RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Confusion
Accession: DOID:9000348
browse the term
Definition: A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.
Synonyms: exact_synonym: Bewilderment; Confusional State; Confusional States; Disorientation; Post-Ictal Confusion; Reactive Confusion
primary_id: MESH:D003221
xref: EFO:0020914
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Col5a1
collagen type V alpha 1 chain
ISO
ClinVar Annotator: match by term: Confusion
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
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Cpa6
carboxypeptidase A6
ISO
ClinVar Annotator: match by term: Confusion
ClinVar
PMID:21922598 PMID:23105115 PMID:25401298 PMID:25741868 PMID:26467025 PMID:26648591 PMID:28492532 PMID:28761347 PMID:29180823 PMID:29358611 PMID:32581362 PMID:34531397 PMID:37541188 PMID:38088023 More...
NCBI chr 5:8,526,708...8,888,492
Ensembl chr 5:8,526,741...8,888,485
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Crat
carnitine O-acetyltransferase
ISO
ClinVar Annotator: match by term: CARNITINE ACETYLTRANSFERASE DEFICIENCY
ClinVar
PMID:28492532 PMID:31448845
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
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Agtr1a
angiotensin II receptor, type 1a
IEP
RGD
PMID:24814703
RGD:10047100
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Agtr1b
angiotensin II receptor, type 1b
IEP
RGD
PMID:24814703
RGD:10047100
NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
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Bdnf
brain-derived neurotrophic factor
treatment
IEP ISO
associated with brain ischemia
RGD
PMID:29571823 PMID:33324197 PMID:29599834 PMID:34964700
RGD:401959211 , RGD:405850212 , RGD:401976548 , RGD:401965400
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Creb1
cAMP responsive element binding protein 1
treatment
IDA ISO
protein:decreased phosphorylation:hippocampus
RGD
PMID:29571823 PMID:37736695 PMID:36688960
RGD:401959211 , RGD:401960090 , RGD:401959611
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Gdnf
glial cell derived neurotrophic factor
treatment
IEP ISO IDA
protein:decreased expression:hippocampus,urine protein:altered expression:hippocampus, urine associated with rheumatic heart disease;protein:increased expression:serum
RGD
PMID:36688960 PMID:34728231 PMID:29512789 PMID:28918204 PMID:33324197 PMID:25251457 More...
RGD:401959611 , RGD:405866364 , RGD:405850251 , RGD:405850250 , RGD:405850212 , RGD:405849389
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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Igfbp7
insulin-like growth factor binding protein 7
ISO
protein:increased expression:plasma (human)
RGD
PMID:25543030
RGD:401960875
NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
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Il1b
interleukin 1 beta
treatment
IDA IEP
protein:increased expression:hippocampus (rat)
RGD
PMID:22959208 PMID:33390808 PMID:29571823
RGD:7204702 , RGD:401965467 , RGD:401959211
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
treatment
ISO
human protein in a rat model
RGD
PMID:23077050
RGD:8551854
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il6
interleukin 6
IEP
protein:increased expression:hippocampus (rat)
RGD
PMID:33390808
RGD:401965467
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ireb2
iron responsive element binding protein 2
IEP
protein:increased expression:hippocampus (rat)
RGD
PMID:23229539
RGD:12904023
NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
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Mapk1
mitogen activated protein kinase 1
treatment
IDA ISO
protein:decreased phosphorylation:hippocampus
RGD
PMID:36688960 PMID:37736695
RGD:401959611 , RGD:401960090
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
treatment
IDA ISO
protein:decreased phosphorylation:hippocampus
RGD
PMID:36688960 PMID:37736695
RGD:401959611 , RGD:401960090
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Ngf
nerve growth factor
treatment
ISO IEP
associated with brain ischemia
RGD
PMID:30481505 PMID:30481505 PMID:34964700 PMID:29599834
RGD:401965395 , RGD:401965395 , RGD:401965400 , RGD:401976548
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
treatment
IDA IEP
associated with Traumatic Brain Injuries;mRNA:decreased expression:hippocampus, hypothalamus
RGD
PMID:28086911 PMID:36637480
RGD:408345237 , RGD:408364984
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
IEP IMP
protein:increased expression:hippocampus (rat)
RGD
PMID:33390808 PMID:33390808
RGD:401965467 , RGD:401965467
NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
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Tnf
tumor necrosis factor
treatment
IEP
protein:increased expression:hippocampus (rat)
RGD
PMID:29571823 PMID:33390808
RGD:401959211 , RGD:401965467
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ache
acetylcholinesterase
disease_progression
ISO
RGD
PMID:8043620
RGD:405855847
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Htr1a
5-hydroxytryptamine receptor 1A
IEP
mRNA, protein:increased expression:hippocampal formation, amygdala
RGD
PMID:27760517
RGD:405850209
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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