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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Obstetric Labor Complications
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Accession:DOID:9000610 term browser browse the term
Definition:Medical problems associated with OBSTETRIC LABOR, such as BREECH PRESENTATION; PREMATURE OBSTETRIC LABOR; HEMORRHAGE; or others. These complications can affect the well-being of the mother, the FETUS, or both.
Synonyms:exact_synonym: Labor Complication;   Labor Complications;   Obstetric Labor Complication
 primary_id: MESH:D007744;   RDO:0004699
For additional species annotation, visit the Alliance of Genome Resources.


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chorioamnionitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor IEP RGD PMID:22578261 RGD:6767308 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G FAS Fas cell surface death receptor IEP protein:increased expression:villous trophoblast RGD PMID:12700199 RGD:12904022 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G IL1A interleukin 1 alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:21493953 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL6 interleukin 6 IEP protein:increased expression:plasma
protein:increased expression: cervicovaginal fluid :
associated with Premature Birth;protein:increased expression:tracheal aspirate fluid:
RGD PMID:15547537 PMID:25687566 PMID:25011638 RGD:5128667, RGD:12792243, RGD:12791291 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LTA lymphotoxin alpha severity IAGP associated with Premature Birth;DNA:SNP:promoter:250G>A (human) RGD PMID:15128916 RGD:12904055 NCBI chr 6:31,560,550...31,574,324
Ensembl chr 6:31,572,054...31,574,324
JBrowse link
G MBL2 mannose binding lectin 2 susceptibility IAGP DNA:polymorphism:exon:p.G54D(human) RGD PMID:15723707 RGD:12910932 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
JBrowse link
G MMP9 matrix metallopeptidase 9 severity IEP protein:increased expression:respiratory system fluid/secretion RGD PMID:12712078 RGD:13204828 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G TGFB1 transforming growth factor beta 1 severity IEP protein:increased expression:amniotic fluid RGD PMID:19332995 RGD:4145137 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor no_association
severity
IAGP associated with Premature Birth;DNA:SNP:promoter:c.-308 G>A (human)
associated with Premature Birth;DNA:SNP:promoter:c.-238G>A (human)
RGD PMID:15128916 PMID:15128916 RGD:12904055, RGD:12904055 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 IEP associated with Premature Obstetric Labor;protein:increased expression:amniotic fluid: RGD PMID:19591072 RGD:127229904 NCBI chr 6:41,267,385...41,286,692
Ensembl chr 6:41,267,926...41,286,682
JBrowse link
placental abruption term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase EXP CTD Direct Evidence: marker/mechanism CTD PMID:17376725 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288
JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15633187 NCBI chr14:64,388,353...64,460,025
Ensembl chr14:64,388,031...64,463,457
JBrowse link
G NOS3 nitric oxide synthase 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11354626 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa susceptibility IDA RGD PMID:9855597 RGD:11564329 NCBI chr 2:127,418,143...127,429,246
Ensembl chr 2:127,418,427...127,429,242
JBrowse link
Premature Birth term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRAF B-Raf proto-oncogene, serine/threonine kinase IAGP ClinVar Annotator: match by term: Premature birth ClinVar PMID:16439621 PMID:16474404 PMID:17366577 PMID:17483702 PMID:17704260 More... NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929
JBrowse link
G CAT catalase EXP CTD Direct Evidence: marker/mechanism CTD PMID:26055944 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G EDN1 endothelin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25230003 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G GSTM1 glutathione S-transferase mu 1 susceptibility IAGP RGD PMID:22949524 RGD:10450837 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTT1 glutathione S-transferase theta 1 susceptibility IAGP DNA:deletion:: (human) RGD PMID:22949524 PMID:18320229 RGD:10450837, RGD:12792239
G IL4 interleukin 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26055944 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26055944 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LTF lactotransferrin EXP CTD Direct Evidence: therapeutic CTD PMID:16640825 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234
JBrowse link
G MBL2 mannose binding lectin 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16912583 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
JBrowse link
G MMP9 matrix metallopeptidase 9 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24429678 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G NF1 neurofibromin 1 IAGP ClinVar Annotator: match by term: Premature birth ClinVar PMID:25741868 PMID:28492532 NCBI chr17:31,094,927...31,377,677
Ensembl chr17:31,094,927...31,382,116
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase EXP CTD Direct Evidence: marker/mechanism CTD PMID:29709520 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G PGF placental growth factor IEP RGD PMID:20822327 RGD:6483609 NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26055944 PMID:27748297 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G SOD2 superoxide dismutase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26055944 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TNF tumor necrosis factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:27748297 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VARS1 valyl-tRNA synthetase 1 IAGP ClinVar Annotator: match by term: Premature birth ClinVar PMID:25741868 PMID:30275004 NCBI chr 6:31,777,518...31,795,928
Ensembl chr 6:31,777,518...31,795,752
JBrowse link
Premature Obstetric Labor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18606702 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G GJB2 gap junction protein beta 2 ISO RGD PMID:8612484 RGD:11568660 NCBI chr13:20,187,470...20,192,938
Ensembl chr13:20,187,463...20,192,938
JBrowse link
G IL6 interleukin 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20610570 PMID:22122352 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
PRETERM INTRAVENTRICULAR HEMORRHAGE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNOT1 CCR4-NOT transcription complex subunit 1 IAGP ClinVar Annotator: match by term: Preterm intraventricular hemorrhage ClinVar PMID:25741868 NCBI chr16:58,519,951...58,629,826
Ensembl chr16:58,519,951...58,629,885
JBrowse link
G SEMA6B semaphorin 6B IAGP ClinVar Annotator: match by term: Grade I preterm intraventricular hemorrhage ClinVar PMID:31474318 NCBI chr19:4,542,588...4,581,484
Ensembl chr19:4,542,593...4,581,776
JBrowse link
preterm premature rupture of the membranes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor IEP protein:increased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G MMP1 matrix metallopeptidase 1 IAGP ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:9850057 PMID:11741975 PMID:11875051 PMID:18030675 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
JBrowse link
G MMP8 matrix metallopeptidase 8 IAGP ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:15367487 NCBI chr11:102,711,796...102,724,967
Ensembl chr11:102,711,796...102,727,050
JBrowse link
G SERPINH1 serpin family H member 1 susceptibility IAGP
EXP
ClinVar Annotator: match by term: Preterm premature rupture of the membranes
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:16938879 PMID:25741868 NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783
JBrowse link
G TFPI tissue factor pathway inhibitor IEP protein:decreased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 2:187,464,230...187,554,501
Ensembl chr 2:187,464,230...187,565,760
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 20257
    disease of anatomical entity 18858
      Urogenital Diseases 4839
        Female Urogenital Diseases and Pregnancy Complications 2210
          Pregnancy Complications 590
            Obstetric Labor Complications 36
              Breech Presentation 0
              Cephalopelvic Disproportion 0
              Dystocia + 0
              Fetal Membranes, Premature Rupture + 15
              PRETERM INTRAVENTRICULAR HEMORRHAGE 2
              Postpartum Hemorrhage 0
              Premature Obstetric Labor + 19
              Sheehan syndrome 0
              Uterine Rupture + 0
              Vasa Previa 0
              placenta accreta 0
              placenta praevia + 0
              placental abruption 4
              uterine inversion 0
paths to the root