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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Consciousness Disorders
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Accession:DOID:9000484 term browser browse the term
Definition:Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition.
Synonyms:exact_synonym: Altered Level of Consciousness;   Consciousness Disorder;   Consciousness, Level Altered;   Consciousness, Level Depressed;   Depressed Level of Consciousness;   Semiconsciousness
 primary_id: MESH:D003244

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Brain Death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 treatment ISO mRNA, protein:increased expression:kidney RGD PMID:20819234 PMID:23356498 RGD:10755728 RGD:10766439 NCBI chrNW_004624750:341,699...346,005
Ensembl chrNW_004624750:342,146...345,887 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO mRNA:increased expression:lung (rat) RGD PMID:20810760 RGD:4145365 NCBI chrNW_004624828:2,432,584...2,451,997
Ensembl chrNW_004624828:2,432,550...2,453,071 		JBrowse link
G Inhbb inhibin subunit beta B ISO mRNA:increased expression:kidney (rat) RGD PMID:15808645 RGD:9743920 NCBI chrNW_004624732:24,754,601...24,755,890
Ensembl chrNW_004624732:24,754,618...24,755,995 		JBrowse link
G Itgam integrin subunit alpha M ISO protein:increased expression:neutrophil (rat) RGD PMID:18347540 RGD:329901924 NCBI chrNW_004624782:14,316,505...14,367,841
Ensembl chrNW_004624782:14,318,499...14,367,922 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 ISO RGD PMID:23157661 RGD:7495829 NCBI chrNW_004624786:14,457,382...14,597,027
Ensembl chrNW_004624786:14,457,452...14,597,027 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO RGD PMID:23157661 RGD:7495829 NCBI chrNW_004624870:4,224,108...4,420,217
Ensembl chrNW_004624870:4,287,835...4,416,559 		JBrowse link
Coma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO ClinVar Annotator: match by term: Episodic coma ClinVar PMID:28492532 NCBI chrNW_004624771:1,554,875...2,047,597
Ensembl chrNW_004624771:1,733,215...2,039,784 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8438805 NCBI chrNW_004624765:5,527,029...5,652,343
Ensembl chrNW_004624765:5,528,112...5,651,415 		JBrowse link
G Gcg glucagon ISO CTD Direct Evidence: therapeutic CTD PMID:10464538 NCBI chrNW_004624732:3,361,897...3,370,020
Ensembl chrNW_004624732:3,362,234...3,370,536 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:292422 PMID:5067144 PMID:19397503 NCBI chrNW_004624741:4,200,594...4,201,416
Ensembl chrNW_004624741:4,200,478...4,201,580 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:24729111 NCBI chrNW_004624772:10,732,527...10,742,575
Ensembl chrNW_004624772:10,737,464...10,742,555 		JBrowse link
Post-Head Injury Coma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trh thyrotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:8690305 NCBI chrNW_004624872:866,370...868,624
Ensembl chrNW_004624872:866,365...868,739 		JBrowse link
Stupor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trh thyrotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:416961 PMID:8690305 NCBI chrNW_004624872:866,370...868,624
Ensembl chrNW_004624872:866,365...868,739 		JBrowse link
Syncope term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actl6a actin like 6A ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:19215055 PMID:25741868 PMID:28649782 PMID:31994175 NCBI chrNW_004624730:57,305,105...57,337,653
Ensembl chrNW_004624730:57,305,053...57,337,797 		JBrowse link
G Actn2 actinin alpha 2 ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:23861362 PMID:24033266 PMID:25741868 PMID:26498160 PMID:26899768 More... NCBI chrNW_004624775:13,917,215...13,989,093
Ensembl chrNW_004624775:13,916,883...13,989,153 		JBrowse link
G Ctnna3 catenin alpha 3 ISO ClinVar Annotator: match by term: Syncope ClinVar NCBI chrNW_004624754:285,469...2,182,218
Ensembl chrNW_004624754:285,857...2,034,582 		JBrowse link
G Dsp desmoplakin ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:25741868 NCBI chrNW_004624756:18,036,103...18,083,379
Ensembl chrNW_004624756:18,035,892...18,083,336 		JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:11207363 PMID:12414843 PMID:14504341 PMID:15037716 PMID:15212652 More... NCBI chrNW_004624817:2,593,649...2,607,462
Ensembl chrNW_004624817:2,513,539...2,606,682 		JBrowse link
G Lipt2 lipoyl(octanoyl) transferase 2 ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:11207363 PMID:12414843 PMID:14504341 PMID:15037716 PMID:15212652 More... NCBI chrNW_004624817:2,573,459...2,575,259
Ensembl chrNW_004624817:2,573,479...2,575,259 		JBrowse link
G Mefv MEFV innate immunity regulator, pyrin ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:9668175 PMID:10090880 PMID:10612841 PMID:10787450 PMID:10842288 More... NCBI chrNW_004624824:1,035,172...1,047,632
Ensembl chrNW_004624824:1,035,094...1,047,678 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO ClinVar Annotator: match by term: Syncope ClinVar NCBI chrNW_004624775:12,954,653...13,650,449
Ensembl chrNW_004624775:12,956,042...13,419,381 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:25741868 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
G Ttn titin ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:24033266 PMID:25741868 NCBI chrNW_004624844:484,593...760,155 JBrowse link
Unconsciousness term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cck cholecystokinin ISO CTD Direct Evidence: marker/mechanism CTD PMID:6281507 NCBI chrNW_004624730:77,310,080...77,314,258
Ensembl chrNW_004624730:77,309,633...77,314,384 		JBrowse link
G Trh thyrotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:6281507 NCBI chrNW_004624872:866,370...868,624
Ensembl chrNW_004624872:866,365...868,739 		JBrowse link
Vasovagal Syncope term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppb natriuretic peptide B ISO associated with Syncope;protein:increased expression:serum: RGD PMID:23373852 RGD:7247623 NCBI chrNW_004624818:1,139,776...1,141,010 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14208
    disease of anatomical entity 13924
      nervous system disease 12255
        Neurologic Manifestations 9152
          Neurobehavioral Manifestations 4250
            Consciousness Disorders 24
              Unconsciousness + 24
Path 2
Term Annotations click to browse term
  disease 14208
    disease of anatomical entity 13924
      nervous system disease 12255
        central nervous system disease 10971
          brain disease 10296
            disease of mental health 7369
              cognitive disorder 1962
                Consciousness Disorders 24
                  Unconsciousness + 24
paths to the root