Systemic Inflammatory Response Syndrome - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Systemic Inflammatory Response Syndrome	go back to main search page
Accession:	DOID:9000169	browse the term
Definition:	A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA <36 degrees C; (2) TACHYCARDIA >90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
Synonyms:	exact_synonym:	Sepsis Syndrome; Sepsis Syndromes
	primary_id:	MESH:D018746
	xref:	EFO:1001478

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Rat (396) Mouse (406) Human (549) Chinchilla (332) Bonobo (376) Dog (381) Squirrel (348) Pig (377) Green Monkey (369) Naked Mole-rat (334) All
Genes (381)

Systemic Inflammatory Response Syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

beta-2-microglobulin

associated with infant, premature;protein:increased expression:urine

NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997

G

complement factor H

NCBI chr38:2,878,677...2,956,226

G

coagulation factor III, tissue factor

NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607

G

interleukin 1 beta

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

microRNA mir-223

RNA:increased expression:plasma:

NCBI chr X:50,838,131...50,838,233
Ensembl chr X:50,838,131...50,838,233

G

nitric oxide synthase 2

protein:increased expression:ileum, liver (rat)

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

plasminogen activator, urokinase receptor

disease_progression

NCBI chr 1:111,476,804...111,490,876
Ensembl chr 1:111,476,893...111,490,880

G

thrombomodulin

protein:increased expression:blood

NCBI chr24:599,773...601,649
Ensembl chr24:599,773...601,649

G

TNF receptor superfamily member 1B

mRNA, protein:increased expression:carotid body, jugular ganglion, nodose ganglion (rat)

NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191

G

vitamin D receptor

susceptibility

associated with pneumonia; DNA:SNP: :rs2239185(human)

NCBI chr27:6,852,915...6,909,466
Ensembl chr27:6,852,723...6,909,470

Bacteremia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

associated with Febrile Neutropenia;protein:increased expression:serum (human)

NCBI chr 9:39,008,187...39,009,932

G

CCAAT enhancer binding protein beta

associated with alcohol use disorder;mRNA:increased expression:bone marrow (mouse)

NCBI chr24:36,661,294...36,663,162
Ensembl chr24:36,661,616...36,662,656

G

complement factor H

associated with Meningococcal Infections;

NCBI chr38:2,878,677...2,956,226

G

cytokine inducible SH2 containing protein

susceptibility

ClinVar Annotator: match by term: Bacteremia, susceptibility to, 2

NCBI chr20:38,762,239...38,767,701
Ensembl chr20:38,762,378...38,766,620

G

carboxypeptidase B2

protein:decreased activity:plasma

NCBI chr22:5,074,805...5,126,635
Ensembl chr22:5,074,816...5,126,170

G

C-reactive protein

protein:increased expression:serum:

NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166

G

colony stimulating factor 2

treatment

NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959

G

3-hydroxy-3-methylglutaryl-CoA reductase

severity

NCBI chr 3:30,970,037...30,988,987
Ensembl chr 3:30,970,037...30,990,294

G

intercellular adhesion molecule 1

mRNA:increased expression:lung,thymus,spleen:

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interleukin 17A

associated with Respiratory Distress Syndrome, Adult; protein:increased expression:serum

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 27

protein:increased expression:blood serum (human)

NCBI chr 6:18,243,988...18,248,369
Ensembl chr 6:18,244,040...18,247,635

G

inter-alpha-trypsin inhibitor heavy chain 4

protein:increased expression:liver, serum

G

MAPK activated protein kinase 3

ClinVar Annotator: match by term: Bacteremia, susceptibility to, 2

NCBI chr20:38,731,492...38,759,000
Ensembl chr20:38,732,397...38,758,494

G

mannose binding lectin 1

treatment

associated with Multiple Myeloma:DNA:polymorphism:exon:

NCBI chr 4:29,419,886...29,424,377

G

nucleotide binding oligomerization domain containing 2

severity

associated with Staphylococcal Infections;

NCBI chr 2:64,636,850...64,667,232
Ensembl chr 2:64,635,519...64,667,232

G

plasminogen activator, tissue type

CTD Direct Evidence: therapeutic

NCBI chr16:23,469,590...23,496,013

G

plasminogen activator, urokinase receptor

severity

NCBI chr 1:111,476,804...111,490,876
Ensembl chr 1:111,476,893...111,490,880

G

serpin family C member 1

treatment

NCBI chr 7:25,322,668...25,333,022
Ensembl chr 7:25,316,129...25,332,987

G

superoxide dismutase 2

mRNA:increased expression:liver:

NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706

G

TIR domain containing adaptor protein

ClinVar Annotator: match by term: Bacteremia, susceptibility to, 1

PMID:16991088 PMID:17322885 PMID:18305471 PMID:25741868

NCBI chr 5:8,222,217...8,237,595
Ensembl chr 5:8,221,794...8,226,074

G

toll like receptor 4

susceptibility

DNA:polymorphisms:cds:p.D299G, T399I (human)

NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165

bacterial sepsis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

triggering receptor expressed on myeloid cells 1

exacerbates
ameliorates
treatment

associated with bacterial pneumonia

PMID:16960786 PMID:17230441 PMID:21507332

RGD:126925982 RGD:126928125 RGD:127229902

NCBI chr12:9,990,678...10,000,195
Ensembl chr12:9,990,679...10,000,236

Candidemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD1d molecule

ameliorates

associated with endotoxemia

NCBI chr38:23,489,169...23,491,712

G

EPH receptor B2

exacerbates

NCBI chr 2:76,427,112...76,551,494
Ensembl chr 2:76,428,203...76,612,786

cerebral malaria

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin converting enzyme 2

susceptibility

DNA:SNP:intron 1: C>T

NCBI chr X:11,798,839...11,839,591
Ensembl chr X:11,798,839...11,900,594

G

aquaporin 4

disease_progression

protein:increased expression:astrocyte:

NCBI chr 7:61,855,617...61,868,953
Ensembl chr 7:61,855,744...61,865,089

G

calpastatin

protein:increased express:brain

NCBI chr 3:12,920,514...13,031,974
Ensembl chr 3:12,922,453...13,031,959

G

CD36 molecule (CD36 blood group)

NCBI chr18:20,299,808...20,375,856
Ensembl chr18:20,339,050...20,372,639

G

C-type lectin domain family 12 member A

ameliorates

NCBI chr27:36,040,574...36,051,249
Ensembl chr27:36,040,577...36,051,184

G

interleukin 1 receptor like 1

treatment

NCBI chr10:40,658,191...40,732,097
Ensembl chr10:40,659,041...40,677,357

G

interleukin 33

treatment

protein:increased expression:brain

PMID:25659095 PMID:25682948

RGD:39938955 RGD:40400741

NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721

G

Janus kinase 3

NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805

G

lymphotoxin alpha

NCBI chr12:1,070,608...1,073,053
Ensembl chr12:1,071,192...1,073,067

G

neuregulin 1

treatment

mRNA, protein:increased expression:cerebral cortex (mouse)
human protein in a mouse model

PMID:24433482 PMID:29636063

RGD:39456084 RGD:39456102

NCBI chr16:31,697,958...32,771,888
Ensembl chr16:31,706,851...32,771,932

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141

G

protein kinase AMP-activated catalytic subunit alpha 2

mRNA:decreased expression:brain (mouse)

NCBI chr 5:52,809,792...52,855,072
Ensembl chr 5:52,815,609...52,876,609

G

TNF receptor superfamily member 1B

NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191

Endotoxemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

mRNA:decreased expression:liver (rat)

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

ATP binding cassette subfamily B member 11

NCBI chr36:13,742,895...13,835,312
Ensembl chr36:13,746,964...13,834,974

G

ATP binding cassette subfamily C member 2

NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740

G

ATP binding cassette subfamily C member 8

NCBI chr21:39,963,001...40,037,040
Ensembl chr21:39,962,947...40,036,981

G

angiotensin I converting enzyme

associated with Hemorrhage;protein:decreased activity:plasma (rat)

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

G

acetylcholinesterase

NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702

G

actin alpha cardiac muscle 1

NCBI chr30:2,514,825...2,519,398
Ensembl chr30:2,514,824...2,519,382

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

protein:increased expression:plasma, spleen

NCBI chr31:22,169,821...22,178,879
Ensembl chr31:22,170,381...22,178,945

G

adiponectin, C1Q and collagen domain containing

associated with Obesity

NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844

G

adiponectin receptor 2

severity

associated with obesity;mRNA:decreased expression:liver (rat)

NCBI chr27:43,739,269...43,840,116
Ensembl chr27:43,741,679...43,878,467

G

adrenoceptor alpha 2A

onset

mRNA:increased expression:spleen

NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684

G

angiotensin II receptor type 2

protein:decreased expression:kidney

NCBI chr X:88,703,551...88,708,451
Ensembl chr X:88,705,765...88,706,853

G

aryl hydrocarbon receptor

severity

NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444

G

AKT serine/threonine kinase 1

NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193

G

aldolase, fructose-bisphosphate A

NCBI chr 6:18,077,241...18,083,053

G

arachidonate 5-lipoxygenase

CTD Direct Evidence: marker/mechanism

NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609

G

apolipoprotein A1

treatment

PMID:18593575 PMID:23227448

RGD:7241573 RGD:7241868

NCBI chr 5:16,740,071...16,742,081
Ensembl chr 5:16,740,130...16,741,943

G

apolipoprotein B

NCBI chr17:15,877,937...15,916,032
Ensembl chr17:15,878,244...15,915,135

G

apolipoprotein E

rat model treated with human protein

NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440

G

argininosuccinate lyase

NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424

G

argininosuccinate synthase 1

NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904

G

activating transcription factor 2

treatment

protein:increased expression, increased activity:small intestine mucosa

PMID:21641970 PMID:24312512

RGD:10047418 RGD:5135029

NCBI chr36:19,032,376...19,103,382
Ensembl chr36:19,010,717...19,103,292

G

ATP synthase F1 subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 7:45,118,188...45,127,048
Ensembl chr 7:45,117,657...45,127,048

G

BCL2 associated X, apoptosis regulator

mRNA:increased expression:diaphragm

NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464

G

butyrylcholinesterase

NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583

G

BCL2 apoptosis regulator

mRNA:decreased expression:diaphragm

NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658

G

complement C5a receptor 1

mRNA:increased expression:lung

NCBI chr 1:108,659,637...108,704,217
Ensembl chr 1:108,659,637...108,675,401

G

caspase 3

mRNA:increased expression:diaphragm

NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505

G

caspase 7

NCBI chr28:24,599,866...24,630,018
Ensembl chr28:24,599,493...24,628,668

G

caspase 9

treatment

NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484

G

cystathionine beta-synthase

severity

mRNA:increased expression:liver (rat)
Protein:increased expression:spleen, lung (mouse)

PMID:16100527 PMID:24702258 PMID:27748832

RGD:40903019 RGD:40903035 RGD:40903049

NCBI chr31:37,230,900...37,247,170

G

C-C motif chemokine ligand 2

protein:increased expression:plasma

NCBI chr 9:39,008,187...39,009,932

G

C-C motif chemokine ligand 5

protein:increased expression:plasma

NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852

G

chemokine (C-C motif) receptor 1

NCBI chr20:42,421,356...42,427,177
Ensembl chr20:42,421,356...42,426,958

G

CD14 molecule

protein:increased expression:liver, endothelial cell of sinusoid

NCBI chr 2:35,790,505...35,792,967

G

CD40 molecule

protein:decreased nitrosylation:macrophage

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CCAAT enhancer binding protein beta

treatment

PMID:14659593 PMID:15192048

RGD:1625687 RGD:40903034

NCBI chr24:36,661,294...36,663,162
Ensembl chr24:36,661,616...36,662,656

G

carbamoyl-phosphate synthase 1

CTD Direct Evidence: marker/mechanism

NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697

G

citrate synthase

protein:increased expression:gastrocnemius

NCBI chr10:584,000...611,351
Ensembl chr10:584,904...611,436

G

colony stimulating factor 3

treatment

NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108

G

C-X3-C motif chemokine ligand 1

protein:increased expression:atrium endocardium

NCBI chr 2:59,022,794...59,032,095
Ensembl chr 2:59,022,794...59,032,095

G

endothelin 1

mRNA, protein:increased expression:liver (rat)

NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383

G

epoxide hydrolase 2

NCBI chr25:30,045,040...30,107,110
Ensembl chr25:30,045,291...30,107,110

G

erythropoietin

treatment

NCBI chr 6:8,994,211...8,995,954
Ensembl chr 6:8,994,211...8,996,144

G

coagulation factor XII

NCBI chr 4:35,950,642...35,968,137
Ensembl chr 4:35,950,695...35,998,025

G

coagulation factor II, thrombin

treatment
severity

associated with liver cirrhosis;protein:increased expression:blood plasma (human)
associated with liver cirrhosis;protein:increased expression:plasma (human)

PMID:7615203 PMID:9863491 PMID:10604885 PMID:10887118 PMID:20519137 More...

RGD:10449434 RGD:14401592 RGD:14974253 RGD:40818427 RGD:40818436 RGD:5147765 RGD:5147779 RGD:6893482

NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459

G

coagulation factor III, tissue factor

treatment

associated with Protein C Deficiency

PMID:8956768 PMID:20858853 PMID:21396682

RGD:11340208 RGD:11341685 RGD:5147765

NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607

G

coagulation factor V

NCBI chr 7:28,999,481...29,069,603
Ensembl chr 7:28,999,512...29,069,296

G

coagulation factor VII

treatment

PMID:11092686 PMID:16378835

RGD:11041650 RGD:7394782

NCBI chr22:60,572,459...60,582,743
Ensembl chr22:60,571,822...60,597,024

G

coagulation factor VIII

NCBI chr X:122,894,974...123,046,343
Ensembl chr X:122,885,162...123,043,414

G

Fas cell surface death receptor

mRNA, protein:increased expression:spleen (rat)

NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321

G

fibrinogen alpha chain

treatment

NCBI chr15:52,238,305...52,247,017
Ensembl chr15:52,236,198...52,246,975

G

forkhead box P3

protein:increased expression:intestinal mucosa

NCBI chr X:42,331,229...42,362,841
Ensembl chr X:42,344,108...42,350,758

G

GTP cyclohydrolase 1

treatment

mRNA:increased expression:lung
associated with liver cirrhosis

PMID:9388472 PMID:14647062 PMID:16845913

RGD:329961576 RGD:401700399 RGD:401793756

NCBI chr 8:30,733,422...30,784,067
Ensembl chr 8:30,732,608...30,784,156

G

growth factor, augmenter of liver regeneration

NCBI chr 6:38,948,927...38,951,300
Ensembl chr 6:38,949,484...38,951,703

G

growth hormone receptor

mRNA:decreased expression:liver

PMID:12217886 PMID:12654216

RGD:2307380 RGD:625688

NCBI chr 4:67,021,821...67,245,499
Ensembl chr 4:67,022,252...67,290,473

G

glutamic--pyruvic transaminase

treatment

NCBI chr13:37,923,757...37,927,843
Ensembl chr13:37,924,422...37,926,156

G

glutathione-disulfide reductase

treatment

NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752

G

high mobility group box 1

protein:increased expression:heart, serum

NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165

G

heme oxygenase 1

treatment

NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773

G

heat shock transcription factor 1

treatment

NCBI chr13:37,724,741...37,745,259
Ensembl chr13:37,724,759...37,745,252

G

heat shock protein family A (Hsp70) member 9

CTD Direct Evidence: marker/mechanism

NCBI chr11:26,122,917...26,142,458
Ensembl chr11:26,121,499...26,142,434

G

heat shock protein family D (Hsp60) member 1

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:medulla oblongata

PMID:16675490 PMID:16741687

NCBI chr37:7,010,421...7,025,912

G

intercellular adhesion molecule 1

protein:increased expression:lung (rat)

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

indoleamine 2,3-dioxygenase 1

PMID:24930766 PMID:28077574

RGD:39939032 RGD:39939117

NCBI chr16:25,391,759...25,407,161
Ensembl chr16:25,391,754...25,407,048

G

indoleamine 2,3-dioxygenase 2

NCBI chr16:25,319,035...25,375,085
Ensembl chr16:25,319,035...25,385,515

G

interferon gamma

protein:increased expression:serum:

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

insulin like growth factor 1

mRNA, protein:decreased expression:liver, serum

PMID:12217886 PMID:18492809

RGD:10402757 RGD:625688

NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794

G

insulin like growth factor binding protein acid labile subunit

NCBI chr 6:39,115,744...39,118,831
Ensembl chr 6:39,114,315...39,119,652

G

insulin like growth factor binding protein 1

NCBI chr16:1,037,169...1,040,996
Ensembl chr16:1,037,162...1,167,094

G

insulin like growth factor binding protein 3

mRNA, protein:decreased expression:liver, serum

NCBI chr16:1,021,855...1,027,604
Ensembl chr16:1,021,972...1,026,392

G

insulin like growth factor binding protein 5

NCBI chr37:23,575,265...23,596,970
Ensembl chr37:23,579,841...23,596,870

G

interleukin 10

treatment

protein:increased expression:plasma

PMID:19302852 PMID:27943364 PMID:28664613

RGD:14975137 RGD:14975170 RGD:2311055

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 13

treatment

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 1 alpha

protein:increased expression:plasma

PMID:9636192 PMID:22426124

RGD:6907109 RGD:7794786

NCBI chr17:36,969,581...36,979,445
Ensembl chr17:36,970,573...36,979,435

G

interleukin 1 beta

protein:increased expression:plasma

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 1 receptor antagonist

treatment

mRNA:increased expression:lung, spleen, liver (rat)

PMID:1385928 PMID:8855299

RGD:11522760 RGD:8551846

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

interleukin 32

ameliorates

human gene in a mouse model

NCBI chr 6:38,119,287...38,122,979

G

interleukin 6

associated with Diabetes Mellitus, Experimental; Protein:increased expression:extracellular space (rat)
protein:increased expression:serum (rat)

PMID:19449282 PMID:21396682 PMID:22227956

RGD:2307179 RGD:5147765 RGD:6893482

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

interleukin 1 receptor associated kinase 3

mRNA, protein:increased expression:blood (human)

NCBI chr10:8,683,541...8,730,757
Ensembl chr10:8,684,242...8,729,268

G

insulin receptor substrate 1

protein:increased tyrosine nitration, decreased tyrosine phosphorylation:skeletal muscle

NCBI chr25:39,624,554...39,687,991

G

integrin subunit alpha 2b

NCBI chr 9:19,049,643...19,064,019
Ensembl chr 9:19,050,001...19,063,992

G

integrin subunit beta 3

NCBI chr 9:9,179,667...9,231,061
Ensembl chr 9:9,182,562...9,231,451

G

kelch like ECH associated protein 1

NCBI chr20:50,651,070...50,661,178
Ensembl chr20:50,650,711...50,658,496

G

lipopolysaccharide binding protein

treatment

mRNA:increased expression:hepatocyte

PMID:8418776 PMID:8593028 PMID:16307218

RGD:9685191 RGD:9685193 RGD:9685196

NCBI chr24:26,810,369...26,833,515
Ensembl chr24:26,809,843...26,833,434

G

lipocalin 2

mRNA:increased expression:brain,liver

NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038

G

microtubule associated protein 2

mRNA, protein:decreased expression:neuron

NCBI chr37:17,316,899...17,611,360
Ensembl chr37:17,466,678...17,607,803

G

mitogen-activated protein kinase 14

treatment

protein:increased activity:small intestine mucosa

PMID:21641970 PMID:24312512

RGD:10047418 RGD:5135029

NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603

G

mitogen-activated protein kinase 8

protein:increased phophorylation:hippocampus (rat)

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

G

melanocortin 4 receptor

mRNA:increased expression:paraventricular nucleus (rat)

NCBI chr 1:16,131,829...16,132,827
Ensembl chr 1:16,131,589...16,133,079

G

macrophage migration inhibitory factor

protein:increased expression:plasma

G

microRNA mir-155

treatment

associated with familial hyperlipidemia

PMID:28264607 PMID:28970282 PMID:29079998 PMID:29979224

RGD:21079445 RGD:21081538 RGD:21081539 RGD:24922204

NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833

G

membrane metalloendopeptidase

severity

NCBI chr23:48,966,222...49,059,919
Ensembl chr23:48,971,066...49,059,919

G

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

NCBI chr 5:28,949,631...28,957,915
Ensembl chr 5:28,949,631...28,958,222

G

transcription initiation factor TFIID subunit 4

NCBI chr 2:59,624,845...59,630,386

G

metallothionein 1H

mRNA:increased expression:liver (rat)

NCBI chr 2:59,607,926...59,608,825
Ensembl chr 2:59,607,927...59,626,727

G

mucin 2, oligomeric mucus/gel-forming

NCBI chr18:45,416,347...45,438,226

G

myosin heavy chain 6

G

myosin heavy chain 7

NCBI chr 8:3,660,155...3,677,650
Ensembl chr 8:3,629,585...3,792,725

G

NFE2 like bZIP transcription factor 2

treatment

NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524

G

NFKB inhibitor alpha

exacerbates
treatment

PMID:10229101 PMID:19098124

RGD:126908017 RGD:126928139

NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433

G

nitric oxide synthase 2

mRNA, protein:increased expression:intestine
CTD Direct Evidence: marker/mechanism

PMID:12620498 PMID:16787348 PMID:20519137

RGD:4891470 RGD:5147779

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

nitric oxide synthase 3

protein:increased expression:aorta (rat)

NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277

G

neuropeptide Y

treatment

NCBI chr14:37,824,579...37,831,289
Ensembl chr14:37,823,861...37,831,443

G

nuclear receptor subfamily 3 group C member 1

NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755

G

ornithine transcarbamylase

CTD Direct Evidence: marker/mechanism

NCBI chr X:33,130,921...33,200,441
Ensembl chr X:33,131,040...33,199,595

G

phosphoenolpyruvate carboxykinase 1

PMID:12217886 PMID:19268478

RGD:10427879 RGD:625688

NCBI chr24:42,538,858...42,544,200
Ensembl chr24:42,538,882...42,544,198

G

phosphoenolpyruvate carboxykinase 2, mitochondrial

mRNA,protein:decreased expression,decreased activity:liver:

NCBI chr 8:4,099,016...4,107,870
Ensembl chr 8:4,098,671...4,107,865

G

proprotein convertase subtilisin/kexin type 1

NCBI chr 3:13,233,342...13,276,921
Ensembl chr 3:13,233,594...13,274,094

G

proprotein convertase subtilisin/kexin type 2

NCBI chr24:5,507,997...5,765,911
Ensembl chr24:5,508,714...5,766,153

G

platelet and endothelial cell adhesion molecule 1

NCBI chr 9:12,166,124...12,219,553
Ensembl chr 9:12,166,775...12,219,778

G

placental growth factor

protein:increased expression:multiple

NCBI chr 8:48,059,554...48,110,534
Ensembl chr 8:48,059,552...48,075,170

G

phospholipase A2 group VII

protein:increased expression: :

NCBI chr12:14,866,229...14,908,230
Ensembl chr12:14,866,229...14,908,114

G

plasminogen activator, tissue type

treatment

NCBI chr16:23,469,590...23,496,013

G

peroxisome proliferator activated receptor gamma

protein:increased expression:small intestine mucosa

NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981

G

protein kinase AMP-activated catalytic subunit alpha 1

mRNA:decreased expression:epididymal fat pad

NCBI chr 4:68,579,061...68,614,548
Ensembl chr 4:68,579,037...68,611,841

G

parkin RBR E3 ubiquitin protein ligase

protein:increased expression:liver, mitochondrion (mouse)

NCBI chr 1:49,886,887...51,201,930
Ensembl chr 1:49,889,005...51,201,764

G

protein C, inactivator of coagulation factors Va and VIIIa

treatment

PMID:18205901 PMID:23170801

RGD:11100030 RGD:11100034

NCBI chr19:23,173,626...23,183,634
Ensembl chr19:23,173,635...23,183,563

G

platelet activating factor receptor

treatment

NCBI chr 2:72,225,386...72,256,353
Ensembl chr 2:72,225,386...72,256,352

G

prostaglandin E receptor 4

protein:increased expression:paraventricular hypothalamic nucleus parvicellular division (rat)

NCBI chr 4:68,663,362...68,676,241
Ensembl chr 4:68,663,364...68,676,358

G

prostaglandin I2 synthase

treatment

NCBI chr24:36,129,091...36,162,525
Ensembl chr24:36,132,173...36,162,509

G

prostaglandin-endoperoxide synthase 2

NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903

G

renin

protein:increased activity:blood plasma (mouse)
protein:increased activity:blood plasma (rat)

PMID:16512638 PMID:30027346

RGD:125097481 RGD:125097499

NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012

G

serpin family C member 1

treatment

PMID:15995859 PMID:16457847 PMID:20519137 PMID:21396682

RGD:1599326 RGD:1599332 RGD:5147765 RGD:5147779

NCBI chr 7:25,322,668...25,333,022
Ensembl chr 7:25,316,129...25,332,987

G

serpin family E member 1

treatment

PMID:21396682 PMID:25396762

RGD:10449434 RGD:5147765

NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301

G

serpin family F member 1

protein:increased expression:plasma (human)

NCBI chr 9:45,891,368...45,902,768
Ensembl chr 9:45,891,410...45,902,765

G

serpin family G member 1

treatment

NCBI chr18:38,570,354...38,580,751
Ensembl chr18:38,570,607...38,581,665

G

solute carrier family 18 member A3

protein:decreased expression:parietal cortex

NCBI chr28:1,476,873...1,478,538
Ensembl chr28:1,476,774...1,478,505

G

solute carrier family 22 member 1

treatment

NCBI chr 1:49,268,978...49,296,522

G

solute carrier family 22 member 2

treatment

NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435

G

solute carrier family 38 member 3

NCBI chr20:39,108,387...39,122,526
Ensembl chr20:39,109,211...39,114,849

G

solute carrier family 38 member 5

NCBI chr X:41,709,441...41,718,702
Ensembl chr X:41,709,467...41,717,080

G

solute carrier family 7 member 5

NCBI chr 5:65,313,105...65,343,858
Ensembl chr 5:65,313,105...65,343,858

G

secretory leukocyte peptidase inhibitor

NCBI chr24:32,566,030...32,568,406
Ensembl chr24:32,566,026...32,568,420

G

suppressor of cytokine signaling 1

mRNA:increased expression:liver, skeletal muscle

NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557

G

suppressor of cytokine signaling 3

mRNA:increased expression:liver, skeletal muscle

PMID:12217886 PMID:15169905

RGD:2298923 RGD:625688

NCBI chr 9:2,859,267...2,859,944

G

superoxide dismutase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706

G

secreted protein acidic and cysteine rich

mRNA, protein:decreased expression:kidney

NCBI chr 4:57,659,541...57,682,147
Ensembl chr 4:57,659,650...57,681,711

G

signal transducer and activator of transcription 5B

protein:decreased tyrosine phosphorylation:liver

NCBI chr 9:20,647,712...20,718,453
Ensembl chr 9:20,691,483...20,716,485

G

thromboxane A2 receptor

PMID:2580129 PMID:15647606

RGD:11059531 RGD:1601450

NCBI chr20:55,819,866...55,829,395
Ensembl chr20:55,824,410...55,828,980

G

thromboxane A synthase 1

NCBI chr16:8,870,283...9,032,105
Ensembl chr16:8,870,284...9,023,462

G

tryptophan 2,3-dioxygenase

severity

NCBI chr15:53,406,110...53,424,260
Ensembl chr15:53,405,957...53,423,958

G

tissue factor pathway inhibitor

treatment

NCBI chr36:29,457,131...29,546,455
Ensembl chr36:29,459,371...29,511,310

G

thrombomodulin

mRNA:decreased expression:endothelial cell

PMID:12611420 PMID:19487933 PMID:20348393

RGD:1601652 RGD:5684988 RGD:5685037

NCBI chr24:599,773...601,649
Ensembl chr24:599,773...601,649

G

TIMP metallopeptidase inhibitor 3

NCBI chr10:30,627,154...30,681,520
Ensembl chr10:30,627,154...30,694,288

G

toll like receptor 2

treatment

NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241

G

toll like receptor 4

disease_progression
treatment

mRNA:increased expression:liver:

PMID:22172266 PMID:23977376

RGD:14697731 RGD:7241094

NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165

G

tumor necrosis factor

treatment

XCO:0000822 JTE-607
associated with liver cirrhosis
protein:increased expression:plasma
protein:increased expression:plasma (rat)

PMID:8283134 PMID:10493164 PMID:12813371 PMID:15242491 PMID:17324147 More...

RGD:14995427 RGD:14995443 RGD:15023464 RGD:38501090 RGD:40903016 RGD:4891465 RGD:5147765 RGD:5147779

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

triggering receptor expressed on myeloid cells 1

treatment

PMID:15585833 PMID:21507332

RGD:126925982 RGD:126928122

NCBI chr12:9,990,678...10,000,195
Ensembl chr12:9,990,679...10,000,236

G

vascular cell adhesion molecule 1

mRNA:increased expression:brain:

NCBI chr 6:49,341,669...49,359,841
Ensembl chr 6:49,342,151...49,359,933

G

von Willebrand factor

protein:increased expression:endothelial cell:

NCBI chr27:38,834,812...38,972,614
Ensembl chr27:38,833,837...39,320,142

G

zinc finger CCCH-type containing 7B

associated with Kidney Reperfusion Injury; protein:altered localization:kidney (rat)

NCBI chr10:23,882,379...23,944,850
Ensembl chr10:23,884,981...23,920,131

endotoxin shock

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

GTP cyclohydrolase 1

treatment

NCBI chr 8:30,733,422...30,784,067
Ensembl chr 8:30,732,608...30,784,156

G

5-hydroxytryptamine receptor 2A

treatment

NCBI chr22:4,453,715...4,510,934
Ensembl chr22:4,453,715...4,511,037

Fetal Inflammatory Response Syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 6

associated with Premature Birth;

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

Fungemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD274 molecule

treatment

NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522

G

programmed cell death 1

treatment

protein:increased expression:CD4 Tcell, CD8 Tcell:

NCBI chr25:51,606,559...51,618,903
Ensembl chr25:51,608,173...51,618,723

malaria

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1

susceptibility
treatment

DNA:hypermethylation:promoter
DNA:SNPs,haplotype: :rs2032582, rs1128503 (human)
DNA:SNP: :c3435C>T(human)
DNA:haplotype: :1236C>T, 2677G>T,3435C>T (human)

PMID:17015054 PMID:19331170 PMID:28422980 PMID:28934955

RGD:39456120 RGD:39456123 RGD:39457679 RGD:39457680

NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727

G

angiotensin I converting enzyme

severity

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

G

atypical chemokine receptor 1

ClinVar Annotator: match by term: Plasmodium vivax, resistance to

PMID:7663520 PMID:8547665 PMID:8651934 PMID:10570183 PMID:10791881 More...

NCBI chr38:22,762,584...22,765,330
Ensembl chr38:22,758,013...22,763,958

G

activation induced cytidine deaminase

protein:increased expression: B cell

NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789

G

ankyrin 1

OMIM:609148 | OMIM:611162

NCBI chr16:23,858,299...23,966,181
Ensembl chr16:23,766,193...23,964,226

G

apolipoprotein E

DNA:missense mutations:cds:p.C112R, p.C158R (human)

NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440

G

aquaporin 4

OMIM:609148 | OMIM:611162

NCBI chr 7:61,855,617...61,868,953
Ensembl chr 7:61,855,744...61,865,089

G

cystathionine beta-synthase

susceptibility

DNA:insertion:cds: (844ins68) (human)

NCBI chr31:37,230,900...37,247,170

G

CD163 molecule

exacerbates
severity

protein:increased expression:blood plasma (human)
protein:altered expression:blood plasma (human)

PMID:18632918 PMID:22290142

RGD:127285797 RGD:149735529

NCBI chr27:37,669,757...37,700,746
Ensembl chr27:37,669,827...37,753,106

G

CD1d molecule

ameliorates
exacerbates

PMID:12938235 PMID:24703850

RGD:127345117 RGD:127345121

NCBI chr38:23,489,169...23,491,712

G

CD36 molecule (CD36 blood group)

ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to | ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:10890433 PMID:18305138 PMID:19403559 PMID:25741868 PMID:28960434 More...

NCBI chr18:20,299,808...20,375,856
Ensembl chr18:20,339,050...20,372,639

G

CD40 molecule

severity

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD40 ligand

severity

NCBI chr X:107,001,421...107,023,007
Ensembl chr X:107,010,890...107,023,006

G

cytokine inducible SH2 containing protein

susceptibility

ClinVar Annotator: match by term: Malaria, susceptibility to

NCBI chr20:38,762,239...38,767,701
Ensembl chr20:38,762,378...38,766,620

G

C-reactive protein

CTD Direct Evidence: marker/mechanism

NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166

G

cytotoxic T-lymphocyte associated protein 4

treatment
disease_progression

NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874

G

EPH receptor B2

mRNA:increased expression:liver

NCBI chr 2:76,427,112...76,551,494
Ensembl chr 2:76,428,203...76,612,786

G

EPH receptor B3

NCBI chr34:17,422,746...17,433,769
Ensembl chr34:17,422,842...17,462,954

G

EPH receptor B6

NCBI chr16:6,706,302...6,718,566
Ensembl chr16:6,706,313...6,718,566

G

Fc fragment of IgG receptor IIb

ClinVar Annotator: match by term: Malaria, resistance to

PMID:12115230 PMID:15459183 PMID:16115811 PMID:16170323 PMID:17435165 More...

NCBI chr38:20,980,777...20,994,403

G

forkhead box P3

disease_progression

PMID:16169501 PMID:19338000

RGD:38455985 RGD:38455992

NCBI chr X:42,331,229...42,362,841
Ensembl chr X:42,344,108...42,350,758

G

glucose-6-phosphate dehydrogenase

severity
susceptibility

DNA:point mutation:cds:c.968T>C (human)
ClinVar Annotator: match by term: Malaria, susceptibility to
DNA:SNPs: :multiple

RGD
ClinVar
OMIM

PMID:5448 PMID:16832 PMID:511159 PMID:736032 PMID:853376 More...

RGD:10449111 RGD:10449115

NCBI chr X:122,217,317...122,231,862
Ensembl chr X:122,205,683...122,231,678

G

glycophorin A (MNS blood group)

NCBI chr15:43,018,705...43,049,726
Ensembl chr15:43,018,708...43,049,665

G

glycophorin C

ClinVar Annotator: match by term: Malaria, resistance to

PMID:1991173 PMID:5011657 PMID:8157284 PMID:11719395 PMID:12469115 More...

NCBI chr19:23,946,413...23,988,970
Ensembl chr19:23,946,494...23,988,415

G

heme oxygenase 1

OMIM:609148 | OMIM:611162

NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773

G

intercellular adhesion molecule 1

susceptibility

ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to | ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:9259284 PMID:9861406 PMID:10417733 PMID:10699175 PMID:23609612 More...

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

interferon gamma

OMIM:609148 | OMIM:611162

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:1945893 PMID:3198117 PMID:6805883 PMID:7803800 PMID:8244337 More...

NCBI chr X:122,232,052...122,253,499
Ensembl chr X:122,235,878...122,250,562

G

interleukin 1 receptor like 1

NCBI chr10:40,658,191...40,732,097
Ensembl chr10:40,659,041...40,677,357

G

interleukin 21

exacerbates

NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266

G

interleukin 27

ameliorates

PMID:24522137 PMID:26968425

RGD:11530371 RGD:126790512

NCBI chr 6:18,243,988...18,248,369
Ensembl chr 6:18,244,040...18,247,635

G

interleukin 33

protein:increased expression:serum:

NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721

G

complement receptor type 2

ClinVar Annotator: match by term: Malaria, severe, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:10528197 PMID:14694201 PMID:20855594 PMID:25741868

NCBI chr 7:6,456,238...6,480,672

G

hemoglobin subunit beta-like

resistance

Hemoglobin C; DNA:polymorphism:CDS:69G>A, amino acid E6K
ClinVar Annotator: match by term: Malaria, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to

RGD
ClinVar
OMIM

PMID:14973 PMID:49057 PMID:81926 PMID:88735 PMID:893136 More...

NCBI chr21:28,187,535...28,188,991

G

lymphotoxin beta receptor

CTD Direct Evidence: marker/mechanism

NCBI chr27:38,598,725...38,605,829
Ensembl chr27:38,599,268...38,605,780

G

MAPK activated protein kinase 3

ClinVar Annotator: match by term: Malaria, susceptibility to

NCBI chr20:38,731,492...38,759,000
Ensembl chr20:38,732,397...38,758,494

G

microRNA mir-122

treatment

NCBI chr 1:17,593,858...17,593,915
Ensembl chr 1:17,593,837...17,593,929

G

microRNA mir-142

treatment

NCBI chr 9:32,977,393...32,977,455
Ensembl chr 9:32,977,382...32,977,468

G

microRNA let-7c

treatment

NCBI chr31:13,259,522...13,259,588
Ensembl chr31:13,259,502...13,259,609

G

marker of proliferation Ki-67

associated with Lung Neoplasms

NCBI chr28:36,920,679...36,939,336
Ensembl chr28:36,913,023...36,939,486

G

natural cytotoxicity triggering receptor 3

susceptibility

ClinVar Annotator: match by term: Malaria, severe, susceptibility to

NCBI chr12:1,086,698...1,104,268
Ensembl chr12:1,086,841...1,089,481

G

nitric oxide synthase 2

ClinVar Annotator: match by term: Malaria, resistance to | ClinVar Annotator: match by term: Malaria, severe, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:9457101 PMID:12433515 PMID:31995689

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

pyruvate kinase L/R

susceptibility

DNA:mutations, haplotype:multiple (human)
OMIM:609148 | OMIM:611162
DNA:missense mutation:cds:p.I90N (mouse)

PMID:14595440 PMID:20377593

RGD:11535999 RGD:11537407

NCBI chr 7:42,263,899...42,272,770
Ensembl chr 7:42,263,761...42,272,755

G

perforin 1

NCBI chr 4:21,497,865...21,502,429
Ensembl chr 4:21,498,249...21,500,864

G

protein C receptor

disease_progression

NCBI chr24:24,184,063...24,188,452
Ensembl chr24:24,184,370...24,187,910

G

solute carrier family 19 member 1

DNA:SNP::g.80G>A (human)

NCBI chr31:38,958,332...38,971,091
Ensembl chr31:38,967,013...38,971,094

G

solute carrier family 4 member 1

ClinVar Annotator: match by term: Malaria, cerebral, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to

PMID:1378323 PMID:1722314 PMID:1737855 PMID:2146504 PMID:6338046 More...

NCBI chr 9:19,142,884...19,159,449
Ensembl chr 9:19,146,480...19,157,915

G

secreted phosphoprotein 1

NCBI chr32:11,354,070...11,362,325
Ensembl chr32:11,353,953...11,362,069

G

T-box transcription factor 21

NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261

G

TIR domain containing adaptor protein

ClinVar Annotator: match by term: Malaria, resistance to

PMID:16991088 PMID:17322885 PMID:18305471 PMID:25741868

NCBI chr 5:8,222,217...8,237,595
Ensembl chr 5:8,221,794...8,226,074

G

tumor necrosis factor

susceptibility

ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to

PMID:8056188 PMID:9818939 PMID:10369255 PMID:10450718 PMID:11261930 More...

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

triggering receptor expressed on myeloid cells 1

severity

DNA:SNP: :rs2234237A>T (human)

NCBI chr12:9,990,678...10,000,195
Ensembl chr12:9,990,679...10,000,236

G

thymic stromal lymphopoietin

mRNA:altered expression:multiple (mouse)

NCBI chr 3:1,502,469...1,507,696
Ensembl chr 3:1,503,188...1,507,696

Malarial Anemia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

low affinity immunoglobulin gamma Fc region receptor III

susceptibility
severity

DNA:polymorphism: :p.F176V (human)

PMID:20231419 PMID:23045477

RGD:11040771 RGD:11344971

NCBI chr38:21,054,870...21,060,948

G

solute carrier family 4 member 1

severity

DNA:snp:promoter:g.-5699T>C (human)

NCBI chr 9:19,142,884...19,159,449
Ensembl chr 9:19,146,480...19,157,915

G

toll like receptor 9

susceptibility

DNA:SNP:promoter:g.-1237T>C (rs5743836) (human)

NCBI chr20:37,529,322...37,547,117
Ensembl chr20:37,542,340...37,547,114
Ensembl chr20:37,542,340...37,547,114

Neonatal Sepsis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 27

protein:increased expression:blood serum (mouse)
protien:increased expression:blood serum (human)

PMID:22766719 PMID:31818960

RGD:126790524 RGD:126790543

NCBI chr 6:18,243,988...18,248,369
Ensembl chr 6:18,244,040...18,247,635

Plasmodium falciparum malaria

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

susceptibility

DNA:SNPs,haplotype:multiple

NCBI chr 9:49,746,749...49,758,317
Ensembl chr 9:49,748,693...49,758,479

G

ADAM metallopeptidase with thrombospondin type 1 motif 13

protein:decreased activity:plasma (human)

NCBI chr 9:49,839,252...49,867,295
Ensembl chr 9:49,839,252...49,867,295

G

basigin

CTD Direct Evidence: therapeutic

PMID:22080952 PMID:26195724

NCBI chr20:57,942,703...57,951,089
Ensembl chr20:57,943,276...57,951,061

G

calpastatin

protein:alter localization:erythrocyte

NCBI chr 3:12,920,514...13,031,974
Ensembl chr 3:12,922,453...13,031,959

G

chemokine (C-C motif) ligand 4

mRNA, protein:increased expression:blood,

NCBI chr 9:37,681,342...37,682,691
Ensembl chr 9:37,676,966...37,710,209

G

C-type lectin domain containing 11A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:106,078,055...106,080,473
Ensembl chr 1:106,078,291...106,080,517

G

major histocompatibility complex, class II, DQ beta 1

susceptibility

DNA:polymorphism:cds:HLA-DQB1*0501 (human)

NCBI chr12:2,305,307...2,307,711

G

Fas cell surface death receptor

CTD Direct Evidence: marker/mechanism

NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321

G

glucose-6-phosphate dehydrogenase

severity

DNA:missense mutation:cds:202G>A (p.V68M) (human)

NCBI chr X:122,217,317...122,231,862
Ensembl chr X:122,205,683...122,231,678

G

glutathione S-transferase pi 1

severity

NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182

G

interleukin 13

protein:increased expression:plasma

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

complement receptor type 2

CTD Direct Evidence: marker/mechanism

PMID:9230440 PMID:11724985

NCBI chr 7:6,456,238...6,480,672

G

hemoglobin subunit beta-like

CTD Direct Evidence: marker/mechanism

NCBI chr21:28,187,535...28,188,991

G

mannose binding lectin 1

susceptibility

DNA:haplotype:exon:

NCBI chr 4:29,419,886...29,424,377

G

tumor necrosis factor

severity

protein:increased expression:plasma

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

Plasmodium vivax malaria

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

atypical chemokine receptor 1

ClinVar Annotator: match by term: Resistance to Plasmodium vivax infection

PMID:7663520 PMID:8547665 PMID:8651934 PMID:10570183 PMID:10791881 More...

NCBI chr38:22,762,584...22,765,330
Ensembl chr38:22,758,013...22,763,958

Pregnancy-associated Malaria

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 10

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

Sepsis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

mRNA:increased expression:liver

PMID:9843780 PMID:15167684

RGD:10046033 RGD:1598509

NCBI chr27:36,654,328...36,695,775

G

ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

severity

DNA:polymorphism:cds:allele A (human)

NCBI chr 9:49,746,749...49,758,317
Ensembl chr 9:49,748,693...49,758,479

G

angiotensin I converting enzyme

susceptibility

DNA:insertion/deletion:intron:

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

G

adiponectin, C1Q and collagen domain containing

mRNA, protein:decreasedexpression:serum, omental fat pad:

PMID:16488436 PMID:19481767 PMID:21962804

RGD:1599144 RGD:5686408 RGD:5686835

NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844

G

adrenomedullin

treatment

associated with Jaundice,Obstructive;
CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma:

PMID:14766677 PMID:19009024 PMID:20132852

RGD:7364952 RGD:7364986

NCBI chr21:33,472,197...33,474,472
Ensembl chr21:33,471,623...33,474,495

G

adenosine A2a receptor

CTD Direct Evidence: marker/mechanism

NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598

G

adenosine A2b receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 5:39,884,375...39,908,214

G

adrenoceptor alpha 2A

disease_progression

NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684

G

adrenoceptor beta 2

mRNA,protein:decreased expression:liver:

PMID:10409266 PMID:16603198

RGD:1598745 RGD:8548498

NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298

G

adrenoceptor beta 3

mRNA, protein:increased expression:heart left ventricle (human)

NCBI chr16:27,445,601...27,446,796
Ensembl chr16:27,445,601...27,447,521

G

advanced glycosylation end-product specific receptor

treatment

NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129

G

5'-aminolevulinate synthase 1

mRNA:increased expression:duodenum, jejunum, ileum (rat)

NCBI chr20:37,552,813...37,566,417
Ensembl chr20:37,552,814...37,566,638

G

albumin

disease_progression

protein:decreased expression:serum:

NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709

G

aldehyde dehydrogenase 2 family member

treatment

associated with heat shock treatment;protein:altered expression, altered phosphorylation:liver, mitochondria (rat)

NCBI chr26:9,319,109...9,361,021

G

angiopoietin 1

CTD Direct Evidence: therapeutic

NCBI chr13:8,068,920...8,312,090
Ensembl chr13:8,048,205...8,311,618

G

apolipoprotein A1

treatment

NCBI chr 5:16,740,071...16,742,081
Ensembl chr 5:16,740,130...16,741,943

G

arginase 2

protein:decreased expression:lung

NCBI chr 8:41,588,051...41,619,406
Ensembl chr 8:41,588,150...41,619,402

G

ATM serine/threonine kinase

treatment

NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

NCBI chr 6:18,384,981...18,400,038
Ensembl chr 6:18,385,007...18,400,036

G

B9 domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885

G

bile acid-CoA:amino acid N-acyltransferase

NCBI chr11:58,102,057...58,116,750
Ensembl chr11:58,102,592...58,109,389

G

BCL2 associated agonist of cell death

treatment

protein:increased localization:mitochondrion

PMID:22683079 PMID:24011917

RGD:10053647 RGD:10053707

NCBI chr18:52,781,335...52,791,789
Ensembl chr18:52,781,921...52,791,405

G

complement C3

protein:increased expression:liver
mRNA:increased expression:kidney

PMID:3339873 PMID:24154627

RGD:11040886 RGD:7411622

NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761

G

complement C5

protein:increased activation:plasma

PMID:14688199 PMID:18648551

RGD:1600599 RGD:5130170

NCBI chr11:73,953,727...74,029,919
Ensembl chr11:73,953,727...74,029,851

G

complement C5a receptor 1

disease_progression

PMID:12897064 PMID:18648551

RGD:5130170 RGD:5130176

NCBI chr 1:108,659,637...108,704,217
Ensembl chr 1:108,659,637...108,675,401

G

complement C6

severity

NCBI chr 4:68,223,626...68,318,773
Ensembl chr 4:68,253,255...68,318,252

G

calcium voltage-gated channel subunit alpha1 S

protein:decreased expression:diaphragmaticus muscle

NCBI chr 7:2,108,716...2,172,246
Ensembl chr 7:2,108,455...2,303,220

G

cathelicidin antimicrobial peptide

NCBI chr20:40,790,823...40,792,781
Ensembl chr20:40,790,811...40,792,794

G

caspase 3

treatment

CTD Direct Evidence: marker/mechanism

PMID:16003065 PMID:29180187 PMID:32062619

NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505

G

caspase 6

protein:increased activity:thymus, T cell

NCBI chr32:29,897,706...29,910,522
Ensembl chr32:29,897,823...29,911,469

G

caspase 8

treatment

PMID:18570579 PMID:29180187

RGD:13782295 RGD:2311435

NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822

G

caspase 9

treatment

NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484

G

calpastatin

NCBI chr 3:12,920,514...13,031,974
Ensembl chr 3:12,922,453...13,031,959

G

catalase

severity

NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447

G

cystathionine beta-synthase

susceptibility

DNA:SNP:intron (rs6586282, rs34758144) (human)

NCBI chr31:37,230,900...37,247,170

G

C-C motif chemokine ligand 2

mRNA:increased expression:ileum

NCBI chr 9:39,008,187...39,009,932

G

chemokine (C-C motif) ligand 4

severity

NCBI chr 9:37,681,342...37,682,691
Ensembl chr 9:37,676,966...37,710,209

G

C-C motif chemokine ligand 5

protein:increased secretion:plasma (rat)

NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852

G

CD163 molecule

protein:increased expression:blood serum, CD-14 positive monocyte (human)

NCBI chr27:37,669,757...37,700,746
Ensembl chr27:37,669,827...37,753,106

G

CD1d molecule

treatment

NCBI chr38:23,489,169...23,491,712

G

CD274 molecule

disease_progression

protein:increased expression:monocyte
protein:increased expression:B cell,CD4T cell

PMID:27156867 PMID:29661225 PMID:29702526 PMID:30595665

RGD:40818235 RGD:40818424 RGD:40822808 RGD:41412183

NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522

G

CD28 molecule

severity

Higher soluble CD28 in patients who died

NCBI chr37:12,503,849...12,536,362
Ensembl chr37:12,503,811...12,532,854

G

CD36 molecule (CD36 blood group)

NCBI chr18:20,299,808...20,375,856
Ensembl chr18:20,339,050...20,372,639

G

CD40 molecule

protein:decreased nitrosylation:monocyte

NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301

G

CD40 ligand

mRNA:increased expression:heart (rat)

NCBI chr X:107,001,421...107,023,007
Ensembl chr X:107,010,890...107,023,006

G

cyclin dependent kinase inhibitor 1A

NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281

G

CCAAT enhancer binding protein beta

protein:increased expression:skeletal muscle

NCBI chr24:36,661,294...36,663,162
Ensembl chr24:36,661,616...36,662,656

G

CCAAT enhancer binding protein delta

protein:increased expression:skeletal muscle

NCBI chr35:74,994...77,816

G

complement factor B

treatment

NCBI chr12:1,400,143...1,406,267

G

complement factor H

treatment

associated with Jaundice,Obstructive;
protein:decreased expression:plasma:

PMID:19009024 PMID:20132852

RGD:7364952 RGD:7364986

NCBI chr38:2,878,677...2,956,226

G

carboxypeptidase B2

protein:increased activity:plasma:

NCBI chr22:5,074,805...5,126,635
Ensembl chr22:5,074,816...5,126,170

G

corticotropin releasing hormone

protein:increased expression:hypothalamus (rat)

NCBI chr29:15,831,944...15,840,560
Ensembl chr29:15,831,944...15,834,384

G

C-reactive protein

protein:increased expression:blood:

PMID:19060982 PMID:21797109

RGD:6482315 RGD:9491784

NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166

G

citrate synthase

protein:decreased expression:cerebral cortex

NCBI chr10:584,000...611,351
Ensembl chr10:584,904...611,436

G

colony stimulating factor 2

protein:increased expression:plasma:

NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959

G

colony stimulating factor 3

treatment

CTD Direct Evidence: therapeutic

PMID:8706460 PMID:17505274

NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108

G

C-X3-C motif chemokine receptor 1

protein:increased expression:lung, macrophage

NCBI chr23:8,937,069...8,954,738
Ensembl chr23:8,938,906...8,952,808

G

C-X-C motif chemokine ligand 8

exacerbates

protein:increased expression:blood plasma (human)

NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354

G

C-X-C motif chemokine receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247

G

cytochrome P450 family 1 subfamily A member 1

mRNA, protein:decreased expression:liver

NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866

G

cytochrome P450 family 1 subfamily A member 2

PMID:15665729 PMID:18360687

RGD:2303376 RGD:5147745

NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135

G

cytochrome P450 family 2 subfamily E member 1

NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754

G

cytochrome P450 family 2 subfamily J member 2

NCBI chr 5:49,942,241...49,986,603
Ensembl chr 5:49,942,193...49,984,617

G

endothelin 1

mRNA, protein:increased expression:multiple (rat)

NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383

G

eukaryotic translation initiation factor 2B subunit epsilon

protein:increased serine phosphorylation:gastrocnemius

NCBI chr34:17,038,163...17,047,390
Ensembl chr34:17,038,203...17,046,928

G

eukaryotic translation initiation factor 2 subunit alpha

NCBI chr 8:41,354,400...41,371,676
Ensembl chr 8:41,351,244...41,371,056

G

eukaryotic translation initiation factor 4E

NCBI chr32:21,064,202...21,108,998
Ensembl chr32:21,065,270...21,124,483

G

elastase, neutrophil expressed

associated with Klebsiella Infections;

NCBI chr20:57,789,044...57,790,932
Ensembl chr20:57,788,062...57,790,932

G

ectonucleoside triphosphate diphosphohydrolase 1

protein:increased activity:lymphocyte:

NCBI chr28:9,181,851...9,311,835
Ensembl chr28:9,211,050...9,323,939

G

estrogen receptor 2

NCBI chr 8:38,645,917...38,715,347
Ensembl chr 8:38,645,430...38,702,691

G

coagulation factor XI

NCBI chr16:44,469,609...44,492,833
Ensembl chr16:44,469,632...44,540,292

G

coagulation factor II, thrombin

treatment

PMID:12361199 PMID:19705256

RGD:10449428 RGD:7387324

NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459

G

coagulation factor III, tissue factor

treatment

PMID:9875912 PMID:26311287

RGD:11340217 RGD:11341736

NCBI chr 6:54,709,581...54,720,603
Ensembl chr 6:54,708,471...54,720,607

G

coagulation factor V

severity
treatment

PMID:12000738 PMID:16235188

RGD:1598921 RGD:4892622

NCBI chr 7:28,999,481...29,069,603
Ensembl chr 7:28,999,512...29,069,296

G

coagulation factor VII

treatment

protein:decreased activity:plasma (rat)

PMID:3660344 PMID:12000738

RGD:1598921 RGD:2312320

NCBI chr22:60,572,459...60,582,743
Ensembl chr22:60,571,822...60,597,024

G

coagulation factor IX

treatment

NCBI chr X:109,501,341...109,533,798
Ensembl chr X:109,501,341...109,533,798

G

Fas cell surface death receptor

mRNA:increased expression:liver

NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321

G

Fas ligand

mRNA:increased expression:liver

NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224

G

fibrinogen alpha chain

protein:decreased expression:serum (rat)

NCBI chr15:52,238,305...52,247,017
Ensembl chr15:52,236,198...52,246,975

G

fms related receptor tyrosine kinase 1

disease_progression

Pneumonia associated sepsis

NCBI chr25:11,231,958...11,410,379
Ensembl chr25:11,231,737...11,407,621

G

forkhead box P3

severity

NCBI chr X:42,331,229...42,362,841
Ensembl chr X:42,344,108...42,350,758

G

FYN proto-oncogene, Src family tyrosine kinase

protein:decreased phosphorylation, decreased activity:T cell (rat)

NCBI chr12:68,105,060...68,316,630
Ensembl chr12:68,075,184...68,316,541

G

growth arrest specific 6

NCBI chr22:60,975,196...61,005,869
Ensembl chr22:60,974,849...61,005,875

G

GATA binding protein 3

severity

NCBI chr 2:28,068,143...28,098,445
Ensembl chr 2:28,069,051...28,087,760

G

GTP cyclohydrolase 1

treatment

associated with Staphylococcal Infections

PMID:12441764 PMID:29428597

RGD:401700401 RGD:401717570

NCBI chr 8:30,733,422...30,784,067
Ensembl chr 8:30,732,608...30,784,156

G

growth factor, augmenter of liver regeneration

protein:increased expression:serum:

NCBI chr 6:38,948,927...38,951,300
Ensembl chr 6:38,949,484...38,951,703

G

growth hormone receptor

NCBI chr 4:67,021,821...67,245,499
Ensembl chr 4:67,022,252...67,290,473

G

ghrelin and obestatin prepropeptide

mRNA,protein:decreased expression:aorta,heart, intestine, plasma:

NCBI chr20:8,092,921...8,097,512
Ensembl chr20:8,092,957...8,097,510

G

growth hormone secretagogue receptor

disease_progression

NCBI chr34:36,691,132...36,694,304
Ensembl chr34:36,690,224...36,694,312

G

gap junction protein alpha 5

mRNA, protein:increased expression:aorta endothelium

NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315

G

glycoprotein Ib platelet subunit alpha

exacerbates

associated with thrombocytopenia

NCBI chr 5:31,681,605...31,683,261

G

glutamic--pyruvic transaminase

treatment

PMID:25243423 PMID:26814114

RGD:14975161 RGD:401717564

NCBI chr13:37,923,757...37,927,843
Ensembl chr13:37,924,422...37,926,156

G

glutamate ionotropic receptor NMDA type subunit 2A

protein:increased expression:lung (rat)

NCBI chr 6:32,132,070...32,678,319
Ensembl chr 6:32,303,121...32,668,960

G

G protein-coupled receptor kinase 2

protein: increased expression: neutrophils

NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428

G

G protein-coupled receptor kinase 5

protein: increased expression: neutrophils

NCBI chr28:29,424,350...29,636,552
Ensembl chr28:29,424,593...29,632,741

G

glycogen synthase kinase 3 beta

protein:decreased phosphorylation,increased activity: :

NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666

G

gelsolin

protein:decreased expression:blood serum (human)

NCBI chr11:74,248,227...74,268,129
Ensembl chr11:74,233,457...74,268,129

G

hepatitis A virus cellular receptor 1

disease_progression

NCBI chr 4:53,012,223...53,066,611
Ensembl chr 4:53,046,970...53,128,952
Ensembl chr 4:53,046,970...53,128,952

G

histone deacetylase 4

NCBI chr25:49,318,621...49,545,314
Ensembl chr25:49,317,349...49,453,478

G

histone deacetylase 6

NCBI chr X:42,004,268...42,024,726
Ensembl chr X:42,004,591...42,024,427

G

high mobility group box 1

treatment

CTD Direct Evidence: marker/mechanism

PMID:19265175 PMID:19623040 PMID:20936717 PMID:23146691

RGD:10402067 RGD:10402173

NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165

G

15-hydroxyprostaglandin dehydrogenase

protein: decreased expression

NCBI chr25:24,964,908...24,993,276
Ensembl chr25:24,964,908...24,993,297

G

heat shock protein family D (Hsp60) member 1

associated with burns;protein:decreased expression:skeletal muscle

PMID:16483253 PMID:23143056

RGD:10402864 RGD:1624233

NCBI chr37:7,010,421...7,025,912

G

HtrA serine peptidase 2

treatment

NCBI chr17:48,610,408...48,613,399
Ensembl chr17:48,610,408...48,613,399

G

intercellular adhesion molecule 1

mRNA:increased expression:brain (rat)

NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914

G

indoleamine 2,3-dioxygenase 1

treatment

NCBI chr16:25,391,759...25,407,161
Ensembl chr16:25,391,754...25,407,048

G

interferon gamma

treatment

CTD Direct Evidence: marker/mechanism

PMID:9806674 PMID:27598601 PMID:28711488

RGD:14974250 RGD:14975121

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

interleukin 10

treatment

protein:increased expression:serum
CTD Direct Evidence: therapeutic

PMID:11441115 PMID:19371254 PMID:24055021 PMID:27488951 PMID:28108420

RGD:14975261 RGD:14975262 RGD:2311053 RGD:7364867

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 12B

protein:increased expression:peritoneal fluid, plasma

NCBI chr 4:51,178,637...51,194,606
Ensembl chr 4:51,183,568...51,193,228

G

interleukin 13

protein:decreased expression:ileum

PMID:10679115 PMID:21159497

RGD:4145654 RGD:8549643

NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388

G

interleukin 16

associated with Shock, Hemorrhagic;protein:increased expression:lung

NCBI chr 3:56,473,485...56,575,504
Ensembl chr 3:56,473,486...56,575,104

G

interleukin 17A

NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513

G

interleukin 17D

treatment
severity

protein:increased expression:blood serum (human)

NCBI chr25:17,386,815...17,390,315

G

interleukin 1 beta

treatment

CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma

PMID:17529909 PMID:21429520 PMID:32062619

RGD:1626657 RGD:7175319

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 1 receptor like 1

severity

NCBI chr10:40,658,191...40,732,097
Ensembl chr10:40,659,041...40,677,357

G

interleukin 1 receptor antagonist

disease_progression
susceptibility
severity

mRNA:increased expression:pituitary gland (rat)
DNA:repeats: :
associated with Premature Birth;DNA:polymorphism::
protein:increased expression:serum (human)
mRNA, protein:increased expression:lung

PMID:8196140 PMID:10048466 PMID:11876758 PMID:17014550 PMID:20454520 More...

RGD:11528543 RGD:12910846 RGD:4142852 RGD:6907358 RGD:6909139 RGD:7175061

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

interleukin 22

protein:increased expression:plasma

NCBI chr10:10,487,367...10,492,238
Ensembl chr10:10,487,262...10,492,371

G

interleukin 27

disease_progression
severity
exacerbates

DNA:SNP:promoter:-964A>G (rs153109) (human)
associated with Herpesviridae Infections;protein:increased expression:blood serum, spleen (mouse)
mRNA:increased expression:blood, leukocyte (human)
protein:increased expression:blood (human)

PMID:18227999 PMID:20493722 PMID:22965735 PMID:26767500 PMID:30268141

RGD:126790502 RGD:126790509 RGD:126790536 RGD:126790537 RGD:126790544

NCBI chr 6:18,243,988...18,248,369
Ensembl chr 6:18,244,040...18,247,635

G

interleukin 33

severity

protein:increased expression:plasma, peritoneal fluid:
protein:increased expression:plasma:

PMID:25665614 PMID:29672927 PMID:29935165

RGD:39939028 RGD:40400739 RGD:40400895

NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721

G

interleukin 4

protein:increased expression:plasma

NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534

G

interleukin 6

treatment

CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Non-Insulin-Dependent; mRNA, protein:increased expression:liver, extracellular space (rat)

PMID:19079684 PMID:25317848 PMID:27598601 PMID:32062619

RGD:11062009 RGD:14975121 RGD:2307280

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

interleukin 1 receptor associated kinase 4

NCBI chr27:10,313,782...10,340,652
Ensembl chr27:10,314,187...10,340,682

G

insulin receptor substrate 1

protein:decreased tyrosine phosphorylation, increased serine phosphorylation:gastrocnemius

NCBI chr25:39,624,554...39,687,991

G

integrin subunit alpha 4

protein:increased expression:neutrophil

NCBI chr36:24,670,464...24,686,719
Ensembl chr36:24,653,408...24,729,057

G

integrin subunit alpha M

exacerbates

protein:increased expression:neutrophil (rat)

NCBI chr 6:16,944,062...16,996,525
Ensembl chr 6:16,808,971...16,996,286

G

Janus kinase 2

treatment

NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997

G

kelch like ECH associated protein 1

NCBI chr20:50,651,070...50,661,178
Ensembl chr20:50,650,711...50,658,496

G

kallikrein B1

NCBI chr16:44,492,735...44,517,854
Ensembl chr16:44,469,632...44,540,292

G

killer cell lectin like receptor K1

susceptibility

associated with Gram-Negative Bacterial Infections

NCBI chr27:35,634,938...35,658,978
Ensembl chr27:35,639,280...35,658,882

G

lipopolysaccharide binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr24:26,810,369...26,833,515
Ensembl chr24:26,809,843...26,833,434

G

lipocalin 2

exacerbates

NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038

G

leptin

NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395

G

lipase C, hepatic type

protein:decreased expression:diaphragm, heart, adipose tissue (rat)

NCBI chr30:23,432,460...23,584,037
Ensembl chr30:23,432,493...23,584,037

G

metallothionein-1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:59,603,021...59,604,173
Ensembl chr 2:59,603,014...59,604,132

G

peptidylprolyl isomerase A (cyclophilin A) pseudogene

treatment

NCBI chr 7:80,937,433...80,938,175

G

lymphotoxin alpha

CTD Direct Evidence: marker/mechanism

NCBI chr12:1,070,608...1,073,053
Ensembl chr12:1,071,192...1,073,067

G

lactotransferrin

NCBI chr20:42,231,994...42,263,202
Ensembl chr20:42,231,994...42,263,202

G

mitogen-activated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

G

mitogen-activated protein kinase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

G

mitogen-activated protein kinase 8

treatment

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

G

mannose binding lectin 1

susceptibility

associated with Premature Birth;DNA:polymorphism:exon:

NCBI chr 4:29,419,886...29,424,377

G

mitofusin 2

mRNA:decreased expression:liver (rat)

NCBI chr 2:84,284,719...84,310,715
Ensembl chr 2:84,284,719...84,308,225

G

macrophage migration inhibitory factor

CTD Direct Evidence: therapeutic
protein:increased expression:serum

PMID:9892616 PMID:17585860

G

microRNA mir-143

exacerbates

NCBI chr 4:59,534,535...59,534,589
Ensembl chr 4:59,534,535...59,534,594

G

microRNA mir-155

PMID:27434558 PMID:29979224

RGD:21079467 RGD:21081538

NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833

G

microRNA mir-223

RNA:increased expression:plasma:

NCBI chr X:50,838,131...50,838,233
Ensembl chr X:50,838,131...50,838,233

G

microRNA mir-494

RNA:decreased expression:plasma

NCBI chr 8:69,261,385...69,261,465
Ensembl chr 8:69,261,385...69,261,465

G

matrix metallopeptidase 1

NCBI chr 5:28,978,385...28,986,644
Ensembl chr 5:28,978,473...28,986,648

G

matrix metallopeptidase 2

treatment

NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113

G

matrix metallopeptidase 9

treatment

CTD Direct Evidence: marker/mechanism

PMID:16003065 PMID:23479197

NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293

G

myeloperoxidase

NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820

G

mitochondrially encoded cytochrome b

protein:decreased expression:mitochondrion, skeletal muscle

NCBI chr MT:14,183...15,322
Ensembl chr MT:14,183...15,322

G

metallothionein 1H

CTD Direct Evidence: marker/mechanism

NCBI chr 2:59,607,926...59,608,825
Ensembl chr 2:59,607,927...59,626,727

G

mechanistic target of rapamycin kinase

NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114

G

myosin light chain kinase

NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181

G

NADH:ubiquinone oxidoreductase subunit B8

NCBI chr28:13,249,067...13,253,670
Ensembl chr28:13,249,070...13,253,619

G

neurofilament heavy chain

severity

NCBI chr26:22,726,523...22,735,129
Ensembl chr26:22,726,526...22,735,125

G

neurofilament light chain

disease_progression

NCBI chr25:32,463,361...32,468,965
Ensembl chr25:32,463,452...32,467,224

G

NFKB inhibitor alpha

treatment

NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433

G

nucleotide binding oligomerization domain containing 2

susceptibility

mRNA:increased expression:intestine mucosa (rat)
DNA:missense mutations, frameshift mutation:cds:p.R702W, p.G908R, 3020_3021insC (human)

PMID:21460759 PMID:24059417

RGD:5508752 RGD:8547531

NCBI chr 2:64,636,850...64,667,232
Ensembl chr 2:64,635,519...64,667,232

G

nitric oxide synthase 1

NCBI chr26:13,787,341...13,895,176
Ensembl chr26:13,786,309...13,962,332

G

nitric oxide synthase 2

CTD Direct Evidence: marker/mechanism
associated with lung injury

PMID:15665729 PMID:17138957 PMID:20035746 PMID:21184738

RGD:4891414 RGD:5147745

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

nitric oxide synthase 3

CTD Direct Evidence: marker/mechanism
protein:increased expression:heart

PMID:17999941 PMID:20035746

NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277

G

NADPH oxidase 1

ameliorates

NCBI chr X:74,784,627...74,811,796
Ensembl chr X:74,785,168...74,811,698

G

nuclear receptor subfamily 3 group C member 1

treatment

protein:decreased expression:alveolar macrophage

PMID:21057058 PMID:21787473

RGD:4892317 RGD:7174711

NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755

G

ornithine transcarbamylase

mRNA:decreased expression:liver (rat)

NCBI chr X:33,130,921...33,200,441
Ensembl chr X:33,131,040...33,199,595

G

programmed cell death 1

disease_progression

protein:increased expression:T cell
protein:increased expression:B cell,CD4T cell

PMID:19332785 PMID:27156867 PMID:29661225 PMID:29702526 PMID:30595665

RGD:40818235 RGD:40818273 RGD:40818424 RGD:40822808 RGD:41412183

NCBI chr25:51,606,559...51,618,903
Ensembl chr25:51,608,173...51,618,723

G

programmed cell death 1 ligand 2

protein:increased expression:CD27B cell

NCBI chr 1:93,631,676...93,698,560
Ensembl chr 1:93,631,979...93,689,266

G

platelet and endothelial cell adhesion molecule 1

disease_progression

protein:increased expression:myeloid suppressor cell (mouse)

NCBI chr 9:12,166,124...12,219,553
Ensembl chr 9:12,166,775...12,219,778

G

placental growth factor

protein:increased expression:plasma

NCBI chr 8:48,059,554...48,110,534
Ensembl chr 8:48,059,552...48,075,170

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141

G

phospholipase A2 group IVA

protein:increased activity:liver

NCBI chr 7:19,804,412...19,955,215
Ensembl chr 7:19,832,664...19,966,936

G

plasminogen activator, tissue type

treatment

NCBI chr16:23,469,590...23,496,013

G

plasminogen activator, urokinase

disease_progression

Pneumonia associated sepsis

NCBI chr 4:24,329,139...24,333,893
Ensembl chr 4:24,328,925...24,334,851

G

plasminogen activator, urokinase receptor

protein:increased expression:plasma

NCBI chr 1:111,476,804...111,490,876
Ensembl chr 1:111,476,893...111,490,880

G

peroxisome proliferator activated receptor alpha

severity

DNA:knockout::associated with more severe disease
RNA:decreased expression:blood:associated with more severe disease

NCBI chr10:19,934,020...20,006,096
Ensembl chr10:19,934,165...20,006,146

G

PPARG coactivator 1 alpha

mRNA:decreased expression:skeletal muscle

NCBI chr 3:85,645,942...86,284,570
Ensembl chr 3:86,016,140...86,281,269

G

PPARG coactivator 1 beta

mRNA:decreased expression:skeletal muscle

NCBI chr 4:59,167,041...59,278,977
Ensembl chr 4:59,174,604...59,279,464

G

protein kinase C theta

protein:decreased expression:lymphocyte

NCBI chr 2:29,319,123...29,505,338
Ensembl chr 2:29,318,870...29,505,337

G

protein C, inactivator of coagulation factors Va and VIIIa

disease_progression
treatment

mRNA, protein:decreased expression:liver, plasma
CTD Direct Evidence: therapeutic

PMID:11820775 PMID:15241104 PMID:17556722 PMID:22940033

RGD:11100029 RGD:11250412

NCBI chr19:23,173,626...23,183,634
Ensembl chr19:23,173,635...23,183,563

G

Rac family small GTPase 1

mRNA:increased expression:blood serum (human)

NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216

G

RELA proto-oncogene, NF-kB subunit

protein:increased expression:nucleus, lung

NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875

G

resistin

protein:increased expression:serum

NCBI chr20:52,434,148...52,435,627
Ensembl chr20:52,434,271...52,435,624

G

receptor interacting serine/threonine kinase 3

ameliorates
no_association

PMID:22195746 PMID:23835476 PMID:32152555

RGD:127229908 RGD:127229909 RGD:127229919

NCBI chr 8:4,304,167...4,309,514
Ensembl chr 8:4,305,250...4,309,325

G

ribosomal protein L4

CTD Direct Evidence: marker/mechanism

NCBI chr30:30,766,891...30,771,808
Ensembl chr30:30,766,895...30,771,808

G

ribosomal protein L9

CTD Direct Evidence: marker/mechanism

NCBI chr 3:72,989,526...72,993,944
Ensembl chr 3:72,989,592...72,993,949

G

retinoid X receptor alpha

protein:altered localization:liver
protein:decreased expression:liver

PMID:17483744 PMID:19008781

RGD:1643106 RGD:2317466

NCBI chr 9:50,525,195...50,575,720
Ensembl chr 9:50,484,567...50,573,119

G

ryanodine receptor 1

mRNA:increased expression:fast muscle tissue
protein:decreased expression:diaphragmaticus muscle

PMID:18520643 PMID:28044347

RGD:329849107 RGD:329849111

NCBI chr 1:114,461,350...114,579,577
Ensembl chr 1:114,461,348...114,579,493

G

S100 calcium binding protein B

NCBI chr31:39,783,990...39,788,289
Ensembl chr31:39,784,506...39,788,183

G

selectin L

PMID:15677732 PMID:16026013

RGD:5685706 RGD:5686285

NCBI chr 7:28,906,752...28,927,959
Ensembl chr 7:28,906,809...29,094,008

G

selectin P

protein:increased expression:multiple

NCBI chr 7:28,956,428...28,997,266
Ensembl chr 7:28,958,486...28,996,313

G

serpin family E member 1

treatment

associated with Pneumonia; protein:increased expression:plasma

PMID:12000738 PMID:19753144

RGD:1598921 RGD:4144830

NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301

G

solute carrier family 38 member 2

NCBI chr27:8,056,289...8,068,988
Ensembl chr27:8,018,880...8,066,331

G

solute carrier organic anion transporter family member 1B2

mRNA:decreased expression:liver

NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989

G

suppressor of cytokine signaling 1

mRNA:increased expression:liver
protein:increased expression:gastrocnemius

PMID:11312157 PMID:12644450

RGD:2298924 RGD:634751

NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557

G

suppressor of cytokine signaling 2

protein:increased expression:gastrocnemius

NCBI chr15:33,761,434...33,788,973
Ensembl chr15:33,785,545...33,877,869

G

suppressor of cytokine signaling 3

protein:increased expression:gastrocnemius
mRNA:increased expression:liver

PMID:11312157 PMID:12644450

RGD:2298924 RGD:634751

NCBI chr 9:2,859,267...2,859,944

G

superoxide dismutase 1

NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815

G

superoxide dismutase 2

mRNA, protein:increased expression:lung

NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706

G

superoxide dismutase 3

NCBI chr 3:85,382,698...85,387,144
Ensembl chr 3:85,382,484...85,387,455

G

signal transducer and activator of transcription 1

protein:increased activity:liver, lung, small intestine

NCBI chr37:1,513,438...1,549,837
Ensembl chr37:1,507,219...1,550,178

G

signal transducer and activator of transcription 3

treatment

NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672

G

signal transducer and activator of transcription 4

NCBI chr37:1,566,563...1,685,378
Ensembl chr37:1,566,585...1,829,894

G

signal transducer and activator of transcription 6

severity

NCBI chr10:1,232,515...1,247,011
Ensembl chr10:1,233,691...1,247,075

G

T-box transcription factor 21

severity

NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261

G

tissue factor pathway inhibitor

protein:decreased activity:plasma:

NCBI chr36:29,457,131...29,546,455
Ensembl chr36:29,459,371...29,511,310

G

transforming growth factor beta induced

CTD Direct Evidence: marker/mechanism

NCBI chr11:23,932,038...23,971,983
Ensembl chr11:23,938,453...23,971,607

G

thrombomodulin

NCBI chr24:599,773...601,649
Ensembl chr24:599,773...601,649

G

toll like receptor 2

associated with Liver Diseases;mRNA:increased expression:liver
associated with Burns;mRNA:increased expression:liver, lung, kidney

PMID:12831613 PMID:14604479 PMID:19489280

RGD:1302750 RGD:2312497 RGD:2312732

NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241

G

toll like receptor 4

associated with Liver Diseases;mRNA:increased expression:liver
CTD Direct Evidence: marker/mechanism

PMID:14604479 PMID:19489280 PMID:20624996

RGD:2312497 RGD:2312732

NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165

G

toll like receptor 6

mRNA:increased expression:plasma

NCBI chr 3:73,504,357...73,523,964
Ensembl chr 3:73,520,706...73,523,099

G

tumor necrosis factor

treatment

mRNA:increased expression:heart
CTD Direct Evidence: marker/mechanism

PMID:8741040 PMID:9806674 PMID:15489642 PMID:15665729 PMID:19695174 More...

RGD:14975262 RGD:4144094 RGD:5147745 RGD:7364867

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

DNA topoisomerase II alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 9:22,207,501...22,237,497
Ensembl chr 9:22,207,638...22,237,496

G

tripeptidyl peptidase 2

mRNA, protein:increased expression, increased activity:extensor digitorum longus (rat)

NCBI chr22:52,105,821...52,176,213
Ensembl chr22:52,105,886...52,175,426

G

triggering receptor expressed on myeloid cells 1

treatment
disease_progression

mRNA:decreased expression:polymorph nuclear cell:

PMID:22147417 PMID:22809118 PMID:22996209

RGD:126925981 RGD:126925987 RGD:127284847

NCBI chr12:9,990,678...10,000,195
Ensembl chr12:9,990,679...10,000,236

G

thymic stromal lymphopoietin

treatment
disease_progression

protein:increased expression:peritoneum, plasma (mouse)

PMID:24990542 PMID:26934097

RGD:38549375 RGD:38596335

NCBI chr 3:1,502,469...1,507,696
Ensembl chr 3:1,503,188...1,507,696

G

xanthine dehydrogenase

treatment

NCBI chr17:24,900,708...24,960,748
Ensembl chr17:24,901,447...24,971,935

G

X-linked inhibitor of apoptosis

ClinVar Annotator: match by term: Sepsis

PMID:17080092 PMID:21119115 PMID:25666262 PMID:25741868 PMID:27747465 More...

NCBI chr X:95,300,234...95,356,103
Ensembl chr X:95,331,827...95,351,582

G

zinc finger CCCH-type containing 7B

mRNA, protein:increased expression:muscle part of extensor digitorum longus (rat)

NCBI chr10:23,882,379...23,944,850
Ensembl chr10:23,884,981...23,920,131

toxic shock syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

treatment

NCBI chr27:36,654,328...36,695,775

G

angiotensin I converting enzyme

severity

DNA:SNP, insertion/deletion:promoter, intron: (rs4291, rs4646994)

NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358

G

adenosine kinase

NCBI chr 4:24,540,626...25,047,032
Ensembl chr 4:24,540,659...25,046,464

G

adrenomedullin

PMID:17318497 PMID:17766482

RGD:1625310 RGD:1642599

NCBI chr21:33,472,197...33,474,472
Ensembl chr21:33,471,623...33,474,495

G

adrenoceptor beta 2

treatment
disease_progression

DNA:polymorphism: :rs1042717(human)

PMID:16076286 PMID:19850944

RGD:8548487 RGD:8548529

NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298

G

advanced glycosylation end-product specific receptor

NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129

G

aquaporin 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:43,592,266...43,603,903
Ensembl chr14:43,578,721...43,605,720

G

complement C5a receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:108,659,637...108,704,217
Ensembl chr 1:108,659,637...108,675,401

G

cholecystokinin B receptor

mRNA:increased expression:myocardium

NCBI chr21:29,602,066...29,606,343
Ensembl chr21:29,604,150...29,605,725

G

C-C motif chemokine ligand 2

disease_progression

NCBI chr 9:39,008,187...39,009,932

G

CD274 molecule

severity

protein:increased expression:serum
protein:increased expression:lymphocyte, mononcyte

PMID:26063974 PMID:29702526

RGD:40822808 RGD:41410786

NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522

G

MHC class II DR alpha chain

disease_progression

associated with Burns
CTD Direct Evidence: marker/mechanism

PMID:15644645 PMID:17568330 PMID:28771573

RGD:5490160 RGD:5490203

NCBI chr12:2,133,026...2,137,825
Ensembl chr12:2,132,499...2,168,975

G

elastase, neutrophil expressed

treatment

NCBI chr20:57,789,044...57,790,932
Ensembl chr20:57,788,062...57,790,932

G

enolase 2

proteiin:increased expression:serum

NCBI chr27:38,120,404...38,128,543
Ensembl chr27:38,119,413...38,129,182

G

coagulation factor II, thrombin

severity

protein:decreased expression:blood plasma (human)

NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459

G

FA complementation group C

NCBI chr 1:71,388,931...71,678,019
Ensembl chr 1:71,487,601...71,678,506

G

GC vitamin D binding protein

CTD Direct Evidence: marker/mechanism

NCBI chr13:60,795,305...60,828,038
Ensembl chr13:60,795,305...60,827,929

G

G protein-coupled receptor kinase 2

mRNA:decreased expression:polymorphonuclear leukocyte

NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428

G

MHC class II DLA DRB1 beta chain

mRNA:decreased expression:blood

NCBI chr12:2,151,409...2,164,564

G

heme oxygenase 1

NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773

G

heat shock protein 70

susceptibility

associated wit community-acquired pneumonia;DNA:SNP: :1267A>G (human)

NCBI chr12:1,285,282...1,287,670

G

indoleamine 2,3-dioxygenase 1

severity

protein:increased activity, increased expression:plasma, heart (human)

NCBI chr16:25,391,759...25,407,161
Ensembl chr16:25,391,754...25,407,048

G

interferon gamma

protein:increased expression:plasma

NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698

G

interleukin 10

severity
onset

protein:increased expression:lung (mouse)
protein:increased expression:plasma

PMID:7593621 PMID:12117955 PMID:25403265 PMID:28659355

RGD:11049456 RGD:1598471 RGD:38455982 RGD:40890272

NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057

G

interleukin 19

protein:increased expression:serum

NCBI chr 7:6,000,994...6,006,959
Ensembl chr 7:6,000,907...6,006,870

G

interleukin 1 beta

severity

protein:increased expression:lung (mouse)

NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458

G

interleukin 1 receptor antagonist

susceptibility
treatment

associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphism::
human gene in a mouse model

PMID:15516267 PMID:23014359

RGD:11522756 RGD:8551736

NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329

G

interleukin 20 receptor subunit alpha

mRNA:increased expression:multiple

NCBI chr 1:29,506,582...29,545,882
Ensembl chr 1:29,506,689...29,546,006

G

interleukin 20 receptor subunit beta

mRNA:increased expression:multiple

NCBI chr23:33,384,057...33,421,619
Ensembl chr23:33,384,486...33,420,016

G

interleukin 27

protein, mRNA:increased expression:blood serum, spleen (mouse)

NCBI chr 6:18,243,988...18,248,369
Ensembl chr 6:18,244,040...18,247,635

G

interleukin 6

treatment

NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519

G

mannose binding lectin 1

susceptibility

associated with acute pyelonephritis;DNA:SNPs, missense mutations, haplotypes:promoter, cds:multiple

NCBI chr 4:29,419,886...29,424,377

G

melanocortin 2 receptor

protein:increased expression:liver (rat)

NCBI chr 1:24,351,219...24,390,071
Ensembl chr 1:24,388,280...24,389,170

G

macrophage migration inhibitory factor

PMID:17381395 PMID:17565848

RGD:1641978 RGD:4891013

G

microRNA mir-155

NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833

G

microRNA mir-21

exacerbates
ameliorates

PMID:28437377 PMID:31189875

RGD:41404641 RGD:41404698

NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624

G

microRNA mir-494

severity

NCBI chr 8:69,261,385...69,261,465
Ensembl chr 8:69,261,385...69,261,465

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

susceptibility

associated with Burns; DNA:missense mutation:cds:m.4216T>C (human)

NCBI chr MT:2,747...3,702
Ensembl chr MT:2,747...3,703

G

NFKB inhibitor alpha

treatment

NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433

G

nitric oxide synthase 2

CTD Direct Evidence: marker/mechanism

PMID:8745224 PMID:16601845

NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588

G

natriuretic peptide C

protein:increased expression:plasma

NCBI chr25:43,714,545...43,718,969
Ensembl chr25:43,717,939...43,718,996

G

8-oxoguanine DNA glycosylase

NCBI chr20:8,486,150...8,491,448
Ensembl chr20:8,480,005...8,491,264

G

poly(ADP-ribose) polymerase 1

NCBI chr 7:38,503,072...38,542,556
Ensembl chr 7:38,503,067...38,542,127

G

programmed cell death 1

severity

protein:increased expression:serum
protein:increased expression:lymphocyte, mononcyte

PMID:26063974 PMID:29702526

RGD:40822808 RGD:41410786

NCBI chr25:51,606,559...51,618,903
Ensembl chr25:51,608,173...51,618,723

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

severity

NCBI chr 5:62,884,596...62,936,882
Ensembl chr 5:62,909,009...62,935,971

G

plasminogen activator, urokinase receptor

NCBI chr 1:111,476,804...111,490,876
Ensembl chr 1:111,476,893...111,490,880

G

protein C, inactivator of coagulation factors Va and VIIIa

treatment

PMID:19320827 PMID:21850534

RGD:11100015 RGD:11100041

NCBI chr19:23,173,626...23,183,634
Ensembl chr19:23,173,635...23,183,563

G

pentraxin 3

protein:increased expression:plasma (human)

NCBI chr23:50,952,835...50,958,607
Ensembl chr23:50,952,885...50,958,167

G

renin

exacerbates

protein:increased activity:blood plasma (human)

NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012

G

selectin L

protein:increased expression:plasma

NCBI chr 7:28,906,752...28,927,959
Ensembl chr 7:28,906,809...29,094,008

G

serpin family C member 1

treatment

NCBI chr 7:25,322,668...25,333,022
Ensembl chr 7:25,316,129...25,332,987

G

serpin family E member 1

susceptibility

associated with Pneumonia; DNA:polymorphism:promoter:rs1799768 (human)

NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301

G

serpin family F member 1

severity

protein:decreased expression:plasma (human)

NCBI chr 9:45,891,368...45,902,768
Ensembl chr 9:45,891,410...45,902,765

G

serpin family G member 1

treatment

NCBI chr18:38,570,354...38,580,751
Ensembl chr18:38,570,607...38,581,665

G

surfactant protein B

associated with Pneumonia;DNA:polymorphism: :1580C>T (human)

NCBI chr17:39,419,305...39,428,513
Ensembl chr17:39,386,584...39,426,229

G

suppressor of cytokine signaling 1

severity

NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557

G

thromboxane A2 receptor

treatment

NCBI chr20:55,819,866...55,829,395
Ensembl chr20:55,824,410...55,828,980

G

tissue factor pathway inhibitor

treatment

NCBI chr36:29,457,131...29,546,455
Ensembl chr36:29,459,371...29,511,310

G

thrombopoietin

protein:increased expression:serum:

NCBI chr34:17,245,006...17,255,250
Ensembl chr34:17,247,731...17,253,033

G

tumor necrosis factor

treatment

protein:increased expression:peritoneal macrophage, cell surface (rat)
CTD Direct Evidence: marker/mechanism

PMID:2213560 PMID:12622907 PMID:20054000

RGD:10449465 RGD:1598936

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

G

triggering receptor expressed on myeloid cells 1

mRNA:decreased expression:polymorphonuclear leukocyte

NCBI chr12:9,990,678...10,000,195
Ensembl chr12:9,990,679...10,000,236

G

zinc finger CCCH-type containing 12A

NCBI chr15:4,972,369...4,984,218
Ensembl chr15:4,972,956...4,980,371

Viremia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone marrow stromal cell antigen 2

associated with Retroviridae Infections;

NCBI chr20:45,383,757...45,387,420
Ensembl chr20:45,383,915...45,387,178

G

interleukin 2 receptor subunit beta

NCBI chr10:27,370,797...27,388,775
Ensembl chr10:27,370,797...27,388,775

Term paths to the root

Path 1
Term	Annotations
disease	17773
syndrome	10064
Systemic Inflammatory Response Syndrome	381
Cytokine Release Syndrome	0
Fetal Inflammatory Response Syndrome	1
Sepsis +	379
Path 2
Term	Annotations
disease	17773
Pathological Conditions, Signs and Symptoms	12020
Pathologic Processes	7484
Shock	399
Systemic Inflammatory Response Syndrome	381
Cytokine Release Syndrome	0
Fetal Inflammatory Response Syndrome	1
Sepsis +	379

paths to the root