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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Consciousness Disorders
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Accession:DOID:9000484 term browser browse the term
Definition:Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition.
Synonyms:exact_synonym: Altered Level of Consciousness;   Consciousness Disorder;   Consciousness, Level Altered;   Consciousness, Level Depressed;   Depressed Level of Consciousness;   Semiconsciousness
 primary_id: MESH:D003244;   RDO:0005266
For additional species annotation, visit the Alliance of Genome Resources.


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Brain Death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 treatment IEP
IMP
mRNA, protein:increased expression:kidney RGD PMID:23356498, PMID:20819234 RGD:10755728, RGD:10766439 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP mRNA:increased expression:lung (rat) RGD PMID:20810760 RGD:4145365 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Inhbb inhibin subunit beta B IEP mRNA:increased expression:kidney (rat) RGD PMID:15808645 RGD:9743920 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IDA RGD PMID:23157661 RGD:7495829 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 IDA RGD PMID:23157661 RGD:7495829 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
Coma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cps1 carbamoyl-phosphate synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8438805 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18359183 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Gcg glucagon ISO CTD Direct Evidence: therapeutic CTD PMID:10464538 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:292422 PMID:5067144 PMID:19397503 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Tshb thyroid stimulating hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:24729111 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
Post-Head Injury Coma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trh thyrotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:8690305 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
Stupor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trh thyrotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:416961 PMID:8690305 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
Syncope term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn2 actinin alpha 2 ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:23861362 PMID:24033266 PMID:25741868 PMID:26498160 PMID:26899768 PMID:28492532 PMID:30959811 NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653
JBrowse link
G Ctnna3 catenin alpha 3 ISO ClinVar Annotator: match by term: Syncope ClinVar NCBI chr20:25,063,124...26,640,428
Ensembl chr20:26,516,836...26,589,209
JBrowse link
G Dsp desmoplakin ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:25741868 NCBI chr17:27,286,811...27,334,453
Ensembl chr17:27,286,796...27,334,379
JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:11207363 PMID:12414843 PMID:14504341 PMID:15037716 PMID:15212652 PMID:16449802 PMID:17395131 PMID:23861362 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 1:165,189,934...165,196,949
Ensembl chr 1:165,189,985...165,196,948
JBrowse link
G Lipt2 lipoyl(octanoyl) transferase 2 ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:11207363 PMID:12414843 PMID:14504341 PMID:15037716 PMID:15212652 PMID:16449802 PMID:17395131 PMID:23861362 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 1:165,170,645...165,172,972
Ensembl chr 1:165,170,645...165,172,972
JBrowse link
G Mefv MEFV innate immuity regulator, pyrin ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:9668175 PMID:10090880 PMID:10611954 PMID:10612841 PMID:11464238 PMID:16730661 PMID:17489852 PMID:19253030 PMID:19934083 PMID:20041150 PMID:21153919 PMID:21246368 PMID:21413889 PMID:22207183 PMID:23588594 PMID:23907647 PMID:23981758 PMID:24033266 PMID:24251727 PMID:24469716 PMID:24929125 PMID:25741868 PMID:26003477 PMID:27364639 PMID:27733942 PMID:28483595 PMID:28492532 PMID:29543225 NCBI chr10:12,045,813...12,056,229
Ensembl chr10:12,046,541...12,056,311
JBrowse link
G Ryr2 ryanodine receptor 2 ISO ClinVar Annotator: match by term: Syncope ClinVar NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:25741868 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Ttn titin ISO ClinVar Annotator: match by term: Syncope ClinVar PMID:24033266 PMID:25741868 NCBI chr 3:63,565,160...63,837,815 JBrowse link
Unconsciousness term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cck cholecystokinin ISO CTD Direct Evidence: marker/mechanism CTD PMID:6281507 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Pten phosphatase and tensin homolog ISO ClinVar Annotator: match by term: Loss of consciousness ClinVar PMID:25741868 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Trh thyrotropin releasing hormone ISO CTD Direct Evidence: therapeutic CTD PMID:6281507 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
Vasovagal Syncope term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppb natriuretic peptide B ISO associated with Syncope;protein:increased expression:serum: RGD PMID:23373852 RGD:7247623 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17129
    disease of anatomical entity 16476
      nervous system disease 12074
        Neurologic Manifestations 5408
          Neurobehavioral Manifestations 3679
            Consciousness Disorders 23
              Unconsciousness + 23
Path 2
Term Annotations click to browse term
  disease 17129
    disease of anatomical entity 16476
      nervous system disease 12074
        central nervous system disease 10353
          brain disease 9712
            disease of mental health 7022
              cognitive disorder 1949
                Consciousness Disorders 23
                  Unconsciousness + 23
paths to the root