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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Pleural Neoplasms
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Accession:DOID:9000315 term browser browse the term
Definition:Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
Synonyms:exact_synonym: Pleural Neoplasm
 primary_id: MESH:D010997;   RDO:0006359
For additional species annotation, visit the Alliance of Genome Resources.



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Pleural Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23435014 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16221779 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
Malignant Pleural Effusions term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase disease_progression ISO protein:increased activity:serum:
protein:decreased expression:serum:
RGD PMID:27300446 PMID:1818842 PMID:1689629 RGD:152995272, RGD:152998934, RGD:152995292 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Il10 interleukin 10 ISO RGD PMID:30695099 RGD:14975123 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
malignant pleural mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bap1 Brca1 associated protein 1 disease_progression ISO RGD PMID:27422796 RGD:127229946 NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 exacerbates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 ameliorates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ameliorates ISO RGD PMID:18722110 RGD:151667912 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO mRNA:increased expression:peritoneum�� (human) RGD PMID:24722292 RGD:150524278 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Emx2 empty spiracles homeobox 2 exacerbates ISO mRNA:decreased expression:mesothelium of pleural cavity (human) RGD PMID:25023662 RGD:153323312 NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit disease_progression ISO mRNA, protein:increased expression:pleura RGD PMID:22028491 RGD:126781718 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G Il7r interleukin 7 receptor disease_progression ISO RGD PMID:26155428 RGD:151347688 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Kdm6a lysine demethylase 6A ISO mRNA:increased expression:mesothelium of pleural cavity (human) RGD PMID:28197626 RGD:150429737 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062
JBrowse link
G Mir192 microRNA 192 ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055
JBrowse link
G Mir193a microRNA 193a ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454
JBrowse link
G Mir200b microRNA 200b ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366
JBrowse link
G Mlh1 mutL homolog 1 disease_progression ISO RGD PMID:23810210 RGD:126848799 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ameliorates ISO protein:increased expression:mesothelium of pleural cavity (human) RGD PMID:22011668 RGD:153002578 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor disease_progression ISO DNA:loss of heterozygosity RGD PMID:27378628 PMID:26928227 PMID:26493618 RGD:150530638, RGD:150429647, RGD:11553131 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
JBrowse link
G Rad21 RAD21 cohesin complex component ISO RGD PMID:19380173 RGD:150520037 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase disease_progression ISO DNA:mutations:CDS:multiple (human) RGD PMID:26928227 PMID:33691361 RGD:150429647, RGD:150520202 NCBI chr 8:110,511,808...110,597,489
Ensembl chr 8:110,511,772...110,597,489
JBrowse link
G Slc7a5 solute carrier family 7 member 5 disease_progression ISO protein:increased expression:pleura RGD PMID:22199264 PMID:24912849 RGD:151361201, RGD:151660330 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Smo smoothened, frizzled class receptor disease_progression ISO DNA:missense mutations RGD PMID:23379358 PMID:33209614 RGD:150521620, RGD:150521621 NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Xiap X-linked inhibitor of apoptosis ameliorates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18215
    disease of anatomical entity 17576
      respiratory system disease 3410
        Respiratory Tract Neoplasms 992
          Pleural Neoplasms 25
            Malignant Pleural Effusions 4
            benign fibrous mesothelioma 0
            pleural cancer + 20
            pleural lipoma 0
Path 2
Term Annotations click to browse term
  disease 18215
    disease of anatomical entity 17576
      respiratory system disease 3410
        thoracic disease 1966
          Thoracic Neoplasms 1436
            Respiratory Tract Neoplasms 992
              Pleural Neoplasms 25
                Malignant Pleural Effusions 4
                benign fibrous mesothelioma 0
                pleural cancer + 20
                pleural lipoma 0
paths to the root