGD:2304129 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G Pdyn prodynorphin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17670969 PMID:20068450 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin ISO CTD Direct Evidence: therapeutic CTD PMID:15833551 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Plcb1 phospholipase C beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16405873 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Pnoc prepronociceptin ISO CTD Direct Evidence: therapeutic CTD PMID:19231294 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867 		JBrowse link
G Pomc proopiomelanocortin ISO
IMP		 CTD Direct Evidence: marker/mechanism|therapeutic
associated with Inflammation		 CTD
RGD		 PMID:4345333 PMID:6094376 PMID:20084599 PMID:17223201 RGD:407574731 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IMP RGD PMID:18387855 RGD:2301890 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A treatment IDA RGD PMID:20359166 RGD:10002735 NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 IEP protein:increased expression:spinal cord RGD PMID:12384231 RGD:7775057 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Prokr1 prokineticin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr 4:120,022,301...120,033,367
Ensembl chr 4:120,021,747...120,033,379 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IEP
IMP		 associated with Osteoarthritis, Knee;mRNA, protein:increased expression:spinal cord RGD PMID:18637715 PMID:17942724 RGD:2300223, RGD:2300252 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 susceptibility IMP
ISO
IEP		 associated with lung neoplasm;DNA:SNP:exon:rs5275 (human)
associated with Osteoarthritis, Knee;mRNA, protein:increased expression:spinal cord		 RGD PMID:18497304 PMID:19773451 PMID:18637715 RGD:2300228, RGD:5135482, RGD:2300223 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptn pleiotrophin severity ISO RGD PMID:20826137 RGD:10043829 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 ISO RGD PMID:17918738 RGD:1643217 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19248819 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Tac1 tachykinin, precursor 1 IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:7694222 PMID:10445233 PMID:17493276 RGD:2304337 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:18407414 RGD:2304276 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tacr3 tachykinin receptor 3 IMP RGD PMID:19093101 RGD:2304256 NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791 		JBrowse link
G Tjp1 tight junction protein 1 IEP associated with Inflammation;protein:increased expression:brain RGD PMID:19319146 RGD:2325136 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr2 toll-like receptor 2 IDA RGD PMID:24204973 RGD:8553185 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 IMP RGD PMID:18662331 RGD:2312574 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18582539 PMID:20383154 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP protein:increased expression:dorsal root ganglion (rat) RGD PMID:21248590 RGD:5130897 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Trh thyrotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:6409194 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20601631 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16996476 PMID:17575321 PMID:20422007 PMID:23006841 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: therapeutic CTD PMID:9920454 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
Abdominal Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hfe homeostatic iron regulator ISO ClinVar Annotator: match by term: Abdominal pain ClinVar PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Hmbs hydroxymethylbilane synthase ISO ClinVar Annotator: match by term: Abdominal pain ClinVar NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IDA RGD PMID:24291101 RGD:10043376 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
Acute Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase susceptibility ISO associated with Anemia, Sickle Cell;DNA:polymorphism:cds:p.V158M(human) RGD PMID:25102390 RGD:13450943 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
amyotrophic neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Septin9 septin 9 ISO ClinVar Annotator: match by term: Amyotrophic neuralgia | ClinVar Annotator: match by term: Amyotrophy, hereditary neuralgic | ClinVar Annotator: match by term: Hereditary Neuralgic Amyotrophy (HNA) ClinVar PMID:16186812 PMID:17546647 PMID:18492087 PMID:19139049 PMID:19204161 More... NCBI chr10:102,409,798...102,579,056
Ensembl chr10:102,409,711...102,579,055 		JBrowse link
Angina Pectoris term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 ISO RGD PMID:11527135 RGD:5129114 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 ISO RGD PMID:11527135 RGD:5129114 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Avp arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11128043 PMID:11791009 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Cpb2 carboxypeptidase B2 ISO RGD PMID:12624641 RGD:1598479 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Mir146a microRNA 146a ISO miRNA:increased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir155 microRNA 155 ISO miRNA:decreased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir21 microRNA 21 ISO miRNA:increased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:1730212 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Ppbp pro-platelet basic protein ISO protein:increased expression:plasma RGD PMID:17045893 RGD:401794448 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:16421174 RGD:1581390 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
Arthralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf3 colony stimulating factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7543699 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Mvk mevalonate kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:10369261 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO ClinVar Annotator: match by term: Arthralgia ClinVar PMID:25741868 PMID:28492532 PMID:30311386 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Wnt10a Wnt family member 10A ISO ClinVar Annotator: match by term: Arthralgias ClinVar PMID:24449199 PMID:28492532 NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400 		JBrowse link
Back Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr2a 5-hydroxytryptamine receptor 2A IDA RGD PMID:17268262 RGD:1624379 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12227717 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
Cancer Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr4 C-X-C motif chemokine receptor 4 IEP
IMP		 mRNA,protein:increased expression:spinal cord: RGD PMID:28108674 PMID:28638088 RGD:13463594, RGD:13838657 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 ameliorates IMP RGD PMID:26738857 RGD:243048441 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Jak2 Janus kinase 2 treatment IEP RGD PMID:30027795 RGD:149735350 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mir338 microRNA 338 IEP RNA:decreased expression:spinal cord: RGD PMID:28108674 RGD:13463594 NCBI chr10:105,297,923...105,297,988 JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma IEP mRNA, protein:increased expression:spinal cord (rat) RGD PMID:25919859 RGD:152025537 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Robo1 roundabout guidance receptor 1 exacerbates IMP RGD PMID:26738857 RGD:243048441 NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203 		JBrowse link
G Slit2 slit guidance ligand 2 ameliorates IMP RGD PMID:26738857 RGD:243048441 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
Chest Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:2563132 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Myh6 myosin heavy chain 6 ISO ClinVar Annotator: match by term: Chest pain ClinVar PMID:25741868 PMID:27600940 PMID:28492532 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 ISO ClinVar Annotator: match by term: Chest pain ClinVar PMID:7731997 PMID:7796500 PMID:8483915 PMID:8541871 PMID:8951566 More... NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
Chronic Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor IEP protein:increased expression:frontal cortex, neuron
mRNA:decreased expression:anterior cingulate cortex 		RGD PMID:11360665 PMID:24518228 RGD:5684922, RGD:10059366 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 ISO ClinVar Annotator: match by term: Chronic pain ClinVar PMID:7711730 PMID:9600456 PMID:10090476 PMID:12410208 PMID:12673791 More... NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30657865 RGD:14746966 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IEP protein:increased expression:frontal cortex, neuron RGD PMID:11360665 RGD:5684922 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21634377 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516 		JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:24204973 RGD:8553185 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:24204973 RGD:8553185 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Dysmenorrhea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10440088 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 severity ISO DNA:polymorphism:cds:p.Arg296Cys(human) RGD PMID:11055624 RGD:401901272 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta ISO protein:increased expression:ectopic endometrium: RGD PMID:22572543 RGD:9588664 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 severity ISO DNA:deletion,polymorphism:: RGD PMID:11055624 RGD:401901272 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:10440088 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
Exertional Myalgia, Muscle Stiffness and Myoglobinuria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmd dystrophin ISO ClinVar Annotator: match by term: Exertional myalgia, muscle stiffness and myoglobinuria ClinVar PMID:19367636 PMID:21104870 PMID:25637381 PMID:25741868 PMID:26066469 More... NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
Eye Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:4327920 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
familial episodic pain syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 ISO ClinVar Annotator: match by term: Familial episodic pain syndrome 1 | ClinVar Annotator: match by term: TRPA1-related condition OMIM
ClinVar		 PMID:20547126 PMID:25741868 PMID:36430572 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
familial episodic pain syndrome 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO ClinVar Annotator: match by term: Episodic pain syndrome, familial, 2 OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:23115331 PMID:24820863 PMID:24998131 More... NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
familial episodic pain syndrome 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn11a sodium voltage-gated channel alpha subunit 11 ISO
ISS		 ClinVar Annotator: match by term: Episodic pain syndrome, familial, 3
OMIM:615552		 OMIM
ClinVar
MouseDO		 PMID:9536098 PMID:17576681 PMID:24207120 PMID:24776970 PMID:25741868 More... NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044 		JBrowse link
Headache term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf3 colony stimulating factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10864982 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Fkrp fukutin related protein ISO ClinVar Annotator: match by term: Headache ClinVar PMID:11741828 PMID:12666124 PMID:14647208 PMID:15060126 PMID:15574464 More... NCBI chr 1:77,479,641...77,486,954
Ensembl chr 1:77,476,084...77,486,992 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12910066 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7537110 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 ISO ClinVar Annotator: match by term: Headache ClinVar PMID:10521290 PMID:11333381 PMID:11349231 PMID:11479732 PMID:11754101 More... NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:7080326 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO human protein in rat model RGD PMID:21036476 RGD:5131274 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein ISO DNA:missense mutation: :p.H611R (human) RGD PMID:17719176 RGD:8694403 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
Hyperalgesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase treatment IMP RGD PMID:24890317 RGD:9588557 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835 		JBrowse link
G Adk adenosine kinase IMP associated with diabetic neuropathies; RGD PMID:11423084 PMID:9932716 RGD:6482662, RGD:6482666 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510 		JBrowse link
G Adm adrenomedullin IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17043245 PMID:17043245 RGD:1625316 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adora1 adenosine A1 receptor IDA associated with Spinal Cord Injuries RGD PMID:20065990 RGD:5129094 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adra1a adrenoceptor alpha 1A IEP associated with Diabetes Mellitus, Experimental; mRNA:increased expression:dorsal root ganglion RGD PMID:10841349 RGD:5688377 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra2a adrenoceptor alpha 2A IMP RGD PMID:17959985 RGD:6480488 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2c adrenoceptor alpha 2C IMP RGD PMID:20007733 RGD:6893568 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:19283893 RGD:5129125 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment IMP
ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:25014009 PMID:25014009 PMID:24077211 RGD:8695980, RGD:7364865 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:9613798 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aif1 allograft inflammatory factor 1 IEP
ISO		 associated with Alcohol-Induced Disorders, Nervous System; protein:increased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27093858 PMID:17284346 RGD:2313035 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 IDA associated with Hyperglycemia RGD PMID:12505670 RGD:1626082 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12582831 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12582831 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Ano3 anoctamin 3 IMP RGD PMID:23872594 RGD:9681745 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154 		JBrowse link
G Anxa1 annexin A1 IMP
IEP		 protein:increased expression:dorsal root ganglion RGD PMID:9222544 PMID:21990306 RGD:2306950, RGD:7421656 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Aqp4 aquaporin 4 IEP associated with Spinal Cord Injuries;mRNA,protein:increased expression:brain,spinal cord: RGD PMID:16219025 RGD:8695957 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Avp arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:9613798 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bace1 beta-secretase 1 IMP RGD PMID:28012171 RGD:13782150 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bdkrb1 bradykinin receptor B1 IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17989505 PMID:19300402 PMID:19815945 PMID:12927641 PMID:12637034 RGD:1579989, RGD:7241581 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 IMP
ISO		 CTD Direct Evidence: marker/mechanism
associated with Diabetic Neuropathy		 CTD
RGD		 PMID:17989505 PMID:19300402 PMID:19815945 PMID:10188975 PMID:19300402 RGD:4891040, RGD:2313332 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Bdnf brain-derived neurotrophic factor IMP
IEP
IDA
ISO		 associated with Peripheral Nerve Injuries;
associated with inflammation;protein:increased expression:dorsal root ganglion:
associated with Sciatic Neuropathy;
associated with Pancreatitis, Chronic;		 RGD PMID:11425916 PMID:21958434 PMID:10779676 PMID:12435470 PMID:21864655 More... RGD:8657088, RGD:8657122, RGD:8657114, RGD:8657101, RGD:8657099, RGD:8657093, RGD:8657091 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 IEP RGD PMID:23665054 RGD:11560531 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G C3 complement C3 IEP associated with Sciatic Neuropathy;mRNA, protein:increased expression:spinal cord RGD PMID:23588254 RGD:7401259 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B IDA RGD PMID:17567797 RGD:1626313 NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO CTD Direct Evidence: marker/mechanism CTD PMID:19577366 PMID:30552955 PMID:34286406 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I IMP RGD PMID:17112407 RGD:15003199 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11245671 PMID:17881535 PMID:24133248 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Calca calcitonin-related polypeptide alpha IEP
ISO		 associated with inflammation;protein:increased expression:dorsal root ganglion:
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:12787826 PMID:12855330 PMID:15265675 PMID:27093858 PMID:21958434 RGD:8657122 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20053885 PMID:18042863 RGD:7240711 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Capn2 calpain 2 treatment IMP associated with Peripheral Nerve Injuries RGD PMID:25150005 RGD:13792585 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Cartpt CART prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:21167239 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Cat catalase treatment IEP
IMP		 RGD PMID:23952340 PMID:23658840 RGD:9479063, RGD:9479069 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cck cholecystokinin IDA RGD PMID:15647484 RGD:1626108 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Cckbr cholecystokinin B receptor IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11880531 PMID:15647484 RGD:1626108 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IDA
ISO
IEP
IMP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:dorsal root ganglion, spinal cord (rat)		 CTD
RGD		 PMID:17881535 PMID:18419759 PMID:21712071 PMID:20737477 PMID:22531750 RGD:2307043, RGD:8548873, RGD:8548848, RGD:8548845 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP
IDA		 mRNA:increased expression:dorsal root ganglion (rat) RGD PMID:18076762 PMID:18656466 RGD:4890034, RGD:2303121 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IMP
ISO
IEP		 associated with Intervertebral disc disease;
associated with Demyelinating Diseases;
associated with Sciatic Neuropathy;
protein:increased expression:dorsal horn of spinal cord:
associated with Bone Neoplasms;protein:increased expression:spinal cord:		 RGD PMID:18419759 PMID:24462503 PMID:18076762 PMID:24907405 PMID:22721162 More... RGD:2307043, RGD:8661788, RGD:4890034, RGD:8661781, RGD:8548831, RGD:8661772 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 IEP
ISO
IMP		 mRNA:increased expression:dorsal root ganglion (rat)
associated with Spinal Cord Injuries		 RGD PMID:18076762 PMID:22033364 PMID:23147416 PMID:24589480 RGD:4890034, RGD:8551820, RGD:8551809, RGD:8551795 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cfl1 cofilin 1 IEP protein:increased phosphorylation:dorsal root ganglion (rat) RGD PMID:24962708 RGD:11570412 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit ameliorates IMP RGD PMID:15652389 RGD:150530460 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ameliorates IDA associated with sciatic neuropathy; RGD PMID:20619541 RGD:151708701 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17572696 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:17572696 PMID:18664590 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Comt catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:28195063 PMID:20726980 RGD:8662326 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Crcp CGRP receptor component IEP RGD PMID:12895509 RGD:727768 NCBI chr12:26,623,968...26,659,756
Ensembl chr12:26,623,976...26,768,225 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28434951 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO associated with Sciatic Neuropathy; RGD PMID:24253780 RGD:11039470 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Csk C-terminal Src kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16769263 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Ctss cathepsin S IMP
ISO		 associated with Arthritis, Experimental
associated with Colitis		 RGD PMID:22213084 PMID:21802389 RGD:5686870, RGD:5686873 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 treatment IDA
IEP		 associated with Arthritis, Experimental RGD PMID:19249394 PMID:22647647 RGD:2304251, RGD:9491779 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO
IEP
IMP		 associated with Arthritis, Experimental;protein:increased expression:lumbar spinal cord
associated with Inflammation
associated with Sciatic Neuropathy
associated with Bone Neoplasms		 RGD PMID:20609517 PMID:22647647 PMID:16324111 PMID:20524966 PMID:19959384 More... RGD:4891885, RGD:9491779, RGD:9387859, RGD:9354422, RGD:4891942, RGD:4892020 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 IDA RGD PMID:28638088 RGD:13838657 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 IMP RGD PMID:19283893 RGD:5129125 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 treatment IMP RGD PMID:28638088 PMID:30142543 RGD:13838657, RGD:13838658 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cybb cytochrome b-245 beta chain ISO associated with Spinal Cord Injuries; RGD PMID:20679217 RGD:11040629 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 IDA associated with Diabetic neuropathies; RGD PMID:20531396 RGD:7257680 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Drd3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20433900 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment IEP
IDA		 associated with Sciatic Neuropathy RGD PMID:22901764 PMID:22540262 RGD:7771531, RGD:7771574 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp6 dual specificity phosphatase 6 treatment IEP associated with Sciatic Neuropathy RGD PMID:22901764 RGD:7771531 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Edn1 endothelin 1 susceptibility ISO mRNA:increased expression:paw skin (mouse)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19429182 PMID:23347081 PMID:15664691 RGD:8661716, RGD:8661735 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 treatment IMP RGD PMID:20392816 RGD:9685429 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Ep300 E1A binding protein p300 IMP RGD PMID:25263804 RGD:9588307 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epha4 Eph receptor A4 IMP associated with spinal cord injuries; RGD PMID:16959251 RGD:5688783 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Ephx2 epoxide hydrolase 2 IMP RGD PMID:16962614 RGD:5688387 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IEP associated with interstitial cystitis; RGD PMID:30989724 RGD:405295490 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:19285805 RGD:8553066 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 IDA
ISO		 RGD PMID:17056036 PMID:19285805 RGD:5508846, RGD:8553066 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F2 coagulation factor II, thrombin ISO associated with Sciatic Neuropathy RGD PMID:16251448 RGD:7387272 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F2r coagulation factor II (thrombin) receptor severity ISO
IDA		 RGD PMID:19674841 PMID:11877315 PMID:12717003 RGD:7387269, RGD:7387271, RGD:7387270 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Fcgr1a Fc gamma receptor 1A ameliorates IMP RGD PMID:32510872 RGD:127338469 NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP
ISO		 protein:increased expression:dorsal horn of spinal cord, neuron
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27093858 PMID:22160634 RGD:9999169 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase treatment ISO associated with Cerebral Hemorrhage RGD PMID:34102854 RGD:329812008 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Gad1 glutamate decarboxylase 1 treatment ISO
IEP		 protein:increased expression:dorsal horn of spinal cord RGD PMID:26752351 PMID:27277808 RGD:405850208, RGD:405850240 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gal galanin and GMAP prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12787826 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20457222 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfap glial fibrillary acidic protein IEP
ISO		 associated with Spinal Cord Injuries;mRNA,protein:increased expression:brain,spinal cord:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27093858 PMID:16219025 RGD:8695957 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 IDA RGD PMID:16464682 RGD:6218969 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Gja1 gap junction protein, alpha 1 treatment IMP
ISO
IEP		 associated with Sciatic Neuropathy
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:34286406 PMID:24631560 PMID:23374942 RGD:8662447, RGD:8662456 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:25280432 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 treatment ISO RGD PMID:27816787 RGD:405650587 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IDA RGD PMID:29758384 RGD:13792698 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B treatment ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20042082 PMID:24204988 RGD:13210755 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment
severity		 IDA
IMP
IEP		 associated with bone cancer
associated with Complex Regional Pain Syndromes		 RGD PMID:26935064 PMID:22796071 PMID:25466829 PMID:26064176 RGD:13513996, RGD:13792780, RGD:13514049, RGD:13514046 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grm8 glutamate metabotropic receptor 8 ISO RGD PMID:17113112 RGD:6771186 NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP associated with Limb Ischemia;protein:increased expression:foot muscle, plantar RGD PMID:18691814 RGD:9068903 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 treatment IEP
IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:27474498 PMID:24077211 PMID:30142543 RGD:7364865, RGD:13838658 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hoxd1 homeo box D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21151121 NCBI chr 3:59,665,629...59,667,769
Ensembl chr 3:59,665,629...59,667,769 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A IDA
IMP
ISO		 associated with Diabetic neuropathies;
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17888573 PMID:18930597 PMID:20531396 PMID:25584948 PMID:20039957 RGD:7257680, RGD:401938625, RGD:401901200 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP
IDA		 RGD PMID:21693130 PMID:21843960 RGD:6480665, RGD:6482179 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:9452187 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il10 interleukin 10 treatment IEP
ISO
IDA		 associated with Sciatic Neuropathy
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:7582491 PMID:17174526 PMID:23957449 PMID:24077211 PMID:22820166 RGD:7364792, RGD:7364865, RGD:7364827 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 treatment ISO RGD PMID:11399514 RGD:8549555 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il17a interleukin 17A treatment IDA
IMP		 RGD PMID:23192794 PMID:23246025 RGD:9068942, RGD:9222699 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 treatment IMP associated with Peripheral Nerve Injuries RGD PMID:19036970 RGD:8655929 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:12727271 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta IDA
ISO		 CTD Direct Evidence: marker/mechanism
associated with Peripheral Nerve Injuries		 CTD
RGD		 PMID:7582491 PMID:10401557 PMID:12727271 PMID:17320857 PMID:20937348 More... RGD:1626676, RGD:7401209, RGD:7175548, RGD:6482671 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 IMP
ISO		 RGD PMID:19022353 PMID:11585580 RGD:8662898, RGD:8662903 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1rn interleukin 1 receptor antagonist severity
treatment		 IDA
ISO
IMP		 CTD Direct Evidence: marker/mechanism|therapeutic
associated with Arthritis, Experimental; rat model treated with human protein		 CTD
RGD		 PMID:8864563 PMID:15317861 PMID:17174526 PMID:20937348 PMID:23092240 More... RGD:6909165, RGD:8549800, RGD:7401210, RGD:6909175 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 treatment IMP
IDA
IEP		 associated with Sciatic Neuropathy; mRNA,protein:increased expression:spinal cord: RGD PMID:12755376 PMID:18423867 PMID:22189457 RGD:8662973, RGD:8662980, RGD:8662977 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il33 interleukin 33 IMP RGD PMID:29329586 RGD:40400909 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il6 interleukin 6 IEP
ISO		 associated with Foot Injuries; protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:dorsal root ganglion		 CTD
RGD		 PMID:7582491 PMID:10401557 PMID:18652822 PMID:18988309 PMID:23953943 RGD:8662979, RGD:10402830 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor IEP mRNA:increased expression:dorsal root ganglion RGD PMID:23953943 RGD:10402830 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Insr insulin receptor treatment ISO associated with Diabetic Neuropathies
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18331706 PMID:23511693 RGD:10403050 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Itga1 integrin subunit alpha 1 IMP knock-down using a specific monoclonal antibody or RNAi
PGE2-induced		 RGD PMID:15836982 PMID:14984413 RGD:2302139, RGD:2302389 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Itga2 integrin subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18234883 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itga3 integrin subunit alpha 3 IMP knock-down using a specific monoclonal antibody or RNAi RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itga5 integrin subunit alpha 5 IMP epinephrine-induced
knock-down using a specific monoclonal antibody or RNAi		 RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Itgb1 integrin subunit beta 1 IMP knock-down using a specific monoclonal antibody or RNAi RGD PMID:14984413 PMID:15836982 RGD:2302389, RGD:2302139 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 IEP RGD PMID:25972297 RGD:13793383 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Jak2 Janus kinase 2 treatment IMP
ISO		 associated with Diabetic Neuropathies RGD PMID:18636982 PMID:23511693 RGD:6483031, RGD:10403050 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jak3 Janus kinase 3 treatment IEP RGD PMID:21434883 RGD:11533942 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 IMP RGD PMID:17855600 RGD:10411908 NCBI chr 2:195,063,967...195,100,244
Ensembl chr 2:195,071,769...195,099,233 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 ISO RGD PMID:16675954 RGD:9831112 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435 		JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 IEP associated with Bone Neoplasms;protein:decreased expression:dorsal root ganglia (rat) RGD PMID:23352759 RGD:9686417 NCBI chr 7:97,730,219...98,025,652
Ensembl chr 7:97,730,465...98,025,653 		JBrowse link
G Kmo kynurenine 3-monooxygenase treatment IMP RGD PMID:26524415 RGD:13703043 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
G Kng1 kininogen 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2010815 PMID:2128375 PMID:3061568 PMID:7493622 PMID:7582491 More... NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Kng2 kininogen 2 IDA RGD PMID:20868656 RGD:11059894 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29143802 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:23665054 RGD:11560531 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 onset ISO RGD PMID:19427893 RGD:7495807 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12941468 PMID:27093858 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12941468 PMID:27093858 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17237256 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mc1r melanocortin 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19996949 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Mc4r melanocortin 4 receptor IEP protein:increased expression:dorsal root ganglia (rat) RGD PMID:20081244 RGD:6484233 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mecp2 methyl CpG binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33010341 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Men1 menin 1 IEP associated with Sciatic Neuropathy;protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:20369282 RGD:9589142 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871 		JBrowse link
G Mfn2 mitofusin 2 IEP
ISO		 mRNA:decreased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:28587902 PMID:28587902 RGD:12910704 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir15b microRNA 15b IDA RGD PMID:28012171 RGD:13782150 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir17 microRNA 17 severity IMP RGD PMID:26222740 RGD:11074685 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir381 microRNA 381 treatment IDA RGD PMID:30142543 RGD:13838658 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Mir500 microRNA 500 IEP RNA:decreased expression:dorsal horn of spinal cord RGD PMID:27277808 RGD:405850240 NCBI chr  X:15,258,778...15,258,857
Ensembl chr  X:15,258,768...15,258,859 		JBrowse link
G Mir96 microRNA 96 treatment IDA associated with Sciatic Neuropathy RGD PMID:24234845 RGD:11553932 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Mmp3 matrix metallopeptidase 3 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18754875 PMID:22056600 RGD:8693664 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mpz myelin protein zero ISO CTD Direct Evidence: marker/mechanism CTD PMID:16676325 NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:24382350 RGD:10040983 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nectin1 nectin cell adhesion molecule 1 IMP RGD PMID:27394444 RGD:405866373 NCBI chr 8:44,101,776...44,164,863
Ensembl chr 8:44,101,776...44,189,787 		JBrowse link
G Nefh neurofilament heavy chain treatment IEP RGD PMID:21071147 RGD:27226885 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Ngf nerve growth factor treatment ISO
IMP
IDA		 associated with Cystitis
associated with Osteoarthritis, Experimental
CTD Direct Evidence: marker/mechanism
associated with Peripheral Nerve Injuries;		 CTD
RGD		 PMID:20457222 PMID:16203088 PMID:27208420 PMID:24095693 PMID:11425916 More... RGD:7242799, RGD:405100717, RGD:402463955, RGD:8657088, RGD:7242849, RGD:7242803 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor treatment IMP associated with Brachial Plexus Neuropathies RGD PMID:23324933 RGD:10413898 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nlgn2 neuroligin 2 IMP RGD PMID:23891900 RGD:9831150 NCBI chr10:54,544,461...54,557,854
Ensembl chr10:54,544,588...54,558,434 		JBrowse link
G Nos1 nitric oxide synthase 1 IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19300402 PMID:23909597 RGD:7257597 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17989504 PMID:19300402 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npy neuropeptide Y treatment IEP associated with Sciatic Neuropathy RGD PMID:19556004 RGD:10448929 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nrg1 neuregulin 1 IEP associated with Sciatic Neuropathy
associated with interstitial cystitis;		 RGD PMID:22212401 PMID:30989724 RGD:10449019, RGD:405295490 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Ntf3 neurotrophin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:15659614 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IMP RGD PMID:17667845 PMID:20351485 RGD:5144120, RGD:5684352 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO
IEP		 associated with inflammation;protein:increased expression:dorsal root ganglion: RGD PMID:12470870 PMID:21958434 RGD:8657091, RGD:8657122 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Ntsr1 neurotensin receptor 1 IDA RGD PMID:22396077 RGD:9743902 NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377 		JBrowse link
G Oprk1 opioid receptor, kappa 1 treatment IMP associated with Diabetes Mellitus, Experimental; RGD PMID:16924480 RGD:9834947 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IEP associated with Sciatic Neuropathy;mRNA:increased expression:spinal cord lumbar segment,dorsal root ganglion: RGD PMID:12106803 RGD:9835017 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17996026 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G P2rx2 purinergic receptor P2X 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19383439 NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891 		JBrowse link
G P2rx3 purinergic receptor P2X 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19383439 NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178 		JBrowse link
G P2rx4 purinergic receptor P2X 4 treatment IMP associated with Peripheral Nerve Injuries; RGD PMID:29927790 RGD:40924654 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G P2ry12 purinergic receptor P2Y12 ISO
IMP		 RGD PMID:20398327 PMID:20136836 RGD:6480525, RGD:6480526 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361 		JBrowse link
G Pawr pro-apoptotic WT1 regulator treatment IDA RGD PMID:17179954 RGD:9835416 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pdyn prodynorphin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17670969 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:23235561 RGD:10003116 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pla2g4a phospholipase A2 group 4A IMP RGD PMID:16203828 RGD:1642461 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pnoc prepronociceptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12665541 PMID:19231294 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867 		JBrowse link
G Pomc proopiomelanocortin treatment IMP associated with Inflammation RGD PMID:19934807 RGD:407580522 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha IMP RGD PMID:26732138 RGD:11572421 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Prkcb protein kinase C, beta IDA associated with inflammation;protein:increased activity:spinal cord RGD PMID:16360284 RGD:1625519 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkce protein kinase C, epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:11738263 PMID:12582831 PMID:20457222 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkcg protein kinase C, gamma treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19955894 PMID:27093858 PMID:12560106 RGD:28867224 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prkcz protein kinase C, zeta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27899695 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 treatment ISO RGD PMID:14973199 RGD:7775058 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Prok2 prokineticin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385 		JBrowse link
G Prokr1 prokineticin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr 4:120,022,301...120,033,367
Ensembl chr 4:120,021,747...120,033,379 		JBrowse link
G Ptafr platelet-activating factor receptor treatment IMP RGD PMID:16925995 RGD:10041052 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Ptger1 prostaglandin E receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11375261 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Ptger3 prostaglandin E receptor 3 IEP protein:increased expression:lumbar spinal cord dorsal horn (rat) RGD PMID:17413918 RGD:5688169 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptger4 prostaglandin E receptor 4 treatment IMP RGD PMID:20423341 RGD:10003041 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptges3 prostaglandin E synthase 3 IMP RGD PMID:16192391 RGD:5688057 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IEP
ISO		 protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17989504 PMID:17413918 RGD:5688169 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17112505 PMID:17989504 PMID:15464832 RGD:5688224 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pthlh parathyroid hormone-like hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:16769263 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18976650 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 treatment IMP associated with lesion of sciatic nerve RGD PMID:27641322 RGD:13524513 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16545521 PMID:19070548 RGD:6484253 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23264124 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044 		JBrowse link
G Sin3a SIN3 transcription regulator family member A IEP associated with Arthritis, Experimental;mRNA:decreased expression:spinal cord, neuron RGD PMID:17553988 RGD:9495916 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192 		JBrowse link
G Slc12a5 solute carrier family 12 member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20086212 NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 IEP protein:increased expression:dorsal horn of spinal cord, neuron RGD PMID:22160634 RGD:9999169 NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079 		JBrowse link
G Sparc secreted protein acidic and cysteine rich ISO CTD Direct Evidence: marker/mechanism CTD PMID:20714283 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IEP protein:increased phosphorylation:spinal cord RGD PMID:27394444 RGD:405866373 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IMP RGD PMID:24098399 RGD:8694290 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Syn2 synapsin II ISO CTD Direct Evidence: marker/mechanism CTD PMID:18701217 NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192 		JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8864563 PMID:9714424 PMID:10499367 PMID:12351280 PMID:12787826 More... NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15964684 PMID:17123731 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33607128 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 IMP associated with Experimental Pancreatitis, Chronic RGD PMID:26645248 RGD:14995470 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Thbd thrombomodulin treatment ISO associated with Inflammation
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:27474498 PMID:24004409 RGD:11038687 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Tlr2 toll-like receptor 2 ISO
IDA		 RGD PMID:17355971 PMID:24204973 RGD:8553059, RGD:8553185 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 IMP
ISO		 RGD PMID:20714435 PMID:24204973 PMID:15809417 RGD:4144070, RGD:8553185, RGD:7815040 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor IMP
ISO
IDA
IEP		 CTD Direct Evidence: marker/mechanism
associated with Diabetic Neuropathies;
mRNA,protein:increased expression:spinal cord:
protein:increased expression:lumbar vertebra:		 CTD
RGD		 PMID:7582491 PMID:7881729 PMID:10401557 PMID:12727271 PMID:16472913 More... RGD:7387300, RGD:7401179, RGD:7394757, RGD:7394741, RGD:7394737, RGD:7387302, RGD:7387300 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B ISO CTD Direct Evidence: therapeutic CTD PMID:16769263 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A treatment IMP
IEP
ISO		 associated with Sciatic Neuropathy RGD PMID:12752784 PMID:22652595 PMID:21712071 PMID:24257399 PMID:20417692 More... RGD:5130913, RGD:8661750, RGD:8548873, RGD:8661737, RGD:8661726, RGD:5130939 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO
IMP		 associated with Sciatic Neuropathy RGD PMID:18463260 PMID:22652595 RGD:5130960, RGD:8661750 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IMP
ISO		 associated with Peripheral Nerve Injuries;
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18234885 PMID:21481532 PMID:23523557 PMID:18954467 RGD:10043618 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 IMP associated with Inflammation RGD PMID:19439599 RGD:7247605 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 IMP RGD PMID:19439599 RGD:7247605 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IEP
ISO		 associated with inflammation;protein:increased expression:dorsal root ganglion:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12151517 PMID:18234885 PMID:18774343 PMID:23006841 PMID:21958434 RGD:8657122 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18234883 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517 		JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12787826 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
Hypoalgesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp4 aquaporin 4 ISO RGD PMID:20851747 RGD:8696005 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Hdac4 histone deacetylase 4 ISO RGD PMID:19672313 RGD:9681457 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
IMMUNODEFICIENCY 108 WITH AUTOINFLAMMATION term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpe CCAAT/enhancer binding protein epsilon ISO ClinVar Annotator: match by term: CEBPE-related condition | ClinVar Annotator: match by term: Pelger-Huet-like anomaly and episodic fever with abdominal pain OMIM
ClinVar		 PMID:4831644 PMID:25741868 PMID:26104880 PMID:28492532 PMID:31201888 NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814 		JBrowse link
INTELLECTUAL DEVELOPMENTAL DISORDER WITH GASTROINTESTINAL DIFFICULTIES AND HIGH PAIN THRESHOLD term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D ISO ClinVar Annotator: match by term: Intellectual developmental disorder with gastrointestinal difficulties and high pain threshold | ClinVar Annotator: match by term: PPM1D-related condition OMIM
ClinVar		 PMID:23907125 PMID:24262437 PMID:25741868 PMID:28343630 PMID:28492532 More... NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607 		JBrowse link
intermediate coronary syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO mRNA:increased expression:ventricular myocardium (human)
mRNA:increased expression:myocardium		 RGD PMID:15131005 PMID:11451295 RGD:8142363, RGD:8548894 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Agt angiotensinogen ISO mRNA:increased expression:myocardium RGD PMID:11451295 RGD:8548894 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO mRNA:increased expression:myocardium RGD PMID:11451295 RGD:8548894 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO protein:increased serine phosphorylation:platelet RGD PMID:20467748 RGD:5509094 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apoa4 apolipoprotein A4 ISO protein:decreased expression:blood plasma (human) RGD PMID:20367977 RGD:5685646 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO RGD PMID:16186425 RGD:4891111 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Crp C-reactive protein disease_progression ISO RGD PMID:9761079 RGD:9491780 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Edn1 endothelin 1 ISO associated with Coronary Artery Disease;protein:increased expression:coronary sinus, plasma (human) RGD PMID:14556009 RGD:8661755 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G F7 coagulation factor VII ISO protein:increased expression:plasma (human) RGD PMID:10653827 RGD:2312399 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:18333374 RGD:5508458 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Itga2 integrin subunit alpha 2 susceptibility ISO RGD PMID:15104219 RGD:1582303 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itgam integrin subunit alpha M ameliorates ISO protein:decreased expression:neutrophil (human) RGD PMID:18043994 RGD:329901840 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 ISO RGD PMID:10486281 RGD:1582334 NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708 		JBrowse link
G Mir126a microRNA 126a disease_progression ISO RGD PMID:32595526 RGD:401851053 NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180 		JBrowse link
G Mir21 microRNA 21 ISO RNA:decreased expression:serum RGD PMID:32595526 RGD:401851053 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO RGD PMID:14675588 RGD:1582536 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Pappa pappalysin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11586954 NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666 		JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:2382605 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pten phosphatase and tensin homolog ISO RNA:increased expression:serum RGD PMID:32595526 RGD:401851053 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Selp selectin P ISO protein:increased expression:serum RGD PMID:21162967 RGD:6219003 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO RGD PMID:8122184 RGD:11035255 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Sod3 superoxide dismutase 3 ISO RGD PMID:14592844 RGD:1580841 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Txn1 thioredoxin 1 ISO RGD PMID:15749180 RGD:1580784 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
Low Back Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: therapeutic CTD PMID:7888893 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Sparc secreted protein acidic and cysteine rich ISO CTD Direct Evidence: marker/mechanism CTD PMID:20714283 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
Microvascular Angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb1 bradykinin receptor B1 ISO mRNA:increased expression:blood, mononuclear cell RGD PMID:17852785 RGD:4890450 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO mRNA:increased expression:blood, mononuclear cell RGD PMID:17852785 RGD:4890450 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO DNA:transition:cds:g.677C>T (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17491230 PMID:17491230 RGD:4891159 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B ISO protein:decreased expression:serum RGD PMID:15648548 RGD:1620974 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
Musculoskeletal Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25218601 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Esr1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25218601 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25218601 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
Myalgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lama2 laminin subunit alpha 2 ISO ClinVar Annotator: match by term: Myalgia ClinVar PMID:9674786 PMID:18700894 PMID:25741868 PMID:28445022 PMID:28492532 More... NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530 		JBrowse link
G Ryr1 ryanodine receptor 1 ISO ClinVar Annotator: match by term: Myalgia ClinVar PMID:24195946 PMID:25741868 PMID:28259615 PMID:28492532 PMID:33564012 More... NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 ISO ClinVar Annotator: match by term: Myalgia ClinVar PMID:8528245 PMID:9734597 PMID:10988270 PMID:12039972 PMID:17329572 More... NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO ClinVar Annotator: match by term: Myalgia ClinVar PMID:25741868 PMID:28492532 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
Myopathy with Myalgia, increased Serum Creatine Kinase, and with or without Episodic Rhabdomyolysis 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlip muscular LMNA-interacting protein ISO ClinVar Annotator: match by term: Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis OMIM
ClinVar		 PMID:34581780 PMID:34935254 PMID:35672413 PMID:35915960 NCBI chr 8:77,935,087...78,204,725
Ensembl chr 8:77,935,079...78,204,254 		JBrowse link
Myopathy with Myalgia, increased Serum Creatine Kinase, and with or without Episodic Rhabdomyolysis 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dtna dystrobrevin, alpha ISO ClinVar Annotator: match by term: MYOPATHY WITH MYALGIA, INCREASED SERUM CREATINE KINASE, AND WITH OR WITHOUT EPISODIC RHABDOMYOLYSIS 2 OMIM
ClinVar		 PMID:36799992 NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261 		JBrowse link
Neck Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase severity ISO associated with breast cancer;DNA:missense mutation:cds:p.V158M (human) RGD PMID:21898113 RGD:8662332 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A IEP RGD PMID:12946573 RGD:6893571 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2c adrenoceptor alpha 2C IEP RGD PMID:12946573 RGD:6893571 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Aqp9 aquaporin 9 ameliorates IMP RGD PMID:31746418 RGD:152995474 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17442347 PMID:18400411 PMID:19339603 PMID:24133248 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 ameliorates IMP RGD PMID:24659417 RGD:401940123 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cfl1 cofilin 1 treatment IEP associated with Sciatic Neuropathy RGD PMID:27216618 RGD:11568694 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Ctss cathepsin S IEP
IMP		 RGD PMID:18700000 PMID:17551020 RGD:5686878, RGD:5686911 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Ctsz cathepsin Z IEP RGD PMID:18700000 RGD:5686878 NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17292584 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17720801 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Drd1 dopamine receptor D1 IEP RGD PMID:22171983 RGD:6907447 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 IMP
IEP		 RGD PMID:22902996 PMID:22171983 RGD:6907443, RGD:6907447 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Foxp3 forkhead box P3 treatment IEP
ISO		 mRNA:increased expression: L4-L5 of the spinal cord RGD PMID:30858084 PMID:30858084 RGD:38599004, RGD:38599004 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gal galanin and GMAP prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment IMP RGD PMID:19922668 RGD:401700384 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Gja1 gap junction protein, alpha 1 ISO associated with Spinal Cord Injuries; RGD PMID:22951907 RGD:7364890 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IEP RGD PMID:24659417 RGD:401940123 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grk1 G protein-coupled receptor kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment IEP RGD PMID:24216329 RGD:13792703 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840219 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274 		JBrowse link
G Hmgb1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A ISO protein:increased expression:dorsal raphe nucleus RGD PMID:31045847 RGD:405849276 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28011743 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Il10 interleukin 10 treatment IDA
IMP
ISO		 RGD PMID:16949747 PMID:25078297 PMID:24077211 RGD:1598632, RGD:11049468, RGD:7364865 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Itgam integrin subunit alpha M IEP mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Kdr kinase insert domain receptor IEP RGD PMID:20705122 RGD:5684389 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mir135a microRNA 135a ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 7:26,611,990...26,612,089
Ensembl chr 7:26,611,990...26,612,089 		JBrowse link
G Mir135b microRNA 135b ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr13:43,638,857...43,638,953
Ensembl chr13:43,638,857...43,638,953 		JBrowse link
G Mir154 microRNA 154 IMP RGD PMID:31746418 RGD:152995474 NCBI chr 6:128,752,947...128,753,030
Ensembl chr 6:128,752,947...128,753,030 		JBrowse link
G Mir208a microRNA 208a ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr15:28,425,570...28,425,652 JBrowse link
G Mir221 microRNA 221 treatment IMP RGD PMID:27059231 RGD:151347419 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir223 microRNA 223 treatment IDA RGD PMID:28580822 RGD:25824768 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 IEP RGD PMID:23386250 RGD:329337338 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 treatment IEP RGD PMID:23386250 RGD:329337338 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Nos1 nitric oxide synthase 1 treatment IDA RGD PMID:23342771 RGD:7257658 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14718584 PMID:18400411 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G P2ry12 purinergic receptor P2Y12 IMP RGD PMID:20665560 RGD:6480524 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361 		JBrowse link
G Pomc proopiomelanocortin treatment IMP RGD PMID:23624847 RGD:407574732 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30152261 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19557861 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 treatment IEP RGD PMID:27059231 RGD:151347419 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase treatment IEP RGD PMID:33746000 RGD:150521727 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment IEP RGD PMID:24979268 RGD:11073677 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 IEP mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20846523 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421 		JBrowse link
Nociceptive Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment IEP RGD PMID:21107265 RGD:405650611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Grm8 glutamate metabotropic receptor 8 ISO RGD PMID:17113112 RGD:6771186 NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831 		JBrowse link
G Pdyn prodynorphin IDA RGD PMID:25663984 RGD:401851903 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Pomc proopiomelanocortin ISO RGD PMID:21380811 RGD:5508807 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:21371033 RGD:6483537 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgis prostaglandin I2 synthase ameliorates ISO RGD PMID:26611322 RGD:11536046 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Vip vasoactive intestinal peptide IDA RGD PMID:19467283 RGD:5685608 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
Painful Neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 ISO
IEP		 protein:increased expression:medulla oblongata, dorsal horn of spinal cord (mouse)
protein:increased expression:ipsilateral side, dorsal root ganglion (rat)		 RGD PMID:22721162 PMID:15041200 RGD:8548831, RGD:8548884 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ep300 E1A binding protein p300 treatment IMP
IEP		 mRNA:increased expression:lumbar spinal cord (rat) RGD PMID:23176208 PMID:23176208 RGD:7327202, RGD:7327202 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Hmgb1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27474498 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Thbd thrombomodulin ISO CTD Direct Evidence: therapeutic CTD PMID:27474498 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Tlr4 toll-like receptor 4 treatment ISO RGD PMID:18615568 RGD:7815041 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor ISO
IMP		 protein:increased expression:Schwann cell RGD PMID:11376190 PMID:10825476 PMID:9514564 PMID:18394803 RGD:7394735, RGD:7394741, RGD:7394740, RGD:7394739 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
paroxysmal extreme pain disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Paroxysmal extreme pain disorder ClinVar PMID:25741868 PMID:34298581 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO ClinVar Annotator: match by term: Paroxysmal extreme pain disorder | ClinVar Annotator: match by term: RECTAL PAIN, FAMILIAL
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:15955112 PMID:17145499 PMID:17679678 PMID:18060017 PMID:18414213 More... NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516 		JBrowse link
Postherpetic Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn8a sodium voltage-gated channel alpha subunit 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516 		JBrowse link
Postoperative Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO CTD Direct Evidence: therapeutic CTD PMID:20627697 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28434951 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Dusp6 dual specificity phosphatase 6 ISO associated with Inflammation RGD PMID:24155322 RGD:7771585 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
Prinzmetal angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:plasma RGD PMID:9415270 RGD:8547713 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 ISO RGD PMID:11984590 RGD:1581700 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603 		JBrowse link
Referred Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor IMP RGD PMID:23313710 RGD:8655857 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
Renal Colic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein ISO associated with Urolithiasis; RGD PMID:20206981 RGD:6909142 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 IMP RGD PMID:16176350 RGD:2302154 NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B treatment IDA RGD PMID:22425187 RGD:7245944 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
Stable Angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F7 coagulation factor VII ISO protein:increased activity:plasma (human) RGD PMID:17357481 RGD:11049525 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G Mir126a microRNA 126a ISO RNA:decreased expression:plasma RGD PMID:27900989 RGD:401850572 NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Rbp4 retinol binding protein 4 ISO protein:increased expression:blood serum (human) RGD PMID:25142320 RGD:329845867 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Tlr4 toll-like receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Toothache term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npy1r neuropeptide Y receptor Y1 ISO CTD Direct Evidence: therapeutic CTD PMID:18809749 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
Visceral Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A IMP RGD PMID:20047711 RGD:6480482 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO associated with Colitis; protein:increased expression:dorsal root ganglion: RGD PMID:21997550 PMID:19932037 RGD:8655978, RGD:8657331 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Ephb2 Eph receptor B2 ameliorates ISO RGD PMID:33880135 RGD:127285657 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment IMP
ISO		 DNA:haplotype RGD PMID:25783971 PMID:25783971 RGD:401700391, RGD:401700391 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Penk proenkephalin treatment ISO RGD PMID:23316929 RGD:10003040 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IMP associated with Colitis; RGD PMID:23099257 RGD:10043788 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 IMP RGD PMID:24388923 RGD:13825245 NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:138,308,084...138,476,768 		JBrowse link
G Trpc4Tn(sb-T2/Bart3)2.192Mcwi transient receptor potential cation channel, subfamily C, member 4; transposon insertion 2.192, Medical College of Wisconsin IMP RGD PMID:24388923 RGD:13825245
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19104
    Pathological Conditions, Signs and Symptoms 13617
      Signs and Symptoms 11197
        Neurologic Manifestations 10431
          Pain 349
            Abdominal Pain + 4
            Acute Pain 1
            Arthralgia + 4
            Back Pain + 3
            Breakthrough Pain 0
            Cancer Pain 7
            Chest Pain + 44
            Chronic Pain 7
            Earache 0
            Eye Pain 1
            Facial Pain + 1
            Flank Pain 0
            Glossalgia 0
            Headache + 8
            Hyperalgesia 211
            Hypoalgesia 2
            INTELLECTUAL DEVELOPMENTAL DISORDER WITH GASTROINTESTINAL DIFFICULTIES AND HIGH PAIN THRESHOLD 1
            Intractable Pain 0
            Labor Pain 0
            Levator Syndrome 0
            Mastodynia 0
            Metatarsalgia + 0
            Musculoskeletal Pain + 10
            Neck Pain 1
            Neuralgia + 59
            Nociceptive Pain + 19
            Painful Neuropathy 6
            Pelvic Pain + 5
            Postoperative Pain + 5
            Referred Pain 1
            Renal Colic 1
            familial episodic pain syndrome + 3
            paroxysmal extreme pain disorder 2
paths to the root