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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Confusion
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Accession:DOID:9000348 term browser browse the term
Definition:A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation.
Synonyms:exact_synonym: Bewilderment;   Confusional State;   Confusional States;   Disorientation;   Post-Ictal Confusion;   Reactive Confusion
 primary_id: MESH:D003221
 xref: EFO:0020914



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Confusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col5a1 collagen type V alpha 1 chain ISO ClinVar Annotator: match by term: Confusion ClinVar PMID:25741868 PMID:28492532 NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
JBrowse link
G Cpa6 carboxypeptidase A6 ISO ClinVar Annotator: match by term: Confusion ClinVar PMID:21922598 PMID:23105115 PMID:25401298 PMID:25741868 PMID:26467025 More... NCBI chr 5:8,526,708...8,888,492
Ensembl chr 5:8,526,741...8,888,485
JBrowse link
Carnitine Acetyltransferase Deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crat carnitine O-acetyltransferase ISO ClinVar Annotator: match by term: CARNITINE ACETYLTRANSFERASE DEFICIENCY ClinVar PMID:28492532 PMID:31448845 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
JBrowse link
Postoperative Cognitive Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IEP RGD PMID:24814703 RGD:10047100 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b IEP RGD PMID:24814703 RGD:10047100 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Bdnf brain-derived neurotrophic factor treatment IEP
ISO
associated with brain ischemia RGD PMID:29571823 PMID:33324197 PMID:29599834 PMID:34964700 RGD:401959211, RGD:405850212, RGD:401976548, RGD:401965400 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IDA
ISO
protein:decreased phosphorylation:hippocampus RGD PMID:29571823 PMID:37736695 PMID:36688960 RGD:401959211, RGD:401960090, RGD:401959611 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Gdnf glial cell derived neurotrophic factor treatment IEP
ISO
IDA
protein:decreased expression:hippocampus,urine
protein:altered expression:hippocampus, urine
associated with rheumatic heart disease;protein:increased expression:serum
RGD PMID:36688960 PMID:34728231 PMID:29512789 PMID:28918204 PMID:33324197 More... RGD:401959611, RGD:405866364, RGD:405850251, RGD:405850250, RGD:405850212, RGD:405849389 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 ISO protein:increased expression:plasma (human) RGD PMID:25543030 RGD:401960875 NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
JBrowse link
G Il1b interleukin 1 beta treatment IDA
IEP
protein:increased expression:hippocampus (rat) RGD PMID:22959208 PMID:33390808 PMID:29571823 RGD:7204702, RGD:401965467, RGD:401959211 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:23077050 RGD:8551854 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:hippocampus (rat) RGD PMID:33390808 RGD:401965467 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ireb2 iron responsive element binding protein 2 IEP protein:increased expression:hippocampus (rat) RGD PMID:23229539 RGD:12904023 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment IDA
ISO
protein:decreased phosphorylation:hippocampus RGD PMID:36688960 PMID:37736695 RGD:401959611, RGD:401960090 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment IDA
ISO
protein:decreased phosphorylation:hippocampus RGD PMID:36688960 PMID:37736695 RGD:401959611, RGD:401960090 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ngf nerve growth factor treatment ISO
IEP
associated with brain ischemia RGD PMID:30481505 PMID:30481505 PMID:34964700 PMID:29599834 RGD:401965395, RGD:401965395, RGD:401965400, RGD:401976548 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IDA
IEP
associated with Traumatic Brain Injuries;mRNA:decreased expression:hippocampus, hypothalamus RGD PMID:28086911 PMID:36637480 RGD:408345237, RGD:408364984 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 IEP
IMP
protein:increased expression:hippocampus (rat) RGD PMID:33390808 PMID:33390808 RGD:401965467, RGD:401965467 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Tnf tumor necrosis factor treatment IEP protein:increased expression:hippocampus (rat) RGD PMID:29571823 PMID:33390808 RGD:401959211, RGD:401965467 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
subacute delirium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase disease_progression ISO RGD PMID:8043620 RGD:405855847 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A IEP mRNA, protein:increased expression:hippocampal formation, amygdala RGD PMID:27760517 RGD:405850209 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19099
    Pathological Conditions, Signs and Symptoms 13605
      Signs and Symptoms 11184
        Neurologic Manifestations 10420
          Neurobehavioral Manifestations 4693
            Confusion 21
              Carnitine Acetyltransferase Deficiency 1
              subacute delirium + 18
paths to the root