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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:influenza A
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Accession:DOID:9000371 term browser browse the term
Definition:A viral infectious disease that results in infection, located in respiratory tract, has_material_basis_in Influenza virus A, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness. Because type A influenza viruses mutate quickly, creating new strains from one flu season to the next., past flu vaccinations will not prevent infection from a new strain.
Synonyms:exact_synonym: Influenza caused by Influenza A virus;   Influenza due to Influenza A virus
 xref: PMID:27438481


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influenza A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase exacerbates ISO RGD PMID:31509427 RGD:126779564 NCBI chrNW_004955412:10,422,753...10,531,406
Ensembl chrNW_004955412:10,426,135...10,530,545
JBrowse link
G Btk Bruton tyrosine kinase ameliorates ISO Associated with Acute Lung Injury RGD PMID:29516781 RGD:124713566 NCBI chrNW_004955503:7,483,819...7,515,085
Ensembl chrNW_004955503:7,482,793...7,515,120
JBrowse link
G Duox1 dual oxidase 1 ISO protein:decreased expression:blood plasma (human) RGD PMID:24888898 RGD:40903071 NCBI chrNW_004955409:8,228,754...8,256,575
Ensembl chrNW_004955409:8,229,199...8,255,003
JBrowse link
G Duox2 dual oxidase 2 severity ISO RGD PMID:25751630 PMID:28936773 PMID:29556357 RGD:40924644 RGD:40925921 RGD:40925925 NCBI chrNW_004955409:8,270,657...8,288,201
Ensembl chrNW_004955409:8,271,164...8,287,096
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 ISO mRNA:increased expression:nasal cavity mucosa (mouse) RGD PMID:25751630 RGD:40925925 NCBI chrNW_004955449:11,538,869...11,596,502
Ensembl chrNW_004955449:11,538,889...11,593,349
JBrowse link
G Il21 interleukin 21 ISO RGD PMID:25251568 RGD:127285548 NCBI chrNW_004955428:18,057,096...18,065,492
Ensembl chrNW_004955428:18,057,096...18,065,492
JBrowse link
G Il27 interleukin 27 ISO protein:increased expression:blood serum (human) RGD PMID:22343630 RGD:126790513 NCBI chrNW_004955493:6,712,005...6,717,417
Ensembl chrNW_004955493:6,712,005...6,717,417
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 exacerbates ISO RGD PMID:26241898 RGD:11055126 NCBI chrNW_004955429:21,717,153...21,739,349
Ensembl chrNW_004955429:21,716,958...21,741,585
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ameliorates ISO RGD PMID:22514650 RGD:150340681 NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784
JBrowse link
G Marco macrophage receptor with collagenous structure ameliorates ISO RGD PMID:21562316 RGD:41412197 NCBI chrNW_004955459:10,700,645...10,739,222
Ensembl chrNW_004955459:10,698,294...10,739,131
JBrowse link
G Mavs mitochondrial antiviral signaling protein disease_progression ISO RGD PMID:27438481 RGD:40903047 NCBI chrNW_004955415:14,691,918...14,704,782
Ensembl chrNW_004955415:14,695,438...14,703,672
JBrowse link
G Plac8 placenta associated 8 ISO RGD PMID:32639988 RGD:40925929 NCBI chrNW_004955474:6,518,459...6,533,251
Ensembl chrNW_004955474:6,522,204...6,534,312
JBrowse link
G Ppia peptidylprolyl isomerase A ameliorates ISO human gene in a mouse model RGD PMID:27354005 RGD:150429624 NCBI chrNW_004955456:7,381,923...7,383,203 JBrowse link
G Rigi RNA sensor RIG-I ISO mRNA:increased expression:nasal cavity mucosa (mouse) RGD PMID:25751630 RGD:40925925 NCBI chrNW_004955472:3,093,895...3,135,524
Ensembl chrNW_004955472:3,093,939...3,133,987
JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 susceptibility
exacerbates
ISO RGD PMID:27321907 PMID:28410401 PMID:32200799 RGD:127229911 RGD:127229918 RGD:127229922 NCBI chrNW_004955409:35,961,604...35,965,477
Ensembl chrNW_004955409:35,937,880...35,965,712
JBrowse link
G Stat2 signal transducer and activator of transcription 2 exacerbates ISO RGD PMID:30337919 RGD:41789626 NCBI chrNW_004955458:3,953,019...3,973,151
Ensembl chrNW_004955458:3,952,738...3,970,668
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13809
      respiratory system disease 3077
        influenza 104
          Human Influenza 89
            influenza A 16
Path 2
Term Annotations click to browse term
  disease 16063
    disease by infectious agent 1917
      viral infectious disease 1462
        RNA Virus Infections 1231
          Orthomyxoviridae Infections 107
            influenza 104
              Human Influenza 89
                influenza A 16
paths to the root