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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Pain
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Accession:DOID:9000641 term browser browse the term
Definition:An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Synonyms:exact_synonym: Ache;   Burning Pain;   Crushing Pain;   Crushing Pains;   Migratory Pain;   Migratory Pains;   Physical Suffering;   Physical Sufferings;   Radiating Pain;   Radiating Pains;   aches;   burning pains;   splitting pain;   splitting pains
 primary_id: MESH:D010146
 xref: EFO:0003843


show annotations for term's descendants           Sort by:
Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:28193520 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G ACE angiotensin I converting enzyme ISO RGD PMID:18555989 RGD:2325233 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G ADM adrenomedullin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17043245 NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842 		JBrowse link
G AIF1 allograft inflammatory factor 1 ISO associated with Diabetes Mellitus, Experimental; protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:18186080 RGD:2313034 NCBI chr 6:31,276,215...31,278,051
Ensembl chr 6:32,166,301...32,168,125 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17084039 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756 		JBrowse link
G ALB albumin ISO CTD Direct Evidence: therapeutic CTD PMID:4126124 NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:19580807 RGD:2317533 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016 		JBrowse link
G AQP1 aquaporin 1 (Colton blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:20018876 NCBI chr 7:31,524,933...31,538,602
Ensembl chr 7:31,644,331...31,658,141 		JBrowse link
G AVP arginine vasopressin ISO CTD Direct Evidence: therapeutic CTD PMID:2271928 PMID:6094376 NCBI chr20:3,169,094...3,172,900 JBrowse link
G BDKRB1 bradykinin receptor B1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17988733 PMID:20152050 RGD:5129214 NCBI chr14:76,885,923...76,894,456 JBrowse link
G BDKRB2 bradykinin receptor B2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20152050 NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253 		JBrowse link
G BDNF brain derived neurotrophic factor ISO RGD PMID:20452292 RGD:4891137 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17088553 NCBI chr 7:73,917,439...74,410,627
Ensembl chr 7:87,579,004...88,068,482 		JBrowse link
G CASP1 caspase 1 ISO RGD PMID:19853379 RGD:2315887 NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149 		JBrowse link
G CCK cholecystokinin ISO RGD PMID:17157334 RGD:2313635 NCBI chr 3:42,168,012...42,176,358
Ensembl chr 3:42,431,022...42,439,396 		JBrowse link
G CCKBR cholecystokinin B receptor ISO associated with Diabetes Mellitus, Experimental RGD PMID:16527403 RGD:2311323 NCBI chr11:6,393,435...6,405,821
Ensembl chr11:6,075,816...6,088,145 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:18419759 RGD:2307043 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCL22 C-C motif chemokine ligand 22 ISO RGD PMID:11438578 RGD:2306307 NCBI chr16:37,631,861...37,640,208
Ensembl chr16:56,765,367...56,771,213 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO RGD PMID:11438578 RGD:2306307 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO associated with Osteoarthritis, Knee; RGD PMID:18419759 PMID:23185004 RGD:2307043 RGD:8661785 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G CLCN7 chloride voltage-gated channel 7 ISO mRNA:increased expression:spinal cord dorsal horn RGD PMID:11846422 RGD:1600865 NCBI chr16:64,599...95,016
Ensembl chr16:1,498,432...1,519,951 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO CTD Direct Evidence: therapeutic RGD
CTD		 PMID:19193902 PMID:19661434 RGD:2314649 NCBI chr 6:86,017,141...86,044,889 JBrowse link
G CNR2 cannabinoid receptor 2 ISO RGD PMID:19409856 RGD:2316193 NCBI chr 1:23,066,153...23,108,065
Ensembl chr 1:24,050,008...24,051,090 		JBrowse link
G COMT catechol-O-methyltransferase severity ISO associated with Multiple Sclerosis;DNA:polymorphism:cds:rs4680(p.V158M)(human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17084978 PMID:20561508 PMID:24290452 RGD:13450948 RGD:2289747 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G CRH corticotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:16495007 NCBI chr 8:62,714,721...62,716,979
Ensembl chr 8:64,383,419...64,384,009 		JBrowse link
G CSF2 colony stimulating factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8622042 NCBI chr 5:127,496,951...127,499,325
Ensembl chr 5:133,660,775...133,663,146 		JBrowse link
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7541186 PMID:8622042 PMID:10864982 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO associated with Bone Neoplasms RGD PMID:20736819 RGD:4892020 NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 ISO RGD PMID:11438578 RGD:2306307 NCBI chr10:41,296,975...41,384,864
Ensembl chr10:44,552,480...44,564,231 		JBrowse link
G DISC1 DISC1 scaffold protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:20561508 NCBI chr 1:207,180,513...207,594,684
Ensembl chr 1:212,265,520...212,612,079 		JBrowse link
G DRD2 dopamine receptor D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15996639 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935 		JBrowse link
G EDN1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19429182 PMID:20042899 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G GCH1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19081190 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393 		JBrowse link
G GJB1 gap junction protein beta 1 ISO ClinVar Annotator: match by term: Pain ClinVar PMID:16096811 PMID:21291455 PMID:22243284 PMID:25388846 PMID:25741868 More... NCBI chr  X:60,490,579...60,492,606
Ensembl chr  X:70,547,110...70,547,961 		JBrowse link
G GLA galactosidase alpha treatment ISO Allyl isothiocyanate (XCO:0000608)
compared to wild type		 RGD PMID:29563343 RGD:150429980 NCBI chr  X:90,600,412...90,610,594
Ensembl chr  X:100,732,311...100,742,280 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18155693 NCBI chr 9:108,198,350...108,228,887
Ensembl chr 9:137,168,722...137,197,382 		JBrowse link
G HCRT hypocretin neuropeptide precursor ISO CTD Direct Evidence: therapeutic CTD PMID:16202530 NCBI chr17:15,130,581...15,132,024
Ensembl chr17:15,353,203...15,354,594 		JBrowse link
G HFE homeostatic iron regulator ISO ClinVar Annotator: match by term: Pain ClinVar PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591 		JBrowse link
G HGF hepatocyte growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:26000320 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811 		JBrowse link
G HOXD1 homeobox D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21151121 NCBI chr2B:63,468,317...63,470,658 JBrowse link
G HRH1 histamine receptor H1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12128009 PMID:14569158 NCBI chr 3:11,074,451...11,199,871
Ensembl chr 3:11,541,294...11,542,757 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:12595749 PMID:21945716 RGD:5683627 NCBI chr 5:50,045,266...50,049,636
Ensembl chr 5:51,692,416...51,693,684 		JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B ISO RGD PMID:16165284 RGD:1626470 NCBI chr 6:75,309,078...75,313,747
Ensembl chr 6:78,596,408...78,597,580 		JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO RGD PMID:17451674 RGD:1624996 NCBI chr  X:103,673,172...103,999,133
Ensembl chr  X:114,199,485...114,503,201 		JBrowse link
G HTR3B 5-hydroxytryptamine receptor 3B ISO CTD Direct Evidence: marker/mechanism CTD PMID:17600820 NCBI chr11:108,783,514...108,825,266
Ensembl chr11:112,624,864...112,671,439 		JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17600820 NCBI chr10:87,480,970...87,598,212
Ensembl chr10:91,009,941...91,125,158 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:19853379 RGD:2315887 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO CTD Direct Evidence: therapeutic CTD PMID:15317861 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G IL2 interleukin 2 ISO CTD Direct Evidence: therapeutic CTD PMID:12421473 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer ISO RGD PMID:20626857 RGD:5509945 NCBI chr 5:58,023,704...58,081,895
Ensembl chr 5:59,669,606...59,708,817 		JBrowse link
G KNG1 kininogen 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1281941 PMID:3951883 PMID:10445233 PMID:10543429 PMID:16076651 More... NCBI chr 3:183,751,598...183,778,655
Ensembl chr 3:192,219,462...192,245,149 		JBrowse link
G LOC100972354 interferon alpha-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8759893 NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 ISO ClinVar Annotator: match by term: Pain ClinVar PMID:25741868 PMID:28492532 NCBI chr19:3,114,445...3,148,619
Ensembl chr19:4,064,626...4,097,933 		JBrowse link
G NGF nerve growth factor treatment ISO associated with Cystitis, Interstitial RGD PMID:17905097 PMID:19103210 RGD:2303798 RGD:7242806 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NGFR nerve growth factor receptor ISO associated with Inflammation RGD PMID:20060234 RGD:5144063 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO RGD PMID:18079061 RGD:2292111 NCBI chr 7:142,577,334...142,600,702
Ensembl chr 7:154,730,009...154,755,233 		JBrowse link
G NPPA natriuretic peptide A ISO CTD Direct Evidence: therapeutic CTD PMID:13679232 NCBI chr 1:10,608,025...10,610,287
Ensembl chr 1:11,825,072...11,827,373 		JBrowse link
G NPPB natriuretic peptide B ISO CTD Direct Evidence: therapeutic CTD PMID:27687165 NCBI chr 1:10,621,416...10,622,960
Ensembl chr 1:11,838,518...11,839,995 		JBrowse link
G NPR1 natriuretic peptide receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27687165 NCBI chr 1:129,034,972...129,050,439
Ensembl chr 1:132,664,948...132,679,327 		JBrowse link
G NRG1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20561508 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977 		JBrowse link
G NTSR1 neurotensin receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:20727387 NCBI chr20:59,100,110...59,151,563
Ensembl chr20:60,392,736...60,446,056 		JBrowse link
G OPRD1 opioid receptor delta 1 ISO RGD PMID:12710986 RGD:2316589 NCBI chr 1:28,068,053...28,143,053
Ensembl chr 1:29,112,152...29,163,464 		JBrowse link
G OPRK1 opioid receptor kappa 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9463367 NCBI chr 8:49,650,844...49,677,494
Ensembl chr 8:47,029,313...47,056,577 		JBrowse link
G OPRM1 opioid receptor mu 1 ISO RGD PMID:12710986 RGD:2316589 NCBI chr 6:151,827,323...151,937,658
Ensembl chr 6:156,517,661...157,088,251 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:6094376 PMID:17420069 PMID:17664006 RGD:2304129 NCBI chr20:3,157,246...3,159,013 JBrowse link
G PDYN prodynorphin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17670969 PMID:20068450 NCBI chr20:2,092,171...2,108,141
Ensembl chr20:1,856,850...1,872,452 		JBrowse link
G PENK proenkephalin ISO CTD Direct Evidence: therapeutic CTD PMID:15833551 NCBI chr 8:52,864,388...52,870,144
Ensembl chr 8:50,234,170...50,239,949 		JBrowse link
G PLCB1 phospholipase C beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16405873 NCBI chr20:8,106,665...8,858,572
Ensembl chr20:7,887,960...8,636,019 		JBrowse link
G PNOC prepronociceptin ISO CTD Direct Evidence: therapeutic CTD PMID:19231294 NCBI chr 8:27,596,413...27,622,844
Ensembl chr 8:24,796,638...24,822,758 		JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism|therapeutic
associated with Inflammation		 CTD
RGD		 PMID:4345333 PMID:6094376 PMID:17223201 PMID:20084599 RGD:407574731 NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO RGD PMID:18387855 RGD:2301890 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060 		JBrowse link
G PPP1R9A protein phosphatase 1 regulatory subunit 9A treatment ISO RGD PMID:20359166 RGD:10002735 NCBI chr 7:86,863,919...87,251,634
Ensembl chr 7:100,455,357...100,833,220 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO protein:increased expression:spinal cord RGD PMID:12384231 RGD:7775057 NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882 		JBrowse link
G PROKR1 prokineticin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr2A:68,685,129...68,700,372
Ensembl chr2A:69,808,033...69,822,404 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO associated with Osteoarthritis, Knee;mRNA, protein:increased expression:spinal cord RGD PMID:17942724 PMID:18637715 RGD:2300223 RGD:2300252 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 susceptibility ISO associated with lung neoplasm;DNA:SNP:exon:rs5275 (human)
associated with Osteoarthritis, Knee;mRNA, protein:increased expression:spinal cord		 RGD PMID:18497304 PMID:18637715 PMID:19773451 RGD:2300223 RGD:2300228 RGD:5135482 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G PTN pleiotrophin severity ISO RGD PMID:20826137 RGD:10043829 NCBI chr 7:129,184,786...129,300,815
Ensembl chr 7:141,701,430...141,705,623 		JBrowse link
G SLC6A1 solute carrier family 6 member 1 ISO RGD PMID:17918738 RGD:1643217 NCBI chr 3:10,930,455...10,976,968
Ensembl chr 3:11,296,023...11,323,624 		JBrowse link
G SLC9A1 solute carrier family 9 member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19248819 NCBI chr 1:26,359,818...26,418,910
Ensembl chr 1:27,414,937...27,475,089 		JBrowse link
G TAC1 tachykinin precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:7694222 PMID:10445233 PMID:17493276 RGD:2304337 NCBI chr 7:89,675,834...89,684,391
Ensembl chr 7:103,257,501...103,266,389 		JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:18407414 RGD:2304276 NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018 		JBrowse link
G TACR3 tachykinin receptor 3 ISO RGD PMID:19093101 RGD:2304256 NCBI chr 4:96,022,788...96,162,249
Ensembl chr 4:106,644,943...106,776,172 		JBrowse link
G TJP1 tight junction protein 1 ISO associated with Inflammation;protein:increased expression:brain RGD PMID:19319146 RGD:2325136 NCBI chr15:981,198...1,249,292
Ensembl chr15:26,344,878...26,598,878 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:24204973 RGD:8553185 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:18662331 RGD:2312574 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18582539 PMID:20383154 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased expression:dorsal root ganglion (rat) RGD PMID:21248590 RGD:5130897 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G TRH thyrotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:6409194 NCBI chr 3:127,037,069...127,041,299
Ensembl chr 3:134,383,016...134,387,736 		JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20601631 NCBI chr 8:68,551,685...68,605,336
Ensembl chr 8:70,210,352...70,262,627 		JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:16996476 PMID:17575321 PMID:20422007 PMID:22998799 PMID:23006841 RGD:597976450 NCBI chr17:3,612,781...3,658,608
Ensembl chr17:3,609,952...3,637,579 		JBrowse link
G VIP vasoactive intestinal peptide ISO CTD Direct Evidence: therapeutic CTD PMID:9920454 NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730 		JBrowse link
Abdominal Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HFE homeostatic iron regulator ISO ClinVar Annotator: match by term: Abdominal pain ClinVar PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591 		JBrowse link
G HMBS hydroxymethylbilane synthase ISO ClinVar Annotator: match by term: Abdominal pain ClinVar NCBI chr11:113,923,004...113,931,732
Ensembl chr11:117,852,295...117,860,757 		JBrowse link
G LOC100972354 interferon alpha-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9234591 NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736 		JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 ISO RGD PMID:24291101 RGD:10043376 NCBI chr 8:68,551,685...68,605,336
Ensembl chr 8:70,210,352...70,262,627 		JBrowse link
Acute Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase susceptibility ISO associated with Anemia, Sickle Cell;DNA:polymorphism:cds:p.V158M(human) RGD PMID:25102390 RGD:13450943 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
amyotrophic neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SEPTIN9 septin 9 ISO ClinVar Annotator: match by term: Amyotrophic neuralgia | ClinVar Annotator: match by term: Amyotrophy, hereditary neuralgic | ClinVar Annotator: match by term: Hereditary Neuralgic Amyotrophy (HNA) ClinVar PMID:16186812 PMID:17546647 PMID:18492087 PMID:19139049 PMID:19204161 More... NCBI chr17:71,361,002...71,580,995
Ensembl chr17:76,920,236...77,139,586 		JBrowse link
Angina Pectoris term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 ISO RGD PMID:11527135 RGD:5129114 NCBI chr10:110,642,491...110,646,595 JBrowse link
G ADRB2 adrenoceptor beta 2 ISO RGD PMID:11527135 RGD:5129114 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892 		JBrowse link
G AVP arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11128043 PMID:11791009 NCBI chr20:3,169,094...3,172,900 JBrowse link
G CPB2 carboxypeptidase B2 ISO RGD PMID:12624641 RGD:1598479 NCBI chr13:26,926,788...26,979,767 JBrowse link
G PLAU plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:1730212 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PPBP pro-platelet basic protein ISO protein:increased expression:plasma RGD PMID:17045893 RGD:401794448 NCBI chr 4:50,203,168...50,204,303
Ensembl chr 4:56,035,060...56,037,702 		JBrowse link
G SPP1 secreted phosphoprotein 1 ISO RGD PMID:16421174 RGD:1581390 NCBI chr 4:80,263,711...80,271,466
Ensembl chr 4:90,988,200...90,995,935 		JBrowse link
Arthralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor treatment ISO associated with osteoarthritis RGD PMID:31479064 RGD:597015765 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7543699 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729 		JBrowse link
G MVK mevalonate kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:10369261 NCBI chr12:107,150,477...107,173,978
Ensembl chr12:110,544,991...110,568,524 		JBrowse link
G TSC2 TSC complex subunit 2 ISO ClinVar Annotator: match by term: Arthralgia ClinVar PMID:25741868 PMID:28492532 PMID:30311386 NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569 		JBrowse link
G WNT10A Wnt family member 10A ISO ClinVar Annotator: match by term: Arthralgias ClinVar PMID:24449199 PMID:28492532 NCBI chr2B:106,140,859...106,154,301
Ensembl chr2B:224,736,598...224,747,912 		JBrowse link
Back Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR2A 5-hydroxytryptamine receptor 2A ISO RGD PMID:17268262 RGD:1624379 NCBI chr13:27,976,415...28,042,941
Ensembl chr13:46,694,273...46,759,826 		JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12227717 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779 		JBrowse link
Cancer Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCR4 C-X-C motif chemokine receptor 4 ISO mRNA,protein:increased expression:spinal cord: RGD PMID:28108674 PMID:28638088 RGD:13463594 RGD:13838657 NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 ameliorates ISO RGD PMID:26738857 RGD:243048441 NCBI chr17:7,219,911...7,247,509
Ensembl chr17:7,207,483...7,235,985 		JBrowse link
G JAK2 Janus kinase 2 treatment ISO RGD PMID:30027795 RGD:149735350 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO mRNA, protein:increased expression:spinal cord (rat) RGD PMID:25919859 RGD:152025537 NCBI chr 7:98,841,974...98,885,446
Ensembl chr 7:111,570,148...111,611,614 		JBrowse link
G ROBO1 roundabout guidance receptor 1 exacerbates ISO RGD PMID:26738857 RGD:243048441 NCBI chr 3:78,707,802...79,876,519
Ensembl chr 3:80,581,388...81,569,308 		JBrowse link
G SLIT2 slit guidance ligand 2 ameliorates ISO RGD PMID:26738857 RGD:243048441 NCBI chr 4:14,654,448...15,023,708
Ensembl chr 4:20,158,952...20,314,656 		JBrowse link
Chest Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:2563132 NCBI chr 8:62,714,721...62,716,979
Ensembl chr 8:64,383,419...64,384,009 		JBrowse link
G LOC100978529 myosin-7 ISO ClinVar Annotator: match by term: Chest pain ClinVar PMID:7731997 PMID:7796500 PMID:8483915 PMID:8541871 PMID:8951566 More... NCBI chr14:4,231,344...4,254,295
Ensembl chr14:22,325,812...22,348,763 		JBrowse link
G MYH6 myosin heavy chain 6 ISO ClinVar Annotator: match by term: Chest pain ClinVar PMID:25741868 PMID:27600940 PMID:28492532 NCBI chr14:4,200,616...4,226,193
Ensembl chr14:22,294,965...22,321,331 		JBrowse link
Chronic Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor ISO protein:increased expression:frontal cortex, neuron
mRNA:decreased expression:anterior cingulate cortex 		RGD PMID:11360665 PMID:24518228 RGD:10059366 RGD:5684922 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G CPT2 carnitine palmitoyltransferase 2 ISO ClinVar Annotator: match by term: Chronic pain ClinVar PMID:7711730 PMID:9600456 PMID:10090476 PMID:12410208 PMID:12673791 More... NCBI chr 1:52,469,416...52,487,166
Ensembl chr 1:54,069,334...54,086,994 		JBrowse link
G HFE homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30657865 RGD:14746966 NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO protein:increased expression:frontal cortex, neuron RGD PMID:11360665 RGD:5684922 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21634377 NCBI chr2B:53,468,290...53,643,747
Ensembl chr2B:170,944,974...171,054,013 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:24204973 RGD:8553185 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:24204973 RGD:8553185 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
Dysmenorrhea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10440088 NCBI chr20:3,169,094...3,172,900 JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO protein:increased expression:ectopic endometrium: RGD PMID:22572543 RGD:9588664 NCBI chr20:29,049,993...29,096,957
Ensembl chr20:30,186,069...30,215,487 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 severity ISO DNA:deletion,polymorphism:: RGD PMID:11055624 RGD:401901272 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G LOC100988273 cytochrome P450 2D6-like severity ISO DNA:polymorphism:cds:p.Arg296Cys(human) RGD PMID:11055624 RGD:401901272 NCBI chr22:23,022,449...23,031,627 JBrowse link
G OXT oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:10440088 NCBI chr20:3,157,246...3,159,013 JBrowse link
Exertional Myalgia, Muscle Stiffness and Myoglobinuria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DMD dystrophin ISO ClinVar Annotator: match by term: Exertional myalgia, muscle stiffness and myoglobinuria ClinVar PMID:19367636 PMID:21104870 PMID:25637381 PMID:25741868 PMID:26066469 More... NCBI chr  X:23,728,650...26,338,849
Ensembl chr  X:31,282,415...33,492,733 		JBrowse link
Eye Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:4327920 NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706 		JBrowse link
familial episodic pain syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPA1 transient receptor potential cation channel subfamily A member 1 ISO ClinVar Annotator: match by term: Familial episodic pain syndrome 1 | ClinVar Annotator: match by term: TRPA1-related condition OMIM
ClinVar		 PMID:20547126 PMID:25741868 PMID:36430572 NCBI chr 8:68,551,685...68,605,336
Ensembl chr 8:70,210,352...70,262,627 		JBrowse link
familial episodic pain syndrome 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN10A sodium voltage-gated channel alpha subunit 10 ISO ClinVar Annotator: match by term: Episodic pain syndrome, familial, 2 OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:23115331 PMID:24820863 PMID:24998131 More... NCBI chr 3:38,593,765...38,691,172
Ensembl chr 3:38,876,068...38,972,247 		JBrowse link
familial episodic pain syndrome 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN11A sodium voltage-gated channel alpha subunit 11 ISO ClinVar Annotator: match by term: Episodic pain syndrome, familial, 3 OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:24207120 PMID:24776970 PMID:25741868 More... NCBI chr 3:38,741,485...38,948,400
Ensembl chr 3:39,024,921...39,128,015 		JBrowse link
Headache term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10864982 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729 		JBrowse link
G FKRP fukutin related protein ISO ClinVar Annotator: match by term: Headache ClinVar PMID:11741828 PMID:12666124 PMID:14647208 PMID:15060126 PMID:15574464 More... NCBI chr19:43,738,339...43,748,250
Ensembl chr19:52,273,546...52,276,341 		JBrowse link
G GNRH1 gonadotropin releasing hormone 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12910066 NCBI chr 8:24,700,268...24,707,332
Ensembl chr 8:21,609,407...21,615,936 		JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7537110 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G LOC100972354 interferon alpha-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15951019 NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736 		JBrowse link
G NPC1 NPC intracellular cholesterol transporter 1 ISO ClinVar Annotator: match by term: Headache ClinVar PMID:10521290 PMID:11333381 PMID:11349231 PMID:11479732 PMID:11754101 More... NCBI chr18:16,783,096...16,838,301
Ensembl chr18:20,409,040...20,463,623 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:7080326 NCBI chr20:3,157,246...3,159,013 JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO human protein in rat model RGD PMID:21036476 RGD:5131274 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein ISO DNA:missense mutation: :p.H611R (human) RGD PMID:17719176 RGD:8694403 Ensembl chr 4:6,345,864...6,379,287 JBrowse link
Hyperalgesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABAT 4-aminobutyrate aminotransferase treatment ISO RGD PMID:24890317 RGD:9588557 NCBI chr16:7,609,282...7,718,049
Ensembl chr16:8,888,178...8,958,420 		JBrowse link
G ADK adenosine kinase ISO associated with diabetic neuropathies; RGD PMID:9932716 PMID:11423084 RGD:6482662 RGD:6482666 NCBI chr10:70,672,967...71,236,950
Ensembl chr10:73,342,900...73,902,490 		JBrowse link
G ADM adrenomedullin ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:17043245 RGD:1625316 NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842 		JBrowse link
G ADORA1 adenosine A1 receptor ISO associated with Spinal Cord Injuries RGD PMID:20065990 RGD:5129094 NCBI chr 1:178,728,751...178,769,066
Ensembl chr 1:183,023,466...183,063,760 		JBrowse link
G ADRA1A adrenoceptor alpha 1A ISO associated with Diabetes Mellitus, Experimental; mRNA:increased expression:dorsal root ganglion RGD PMID:10841349 RGD:5688377 NCBI chr 8:25,947,996...26,138,022
Ensembl chr 8:22,853,677...23,044,388 		JBrowse link
G ADRA2A adrenoceptor alpha 2A ISO RGD PMID:17959985 RGD:6480488 NCBI chr10:107,669,860...107,673,685 JBrowse link
G ADRA2C adrenoceptor alpha 2C ISO RGD PMID:20007733 RGD:6893568 NCBI chr 4:3,904,346...3,906,577 JBrowse link
G ADRB1 adrenoceptor beta 1 ISO RGD PMID:19283893 RGD:5129125 NCBI chr10:110,642,491...110,646,595 JBrowse link
G AGER advanced glycosylation end-product specific receptor treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:24077211 PMID:25014009 RGD:7364865 RGD:8695980 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:9613798 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044 		JBrowse link
G AIF1 allograft inflammatory factor 1 ISO associated with Alcohol-Induced Disorders, Nervous System; protein:increased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17284346 PMID:27093858 RGD:2313035 NCBI chr 6:31,276,215...31,278,051
Ensembl chr 6:32,166,301...32,168,125 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B ISO associated with Hyperglycemia RGD PMID:12505670 RGD:1626082 NCBI chr 7:126,400,861...126,417,756
Ensembl chr 7:138,912,953...138,924,095 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12582831 NCBI chr17:7,026,839...7,041,598
Ensembl chr17:7,014,591...7,029,602 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12582831 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016 		JBrowse link
G ANO3 anoctamin 3 ISO RGD PMID:23872594 RGD:9681745 NCBI chr11:26,287,123...26,618,710
Ensembl chr11:26,047,200...26,519,646 		JBrowse link
G ANXA1 annexin A1 ISO protein:increased expression:dorsal root ganglion RGD PMID:9222544 PMID:21990306 RGD:2306950 RGD:7421656 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G AQP4 aquaporin 4 ISO associated with Spinal Cord Injuries;mRNA,protein:increased expression:brain,spinal cord: RGD PMID:16219025 RGD:8695957 NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919 		JBrowse link
G ASL argininosuccinate lyase ISO RGD PMID:12895509 RGD:727768 NCBI chr 7:59,908,648...59,948,822
Ensembl chr 7:73,142,842...73,157,472
Ensembl chr 7:73,142,842...73,157,472 		JBrowse link
G AVP arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:9613798 NCBI chr20:3,169,094...3,172,900 JBrowse link
G BACE1 beta-secretase 1 ISO RGD PMID:28012171 RGD:13782150 NCBI chr11:112,120,950...112,151,505
Ensembl chr11:116,054,303...116,084,812 		JBrowse link
G BDKRB1 bradykinin receptor B1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12637034 PMID:12927641 PMID:17989505 PMID:19300402 PMID:19815945 RGD:1579989 RGD:7241581 NCBI chr14:76,885,923...76,894,456 JBrowse link
G BDKRB2 bradykinin receptor B2 ISO associated with Diabetic Neuropathy
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:10188975 PMID:17989505 PMID:19300402 PMID:19815945 RGD:2313332 RGD:4891040 NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253 		JBrowse link
G BDNF brain derived neurotrophic factor ISO associated with inflammation;protein:increased expression:dorsal root ganglion:
associated with Sciatic Neuropathy;
associated with Peripheral Nerve Injuries;
associated with Pancreatitis, Chronic;		 RGD PMID:10779676 PMID:11425916 PMID:12435470 PMID:12470870 PMID:21499209 More... RGD:8657088 RGD:8657091 RGD:8657093 RGD:8657099 RGD:8657101 RGD:8657114 RGD:8657122 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G BECN1 beclin 1 ISO RGD PMID:23665054 RGD:11560531 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G C3 complement C3 ISO associated with Sciatic Neuropathy;mRNA, protein:increased expression:spinal cord RGD PMID:23588254 RGD:7401259 NCBI chr19:5,708,211...5,753,178
Ensembl chr19:6,629,287...6,674,699 		JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B ISO RGD PMID:17567797 RGD:1626313 NCBI chr 9:108,989,621...109,256,841 JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H ISO CTD Direct Evidence: marker/mechanism CTD PMID:19577366 PMID:30552955 PMID:34286406 Ensembl chr16:1,195,364...1,222,917 JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I ISO RGD PMID:17112407 RGD:15003199 NCBI chr22:20,463,511...20,595,253
Ensembl chr22:38,296,436...38,414,963 		JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11245671 PMID:17881535 PMID:24133248 NCBI chr 7:73,917,439...74,410,627
Ensembl chr 7:87,579,004...88,068,482 		JBrowse link
G CALCA calcitonin related polypeptide alpha ISO CTD Direct Evidence: marker/mechanism|therapeutic
associated with inflammation;protein:increased expression:dorsal root ganglion:		 CTD
RGD		 PMID:12787826 PMID:12855330 PMID:15265675 PMID:21958434 PMID:27093858 RGD:8657122 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267 		JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:18042863 PMID:20053885 RGD:7240711 NCBI chr 5:145,644,164...145,714,143
Ensembl chr 5:151,649,062...151,719,373 		JBrowse link
G CAPN2 calpain 2 treatment ISO associated with Peripheral Nerve Injuries RGD PMID:25150005 RGD:13792585 NCBI chr 1:199,335,582...199,399,267
Ensembl chr 1:204,335,573...204,409,150 		JBrowse link
G CARTPT CART prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:21167239 NCBI chr 5:43,591,683...43,593,586
Ensembl chr 5:44,236,114...44,238,229 		JBrowse link
G CAT catalase treatment ISO RGD PMID:23658840 PMID:23952340 RGD:9479063 RGD:9479069 NCBI chr11:34,413,253...34,446,831
Ensembl chr11:34,289,603...34,323,160 		JBrowse link
G CCK cholecystokinin ISO RGD PMID:15647484 RGD:1626108 NCBI chr 3:42,168,012...42,176,358
Ensembl chr 3:42,431,022...42,439,396 		JBrowse link
G CCKBR cholecystokinin B receptor ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:11880531 PMID:15647484 RGD:1626108 NCBI chr11:6,393,435...6,405,821
Ensembl chr11:6,075,816...6,088,145 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:dorsal root ganglion, spinal cord (rat)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17881535 PMID:18419759 PMID:20737477 PMID:21712071 PMID:22531750 RGD:2307043 RGD:8548845 RGD:8548848 RGD:8548873 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:dorsal root ganglion (rat) RGD PMID:18076762 PMID:18656466 RGD:2303121 RGD:4890034 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO associated with Intervertebral disc disease;
associated with Demyelinating Diseases;
protein:increased expression:dorsal horn of spinal cord:
associated with Sciatic Neuropathy;
associated with Bone Neoplasms;protein:increased expression:spinal cord:		 RGD PMID:18076762 PMID:18419759 PMID:22721162 PMID:23511129 PMID:24462503 More... RGD:2307043 RGD:4890034 RGD:8548831 RGD:8661772 RGD:8661781 RGD:8661788 NCBI chr 3:46,255,725...46,263,285
Ensembl chr 3:47,361,124...47,368,312 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO associated with Spinal Cord Injuries
mRNA:increased expression:dorsal root ganglion (rat)		 RGD PMID:18076762 PMID:22033364 PMID:23147416 PMID:24589480 RGD:4890034 RGD:8551795 RGD:8551809 RGD:8551820 NCBI chr 3:46,273,096...46,278,471
Ensembl chr 3:47,380,321...47,381,379 		JBrowse link
G CFL1 cofilin 1 ISO protein:increased phosphorylation:dorsal root ganglion (rat) RGD PMID:24962708 RGD:11570412 NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806 		JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit ameliorates ISO RGD PMID:15652389 RGD:150530460 NCBI chr15:57,493,730...57,530,463
Ensembl chr15:76,455,165...76,486,376 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17572696 NCBI chr 6:86,017,141...86,044,889 JBrowse link
G CNR2 cannabinoid receptor 2 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:17572696 PMID:18664590 NCBI chr 1:23,066,153...23,108,065
Ensembl chr 1:24,050,008...24,051,090 		JBrowse link
G COMT catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20726980 PMID:28195063 RGD:8662326 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28434951 NCBI chr17:11,261,435...11,313,630
Ensembl chr17:11,650,057...11,701,208 		JBrowse link
G CSF3 colony stimulating factor 3 treatment ISO associated with Sciatic Neuropathy; RGD PMID:24253780 RGD:11039470 NCBI chr17:17,271,074...17,273,493
Ensembl chr17:17,491,276...17,493,729 		JBrowse link
G CSK C-terminal Src kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16769263 NCBI chr15:53,724,814...53,745,710
Ensembl chr15:73,342,703...73,363,476 		JBrowse link
G CTSS cathepsin S ISO associated with Colitis
associated with Arthritis, Experimental		 RGD PMID:21802389 PMID:22213084 RGD:5686870 RGD:5686873 NCBI chr 1:126,084,249...126,118,221
Ensembl chr 1:129,733,996...129,768,318 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 treatment ISO associated with Arthritis, Experimental RGD PMID:19249394 PMID:22647647 RGD:2304251 RGD:9491779 NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO associated with Arthritis, Experimental;protein:increased expression:lumbar spinal cord
associated with Inflammation
associated with Bone Neoplasms
associated with Sciatic Neuropathy		 RGD PMID:16324111 PMID:19959384 PMID:20524966 PMID:20609517 PMID:20736819 More... RGD:4891885 RGD:4891942 RGD:4892020 RGD:9354422 RGD:9387859 RGD:9491779 NCBI chr 3:39,158,346...39,176,604
Ensembl chr 3:39,440,955...39,457,219 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 ISO RGD PMID:28638088 RGD:13838657 NCBI chr10:41,296,975...41,384,864
Ensembl chr10:44,552,480...44,564,231 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7881729 PMID:10401557 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:19283893 RGD:5129125 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 treatment ISO RGD PMID:28638088 PMID:30142543 RGD:13838657 RGD:13838658 NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647 		JBrowse link
G CYBB cytochrome b-245 beta chain ISO associated with Spinal Cord Injuries; RGD PMID:20679217 RGD:11040629 NCBI chr  X:30,230,394...30,267,379
Ensembl chr  X:37,939,704...37,973,183 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 ISO associated with Diabetic neuropathies; RGD PMID:20531396 RGD:7257680 NCBI chr17:7,219,911...7,247,509
Ensembl chr17:7,207,483...7,235,985 		JBrowse link
G DRD3 dopamine receptor D3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20433900 NCBI chr 3:111,265,834...111,317,176
Ensembl chr 3:118,187,636...118,237,403 		JBrowse link
G DUSP1 dual specificity phosphatase 1 treatment ISO associated with Sciatic Neuropathy RGD PMID:22540262 PMID:22901764 RGD:7771531 RGD:7771574 NCBI chr 5:168,121,536...168,124,671
Ensembl chr 5:175,032,803...175,035,960 		JBrowse link
G DUSP6 dual specificity phosphatase 6 treatment ISO associated with Sciatic Neuropathy RGD PMID:22901764 RGD:7771531 NCBI chr12:86,875,289...86,879,731
Ensembl chr12:90,195,482...90,200,321 		JBrowse link
G EDN1 endothelin 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:paw skin (mouse)		 CTD
RGD		 PMID:15664691 PMID:19429182 PMID:23347081 RGD:8661716 RGD:8661735 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 treatment ISO RGD PMID:20392816 RGD:9685429 NCBI chr 8:116,248,587...116,364,966
Ensembl chr 8:118,998,530...119,114,273 		JBrowse link
G EP300 E1A binding protein p300 ISO RGD PMID:25263804 RGD:9588307 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604 		JBrowse link
G EPHA4 EPH receptor A4 ISO associated with spinal cord injuries; RGD PMID:16959251 RGD:5688783 NCBI chr2B:108,664,475...108,818,802
Ensembl chr2B:227,248,958...227,402,790 		JBrowse link
G EPHX2 epoxide hydrolase 2 ISO RGD PMID:16962614 RGD:5688387 NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO associated with interstitial cystitis; RGD PMID:30989724 RGD:405295490 NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006 		JBrowse link
G ESR1 estrogen receptor 1 ISO RGD PMID:19285805 RGD:8553066 NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551 		JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:17056036 PMID:19285805 RGD:5508846 RGD:8553066 NCBI chr14:44,807,875...44,919,780
Ensembl chr14:63,064,402...63,131,303 		JBrowse link
G F2 coagulation factor II, thrombin ISO associated with Sciatic Neuropathy RGD PMID:16251448 RGD:7387272 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157 		JBrowse link
G FCGR1A Fc gamma receptor Ia ameliorates ISO RGD PMID:32510872 RGD:127338469 NCBI chr 1:125,127,073...125,136,911
Ensembl chr 1:128,805,484...128,814,220 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:dorsal horn of spinal cord, neuron		 CTD
RGD		 PMID:22160634 PMID:27093858 RGD:9999169 NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766 		JBrowse link
G FTO FTO alpha-ketoglutarate dependent dioxygenase treatment ISO associated with Cerebral Hemorrhage RGD PMID:34102854 RGD:329812008 NCBI chr16:33,939,300...34,343,419
Ensembl chr16:53,023,425...53,490,231 		JBrowse link
G GAD1 glutamate decarboxylase 1 treatment ISO protein:increased expression:dorsal horn of spinal cord RGD PMID:26752351 PMID:27277808 RGD:405850208 RGD:405850240 NCBI chr2B:58,100,623...58,145,045
Ensembl chr2B:175,558,538...175,602,944 		JBrowse link
G GAL galanin and GMAP prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12787826 NCBI chr11:63,770,758...63,777,421
Ensembl chr11:67,075,547...67,081,696 		JBrowse link
G GDNF glial cell derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20457222 NCBI chr 5:72,539,374...72,566,918
Ensembl chr 5:77,577,313...77,601,362 		JBrowse link
G GFAP glial fibrillary acidic protein ISO CTD Direct Evidence: marker/mechanism
associated with Spinal Cord Injuries;mRNA,protein:increased expression:brain,spinal cord:		 CTD
RGD		 PMID:16219025 PMID:27093858 RGD:8695957 NCBI chr17:12,407,211...12,417,072
Ensembl chr17:12,579,754...12,591,961 		JBrowse link
G GFRA1 GDNF family receptor alpha 1 ISO RGD PMID:16464682 RGD:6218969 NCBI chr10:112,645,574...112,862,413
Ensembl chr10:116,079,063...116,295,164 		JBrowse link
G GJA1 gap junction protein alpha 1 treatment ISO associated with Sciatic Neuropathy
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:23374942 PMID:24631560 PMID:34286406 RGD:8662447 RGD:8662456 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:25280432 NCBI chr 7:1,331,586...1,338,194 JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 treatment ISO RGD PMID:27816787 RGD:405650587 NCBI chr 5:148,879,996...149,206,914
Ensembl chr 5:154,879,080...155,204,660 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr 9:108,198,350...108,228,887
Ensembl chr 9:137,168,722...137,197,382 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A ISO RGD PMID:29758384 RGD:13792698 NCBI chr16:8,682,169...9,105,581
Ensembl chr16:9,919,143...10,336,167 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:20042082 PMID:24204988 RGD:13210755 NCBI chr12:13,543,104...13,987,437
Ensembl chr12:13,969,387...14,388,799 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 treatment
severity		 ISO associated with Complex Regional Pain Syndromes
associated with bone cancer		 RGD PMID:22796071 PMID:25466829 PMID:26064176 PMID:26935064 RGD:13513996 RGD:13514046 RGD:13514049 RGD:13792780 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066 		JBrowse link
G GRM8 glutamate metabotropic receptor 8 ISO RGD PMID:17113112 RGD:6771186 NCBI chr 7:118,430,086...119,249,147 JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO associated with Limb Ischemia;protein:increased expression:foot muscle, plantar RGD PMID:18691814 RGD:9068903 NCBI chr14:42,295,691...42,348,478
Ensembl chr14:60,552,374...60,604,885 		JBrowse link
G HMGB1 high mobility group box 1 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:24077211 PMID:27474498 PMID:30142543 RGD:13838658 RGD:7364865 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G HOXD1 homeobox D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21151121 NCBI chr2B:63,468,317...63,470,658 JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A ISO CTD Direct Evidence: marker/mechanism
associated with Diabetic neuropathies;		 CTD
RGD		 PMID:17888573 PMID:18930597 PMID:20039957 PMID:20531396 PMID:25584948 RGD:401901200 RGD:401938625 RGD:7257680 NCBI chr13:27,976,415...28,042,941
Ensembl chr13:46,694,273...46,759,826 		JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 ISO RGD PMID:21693130 PMID:21843960 RGD:6480665 RGD:6482179 NCBI chr10:87,480,970...87,598,212
Ensembl chr10:91,009,941...91,125,158 		JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:9452187 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G IL10 interleukin 10 treatment ISO associated with Sciatic Neuropathy
CTD Direct Evidence: marker/mechanism|therapeutic		 RGD
CTD		 PMID:7582491 PMID:17174526 PMID:22820166 PMID:23957449 PMID:24077211 RGD:7364792 RGD:7364827 RGD:7364865 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL13 interleukin 13 treatment ISO RGD PMID:11399514 RGD:8549555 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
G IL17A interleukin 17A treatment ISO RGD PMID:23192794 PMID:23246025 RGD:9068942 RGD:9222699 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G IL18 interleukin 18 treatment ISO associated with Peripheral Nerve Injuries RGD PMID:19036970 RGD:8655929 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G IL1A interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:12727271 NCBI chr2A:89,273,482...89,284,421
Ensembl chr2A:113,784,854...113,795,801 		JBrowse link
G IL1B interleukin 1 beta ISO associated with Peripheral Nerve Injuries
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:7582491 PMID:8741165 PMID:10401557 PMID:12727271 PMID:15317861 More... RGD:1626676 RGD:6482671 RGD:7175548 RGD:7401209 NCBI chr2A:89,216,313...89,223,358
Ensembl chr2A:113,846,306...113,853,424 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 ISO RGD PMID:11585580 PMID:19022353 RGD:8662898 RGD:8662903 Ensembl chr2A:103,193,131...103,230,005 JBrowse link
G IL1RN interleukin 1 receptor antagonist treatment
severity		 ISO associated with Arthritis, Experimental; rat model treated with human protein
CTD Direct Evidence: marker/mechanism|therapeutic		 RGD
CTD		 PMID:8864563 PMID:10903985 PMID:15317861 PMID:17174526 PMID:17959986 More... RGD:6909165 RGD:6909175 RGD:7401210 RGD:8549800 NCBI chr2A:88,991,646...89,008,013
Ensembl chr2A:114,061,182...114,078,839 		JBrowse link
G IL2 interleukin 2 treatment ISO associated with Sciatic Neuropathy; mRNA,protein:increased expression:spinal cord: RGD PMID:12755376 PMID:18423867 PMID:22189457 RGD:8662973 RGD:8662977 RGD:8662980 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL33 interleukin 33 ISO RGD PMID:29329586 RGD:40400909 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624 		JBrowse link
G IL6 interleukin 6 ISO associated with Foot Injuries; protein:increased expression:serum:
mRNA:increased expression:dorsal root ganglion
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:7582491 PMID:10401557 PMID:18652822 PMID:18988309 PMID:23953943 RGD:10402830 RGD:8662979 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G IL6R interleukin 6 receptor ISO mRNA:increased expression:dorsal root ganglion RGD PMID:23953943 RGD:10402830 NCBI chr 1:129,761,914...129,824,386
Ensembl chr 1:133,374,078...133,433,089 		JBrowse link
G INSR insulin receptor treatment ISO associated with Diabetic Neuropathies
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18331706 PMID:23511693 RGD:10403050 NCBI chr19:6,393,407...6,578,234
Ensembl chr19:7,260,246...7,414,889 		JBrowse link
G ITGA1 integrin subunit alpha 1 ISO PGE2-induced
knock-down using a specific monoclonal antibody or RNAi		 RGD PMID:14984413 PMID:15836982 RGD:2302139 RGD:2302389 NCBI chr 5:61,073,507...61,247,565
Ensembl chr 5:62,692,673...62,865,769 		JBrowse link
G ITGA2 integrin subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18234883 NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720 		JBrowse link
G ITGA3 integrin subunit alpha 3 ISO knock-down using a specific monoclonal antibody or RNAi RGD PMID:14984413 PMID:15836982 RGD:2302139 RGD:2302389 NCBI chr17:44,145,974...44,181,343
Ensembl chr17:49,019,892...49,055,245 		JBrowse link
G ITGA5 integrin subunit alpha 5 ISO epinephrine-induced
knock-down using a specific monoclonal antibody or RNAi		 RGD PMID:14984413 PMID:15836982 RGD:2302139 RGD:2302389 NCBI chr12:34,326,182...34,350,050
Ensembl chr12:35,052,994...35,075,835 		JBrowse link
G ITGB1 integrin subunit beta 1 ISO knock-down using a specific monoclonal antibody or RNAi RGD PMID:14984413 PMID:15836982 RGD:2302139 RGD:2302389 NCBI chr10:33,023,573...33,081,384
Ensembl chr10:33,608,978...33,644,031 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 ISO RGD PMID:25972297 RGD:13793383 NCBI chr 3:4,448,574...4,802,545
Ensembl chr 3:4,572,921...4,904,811 		JBrowse link
G JAK2 Janus kinase 2 treatment ISO associated with Diabetic Neuropathies RGD PMID:18636982 PMID:23511693 RGD:10403050 RGD:6483031 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626 		JBrowse link
G JAK3 Janus kinase 3 treatment ISO RGD PMID:21434883 RGD:11533942 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G KCNC4 potassium voltage-gated channel subfamily C member 4 ISO RGD PMID:17855600 RGD:10411908 NCBI chr 1:112,860,887...112,884,687
Ensembl chr 1:127,458,968...127,480,182 		JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 ISO RGD PMID:16675954 RGD:9831112 NCBI chr 1:190,576,180...190,807,367
Ensembl chr 1:195,430,994...195,662,840 		JBrowse link
G KCNQ3 potassium voltage-gated channel subfamily Q member 3 ISO associated with Bone Neoplasms;protein:decreased expression:dorsal root ganglia (rat) RGD PMID:23352759 RGD:9686417 NCBI chr 8:128,769,930...129,134,671
Ensembl chr 8:131,755,454...131,815,237 		JBrowse link
G KMO kynurenine 3-monooxygenase treatment ISO RGD PMID:26524415 RGD:13703043 NCBI chr 1:217,094,037...217,157,827
Ensembl chr 1:222,075,268...222,138,866 		JBrowse link
G KNG1 kininogen 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2010815 PMID:2128375 PMID:3061568 PMID:7493622 PMID:7582491 More... NCBI chr 3:183,751,598...183,778,655
Ensembl chr 3:192,219,462...192,245,149 		JBrowse link
G LEPR leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29143802 NCBI chr 1:64,772,612...64,881,886
Ensembl chr 1:66,693,926...66,764,768 		JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 ameliorates ISO associated with sciatic neuropathy; RGD PMID:20619541 RGD:151708701 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha ISO RGD PMID:23665054 RGD:11560531 NCBI chr20:30,887,345...30,888,986
Ensembl chr20:32,010,284...32,020,411 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12941468 PMID:27093858 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12941468 PMID:27093858 Ensembl chr16:30,489,362...30,498,017 JBrowse link
G MAPK7 mitogen-activated protein kinase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17237256 NCBI chr17:31,729,429...31,736,216
Ensembl chr17:36,894,146...36,899,969 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr10:45,806,748...45,936,362 JBrowse link
G MAPK9 mitogen-activated protein kinase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27093858 NCBI chr 5:175,437,167...175,495,469
Ensembl chr 5:182,748,381...182,795,135 		JBrowse link
G MC1R melanocortin 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19996949 NCBI chr16:70,676,447...70,697,636 JBrowse link
G MC4R melanocortin 4 receptor ISO protein:increased expression:dorsal root ganglia (rat) RGD PMID:20081244 RGD:6484233 NCBI chr18:53,744,172...53,747,282
Ensembl chr18:57,069,259...57,070,257 		JBrowse link
G MECP2 methyl-CpG binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33010341 NCBI chr  X:143,571,864...143,647,192
Ensembl chr  X:153,465,204...153,527,854 		JBrowse link
G MEN1 menin 1 ISO associated with Sciatic Neuropathy;protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:20369282 RGD:9589142 NCBI chr11:60,159,009...60,166,222
Ensembl chr11:63,499,962...63,507,164 		JBrowse link
G MFN2 mitofusin 2 ISO CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:spinal cord (rat)		 CTD
RGD		 PMID:28587902 RGD:12910704 NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077 		JBrowse link
G MMP3 matrix metallopeptidase 3 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18754875 PMID:22056600 RGD:8693664 NCBI chr11:97,776,729...97,784,549
Ensembl chr11:101,267,566...101,275,354 		JBrowse link
G MPZ myelin protein zero ISO CTD Direct Evidence: marker/mechanism CTD PMID:16676325 NCBI chr 1:136,691,245...136,720,958
Ensembl chr 1:140,626,039...140,631,273 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO RGD PMID:24382350 RGD:10040983 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841 		JBrowse link
G NECTIN1 nectin cell adhesion molecule 1 ISO RGD PMID:27394444 RGD:405866373 NCBI chr11:114,497,177...114,565,338
Ensembl chr11:118,401,321...118,493,090 		JBrowse link
G NEFH neurofilament heavy chain treatment ISO RGD PMID:21071147 RGD:27226885 NCBI chr22:10,525,738...10,536,788 JBrowse link
G NGF nerve growth factor treatment ISO associated with Cystitis
associated with Osteoarthritis, Experimental
associated with Peripheral Nerve Injuries;
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:11425916 PMID:16203088 PMID:18448607 PMID:20457222 PMID:22839415 More... RGD:402463955 RGD:405100717 RGD:7242799 RGD:7242803 RGD:7242849 RGD:8657088 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NGFR nerve growth factor receptor treatment ISO associated with Brachial Plexus Neuropathies RGD PMID:23324933 RGD:10413898 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G NLGN2 neuroligin 2 ISO RGD PMID:23891900 RGD:9831150 NCBI chr17:7,438,853...7,454,014 JBrowse link
G NOS1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19300402 PMID:23909597 RGD:7257597 NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17989504 PMID:19300402 NCBI chr17:28,984,295...29,021,516
Ensembl chr17:29,471,510...29,617,093 		JBrowse link
G NPY neuropeptide Y treatment ISO associated with Sciatic Neuropathy RGD PMID:19556004 RGD:10448929 NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657 		JBrowse link
G NRG1 neuregulin 1 ISO associated with Sciatic Neuropathy
associated with interstitial cystitis;		 RGD PMID:22212401 PMID:30989724 RGD:10449019 RGD:405295490 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977 		JBrowse link
G NTF3 neurotrophin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:15659614 NCBI chr12:5,551,734...5,615,981
Ensembl chr12:5,530,508...5,533,989 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO RGD PMID:17667845 PMID:20351485 RGD:5144120 RGD:5684352 Ensembl chr 1:136,007,476...136,047,355 JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO associated with inflammation;protein:increased expression:dorsal root ganglion: RGD PMID:12470870 PMID:21958434 RGD:8657091 RGD:8657122 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
G NTSR1 neurotensin receptor 1 ISO RGD PMID:22396077 RGD:9743902 NCBI chr20:59,100,110...59,151,563
Ensembl chr20:60,392,736...60,446,056 		JBrowse link
G OPRK1 opioid receptor kappa 1 treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:16924480 RGD:9834947 NCBI chr 8:49,650,844...49,677,494
Ensembl chr 8:47,029,313...47,056,577 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO associated with Sciatic Neuropathy;mRNA:increased expression:spinal cord lumbar segment,dorsal root ganglion: RGD PMID:12106803 RGD:9835017 Ensembl chr20:62,004,176...62,017,866 JBrowse link
G OPRM1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17996026 NCBI chr 6:151,827,323...151,937,658
Ensembl chr 6:156,517,661...157,088,251 		JBrowse link
G P2RX2 purinergic receptor P2X 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19383439 NCBI chr12:129,969,793...129,974,399 JBrowse link
G P2RX3 purinergic receptor P2X 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19383439 NCBI chr11:52,579,190...52,614,329
Ensembl chr 3:160,070,875...160,106,120 		JBrowse link
G P2RX4 purinergic receptor P2X 4 treatment ISO associated with Peripheral Nerve Injuries; RGD PMID:29927790 RGD:40924654 NCBI chr12:118,807,961...118,832,267
Ensembl chr12:122,178,672...122,202,959 		JBrowse link
G P2RY12 purinergic receptor P2Y12 ISO RGD PMID:20136836 PMID:20398327 RGD:6480525 RGD:6480526 NCBI chr 3:148,364,151...148,412,231 JBrowse link
G PAWR pro-apoptotic WT1 regulator treatment ISO RGD PMID:17179954 RGD:9835416 NCBI chr12:77,114,282...77,224,116
Ensembl chr12:79,969,517...80,070,796 		JBrowse link
G PDYN prodynorphin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17670969 NCBI chr20:2,092,171...2,108,141
Ensembl chr20:1,856,850...1,872,452 		JBrowse link
G PENK proenkephalin treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:23235561 RGD:10003116 NCBI chr 8:52,864,388...52,870,144
Ensembl chr 8:50,234,170...50,239,949 		JBrowse link
G PLA2G4A phospholipase A2 group IVA ISO RGD PMID:16203828 RGD:1642461 NCBI chr 1:162,362,600...162,521,974
Ensembl chr 1:166,512,870...166,672,101 		JBrowse link
G PNOC prepronociceptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12665541 PMID:19231294 NCBI chr 8:27,596,413...27,622,844
Ensembl chr 8:24,796,638...24,822,758 		JBrowse link
G POMC proopiomelanocortin treatment ISO associated with Inflammation RGD PMID:19934807 RGD:407580522 NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706 		JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:26732138 RGD:11572421 NCBI chr 5:129,599,606...129,629,312
Ensembl chr 5:135,751,958...135,765,786 		JBrowse link
G PRKCB protein kinase C beta ISO associated with inflammation;protein:increased activity:spinal cord RGD PMID:16360284 RGD:1625519 NCBI chr16:13,888,936...14,268,759
Ensembl chr16:24,091,289...24,466,203 		JBrowse link
G PRKCE protein kinase C epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:11738263 PMID:12582831 PMID:20457222 NCBI chr2A:45,757,629...46,294,064
Ensembl chr2A:46,688,436...47,220,313 		JBrowse link
G PRKCG protein kinase C gamma treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12560106 PMID:19955894 PMID:27093858 RGD:28867224 NCBI chr19:50,823,372...50,849,003
Ensembl chr19:59,672,097...59,695,977 		JBrowse link
G PRKCZ protein kinase C zeta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27899695 NCBI chr 1:763,942...901,531
Ensembl chr 1:1,920,219...2,045,855 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 treatment ISO RGD PMID:14973199 RGD:7775058 NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882 		JBrowse link
G PROK2 prokineticin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr 3:71,711,334...71,724,865
Ensembl chr 3:73,068,599...73,080,897 		JBrowse link
G PROKR1 prokineticin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16793879 NCBI chr2A:68,685,129...68,700,372
Ensembl chr2A:69,808,033...69,822,404 		JBrowse link
G PTAFR platelet activating factor receptor treatment ISO RGD PMID:16925995 RGD:10041052 NCBI chr 1:27,405,880...27,436,184
Ensembl chr 1:28,447,833...28,448,861 		JBrowse link
G PTGER1 prostaglandin E receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11375261 NCBI chr19:14,035,876...14,038,812 JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO protein:increased expression:lumbar spinal cord dorsal horn (rat) RGD PMID:17413918 RGD:5688169 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063 		JBrowse link
G PTGER4 prostaglandin E receptor 4 treatment ISO RGD PMID:20423341 RGD:10003041 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148 		JBrowse link
G PTGES3 prostaglandin E synthase 3 ISO RGD PMID:16192391 RGD:5688057 NCBI chr12:32,221,908...32,247,228
Ensembl chr12:32,476,835...32,503,181 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17413918 PMID:17989504 RGD:5688169 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15464832 PMID:17112505 PMID:17989504 RGD:5688224 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G PTHLH parathyroid hormone like hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:16769263 NCBI chr12:58,341,361...58,355,804
Ensembl chr12:60,960,071...60,973,750 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18976650 NCBI chr 3:12,510,084...12,590,598
Ensembl chr 3:12,853,415...12,932,871 		JBrowse link
G RGS4 regulator of G protein signaling 4 treatment ISO associated with lesion of sciatic nerve RGD PMID:27641322 RGD:13524513 NCBI chr 1:138,488,317...138,496,497
Ensembl chr 1:142,284,040...142,292,225 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:16545521 PMID:19070548 RGD:6484253 NCBI chr 3:38,593,765...38,691,172
Ensembl chr 3:38,876,068...38,972,247 		JBrowse link
G SCN11A sodium voltage-gated channel alpha subunit 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23264124 NCBI chr 3:38,741,485...38,948,400
Ensembl chr 3:39,024,921...39,128,015 		JBrowse link
G SIN3A SIN3 transcription regulator family member A ISO associated with Arthritis, Experimental;mRNA:decreased expression:spinal cord, neuron RGD PMID:17553988 RGD:9495916 NCBI chr15:54,285,587...54,371,376
Ensembl chr15:73,881,500...73,966,506 		JBrowse link
G SLC12A5 solute carrier family 12 member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20086212 NCBI chr20:42,359,005...42,397,412
Ensembl chr20:43,445,182...43,483,132 		JBrowse link
G SLC17A8 solute carrier family 17 member 8 ISO protein:increased expression:dorsal horn of spinal cord, neuron RGD PMID:22160634 RGD:9999169 NCBI chr12:97,935,177...98,001,240
Ensembl chr12:101,342,113...101,405,844 		JBrowse link
G SPARC secreted protein acidic and cysteine rich ISO CTD Direct Evidence: marker/mechanism CTD PMID:20714283 NCBI chr 5:147,087,903...147,112,466
Ensembl chr 5:153,090,181...153,115,750 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO protein:increased phosphorylation:spinal cord RGD PMID:27394444 RGD:405866373 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 treatment ISO RGD PMID:24098399 RGD:8694290 NCBI chr17:14,928,689...15,003,644
Ensembl chr17:15,152,358...15,227,067 		JBrowse link
G SYN2 synapsin II ISO CTD Direct Evidence: marker/mechanism CTD PMID:18701217 NCBI chr 3:11,935,680...12,118,981
Ensembl chr 3:12,282,573...12,464,413 		JBrowse link
G TAC1 tachykinin precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8864563 PMID:9714424 PMID:10499367 PMID:12351280 PMID:12787826 More... NCBI chr 7:89,675,834...89,684,391
Ensembl chr 7:103,257,501...103,266,389 		JBrowse link
G TACR1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15964684 PMID:17123731 NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018 		JBrowse link
G TCF7L2 transcription factor 7 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33607128 NCBI chr10:109,541,524...109,759,499
Ensembl chr10:112,978,167...113,192,281 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ISO associated with Experimental Pancreatitis, Chronic RGD PMID:26645248 RGD:14995470 NCBI chr 9:70,195,007...70,243,514
Ensembl chr 9:98,332,739...98,362,748 		JBrowse link
G THBD thrombomodulin treatment ISO associated with Inflammation
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:24004409 PMID:27474498 RGD:11038687 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:17355971 PMID:24204973 RGD:8553059 RGD:8553185 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:15809417 PMID:20714435 PMID:24204973 RGD:4144070 RGD:7815040 RGD:8553185 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor ISO mRNA,protein:increased expression:spinal cord:
associated with Diabetic Neuropathies;
CTD Direct Evidence: marker/mechanism
protein:increased expression:lumbar vertebra:		 RGD
CTD		 PMID:7582491 PMID:7881729 PMID:10401557 PMID:10825476 PMID:12727271 More... RGD:7387300 RGD:7387302 RGD:7394737 RGD:7394741 RGD:7394757 RGD:7401179 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO CTD Direct Evidence: therapeutic CTD PMID:16769263 NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A treatment ISO associated with Sciatic Neuropathy RGD PMID:12752784 PMID:20417692 PMID:21145890 PMID:21712071 PMID:22652595 More... RGD:5130913 RGD:5130939 RGD:8548873 RGD:8661726 RGD:8661737 RGD:8661750 NCBI chr12:6,457,617...6,470,969
Ensembl chr12:6,374,257...6,387,613 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO associated with Sciatic Neuropathy RGD PMID:18463260 PMID:22652595 RGD:5130960 RGD:8661750 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
G TPH2 tryptophan hydroxylase 2 ISO RGD PMID:27983993 RGD:597830167 NCBI chr12:69,460,883...69,557,329
Ensembl chr12:72,318,908...72,412,557 		JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism
associated with Peripheral Nerve Injuries;		 CTD
RGD		 PMID:18234885 PMID:18954467 PMID:21481532 PMID:23523557 RGD:10043618 NCBI chr 8:68,551,685...68,605,336
Ensembl chr 8:70,210,352...70,262,627 		JBrowse link
G TRPC1 transient receptor potential cation channel subfamily C member 1 ISO associated with Inflammation RGD PMID:19439599 RGD:7247605 NCBI chr 3:139,757,408...139,841,006
Ensembl chr 3:147,349,056...147,432,332 		JBrowse link
G TRPC6 transient receptor potential cation channel subfamily C member 6 ISO RGD PMID:19439599 RGD:7247605 NCBI chr11:96,414,498...96,551,670
Ensembl chr11:99,919,410...100,050,685 		JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO CTD Direct Evidence: marker/mechanism
associated with inflammation;protein:increased expression:dorsal root ganglion:		 CTD
RGD		 PMID:12151517 PMID:18234885 PMID:18774343 PMID:21958434 PMID:23006841 RGD:8657122 NCBI chr17:3,612,781...3,658,608
Ensembl chr17:3,609,952...3,637,579 		JBrowse link
G TRPV4 transient receptor potential cation channel subfamily V member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18234883 NCBI chr12:107,359,005...107,409,359
Ensembl chr12:110,754,238...110,786,182 		JBrowse link
G VIP vasoactive intestinal peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:12787826 NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730 		JBrowse link
Hypoalgesia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP4 aquaporin 4 ISO RGD PMID:20851747 RGD:8696005 NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919 		JBrowse link
G HDAC4 histone deacetylase 4 ISO RGD PMID:19672313 RGD:9681457 NCBI chr2B:126,287,745...126,649,815
Ensembl chr2B:245,123,061...245,427,054 		JBrowse link
immunodeficiency 108 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEBPE CCAAT enhancer binding protein epsilon ISO ClinVar Annotator: match by term: Pelger-Huet-like anomaly and episodic fever with abdominal pain OMIM
ClinVar		 PMID:4831644 PMID:31201888 NCBI chr14:3,937,200...3,939,112
Ensembl chr14:22,033,654...22,035,219 		JBrowse link
INTELLECTUAL DEVELOPMENTAL DISORDER WITH GASTROINTESTINAL DIFFICULTIES AND HIGH PAIN THRESHOLD term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D ISO ClinVar Annotator: match by term: Intellectual developmental disorder with gastrointestinal difficulties and high pain threshold | ClinVar Annotator: match by term: PPM1D-related condition OMIM
ClinVar		 PMID:23907125 PMID:24262437 PMID:25741868 PMID:28343630 PMID:28492532 More... NCBI chr17:54,698,338...54,761,889
Ensembl chr17:59,824,566...59,887,015 		JBrowse link
intermediate coronary syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme ISO mRNA:increased expression:ventricular myocardium (human)
mRNA:increased expression:myocardium		 RGD PMID:11451295 PMID:15131005 RGD:8142363 RGD:8548894 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G AGT angiotensinogen ISO mRNA:increased expression:myocardium RGD PMID:11451295 RGD:8548894 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044 		JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO mRNA:increased expression:myocardium RGD PMID:11451295 RGD:8548894 NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO protein:increased serine phosphorylation:platelet RGD PMID:20467748 RGD:5509094 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756 		JBrowse link
G APOA4 apolipoprotein A4 ISO protein:decreased expression:blood plasma (human) RGD PMID:20367977 RGD:5685646 NCBI chr11:111,659,186...111,661,790
Ensembl chr11:115,591,788...115,594,382 		JBrowse link
G BDNF brain derived neurotrophic factor ISO RGD PMID:16186425 RGD:4891111 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G CRP C-reactive protein disease_progression ISO RGD PMID:9761079 RGD:9491780 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10660968 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G EDN1 endothelin 1 ISO associated with Coronary Artery Disease;protein:increased expression:coronary sinus, plasma (human) RGD PMID:14556009 RGD:8661755 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G F7 coagulation factor VII ISO protein:increased expression:plasma (human) RGD PMID:10653827 RGD:2312399 NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:18333374 RGD:5508458 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785 		JBrowse link
G ITGA2 integrin subunit alpha 2 susceptibility ISO RGD PMID:15104219 RGD:1582303 NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720 		JBrowse link
G ITGAM integrin subunit alpha M ameliorates ISO protein:decreased expression:neutrophil (human) RGD PMID:18043994 RGD:329901840 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406 		JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 ISO RGD PMID:10486281 RGD:1582334 NCBI chr 3:52,754,664...52,774,867
Ensembl chr 3:53,980,668...53,998,038 		JBrowse link
G MMP1 matrix metallopeptidase 1 ISO RGD PMID:14675588 RGD:1582536 NCBI chr11:97,730,545...97,739,190
Ensembl chr11:101,221,393...101,230,104 		JBrowse link
G PAPPA pappalysin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11586954 NCBI chr 9:87,287,289...87,535,414
Ensembl chr 9:115,671,212...115,883,435 		JBrowse link
G PLAU plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:2382605 NCBI chr10:70,433,340...70,441,569
Ensembl chr10:73,105,895...73,113,136 		JBrowse link
G PTEN phosphatase and tensin homolog ISO RNA:increased expression:serum RGD PMID:32595526 RGD:401851053 NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605 		JBrowse link
G SELP selectin P ISO protein:increased expression:serum RGD PMID:21162967 RGD:6219003 NCBI chr 1:145,071,094...145,112,851
Ensembl chr 1:148,793,677...148,834,701 		JBrowse link
G SERPINC1 serpin family C member 1 treatment ISO RGD PMID:8122184 RGD:11035255 NCBI chr 1:149,421,737...149,435,301
Ensembl chr 1:153,126,031...153,139,369 		JBrowse link
G SOD3 superoxide dismutase 3 ISO RGD PMID:14592844 RGD:1580841 NCBI chr 4:19,195,941...19,201,298
Ensembl chr 4:24,485,059...24,485,781 		JBrowse link
G TXN thioredoxin ISO RGD PMID:15749180 RGD:1580784 NCBI chr 9:81,399,056...81,411,607
Ensembl chr 9:109,565,557...109,578,311 		JBrowse link
Intractable Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11280320 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
Low Back Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: therapeutic CTD PMID:7888893 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779 		JBrowse link
G SPARC secreted protein acidic and cysteine rich ISO CTD Direct Evidence: marker/mechanism CTD PMID:20714283 NCBI chr 5:147,087,903...147,112,466
Ensembl chr 5:153,090,181...153,115,750 		JBrowse link
Microvascular Angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDKRB1 bradykinin receptor B1 ISO mRNA:increased expression:blood, mononuclear cell RGD PMID:17852785 RGD:4890450 NCBI chr14:76,885,923...76,894,456 JBrowse link
G BDKRB2 bradykinin receptor B2 ISO mRNA:increased expression:blood, mononuclear cell RGD PMID:17852785 RGD:4890450 NCBI chr14:76,832,833...76,873,860
Ensembl chr14:96,156,494...96,196,253 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism
DNA:transition:cds:g.677C>T (human)		 CTD
RGD		 PMID:17491230 RGD:4891159 NCBI chr 1:10,548,196...10,568,174
Ensembl chr 1:11,766,334...11,785,419 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b ISO protein:decreased expression:serum RGD PMID:15648548 RGD:1620974 NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422 		JBrowse link
Musculoskeletal Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25218601 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G ESR1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25218601 NCBI chr 6:149,507,599...149,918,523
Ensembl chr 6:154,317,002...154,631,551 		JBrowse link
G GCH1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25218601 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393 		JBrowse link
Myalgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LAMA2 laminin subunit alpha 2 ISO ClinVar Annotator: match by term: Myalgia ClinVar PMID:9674786 PMID:18700894 PMID:25741868 PMID:28445022 PMID:28492532 More... NCBI chr 6:126,672,013...127,307,870
Ensembl chr 6:130,781,781...131,415,337 		JBrowse link
G RYR1 ryanodine receptor 1 ISO ClinVar Annotator: match by term: Myalgia ClinVar PMID:24195946 PMID:25741868 PMID:28259615 PMID:28492532 PMID:33564012 More... NCBI chr19:35,527,466...35,685,446
Ensembl chr19:44,106,036...44,256,327 		JBrowse link
G SLC12A3 solute carrier family 12 member 3 ISO ClinVar Annotator: match by term: Myalgia ClinVar PMID:8528245 PMID:9734597 PMID:10988270 PMID:12039972 PMID:17329572 More... NCBI chr16:37,142,797...37,193,713
Ensembl chr16:56,276,049...56,324,528 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 ISO ClinVar Annotator: match by term: Myalgia ClinVar PMID:25741868 PMID:28492532 NCBI chr 1:42,224,273...42,257,184
Ensembl chr 1:43,600,733...43,634,143 		JBrowse link
Myopathy with Myalgia, increased Serum Creatine Kinase, and with or without Episodic Rhabdomyolysis 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DTNA dystrobrevin alpha ISO ClinVar Annotator: match by term: Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis ClinVar PMID:25741868 PMID:36799992 NCBI chr18:27,706,576...28,116,328
Ensembl chr18:31,524,255...31,705,386 		JBrowse link
G MLIP muscular LMNA interacting protein ISO ClinVar Annotator: match by term: Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis OMIM
ClinVar		 PMID:25741868 PMID:34581780 PMID:34935254 PMID:35672413 PMID:35915960 NCBI chr 6:53,574,541...53,823,395
Ensembl chr 6:55,202,674...55,457,640 		JBrowse link
Myopathy with Myalgia, increased Serum Creatine Kinase, and with or without Episodic Rhabdomyolysis 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DTNA dystrobrevin alpha ISO ClinVar Annotator: match by term: MYOPATHY WITH MYALGIA, INCREASED SERUM CREATINE KINASE, AND WITH OR WITHOUT EPISODIC RHABDOMYOLYSIS 2 OMIM
ClinVar		 PMID:36799992 NCBI chr18:27,706,576...28,116,328
Ensembl chr18:31,524,255...31,705,386 		JBrowse link
Neck Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase severity ISO associated with breast cancer;DNA:missense mutation:cds:p.V158M (human) RGD PMID:21898113 RGD:8662332 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A ISO RGD PMID:12946573 RGD:6893571 NCBI chr10:107,669,860...107,673,685 JBrowse link
G ADRA2C adrenoceptor alpha 2C ISO RGD PMID:12946573 RGD:6893571 NCBI chr 4:3,904,346...3,906,577 JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G AQP9 aquaporin 9 ameliorates ISO RGD PMID:31746418 RGD:152995474 NCBI chr15:37,107,061...37,154,887
Ensembl chr15:55,418,767...55,466,541 		JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17442347 PMID:18400411 PMID:19339603 PMID:24133248 NCBI chr 7:73,917,439...74,410,627
Ensembl chr 7:87,579,004...88,068,482 		JBrowse link
G CDK5 cyclin dependent kinase 5 ameliorates ISO RGD PMID:24659417 RGD:401940123 NCBI chr 7:142,640,630...142,644,785
Ensembl chr 7:154,793,344...154,797,499 		JBrowse link
G CFL1 cofilin 1 treatment ISO associated with Sciatic Neuropathy RGD PMID:27216618 RGD:11568694 NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806 		JBrowse link
G CTSS cathepsin S ISO RGD PMID:17551020 PMID:18700000 RGD:5686878 RGD:5686911 NCBI chr 1:126,084,249...126,118,221
Ensembl chr 1:129,733,996...129,768,318 		JBrowse link
G CTSZ cathepsin Z ISO RGD PMID:18700000 RGD:5686878 NCBI chr20:55,346,241...55,358,354
Ensembl chr20:56,706,511...56,718,941 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr2B:105,387,198...105,400,533
Ensembl chr2B:223,997,066...223,998,148 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17292584 NCBI chr2B:23,744,271...23,748,106
Ensembl chr2B:140,181,829...140,189,647 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17720801 NCBI chr10:99,431,762...99,439,619
Ensembl chr10:102,896,376...102,901,514 		JBrowse link
G DRD1 dopamine receptor D1 ISO RGD PMID:22171983 RGD:6907447 NCBI chr 5:170,787,115...170,792,383
Ensembl chr 5:177,688,917...177,690,257 		JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:22171983 PMID:22902996 RGD:6907443 RGD:6907447 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935 		JBrowse link
G FOXP3 forkhead box P3 treatment ISO mRNA:increased expression: L4-L5 of the spinal cord RGD PMID:30858084 RGD:38599004 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G GAL galanin and GMAP prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr11:63,770,758...63,777,421
Ensembl chr11:67,075,547...67,081,696 		JBrowse link
G GCH1 GTP cyclohydrolase 1 treatment ISO RGD PMID:19922668 RGD:401700384 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393 		JBrowse link
G GFRA1 GDNF family receptor alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr10:112,645,574...112,862,413
Ensembl chr10:116,079,063...116,295,164 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO associated with Spinal Cord Injuries; RGD PMID:22951907 RGD:7364890 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A ISO RGD PMID:24659417 RGD:401940123 NCBI chr16:8,682,169...9,105,581
Ensembl chr16:9,919,143...10,336,167 		JBrowse link
G GRK1 G protein-coupled receptor kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr13:94,816,045...94,838,509
Ensembl chr13:113,867,002...113,885,610 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 treatment ISO RGD PMID:24216329 RGD:13792703 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840219 NCBI chr11:83,514,978...84,077,650
Ensembl chr11:87,107,788...87,868,953 		JBrowse link
G HMGB1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A ISO protein:increased expression:dorsal raphe nucleus RGD PMID:31045847 RGD:405849276 NCBI chr 5:50,045,266...50,049,636
Ensembl chr 5:51,692,416...51,693,684 		JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:28011743 NCBI chr  X:103,673,172...103,999,133
Ensembl chr  X:114,199,485...114,503,201 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:16949747 PMID:24077211 PMID:25078297 RGD:11049468 RGD:1598632 RGD:7364865 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371 		JBrowse link
G IL12B interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 5:154,706,467...154,722,231
Ensembl chr 5:161,325,303...161,335,381 		JBrowse link
G ITGAM integrin subunit alpha M ISO mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406 		JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:20705122 RGD:5684389 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G NFATC1 nuclear factor of activated T cells 1 ISO RGD PMID:23386250 RGD:329337338 NCBI chr18:72,948,067...73,083,180
Ensembl chr18:76,017,454...76,094,453 		JBrowse link
G NFATC4 nuclear factor of activated T cells 4 treatment ISO RGD PMID:23386250 RGD:329337338 NCBI chr14:5,141,699...5,156,021
Ensembl chr14:23,266,702...23,279,249 		JBrowse link
G NOS1 nitric oxide synthase 1 treatment ISO RGD PMID:23342771 RGD:7257658 NCBI chr12:114,784,232...114,938,385
Ensembl chr12:118,163,655...118,314,005 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 Ensembl chr 1:136,007,476...136,047,355 JBrowse link
G OPRM1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14718584 PMID:18400411 NCBI chr 6:151,827,323...151,937,658
Ensembl chr 6:156,517,661...157,088,251 		JBrowse link
G P2RY12 purinergic receptor P2Y12 ISO RGD PMID:20665560 RGD:6480524 NCBI chr 3:148,364,151...148,412,231 JBrowse link
G POMC proopiomelanocortin treatment ISO RGD PMID:23624847 RGD:407574732 NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30152261 NCBI chr10:47,642,312...48,935,188
Ensembl chr10:49,779,211...51,064,882 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 3:38,593,765...38,691,172
Ensembl chr 3:38,876,068...38,972,247 		JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19557861 NCBI chr2B:53,468,290...53,643,747
Ensembl chr2B:170,944,974...171,054,013 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 treatment ISO RGD PMID:27059231 RGD:151347419 NCBI chr16:10,196,432...10,198,205 JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase treatment ISO RGD PMID:33746000 RGD:150521727 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
G TAC1 tachykinin precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18400411 NCBI chr 7:89,675,834...89,684,391
Ensembl chr 7:103,257,501...103,266,389 		JBrowse link
G TGFB1 transforming growth factor beta 1 treatment ISO RGD PMID:24979268 RGD:11073677 NCBI chr19:38,324,009...38,347,003
Ensembl chr19:46,831,659...46,852,973 		JBrowse link
G TLR4 toll like receptor 4 ISO mRNA:increased expression:lumbar vertebra RGD PMID:15145554 RGD:1342461 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20846523 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFSF8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31432094 NCBI chr 9:85,998,567...86,036,373
Ensembl chr 9:114,360,206...114,397,822 		JBrowse link
Nociceptive Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit treatment ISO RGD PMID:21107265 RGD:405650611 NCBI chr14:55,832,570...55,835,984
Ensembl chr14:74,676,316...74,679,766 		JBrowse link
G GRM8 glutamate metabotropic receptor 8 ISO RGD PMID:17113112 RGD:6771186 NCBI chr 7:118,430,086...119,249,147 JBrowse link
G PDYN prodynorphin ISO RGD PMID:25663984 RGD:401851903 NCBI chr20:2,092,171...2,108,141
Ensembl chr20:1,856,850...1,872,452 		JBrowse link
G POMC proopiomelanocortin ISO RGD PMID:21380811 RGD:5508807 NCBI chr2A:25,161,668...25,165,600
Ensembl chr2A:25,258,768...25,262,706 		JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:21371033 RGD:6483537 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148 		JBrowse link
G PTGIS prostaglandin I2 synthase ameliorates ISO RGD PMID:26611322 RGD:11536046 NCBI chr20:45,841,238...45,905,641
Ensembl chr20:46,905,665...46,971,612 		JBrowse link
G VIP vasoactive intestinal peptide ISO RGD PMID:19467283 RGD:5685608 NCBI chr 6:150,564,545...150,573,582
Ensembl chr 6:155,254,652...155,263,730 		JBrowse link
Painful Neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:medulla oblongata, dorsal horn of spinal cord (mouse)
protein:increased expression:ipsilateral side, dorsal root ganglion (rat)		 RGD PMID:15041200 PMID:22721162 RGD:8548831 RGD:8548884 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G EP300 E1A binding protein p300 treatment ISO mRNA:increased expression:lumbar spinal cord (rat) RGD PMID:23176208 RGD:7327202 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604 		JBrowse link
G HMGB1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27474498 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G THBD thrombomodulin ISO CTD Direct Evidence: therapeutic CTD PMID:27474498 NCBI chr20:22,992,341...22,996,415
Ensembl chr20:23,345,917...23,347,812 		JBrowse link
G TLR4 toll like receptor 4 treatment ISO RGD PMID:18615568 RGD:7815041 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:Schwann cell RGD PMID:9514564 PMID:10825476 PMID:11376190 PMID:18394803 RGD:7394735 RGD:7394739 RGD:7394740 RGD:7394741 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
paroxysmal extreme pain disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Paroxysmal extreme pain disorder ClinVar PMID:25741868 PMID:34298581 NCBI chr2B:95,475,320...95,494,286
Ensembl chr2B:213,599,036...213,617,175 		JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 ISO ClinVar Annotator: match by term: Paroxysmal extreme pain disorder | ClinVar Annotator: match by term: RECTAL PAIN, FAMILIAL OMIM
ClinVar		 PMID:15955112 PMID:17145499 PMID:18060017 PMID:18414213 PMID:18518989 More... NCBI chr2B:53,468,290...53,643,747
Ensembl chr2B:170,944,974...171,054,013 		JBrowse link
Postherpetic Neuralgia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11280320 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:25880108 RGD:407987076 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
G SCN8A sodium voltage-gated channel alpha subunit 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr12:36,950,057...37,172,235
Ensembl chr12:37,730,900...37,876,357 		JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23382806 NCBI chr2B:53,468,290...53,643,747
Ensembl chr2B:170,944,974...171,054,013 		JBrowse link
Postoperative Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:20627697 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28434951 NCBI chr17:11,261,435...11,313,630
Ensembl chr17:11,650,057...11,701,208 		JBrowse link
G DUSP6 dual specificity phosphatase 6 ISO associated with Inflammation RGD PMID:24155322 RGD:7771585 NCBI chr12:86,875,289...86,879,731
Ensembl chr12:90,195,482...90,200,321 		JBrowse link
Prinzmetal angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:plasma RGD PMID:9415270 RGD:8547713 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 ISO RGD PMID:11984590 RGD:1581700 NCBI chr12:64,522,172...64,532,848
Ensembl chr12:67,127,263...67,137,128 		JBrowse link
Referred Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor ISO RGD PMID:23313710 RGD:8655857 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
Renal Colic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRP C-reactive protein ISO associated with Urolithiasis; RGD PMID:20206981 RGD:6909142 NCBI chr 1:135,062,102...135,064,402 JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 ISO RGD PMID:16176350 RGD:2302154 NCBI chr10:96,878,280...96,887,830
Ensembl chr10:100,358,095...100,368,640 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B treatment ISO RGD PMID:22425187 RGD:7245944 NCBI chr 1:10,915,743...10,957,765
Ensembl chr 1:12,130,663...12,172,646 		JBrowse link
Stable Angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F7 coagulation factor VII ISO protein:increased activity:plasma (human) RGD PMID:17357481 RGD:11049525 NCBI chr13:94,246,694...94,261,133
Ensembl chr13:113,315,868...113,329,995 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129 		JBrowse link
G RBP4 retinol binding protein 4 ISO protein:increased expression:blood serum (human) RGD PMID:25142320 RGD:329845867 NCBI chr10:90,337,879...90,347,530
Ensembl chr10:93,848,166...93,857,887 		JBrowse link
G TLR4 toll like receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
Toothache term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPY1R neuropeptide Y receptor Y1 ISO CTD Direct Evidence: therapeutic CTD PMID:18809749 NCBI chr 4:155,583,870...155,604,336
Ensembl chr 4:167,372,310...167,381,597 		JBrowse link
Visceral Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A ISO RGD PMID:20047711 RGD:6480482 NCBI chr10:107,669,860...107,673,685 JBrowse link
G BDNF brain derived neurotrophic factor ISO associated with Colitis; protein:increased expression:dorsal root ganglion: RGD PMID:19932037 PMID:21997550 RGD:8655978 RGD:8657331 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G EPHB2 EPH receptor B2 ameliorates ISO RGD PMID:33880135 RGD:127285657 NCBI chr 1:21,895,961...22,107,649
Ensembl chr 1:22,912,570...23,047,118 		JBrowse link
G GCH1 GTP cyclohydrolase 1 treatment ISO DNA:haplotype RGD PMID:25783971 RGD:401700391 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393 		JBrowse link
G PENK proenkephalin treatment ISO RGD PMID:23316929 RGD:10003040 NCBI chr 8:52,864,388...52,870,144
Ensembl chr 8:50,234,170...50,239,949 		JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 ISO associated with Colitis; RGD PMID:23099257 RGD:10043788 NCBI chr 8:68,551,685...68,605,336
Ensembl chr 8:70,210,352...70,262,627 		JBrowse link
G TRPC4 transient receptor potential cation channel subfamily C member 4 ISO RGD PMID:24388923 RGD:13825245 NCBI chr13:18,852,991...19,081,790
Ensembl chr13:37,445,015...37,592,115 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15835
    Pathological Conditions, Signs and Symptoms 12339
      Signs and Symptoms 10388
        Neurologic Manifestations 10069
          Pain 321
            Abdominal Pain + 5
            Acute Pain 1
            Arthralgia + 5
            Back Pain + 3
            Breakthrough Pain 0
            Cancer Pain 6
            Chest Pain + 41
            Chronic Pain 7
            Earache 0
            Eye Pain 1
            Facial Pain + 1
            Flank Pain 0
            Glossalgia 0
            Headache + 9
            Hyperalgesia 204
            Hypoalgesia 2
            INTELLECTUAL DEVELOPMENTAL DISORDER WITH GASTROINTESTINAL DIFFICULTIES AND HIGH PAIN THRESHOLD 1
            Intractable Pain 1
            Labor Pain 0
            Levator Syndrome 0
            Mastodynia 0
            Metatarsalgia + 0
            Musculoskeletal Pain + 10
            Neck Pain 1
            Neuralgia + 53
            Nociceptive Pain + 14
            Painful Neuropathy 6
            Pelvic Pain + 5
            Postoperative Pain + 3
            Referred Pain 1
            Renal Colic 1
            familial episodic pain syndrome + 3
            paroxysmal extreme pain disorder 2
paths to the root