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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Angina Pectoris
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Accession:DOID:9000483 term browser browse the term
Definition:The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Synonyms:exact_synonym: Angor Pectoris;   Stenocardia;   Stenocardias
 primary_id: MESH:D000787
 xref: EFO:0003913


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Angina Pectoris term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 IMP RGD PMID:11527135 RGD:5129114 NCBI chr10:114,043,866...114,046,904
Ensembl chr10:114,043,866...114,046,904 		JBrowse link
G ADRB2 adrenoceptor beta 2 IMP RGD PMID:11527135 RGD:5129114 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623 		JBrowse link
G AVP arginine vasopressin EXP CTD Direct Evidence: marker/mechanism CTD PMID:11128043 PMID:11791009 NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724 		JBrowse link
G CPB2 carboxypeptidase B2 IAGP RGD PMID:12624641 RGD:1598479 NCBI chr13:46,053,186...46,105,033
Ensembl chr13:46,053,186...46,105,033 		JBrowse link
G MIR146A microRNA 146a IEP miRNA:increased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450 		JBrowse link
G MIR155 microRNA 155 IEP miRNA:decreased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MIR21 microRNA 21 IEP miRNA:increased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G PLAU plasminogen activator, urokinase EXP CTD Direct Evidence: therapeutic CTD PMID:1730212 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PPBP pro-platelet basic protein IEP protein:increased expression:plasma RGD PMID:17045893 RGD:401794448 NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190 		JBrowse link
G SPP1 secreted phosphoprotein 1 IDA RGD PMID:16421174 RGD:1581390 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
intermediate coronary syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme IEP mRNA:increased expression:ventricular myocardium (human)
mRNA:increased expression:myocardium		 RGD PMID:15131005 PMID:11451295 RGD:8142363, RGD:8548894 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G AGT angiotensinogen IEP mRNA:increased expression:myocardium RGD PMID:11451295 RGD:8548894 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AGTR1 angiotensin II receptor type 1 IEP mRNA:increased expression:myocardium RGD PMID:11451295 RGD:8548894 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 IEP protein:increased serine phosphorylation:platelet RGD PMID:20467748 RGD:5509094 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G APOA4 apolipoprotein A4 IEP protein:decreased expression:blood plasma (human) RGD PMID:20367977 RGD:5685646 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304 		JBrowse link
G BDNF brain derived neurotrophic factor IEP RGD PMID:16186425 RGD:4891111 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CRP C-reactive protein disease_progression IEP RGD PMID:9761079 RGD:9491780 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:10660968 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G EDN1 endothelin 1 IEP associated with Coronary Artery Disease;protein:increased expression:coronary sinus, plasma (human) RGD PMID:14556009 RGD:8661755 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G F7 coagulation factor VII IEP protein:increased expression:plasma (human) RGD PMID:10653827 RGD:2312399 NCBI chr13:113,105,788...113,120,685
Ensembl chr13:113,105,788...113,120,685 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase IMP RGD PMID:18333374 RGD:5508458 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G ITGA2 integrin subunit alpha 2 susceptibility IAGP RGD PMID:15104219 RGD:1582303 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779 		JBrowse link
G ITGAM integrin subunit alpha M ameliorates IEP protein:decreased expression:neutrophil (human) RGD PMID:18043994 RGD:329901840 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 IDA RGD PMID:10486281 RGD:1582334 NCBI chr 3:52,812,962...52,830,672
Ensembl chr 3:52,812,962...52,830,688 		JBrowse link
G MIR126 microRNA 126 disease_progression IEP RGD PMID:32595526 RGD:401851053 NCBI chr 9:136,670,602...136,670,686
Ensembl chr 9:136,670,602...136,670,686 		JBrowse link
G MIR21 microRNA 21 IEP RNA:decreased expression:serum RGD PMID:32595526 RGD:401851053 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MMP1 matrix metallopeptidase 1 IDA RGD PMID:14675588 RGD:1582536 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G PAPPA pappalysin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11586954 NCBI chr 9:116,153,791...116,402,321
Ensembl chr 9:116,153,791...116,402,321 		JBrowse link
G PLAU plasminogen activator, urokinase EXP CTD Direct Evidence: therapeutic CTD PMID:2382605 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PTEN phosphatase and tensin homolog IEP RNA:increased expression:serum RGD PMID:32595526 RGD:401851053 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G SELP selectin P IEP protein:increased expression:serum RGD PMID:21162967 RGD:6219003 NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193 		JBrowse link
G SERPINC1 serpin family C member 1 treatment IDA RGD PMID:8122184 RGD:11035255 NCBI chr 1:173,903,800...173,917,327
Ensembl chr 1:173,903,800...173,917,327 		JBrowse link
G SOD3 superoxide dismutase 3 IEP RGD PMID:14592844 RGD:1580841 NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842 		JBrowse link
G TXN thioredoxin IEP RGD PMID:15749180 RGD:1580784 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507 		JBrowse link
Microvascular Angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDKRB1 bradykinin receptor B1 IEP mRNA:increased expression:blood, mononuclear cell RGD PMID:17852785 RGD:4890450 NCBI chr14:96,256,210...96,264,763
Ensembl chr14:96,256,210...96,268,967 		JBrowse link
G BDKRB2 bradykinin receptor B2 IEP mRNA:increased expression:blood, mononuclear cell RGD PMID:17852785 RGD:4890450 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase IAGP
EXP		 DNA:transition:cds:g.677C>T (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17491230 PMID:17491230 RGD:4891159 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b IEP protein:decreased expression:serum RGD PMID:15648548 RGD:1620974 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885 		JBrowse link
Prinzmetal angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ICAM1 intercellular adhesion molecule 1 IEP protein:increased expression:plasma RGD PMID:9415270 RGD:8547713 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 ISO RGD PMID:11984590 RGD:1581700 NCBI chr12:21,764,955...21,774,706
Ensembl chr12:21,764,955...21,775,600 		JBrowse link
Stable Angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F7 coagulation factor VII IEP protein:increased activity:plasma (human) RGD PMID:17357481 RGD:11049525 NCBI chr13:113,105,788...113,120,685
Ensembl chr13:113,105,788...113,120,685 		JBrowse link
G MIR126 microRNA 126 IEP RNA:decreased expression:plasma RGD PMID:27900989 RGD:401850572 NCBI chr 9:136,670,602...136,670,686
Ensembl chr 9:136,670,602...136,670,686 		JBrowse link
G MMP9 matrix metallopeptidase 9 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G RBP4 retinol binding protein 4 IEP protein:increased expression:blood serum (human) RGD PMID:25142320 RGD:329845867 NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744 		JBrowse link
G TLR4 toll like receptor 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32344
      cardiovascular system disease 6065
        heart disease 4434
          Myocardial Ischemia 1004
            Angina Pectoris 42
              Microvascular Angina 4
              Stable Angina 6
              intermediate coronary syndrome + 26
Path 2
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32344
      cardiovascular system disease 6065
        vascular disease 3857
          ischemia 1555
            Myocardial Ischemia 1004
              Angina Pectoris 42
                Microvascular Angina 4
                Stable Angina 6
                intermediate coronary syndrome + 26
paths to the root