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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Prehypertension
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Accession:DOID:9000564 term browser browse the term
Definition:Blood pressure levels that are between normotension and hypertension. Individuals with prehypertension are at a higher risk for developing cardiovascular diseases. Generally, prehypertension is defined as SYSTOLIC PRESSURE of 131-139 mm Hg and/or DIASTOLIC PRESSURE of 81-89 when the optimal is 120/80 mm Hg. For diabetics and other metabolism diseases the prehypertension is around 110-129/70-79 mm Hg.
Synonyms:exact_synonym: Pre Hypertension;   Pre-Hypertensions;   Prehypertensions
 primary_id: MESH:D058246

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Prehypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase susceptibility ISO RGD PMID:23096233 RGD:9068479 NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464 		JBrowse link
G F11r F11 receptor ISO RGD PMID:17420334 RGD:7488939 NCBI chrNW_004955468:12,764,968...12,785,956
Ensembl chrNW_004955468:12,765,874...12,785,929 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO protein:decreased expression:stellate interneuron RGD PMID:23172925 RGD:7257670 NCBI chrNW_004955455:13,797,557...13,978,402
Ensembl chrNW_004955455:13,797,545...13,972,566 		JBrowse link
G Pln phospholamban ISO protein:decreased expression, decreased serine phosphorylation:superior cervical ganglion RGD PMID:22252398 RGD:7327185 NCBI chrNW_004955436:1,439,098...1,447,070
Ensembl chrNW_004955436:1,439,098...1,447,070 		JBrowse link
G Rbp4 retinol binding protein 4 ISO associated with obesity; protein:increased expression:blood serum (human) RGD PMID:28639612 RGD:329845595 NCBI chrNW_004955507:112,342...120,050
Ensembl chrNW_004955507:108,669...120,584 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13820
      cardiovascular system disease 4073
        vascular disease 2851
          Prehypertension 5
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