Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Pleural Neoplasms
go back to main search page
Accession:DOID:9000315 term browser browse the term
Definition:Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
Synonyms:exact_synonym: Pleural Neoplasm;   pleura tumor;   pleural cavity neoplasm;   pleural cavity tumor;   pleural tumor
 primary_id: MESH:D010997
 xref: MONDO:0021065;   NCI:C3332


show annotations for term's descendants           Sort by:
Pleural Neoplasms term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23435014 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16221779 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
Malignant Pleural Effusions term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase disease_progression ISO protein:decreased expression:serum:
protein:increased activity:serum:		 RGD PMID:27300446 PMID:1689629 PMID:1818842 RGD:152995272, RGD:152995292, RGD:152998934 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Il10 interleukin 10 ISO RGD PMID:30695099 RGD:14975123 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
malignant pleural mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bap1 Brca1 associated protein 1 disease_progression ISO RGD PMID:27422796 RGD:127229946 NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 exacerbates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 ameliorates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ameliorates ISO RGD PMID:18722110 RGD:151667912 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO mRNA:increased expression:peritoneum�� (human) RGD PMID:24722292 RGD:150524278 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Emx2 empty spiracles homeobox 2 exacerbates ISO mRNA:decreased expression:mesothelium of pleural cavity (human) RGD PMID:25023662 RGD:153323312 NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit disease_progression ISO mRNA, protein:increased expression:pleura RGD PMID:22028491 RGD:126781718 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Il7r interleukin 7 receptor disease_progression ISO RGD PMID:26155428 RGD:151347688 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Kdm6a lysine demethylase 6A ISO mRNA:increased expression:mesothelium of pleural cavity (human) RGD PMID:28197626 RGD:150429737 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Mir192 microRNA 192 ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr 1:203,564,946...203,565,055
Ensembl chr 1:203,564,946...203,565,055 		JBrowse link
G Mir193a microRNA 193a ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454 		JBrowse link
G Mir200b microRNA 200b ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366 		JBrowse link
G Mlh1 mutL homolog 1 disease_progression ISO RGD PMID:23810210 RGD:126848799 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ameliorates ISO protein:increased expression:mesothelium of pleural cavity (human) RGD PMID:22011668 RGD:153002578 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor disease_progression ISO DNA:loss of heterozygosity RGD PMID:27378628 PMID:26928227 PMID:26493618 RGD:150530638, RGD:150429647, RGD:11553131 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667 		JBrowse link
G Rad21 RAD21 cohesin complex component ISO RGD PMID:19380173 RGD:150520037 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase disease_progression ISO DNA:mutations:CDS:multiple (human) RGD PMID:26928227 PMID:33691361 RGD:150429647, RGD:150520202 NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 disease_progression ISO protein:increased expression:pleura RGD PMID:22199264 PMID:24912849 RGD:151361201, RGD:151660330 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Smo smoothened, frizzled class receptor disease_progression ISO DNA:missense mutations RGD PMID:23379358 PMID:33209614 RGD:150521620, RGD:150521621 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Xiap X-linked inhibitor of apoptosis ameliorates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18212
      respiratory system disease 3610
        Respiratory Tract Neoplasms 1022
          Pleural Neoplasms 25
            Malignant Pleural Effusions 4
            benign fibrous mesothelioma 0
            pleural cancer + 20
            pleural lipoma 0
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18212
      respiratory system disease 3610
        thoracic disease 2002
          Thoracic Neoplasms 1471
            Respiratory Tract Neoplasms 1022
              Pleural Neoplasms 25
                Malignant Pleural Effusions 4
                benign fibrous mesothelioma 0
                pleural cancer + 20
                pleural lipoma 0
paths to the root