RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Vascular System Injuries
Accession: DOID:9000352
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Definition: Injuries to blood vessels caused by laceration, contusion, puncture, or crush and other types of injuries. Symptoms vary by site and mode of injuries and may include bleeding, bruising, swelling, pain, and numbness. It does not include injuries secondary to pathologic function or diseases such as ATHEROSCLEROSIS.
Synonyms: exact_synonym: Vascular Injuries; Vascular Injury; Vascular System Injury
primary_id: MESH:D057772 ; RDO:0007794
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Agtr2
angiotensin II receptor type 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16982965
NCBI chrNW_004936479:13,252,678...13,255,570
Ensembl chrNW_004936479:13,252,678...13,255,570
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Apoe
apolipoprotein E
ISO
protein:decreased expression:plasma (rat)
RGD
PMID:21163611 PMID:21416056
RGD:5509868 RGD:6904145
NCBI chrNW_004936706:1,512,438...1,516,805
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Atp7a
ATPase copper transporting alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20671235
NCBI chrNW_004936683:2,874,022...2,936,214
Ensembl chrNW_004936683:2,874,042...2,935,040
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Bdkrb1
bradykinin receptor B1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16982965
NCBI chrNW_004936604:551,774...567,014
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Bdkrb2
bradykinin receptor B2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16982965
NCBI chrNW_004936604:548,844...551,031
Ensembl chrNW_004936604:548,847...549,956
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Grk2
G protein-coupled receptor kinase 2
ISO
protein:increased expression:aorta (rat)
RGD
PMID:28653218
RGD:13513975
NCBI chrNW_004936599:2,437,061...2,456,141
Ensembl chrNW_004936599:2,437,032...2,456,147
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Hmox1
heme oxygenase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19234301
NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311
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Id2
inhibitor of DNA binding 2
ISO
protein:increased expression:carotid artery, blood vessel wall (rat)
RGD
PMID:11706002
RGD:619536
NCBI chrNW_004936532:5,236,175...5,238,689
Ensembl chrNW_004936532:5,236,037...5,238,881
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Iqgap1
IQ motif containing GTPase activating protein 1
ISO
RGD
PMID:15217908
RGD:11049588
NCBI chrNW_004936483:16,489,127...16,594,712
Ensembl chrNW_004936483:16,489,133...16,594,783
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LOC101968921
angiotensin-converting enzyme
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:repeat:intron:IVS13+40(CA)?-26 (rat)
CTD RGD
PMID:9484988 PMID:19258495
RGD:8157602
NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177
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Nfe2l2
NFE2 like bZIP transcription factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19234301
NCBI chrNW_004936509:6,589,967...6,621,171
Ensembl chrNW_004936509:6,590,630...6,620,262
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
RGD
PMID:22552115
RGD:6484736
NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500
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S1pr1
sphingosine-1-phosphate receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29609002
NCBI chrNW_004936748:1,244,962...1,250,093
Ensembl chrNW_004936748:1,245,538...1,250,093
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Spp1
secreted phosphoprotein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11868353
NCBI chrNW_004936905:148,956...156,023
Ensembl chrNW_004936905:148,945...156,079
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19234301
NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766
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