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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Spinal Cord Injuries
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Accession:DOID:9000039 term browser browse the term
Definition:Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Synonyms:exact_synonym: Post Traumatic Myelopathy;   Post-Traumatic Myelopathies;   Spinal Cord Contusion;   Spinal Cord Contusions;   Spinal Cord Injury;   Spinal Cord Laceration;   Spinal Cord Lacerations;   Spinal Cord Transection;   Spinal Cord Transections;   Spinal Cord Trauma;   Spinal Cord Traumas;   Traumatic Myelopathies;   Traumatic Myelopathy
 narrow_synonym: acute spinal cord injury
 primary_id: MESH:D013119;   RDO:0006597
For additional species annotation, visit the Alliance of Genome Resources.



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Spinal Cord Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 treatment ISO mRNA:increased expression:spinal cord RGD PMID:20410530 PMID:25763638 RGD:12790978 RGD:12791993 NCBI chr21:39,963,001...40,037,040
Ensembl chr21:39,962,947...40,036,981
JBrowse link
G ACAN aggrecan ISO protein:altered expression:spinal cord (rat) RGD PMID:14769391 RGD:2315837 NCBI chr 3:51,995,100...52,031,812
Ensembl chr 3:51,969,779...52,031,544
JBrowse link
G ADARB1 adenosine deaminase RNA specific B1 ISO RGD PMID:20456005 RGD:10755338 NCBI chr31:38,715,529...38,799,353
Ensembl chr31:38,678,184...38,796,521
JBrowse link
G ADCYAP1 adenylate cyclase activating polypeptide 1 ISO protein:altered expression:spinal cord,dorsal root ganglion, urinary bladder RGD PMID:15698618 PMID:15913892 RGD:2325306 RGD:2325309 NCBI chr 7:67,682,421...67,691,035 JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing ISO protein:increased expression:serum RGD PMID:16213239 RGD:5686719 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844
JBrowse link
G ADORA1 adenosine A1 receptor ISO protein:decreased expression:spinal cord RGD PMID:17853654 PMID:18289533 PMID:20065990 RGD:4890369 RGD:5129094 RGD:5129096 NCBI chr 7:44,819...74,217
Ensembl chr 7:44,820...73,051
JBrowse link
G ADORA2A adenosine A2a receptor ISO RGD PMID:17559837 RGD:4890378 NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598
JBrowse link
G ADRA1A adrenoceptor alpha 1A ISO mRNA:increased expression:aorta RGD PMID:16524515 RGD:5688371 NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486
JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO protein:increased expression:spinal cord (rat) RGD PMID:20195207 RGD:2325645 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129
JBrowse link
G AIF1 allograft inflammatory factor 1 ISO protein:altered expression:spinal cord dorsal horn (rat) RGD PMID:17158026 RGD:2313037 NCBI chr12:1,104,350...1,106,179
Ensembl chr12:1,104,394...1,106,177
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO RGD PMID:20678995 RGD:10040962 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193
JBrowse link
G AKT1S1 AKT1 substrate 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17457363 NCBI chr 1:106,686,349...106,694,854
Ensembl chr 1:106,687,024...106,693,928
JBrowse link
G AMBRA1 autophagy and beclin 1 regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr18:42,903,815...43,073,918
Ensembl chr18:42,932,513...43,072,827
JBrowse link
G ANKRD1 ankyrin repeat domain 1 ISO mRNA:increased expression:spinal cord, dorsal root ganglion, neuron RGD PMID:17610582 RGD:5133279 NCBI chr28:5,569,120...5,578,393
Ensembl chr28:5,569,501...5,601,956
JBrowse link
G ANP32B acidic nuclear phosphoprotein 32 family member B ISO RGD PMID:25034417 RGD:10401137 NCBI chr11:55,230,017...55,272,744
Ensembl chr11:55,243,854...55,350,194
JBrowse link
G ANXA1 annexin A1 treatment ISO mRNA,protein:increased expression:neuron,glial cell RGD PMID:15248295 PMID:17917587 RGD:10053688 RGD:2306891 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011
JBrowse link
G ANXA2 annexin A2 ISO mRNA,protein:increased expression:neuron,glial cell RGD PMID:15248295 RGD:10053688 NCBI chr30:25,176,845...25,210,244
Ensembl chr30:25,115,842...25,218,281
JBrowse link
G ANXA5 annexin A5 ISO mRNA,protein:increased expression:neuron,glial cell RGD PMID:15248295 RGD:10053688 NCBI chr19:18,419,936...18,450,088
Ensembl chr19:18,407,587...18,570,378
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 ISO RGD PMID:21748659 RGD:10053608 NCBI chr15:38,026,893...38,160,842
Ensembl chr15:38,028,132...38,114,987
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 ISO mRNA:increased expression:spinal cord RGD PMID:18637713 RGD:2315670 NCBI chr15:17,786,808...17,789,422
Ensembl chr15:17,786,357...17,789,422
JBrowse link
G APOE apolipoprotein E ISO DNA:polymorphism:exon: RGD PMID:18581664 PMID:30036659 RGD:13703128 RGD:7771551 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:spinal cord, neuron, astrocyte
CTD
RGD
PMID:18248364 PMID:21092735 RGD:2307072 RGD:5148013 NCBI chr14:43,592,266...43,603,903
Ensembl chr14:43,578,721...43,605,720
JBrowse link
G AQP4 aquaporin 4 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:20517941 PMID:21092735 PMID:21280976 RGD:5148013 RGD:5148027 RGD:5148035 NCBI chr 7:61,855,617...61,868,953
Ensembl chr 7:61,855,744...61,865,089
JBrowse link
G ATF4 activating transcription factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr10:25,528,880...25,531,018
Ensembl chr10:25,528,874...25,530,993
JBrowse link
G ATG5 autophagy related 5 ISO protein:increased expression:axon
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:25040536 PMID:29793971 RGD:11553820 NCBI chr12:63,565,859...63,692,383
Ensembl chr12:63,567,568...63,683,485
JBrowse link
G ATG7 autophagy related 7 ISO protein:increased expression:axon RGD PMID:25040536 RGD:11553820 NCBI chr20:6,916,354...7,154,849
Ensembl chr20:6,916,515...7,154,800
JBrowse link
G ATM ATM serine/threonine kinase ISO protein:increased expression:spinal cord RGD PMID:21748659 RGD:10053608 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207
JBrowse link
G ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO protein:decreased expression:tail, skeletal muscle RGD PMID:21930674 RGD:13782071 NCBI chr 6:18,384,981...18,400,038
Ensembl chr 6:18,385,007...18,400,036
JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO protein:decreased expression:tail, skeletal muscle RGD PMID:21930674 RGD:13782071 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388
JBrowse link
G B9D2 B9 domain containing 2 ISO RGD PMID:15145083 RGD:2302103 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
G BAMBI BMP and activin membrane bound inhibitor ISO mRNA,protein:decreased expression:spinal cord: RGD PMID:28035406 RGD:14390163 NCBI chr 2:17,453,628...17,459,812
Ensembl chr 2:17,455,243...17,462,346
JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:27256506 RGD:13792677 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BCAN brevican treatment ISO RGD PMID:15016081 RGD:9589823 NCBI chr 7:41,313,578...41,330,178
Ensembl chr 7:41,313,579...41,330,178
JBrowse link
G BCL2 BCL2 apoptosis regulator treatment ISO RGD PMID:27256506 RGD:13792677 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G BDNF brain derived neurotrophic factor treatment ISO RGD PMID:16022868 PMID:19203225 PMID:24551172 RGD:10059354 RGD:4891066 RGD:4891112 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480
JBrowse link
G BECN1 beclin 1 treatment ISO protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:21806471 PMID:23852559 PMID:24559459 PMID:29793971 RGD:11561918 RGD:11561922 RGD:6483100 NCBI chr 9:20,204,203...20,215,081
Ensembl chr 9:20,204,220...20,214,236
JBrowse link
G BMP2 bone morphogenetic protein 2 ISO RGD PMID:23770801 RGD:9068404 NCBI chr24:15,199,667...15,211,509
Ensembl chr24:15,200,291...15,212,217
JBrowse link
G BMP4 bone morphogenetic protein 4 treatment ISO RGD PMID:18803859 PMID:23770801 RGD:9068404 RGD:9068437 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557
JBrowse link
G BNIP3 BCL2 interacting protein 3 ISO protein:increased expression:spinal cord RGD PMID:23637053 RGD:11564330 NCBI chr28:40,037,681...40,050,499
Ensembl chr28:40,038,643...40,049,797
JBrowse link
G BNIP3L BCL2 interacting protein 3 like ISO protein:increased expression:spinal cord RGD PMID:23637053 RGD:11564330 NCBI chr25:31,133,512...31,149,750
Ensembl chr25:31,136,168...31,148,905
JBrowse link
G BRCA2 BRCA2 DNA repair associated ISO mRNA,protein:increased expression:spinal cord: RGD PMID:21748659 RGD:10053608 NCBI chr25:7,734,450...7,797,851
Ensembl chr25:7,734,453...7,797,815
JBrowse link
G C1QB complement C1q B chain ISO mRNA:increased expression RGD PMID:16345062 RGD:1599510 NCBI chr 2:76,650,440...76,655,546
Ensembl chr 2:76,650,586...76,655,549
JBrowse link
G CAPN1 calpain 1 treatment ISO RGD PMID:23102374 RGD:13792496 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
JBrowse link
G CAPZB capping actin protein of muscle Z-line subunit beta ISO protein:decreased expression:spinal cord RGD PMID:20141154 RGD:9685028 NCBI chr 2:79,182,668...79,311,529
Ensembl chr 2:79,181,851...79,311,518
JBrowse link
G CASP12 caspase 12 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:19215662 PMID:26884858 RGD:11560925 RGD:2311450 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
JBrowse link
G CASP3 caspase 3 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:14588118 PMID:18378144 PMID:21748659 PMID:27256506 PMID:27339639 RGD:10053608 RGD:13782345 RGD:13792677 RGD:2293322 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G CASP9 caspase 9 treatment ISO RGD PMID:21748659 PMID:27339639 RGD:10053608 RGD:13782345 NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484
JBrowse link
G CAV1 caveolin 1 ISO protein:increased phosphorylation:spinal cord RGD PMID:17275798 RGD:2289124 NCBI chr14:55,458,934...55,494,563
Ensembl chr14:55,461,048...55,492,935
JBrowse link
G CCL13 chemokine (C-C motif) ligand 13 ISO mRNA:increased expression:spinal cord RGD PMID:9698165 RGD:5135274 NCBI chr 9:38,938,944...38,940,231
Ensembl chr 9:38,938,135...38,940,231
JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:spinal cord segment (mouse) RGD PMID:20478301 RGD:4889905 NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852
JBrowse link
G CCND3 cyclin D3 ISO protein:increased expression:spinal cord RGD PMID:18008145 RGD:2316019 NCBI chr12:10,593,786...10,688,304
Ensembl chr12:10,594,712...10,600,891
JBrowse link
G CCNE1 cyclin E1 ISO protein:increased expression:spinal cord RGD PMID:16759516 RGD:2289281 NCBI chr 1:121,688,622...121,697,533
Ensembl chr 1:121,688,796...121,697,649
JBrowse link
G CCNH cyclin H ISO mRNA, protein:increased expression:spinal cord RGD PMID:21710280 RGD:9590263 NCBI chr 3:21,046,477...21,067,305
Ensembl chr 3:21,046,472...21,178,315
JBrowse link
G CCR1 chemokine (C-C motif) receptor 1 ISO RGD PMID:21332278 RGD:5688138 NCBI chr20:42,421,356...42,427,177
Ensembl chr20:42,421,356...42,426,958
JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO protein:increased expression:spinal cord RGD PMID:18338959 RGD:4144888 NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698
JBrowse link
G CD274 CD274 molecule ISO mRNA:increased expression:microglial cell RGD PMID:29665726 RGD:40886268 NCBI chr 1:93,461,735...93,605,772
Ensembl chr 1:93,585,518...93,603,522
JBrowse link
G CDK1 cyclin dependent kinase 1 ISO protein:increased expression:spinal cord dura mater (rat) RGD PMID:19672039 RGD:2316488 NCBI chr 4:12,884,106...12,899,203
Ensembl chr 4:12,883,385...12,899,197
JBrowse link
G CDK19 cyclin dependent kinase 19 ISO mRNA, protein:increased expression:spinal cord RGD PMID:18008145 RGD:2316019 NCBI chr12:67,227,374...67,369,481
Ensembl chr12:67,231,463...67,327,084
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO protein:decreased expression, altered localization:spinal cord, neuron, microglial cell RGD PMID:18319192 RGD:2293615 NCBI chr27:33,609,154...33,613,558
Ensembl chr27:33,611,760...33,612,906
JBrowse link
G CHL1 cell adhesion molecule L1 like ISO protein:increased expression:spinal cord (rat) RGD PMID:21337374 RGD:6483045 NCBI chr20:16,789,697...17,065,861
Ensembl chr20:16,792,960...16,984,613
JBrowse link
G CNR1 cannabinoid receptor 1 ISO RGD PMID:18930143 RGD:2316199 NCBI chr12:47,537,240...47,560,723
Ensembl chr12:47,509,583...47,560,983
JBrowse link
G CNR2 cannabinoid receptor 2 ISO RGD PMID:18930143 RGD:2316199 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126
JBrowse link
G CRH corticotropin releasing hormone ISO protein:altered expression:spinal cord (rat) RGD PMID:20458328 RGD:5490964 NCBI chr29:15,831,944...15,840,560
Ensembl chr29:15,831,944...15,834,384
JBrowse link
G CRP C-reactive protein ISO RGD PMID:22404382 RGD:6903321 NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166
JBrowse link
G CSF2 colony stimulating factor 2 treatment ISO RGD PMID:15658127 RGD:10449531 NCBI chr11:20,342,880...20,346,959
Ensembl chr11:20,344,648...20,346,959
JBrowse link
G CSF3 colony stimulating factor 3 treatment ISO RGD PMID:21953623 RGD:10450511 NCBI chr 9:22,529,643...22,532,326
Ensembl chr 9:22,530,698...22,533,108
JBrowse link
G CSPG4 chondroitin sulfate proteoglycan 4 ISO RGD PMID:19604403 PMID:22042562 PMID:22243800 RGD:5686844 RGD:5686848 RGD:5686859 NCBI chr30:38,465,486...38,498,365
Ensembl chr30:38,465,241...38,497,971
JBrowse link
G CTSS cathepsin S ISO RGD PMID:16344894 RGD:2303423 NCBI chr17:59,893,840...59,910,878
Ensembl chr17:59,893,840...59,910,849
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:19170890 RGD:2311365 NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979
JBrowse link
G CYBA cytochrome b-245 alpha chain ISO mRNA:increased expression:spinal cord RGD PMID:16345062 RGD:1599510 NCBI chr 5:64,692,865...64,701,056
Ensembl chr 5:64,692,123...64,704,893
JBrowse link
G CYBB cytochrome b-245 beta chain ISO mRNA,protein:increased expression:microglia: RGD PMID:20679217 RGD:11040629 NCBI chr  X:32,533,365...32,568,149
Ensembl chr  X:32,533,320...32,568,217
JBrowse link
G DCC DCC netrin 1 receptor ISO RGD PMID:16998900 RGD:2314373 NCBI chr 1:21,788,833...22,494,849
Ensembl chr 1:21,793,328...22,494,967
JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
G DUSP1 dual specificity phosphatase 1 treatment ISO protein:decreased expression:spinal cord RGD PMID:18630599 PMID:19383246 RGD:7771572 RGD:7771580 NCBI chr 4:39,588,833...39,591,065
Ensembl chr 4:39,588,339...39,590,514
JBrowse link
G EFNB2 ephrin B2 ISO mRNA,protein:increased expression:fibroblast, astrocyte
protein:increased phosporylation:spinal cord
RGD PMID:12944508 PMID:33794069 RGD:127285659 RGD:127285804 NCBI chr22:55,567,992...55,609,210
Ensembl chr22:55,566,039...55,609,443
JBrowse link
G EGFR epidermal growth factor receptor ISO protein:increased phosphorylation:spinal cord, astrocyte (rat) RGD PMID:20869112 PMID:21402118 RGD:5131454 RGD:5131525 NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631
JBrowse link
G EIF5A eukaryotic translation initiation factor 5A ISO mRNA, protein:increased expression:gastrocnemius RGD PMID:23238062 RGD:10395360 NCBI chr 5:32,268,103...32,272,970 JBrowse link
G ENDOG endonuclease G ISO RGD PMID:16689664 RGD:8655990 NCBI chr 9:54,809,470...54,812,795
Ensembl chr 9:54,809,530...54,813,042
JBrowse link
G ENO2 enolase 2 ISO protein:increased expression:serum, cerebrospinal fluid RGD PMID:18343116 RGD:2293743 NCBI chr27:38,120,404...38,128,543
Ensembl chr27:38,119,413...38,129,182
JBrowse link
G ENSA endosulfine alpha ISO mRNA:decreased expression:spinal cord RGD PMID:16344894 RGD:2303423 NCBI chr17:59,800,822...59,807,884
Ensembl chr17:59,801,306...59,807,869
JBrowse link
G EPHA3 EPH receptor A3 ISO RGD PMID:16083359 RGD:2301766 NCBI chr33:770,234...1,092,063
Ensembl chr33:769,423...1,115,986
JBrowse link
G EPHA4 EPH receptor A4 ISO RGD PMID:17418490 PMID:17970742 PMID:21931787 RGD:5688750 RGD:5688764 RGD:5688782 NCBI chr37:27,670,143...27,809,642
Ensembl chr37:27,677,566...27,809,646
JBrowse link
G EPHA7 EPH receptor A7 ISO mRNA:increased expression:spinal cord RGD PMID:16983667 RGD:2301957 NCBI chr12:52,134,775...52,305,163
Ensembl chr12:52,137,605...52,305,162
JBrowse link
G EPHB2 EPH receptor B2 ameliorates ISO RGD PMID:12944508 PMID:33794069 RGD:127285659 RGD:127285804 NCBI chr 2:76,427,112...76,551,494
Ensembl chr 2:76,428,203...76,612,786
JBrowse link
G EPO erythropoietin treatment ISO RGD PMID:22196867 RGD:10401074 NCBI chr 6:8,994,211...8,995,954
Ensembl chr 6:8,994,211...8,996,144
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 ISO mRNA, protein:increased expression:spinal cord RGD PMID:11797086 RGD:2289967 NCBI chr10:406,856...424,746
Ensembl chr10:406,633...424,264
JBrowse link
G ESR1 estrogen receptor 1 ISO RGD PMID:25105782 RGD:10045844 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:25105782 RGD:10045844 NCBI chr 8:38,645,917...38,715,347
Ensembl chr 8:38,645,430...38,702,691
JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:16344894 RGD:2303423 NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459
JBrowse link
G FADD Fas associated via death domain treatment ISO RGD PMID:23574812 RGD:11344882 NCBI chr18:48,087,447...48,094,497 JBrowse link
G FAS Fas cell surface death receptor ISO protein:increased expression:cervical spinal cord RGD PMID:17518537 PMID:17703359 PMID:29738767 RGD:13792580 RGD:2290176 RGD:2290177 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
JBrowse link
G FGF1 fibroblast growth factor 1 ISO Human FGF1 used in rat model of spinal cord injury RGD PMID:8662542 PMID:18482974 PMID:20488178 PMID:21663406 RGD:2317692 RGD:5509875 RGD:5509876 RGD:5509877 NCBI chr 2:37,467,431...37,554,770
Ensembl chr 2:37,470,985...37,554,619
JBrowse link
G FGF2 fibroblast growth factor 2 treatment ISO RGD PMID:24968269 RGD:40924652 NCBI chr19:17,403,288...17,463,143
Ensembl chr19:16,994,661...17,463,151
JBrowse link
G FIS1 fission, mitochondrial 1 treatment ISO RGD PMID:26079325 RGD:12437066 NCBI chr 6:8,642,014...8,645,812
Ensembl chr 6:8,642,039...8,648,851
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 ISO mRNA:increased expression:spinal cord, astrocyte, macrophage RGD PMID:17409380 RGD:5684414 NCBI chr25:11,231,958...11,410,379
Ensembl chr25:11,231,737...11,407,621
JBrowse link
G FN1 fibronectin 1 ISO RGD PMID:20347014 RGD:7205459 NCBI chr37:22,456,854...22,522,410
Ensembl chr37:22,420,428...22,523,123
JBrowse link
G FOXO3 forkhead box O3 ISO protein:decreased expression:spinal cord,neuron, astrocyte: RGD PMID:22930444 RGD:10402202 NCBI chr12:65,552,455...65,673,467
Ensembl chr12:65,552,310...65,670,198
JBrowse link
G FOXP3 forkhead box P3 treatment ISO RGD PMID:30287503 RGD:38549580 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758
JBrowse link
G GAP43 growth associated protein 43 treatment ISO RGD PMID:24968269 RGD:40924652 NCBI chr33:19,668,491...19,770,509
Ensembl chr33:19,656,835...19,770,408
JBrowse link
G GDNF glial cell derived neurotrophic factor ISO RGD PMID:22342994 RGD:5688774 NCBI chr 4:70,966,694...70,991,860
Ensembl chr 4:70,971,432...70,989,714
JBrowse link
G GFAP glial fibrillary acidic protein treatment ISO protein:increased expression:spinal cord RGD PMID:10225952 PMID:21250919 PMID:24968269 RGD:40924652 RGD:6480471 RGD:6480511 NCBI chr 9:18,569,868...18,579,463
Ensembl chr 9:18,569,892...18,579,461
JBrowse link
G GHSR growth hormone secretagogue receptor ISO RGD PMID:25261791 RGD:12907564 NCBI chr34:36,691,132...36,694,304
Ensembl chr34:36,690,224...36,694,312
JBrowse link
G GJA1 gap junction protein alpha 1 treatment ISO RGD PMID:23403365 PMID:24183749 RGD:8662431 RGD:8662460 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936
JBrowse link
G GJC2 gap junction protein gamma 2 treatment ISO RGD PMID:26415641 RGD:13208513 NCBI chr14:810,388...819,248
Ensembl chr14:810,386...820,420
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 ISO protein:increased expression:spinal cord (rat) RGD PMID:27150525 RGD:13506243 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 ISO RGD PMID:22975889 RGD:8552988 NCBI chr 6:15,792,072...15,796,922
Ensembl chr 6:15,792,897...15,794,051
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO protein:increased expression:spinal cord, neuron, microglial cell (rat) RGD PMID:23359120 RGD:13792782 NCBI chr 4:35,927,470...35,943,218
Ensembl chr 4:35,913,472...35,943,221
JBrowse link
G GRN granulin precursor ISO mRNA, protein:increased expression:spinal cord: RGD PMID:19946692 RGD:5509603 NCBI chr 9:19,077,430...19,085,443
Ensembl chr 9:19,077,427...19,082,268
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 ISO mRNA:increased expression:lumbar segment of spinal cord (rat) RGD PMID:22160604 RGD:5687769 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200
JBrowse link
G HGF hepatocyte growth factor treatment ISO mRNA,protein:increased expression:spinal cord: RGD PMID:17549731 PMID:22140459 RGD:2317487 RGD:8548666 NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:21092735 RGD:5148013 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692
JBrowse link
G HMGB1 high mobility group box 1 ISO mRNA:increased expression:spinal cord RGD PMID:20195207 RGD:2325645 NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165
JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO RGD PMID:23943397 RGD:10766443 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773
JBrowse link
G HRH3 histamine receptor H3 ISO RGD PMID:16671478 RGD:1626425 NCBI chr24:46,239,883...46,243,123 JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISO protein:decreased expression:spinal cord (rat) RGD PMID:24499940 RGD:10445836 NCBI chr12:12,658,415...12,664,945
Ensembl chr12:12,660,008...12,664,940
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO mRNA: increased expression RGD PMID:21933012 RGD:5685666 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 treatment ISO mRNA,protein:increased expression:spinal cord: RGD PMID:12098653 PMID:30287503 RGD:10402749 RGD:38549580 NCBI chr 6:7,487,164...7,488,576
Ensembl chr 6:7,487,250...7,488,576
JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO RGD PMID:8627308 RGD:11522712 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914
JBrowse link
G ID1 inhibitor of DNA binding 1, HLH protein ISO mRNA:increased expression:spinal cord (rat) RGD PMID:11746449 RGD:9686138 NCBI chr24:21,094,339...21,096,276
Ensembl chr24:21,094,755...21,096,276
JBrowse link
G ID3 inhibitor of DNA binding 3, HLH protein ISO mRNA:increased expression:spinal cord (rat) RGD PMID:11746449 RGD:9686138 NCBI chr 2:75,880,659...75,881,786
Ensembl chr 2:75,880,657...75,882,010
JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:29691718 RGD:14975124 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057
JBrowse link
G IL18 interleukin 18 treatment ISO RGD PMID:18367607 PMID:23140983 RGD:2315889 RGD:8655974 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348
JBrowse link
G IL1B interleukin 1 beta treatment ISO mRNA, protein:increased expression:spinal cord RGD PMID:16038625 PMID:23209732 PMID:29691718 RGD:14975124 RGD:1626673 RGD:7175523 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
JBrowse link
G IL1R1 interleukin 1 receptor type 1 ISO mRNA,protein:increased expression:spinal cord RGD PMID:16456668 RGD:7207035 NCBI chr10:40,825,986...40,897,898
Ensembl chr10:40,827,377...40,897,596
JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO protein:increased expression:serum (human) RGD PMID:16038625 PMID:17964877 RGD:1626673 RGD:6907102 NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329
JBrowse link
G IL4 interleukin 4 ISO RGD PMID:20623539 RGD:5128562 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
JBrowse link
G IL4R interleukin 4 receptor ISO mRNA:increased expression:spinal cord RGD PMID:20623539 RGD:5128562 NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291
JBrowse link
G IL6 interleukin 6 treatment ISO RGD PMID:27085942 PMID:29691718 RGD:11062150 RGD:14975124 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
JBrowse link
G IRF1 interferon regulatory factor 1 ISO RGD PMID:11723173 RGD:2298928 NCBI chr11:20,773,801...20,781,106
Ensembl chr11:20,760,120...20,781,608
JBrowse link
G IRF5 interferon regulatory factor 5 treatment ISO RGD PMID:24968269 RGD:40924652 NCBI chr14:7,724,168...7,734,976
Ensembl chr14:7,724,780...7,742,795
JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 severity ISO protein:decreased expression:cerebrospinal fluid RGD PMID:21559420 RGD:40907059
G JAK2 Janus kinase 2 treatment ISO RGD PMID:23274522 RGD:10411896 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO protein:increased phosphorylation:neuron RGD PMID:21132399 RGD:4889994 NCBI chr 5:50,966,698...50,968,939 JBrowse link
G KCNJ10 potassium inwardly rectifying channel subfamily J member 10 ISO protein:decreased expression:spinal cord RGD PMID:20375134 RGD:8662905 NCBI chr38:22,114,718...22,143,625
Ensembl chr38:22,130,508...22,140,813
JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 treatment ISO RGD PMID:22425721 RGD:9831183 NCBI chr 7:12,893,654...13,092,319
Ensembl chr 7:12,894,149...13,090,110
JBrowse link
G KDM6B lysine demethylase 6B ISO mRNA:increased expression:spinal cord (rat) RGD PMID:22578249 RGD:9587821 NCBI chr 5:32,689,000...32,711,026
Ensembl chr 5:32,696,211...32,710,666
JBrowse link
G KDR kinase insert domain receptor ISO mRNA:increased expression:spinal cord, astrocyte, macrophage RGD PMID:17409380 RGD:5684414 NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042
JBrowse link
G KIF3B kinesin family member 3B ISO protein:increased expression:spinal cord RGD PMID:23093447 RGD:11049594 NCBI chr24:21,661,730...21,706,839
Ensembl chr24:21,661,059...21,802,815
JBrowse link
G KLK6 kallikrein related peptidase 6 ISO protein:increased expression:spinal cord RGD PMID:16987227 RGD:2314866 NCBI chr 1:105,902,147...105,907,585 JBrowse link
G KMO kynurenine 3-monooxygenase ISO mRNA,protein:increased expression:spinal cord: RGD PMID:26524415 RGD:13703043 NCBI chr 7:32,941,487...32,994,541
Ensembl chr 7:32,941,487...32,994,541
JBrowse link
G LEP leptin ISO RGD PMID:19777863 RGD:5128780 NCBI chr14:8,115,396...8,130,946
Ensembl chr14:8,116,122...8,131,395
JBrowse link
G LOC100688969 glyceraldehyde-3-phosphate dehydrogenase-like treatment ISO RGD PMID:27256506 RGD:13792677 NCBI chr  X:51,925,654...51,926,724 JBrowse link
G LOC102151783 inhibitor of DNA binding 2 ISO mRNA:increased expression:spinal cord (rat) RGD PMID:11746449 RGD:9686138 NCBI chr10:54,954,852...54,957,116 JBrowse link
G LOC403934 cell division cycle 42 ISO mRNA:increased expression:spinal cord RGD PMID:15736231 RGD:5688276 NCBI chr 2:77,153,276...77,169,947
Ensembl chr 2:77,153,095...77,199,211
JBrowse link
G LRP1 LDL receptor related protein 1 treatment ISO RGD PMID:23867460 RGD:13800520 NCBI chr10:1,260,256...1,341,705
Ensembl chr10:1,260,719...1,352,271
JBrowse link
G LRP5 LDL receptor related protein 5 treatment ISO RGD PMID:24090150 RGD:12798566 NCBI chr18:49,439,494...49,555,375
Ensembl chr18:49,439,483...49,516,396
JBrowse link
G LUM lumican ISO protein:increased expression:spinal cord RGD PMID:18482974 RGD:2317692 NCBI chr15:31,792,872...31,800,444
Ensembl chr15:31,793,233...31,800,912
JBrowse link
G MAP1B microtubule associated protein 1B ISO protein:increased phosphorylation:spinal cord, neuron RGD PMID:17880387 RGD:2304007 NCBI chr 2:55,175,000...55,258,160
Ensembl chr 2:55,174,837...55,253,975
JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha treatment ISO protein:increased expression:spinal cord RGD PMID:23637053 PMID:23852559 PMID:24559459 RGD:11561918 RGD:11561922 RGD:11564330 NCBI chr24:23,672,343...23,673,937
Ensembl chr24:23,633,579...23,673,921
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr 5:65,669,553...65,683,445 JBrowse link
G MAP2 microtubule associated protein 2 ISO RGD PMID:21704982 RGD:6483323 NCBI chr37:17,316,899...17,611,360
Ensembl chr37:17,466,678...17,607,803
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased expression:white matter and grey matter: RGD PMID:10331432 RGD:10412645 NCBI chr 1:29,107,813...29,306,437
Ensembl chr 1:29,108,591...29,306,503
JBrowse link
G MAPT microtubule associated protein tau treatment ISO RGD PMID:22052241 RGD:8158113 NCBI chr 9:9,572,174...9,674,082
Ensembl chr 9:9,570,557...9,674,349
JBrowse link
G MDM2 MDM2 proto-oncogene ISO protein:increased expression:spinal cord RGD PMID:23595775 RGD:10412063 NCBI chr10:10,936,288...10,963,118
Ensembl chr10:10,893,719...10,962,596
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO mRNA, protein:increased expression:spinal cord (rat) RGD PMID:17549731 RGD:2317487 NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027
JBrowse link
G MFN1 mitofusin 1 treatment ISO protein:altered expression:spinal cord, mitochondrion (rat) RGD PMID:26079325 PMID:26981103 RGD:12437066 RGD:12910837 NCBI chr34:12,785,799...12,816,881
Ensembl chr34:12,785,856...12,815,994
JBrowse link
G MFN2 mitofusin 2 treatment ISO protein:increased expression:spinal cord (rat) RGD PMID:26079325 PMID:28404953 RGD:12437066 RGD:12910735 NCBI chr 2:84,284,719...84,310,715
Ensembl chr 2:84,284,719...84,308,225
JBrowse link
G MIF macrophage migration inhibitory factor ISO mRNA:increased expression:spinal cord, microglial cell RGD PMID:15067555 RGD:1641997
G MIR21 microRNA mir-21 exacerbates ISO RGD PMID:31102912 RGD:41410823 NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624
JBrowse link
G MMP2 matrix metallopeptidase 2 treatment ISO RGD PMID:24436993 RGD:8657106 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113
JBrowse link
G MMP9 matrix metallopeptidase 9 treatment ISO RGD PMID:25763638 RGD:12791993 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
JBrowse link
G MPO myeloperoxidase ISO protein:increased activity:spinal cord RGD PMID:22986158 RGD:6909148 NCBI chr 9:32,927,483...32,938,007
Ensembl chr 9:32,927,483...32,937,820
JBrowse link
G MRC1 mannose receptor C-type 1 treatment ISO RGD PMID:24968269 RGD:40924652 NCBI chr 2:19,090,580...19,185,943
Ensembl chr 2:19,069,120...19,185,691
JBrowse link
G MT-ND3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 ISO RGD PMID:20438613 RGD:5687694 NCBI chr MT:9,496...9,841
Ensembl chr MT:9,496...9,842
JBrowse link
G MTOR mechanistic target of rapamycin kinase treatment ISO RGD PMID:20678995 RGD:10040962 NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114
JBrowse link
G NAPEPLD N-acyl phosphatidylethanolamine phospholipase D ISO mRNA:increased expression:spinal cord RGD PMID:18930143 RGD:2316199 NCBI chr18:16,945,096...16,990,752
Ensembl chr18:16,945,253...17,009,607
JBrowse link
G NCAM1 neural cell adhesion molecule 1 treatment ISO RGD PMID:28529158 RGD:40924632 NCBI chr 5:19,895,587...20,192,334
Ensembl chr 5:19,895,613...20,191,995
JBrowse link
G NCF2 neutrophil cytosolic factor 2 ISO protein:increased expression:spinal cord RGD PMID:14644473 RGD:2314450 NCBI chr 7:16,914,629...16,946,370
Ensembl chr 7:16,904,031...16,945,372
JBrowse link
G NEFH neurofilament heavy chain treatment ISO RGD PMID:18772508 PMID:32168135 RGD:27226888 RGD:9698443 NCBI chr26:22,726,523...22,735,129
Ensembl chr26:22,726,526...22,735,125
JBrowse link
G NEFL neurofilament light chain treatment ISO RGD PMID:18772508 RGD:9698443 NCBI chr25:32,463,361...32,468,965
Ensembl chr25:32,463,452...32,467,224
JBrowse link
G NEFM neurofilament medium chain treatment ISO RGD PMID:18772508 RGD:9698443 NCBI chr25:32,493,517...32,498,615
Ensembl chr25:32,493,675...32,498,570
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment ISO RGD PMID:24747453 RGD:10412730 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524
JBrowse link
G NFKBIA NFKB inhibitor alpha treatment ISO RGD PMID:21134362 RGD:10413867 NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433
JBrowse link
G NGF nerve growth factor ISO RGD PMID:12499054 PMID:16915089 RGD:5144069 RGD:5144073 NCBI chr17:52,900,647...52,901,607
Ensembl chr17:52,900,647...52,901,607
JBrowse link
G NGFR nerve growth factor receptor treatment ISO mRNA:increased expression:spinal cord RGD PMID:11223160 PMID:23748892 RGD:10414079 RGD:5144100 NCBI chr 9:25,598,468...25,621,021
Ensembl chr 9:25,601,074...25,623,274
JBrowse link
G NKX6-1 NK6 homeobox 1 ISO RGD PMID:18687784 RGD:2311166 NCBI chr32:8,256,513...8,263,238
Ensembl chr32:8,256,254...8,262,004
JBrowse link
G NLK nemo like kinase ISO protein:increased expression:grey matter: RGD PMID:24395089 RGD:12791278 NCBI chr 9:42,399,930...42,557,065
Ensembl chr 9:42,400,219...42,556,904
JBrowse link
G NOG noggin treatment ISO RGD PMID:18221366 RGD:10429192 NCBI chr 9:31,453,604...31,456,060 JBrowse link
G NOS1 nitric oxide synthase 1 ISO protein:increased expression:spinal cord RGD PMID:19291395 PMID:20633123 RGD:5131936 RGD:5132595 NCBI chr26:13,787,341...13,895,176
Ensembl chr26:13,786,309...13,962,332
JBrowse link
G NOS2 nitric oxide synthase 2 ISO mRNA:altered expression:thoracic aorta RGD PMID:17287083 RGD:4891407 NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588
JBrowse link
G NOS3 nitric oxide synthase 3 ISO RGD PMID:17287083 RGD:4891407 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO protein:increased expression:spinal cord (rat) RGD PMID:24747453 PMID:28881715 RGD:10412730 RGD:13434916 NCBI chr 5:79,979,593...79,990,875
Ensembl chr 5:79,978,865...79,989,860
JBrowse link
G NTF3 neurotrophin 3 ISO RGD PMID:16022868 RGD:4891112 NCBI chr27:39,383,017...39,454,613
Ensembl chr27:39,383,152...39,454,601
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO mRNA:decreased expression:spinal cord RGD PMID:18585435 RGD:2308892 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO RGD PMID:20597685 PMID:22027236 RGD:5684547 RGD:5684898 NCBI chr 1:74,447,927...74,777,910
Ensembl chr 1:74,449,060...74,777,032
JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 ISO mRNA:decreased expression:spinal cord RGD PMID:18585435 RGD:2308892 NCBI chr 3:51,131,470...51,491,112
Ensembl chr 3:51,138,751...51,513,024
JBrowse link
G OLIG2 oligodendrocyte transcription factor 2 treatment ISO RGD PMID:22173726 PMID:28452182 RGD:40902836 RGD:40902844 NCBI chr31:27,674,112...27,677,521
Ensembl chr31:27,674,107...27,676,822
JBrowse link
G P2RX7 purinergic receptor P2X 7 ISO CTD Direct Evidence: therapeutic CTD PMID:15258577 NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:15696051 PMID:21748659 RGD:10053608 NCBI chr 7:38,503,072...38,542,556
Ensembl chr 7:38,503,067...38,542,127
JBrowse link
G PDCD1 programmed cell death 1 treatment ISO RGD PMID:29665726 RGD:40886268 NCBI chr25:51,606,559...51,618,903
Ensembl chr25:51,608,173...51,618,723
JBrowse link
G PDCD1LG2 programmed cell death 1 ligand 2 ISO mRNA:increased expression:microglial cell RGD PMID:29665726 RGD:40886268 NCBI chr 1:93,631,676...93,698,560
Ensembl chr 1:93,631,979...93,689,266
JBrowse link
G PDGFB platelet derived growth factor subunit B ISO RGD PMID:21568693 RGD:6482306 NCBI chr10:25,798,877...25,819,422
Ensembl chr10:25,798,938...25,817,746
JBrowse link
G PLA2G6 phospholipase A2 group VI ISO protein:increased expression:spinal cord RGD PMID:21868473 RGD:6482718 NCBI chr10:26,499,033...26,559,533
Ensembl chr10:26,509,695...26,634,087
JBrowse link
G PLAU plasminogen activator, urokinase ISO RGD PMID:21573723 RGD:6483797 NCBI chr 4:24,329,139...24,333,893
Ensembl chr 4:24,328,925...24,334,851
JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO RGD PMID:21573723 RGD:6483797 NCBI chr 1:111,476,804...111,490,876
Ensembl chr 1:111,476,893...111,490,880
JBrowse link
G PON1 paraoxonase 1 treatment ISO RGD PMID:12897486 RGD:8547682 NCBI chr14:20,565,620...20,600,774
Ensembl chr14:20,565,641...20,642,985
JBrowse link
G PPARD peroxisome proliferator activated receptor delta ISO RGD PMID:20058304 RGD:2324875 NCBI chr12:4,492,867...4,579,340
Ensembl chr12:4,492,672...4,579,340
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO RGD PMID:22208735 RGD:6484263 NCBI chr 3:85,645,942...86,284,570
Ensembl chr 3:86,016,140...86,281,269
JBrowse link
G PPP1CC protein phosphatase 1 catalytic subunit gamma ISO protein:increased expression:spinal cord, astrocyte, microglial cell RGD PMID:29033188 RGD:13514047 NCBI chr26:8,497,350...8,518,467
Ensembl chr26:8,495,067...8,518,675
JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A ISO mRNA:increased expression:spinal cord (rat)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:17578450 PMID:29793971 RGD:9999410 NCBI chr 1:107,486,399...107,490,151
Ensembl chr 1:107,486,438...107,489,222
JBrowse link
G PRKCG protein kinase C gamma ISO protein:decreased expression:spinal cord (mouse) RGD PMID:10501452 RGD:28867228 NCBI chr 1:103,295,110...103,312,562 JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:microglia, macrophage RGD PMID:11063829 PMID:17184185 RGD:5688221 RGD:5688246 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:18606213 RGD:5135219 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
G PTPRZ1 protein tyrosine phosphatase receptor type Z1 treatment ISO RGD PMID:12895450 PMID:15016081 PMID:18065151 RGD:9589823 RGD:9590113 RGD:9590124 NCBI chr14:59,769,553...59,944,111
Ensembl chr14:59,827,650...59,943,315
JBrowse link
G RARA retinoic acid receptor alpha ISO RGD PMID:16420438 RGD:2314291 NCBI chr 9:22,254,803...22,298,614
Ensembl chr 9:22,254,806...22,289,459
JBrowse link
G RBMX RNA binding motif protein X-linked ISO RGD PMID:23180094 RGD:10053723 NCBI chr  X:107,173,599...107,182,404
Ensembl chr  X:107,175,634...107,182,347
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO RGD PMID:17918744 RGD:2298849 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
JBrowse link
G RGMA repulsive guidance molecule BMP co-receptor a treatment ISO RGD PMID:16585268 RGD:9850138 NCBI chr 3:47,044,342...47,089,923
Ensembl chr 3:47,061,910...47,089,294
JBrowse link
G RPSA ribosomal protein SA ISO RGD PMID:19196078 RGD:11041651 NCBI chr23:9,070,953...9,077,058
Ensembl chr23:9,070,953...9,077,057
JBrowse link
G SCN3A sodium voltage-gated channel alpha subunit 3 ISO RGD PMID:16109750 PMID:16718433 RGD:2317320 RGD:2317321 NCBI chr36:10,300,091...10,405,361
Ensembl chr36:10,302,191...10,377,923
JBrowse link
G SERPINC1 serpin family C member 1 treatment ISO RGD PMID:15792522 RGD:1599333 NCBI chr 7:25,322,668...25,333,022
Ensembl chr 7:25,316,129...25,332,987
JBrowse link
G SHH sonic hedgehog signaling molecule treatment ISO RGD PMID:24837681 RGD:12879409 NCBI chr16:18,650,553...18,663,571
Ensembl chr16:18,484,809...18,662,903
JBrowse link
G SIAH1 siah E3 ubiquitin protein ligase 1 treatment ISO RGD PMID:27256506 RGD:13792677 NCBI chr 2:66,630,795...66,709,497
Ensembl chr 2:66,657,696...66,708,337
JBrowse link
G SLC25A27 solute carrier family 25 member 27 ISO protein:increased expression:spinal cord RGD PMID:18534681 RGD:6482843 NCBI chr12:14,818,385...14,846,688
Ensembl chr12:14,818,541...14,846,700
JBrowse link
G SLIT1 slit guidance ligand 1 ISO RGD PMID:16262652 RGD:2316136 NCBI chr28:10,351,758...10,519,322
Ensembl chr28:10,351,821...10,519,313
JBrowse link
G SLIT2 slit guidance ligand 2 ISO mRNA, protein:increased expression:spinal cord RGD PMID:19783284 RGD:2316127 NCBI chr 3:88,964,707...89,311,817
Ensembl chr 3:88,966,232...89,312,955
JBrowse link
G SLIT3 slit guidance ligand 3 ISO RGD PMID:16262652 RGD:2316136 NCBI chr 4:42,506,680...43,099,053
Ensembl chr 4:42,508,426...43,094,714
JBrowse link
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 ISO protein:increased expression:spinal cord RGD PMID:23595775 RGD:10412063 NCBI chr 6:10,385,781...10,498,071
Ensembl chr 6:10,385,779...10,494,922
JBrowse link
G SOCS2 suppressor of cytokine signaling 2 ISO RGD PMID:11723173 RGD:2298928 NCBI chr15:33,761,434...33,788,973
Ensembl chr15:33,785,545...33,877,869
JBrowse link
G SOD1 superoxide dismutase 1 treatment ISO human gene in a rat model
human protein in a rat model
CTD Direct Evidence: therapeutic
RGD
CTD
PMID:16689664 PMID:17457363 PMID:18722523 RGD:8655939 RGD:8655990 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
G SOX2 SRY-box transcription factor 2 ISO mRNA, protein:increased expression:spinal cord RGD PMID:23169458 RGD:8661675 NCBI chr34:14,853,000...14,855,153 JBrowse link
G SPARC secreted protein acidic and cysteine rich ISO RGD PMID:17611274 RGD:2300052 NCBI chr 4:57,659,541...57,682,147
Ensembl chr 4:57,659,650...57,681,711
JBrowse link
G SPP1 secreted phosphoprotein 1 ISO RGD PMID:15592854 RGD:6483848 NCBI chr32:11,354,070...11,362,325
Ensembl chr32:11,353,953...11,362,069
JBrowse link
G SQSTM1 sequestosome 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr11:1,859,776...1,869,289
Ensembl chr11:1,859,465...1,870,755
JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:18945947 RGD:2304258 NCBI chr17:48,038,010...48,178,971
Ensembl chr17:48,038,010...48,178,971
JBrowse link
G TBP TATA-box binding protein ISO protein:increased expression:spinal cord, astrocyte, microglial cell RGD PMID:24710803 RGD:9681729 NCBI chr12:72,458,959...72,479,271
Ensembl chr12:72,459,041...72,479,124
JBrowse link
G TERT telomerase reverse transcriptase ISO mRNA, protein:increased expression:spinal cord RGD PMID:15798365 PMID:23793903 RGD:11038671 RGD:2291993 NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951
JBrowse link
G TGFB2 transforming growth factor beta 2 ISO RGD PMID:15145083 RGD:2302103 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242
JBrowse link
G THBD thrombomodulin ISO RGD PMID:15307903 RGD:1580060 NCBI chr24:599,773...601,649
Ensembl chr24:599,773...601,649
JBrowse link
G THBS1 thrombospondin 1 ISO protein:increased expression:spinal cord RGD PMID:19719963 RGD:2317939 NCBI chr30:6,770,212...6,786,875
Ensembl chr30:6,769,470...6,784,915
JBrowse link
G TLR1 toll like receptor 1 treatment ISO mRNA:increased expression:spinal cord (mouse) RGD PMID:21970496 RGD:7246886 NCBI chr 3:73,504,359...73,544,822
Ensembl chr 3:73,539,715...73,544,624
JBrowse link
G TLR4 toll like receptor 4 severity ISO RGD PMID:25990044 RGD:14700556 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165
JBrowse link
G TNC tenascin C ISO mRNA:increased expression:spinal cord RGD PMID:11085900 RGD:4889619 NCBI chr11:69,077,532...69,169,673
Ensembl chr11:69,077,535...69,170,281
JBrowse link
G TNF tumor necrosis factor ISO RGD PMID:20633123 RGD:5131936 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased expression:cerebrospinal fluid RGD PMID:16083358 RGD:1624185 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TP53 tumor protein p53 ISO protein:increased expression:spinal cord RGD PMID:23595775 RGD:10412063 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 ISO mRNA,protein:increased expression:urinary bladder, dorsal root ganglion: RGD PMID:21367919 RGD:10043365 NCBI chr29:20,951,736...21,000,956
Ensembl chr29:20,951,716...21,001,208
JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 treatment ISO RGD PMID:19169264 PMID:25763638 RGD:10003030 RGD:12791993 NCBI chr 1:107,261,760...107,304,157
Ensembl chr 1:107,261,756...107,303,346
JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 ISO protein:increased expression:neuron, axon RGD PMID:25040536 RGD:11553820 NCBI chr26:968,714...982,244
Ensembl chr26:970,138...982,229
JBrowse link
G VEGFA vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:spinal cord
CTD
RGD
PMID:21092735 RGD:5148013 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965
JBrowse link
G VHL von Hippel-Lindau tumor suppressor ISO RGD PMID:20125055 RGD:2325181 NCBI chr20:8,206,616...8,211,347
Ensembl chr20:8,206,616...8,211,323
JBrowse link
G VIM vimentin ISO protein:increased expression:spinal cord RGD PMID:10225952 PMID:21250919 RGD:6480471 RGD:6480511 NCBI chr 2:19,671,316...19,679,367
Ensembl chr 2:19,671,316...19,679,466
JBrowse link
G VWF von Willebrand factor ISO RGD PMID:25771801 RGD:13673888 NCBI chr27:38,834,812...38,972,614
Ensembl chr27:38,833,837...39,320,142
JBrowse link
G XBP1 X-box binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29793971 NCBI chr26:22,162,675...22,168,149
Ensembl chr26:22,163,222...22,168,105
JBrowse link
G XDH xanthine dehydrogenase ISO protein:increased expression:spinal cord RGD PMID:1649310 RGD:13209021 NCBI chr17:24,900,708...24,960,748
Ensembl chr17:24,901,447...24,971,935
JBrowse link
G XYLT1 xylosyltransferase 1 ISO RGD PMID:18765417 RGD:2313145 NCBI chr 6:26,742,853...27,041,666
Ensembl chr 6:26,742,853...27,041,666
JBrowse link
Spinal Cord Compression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 ISO mRNA, protein:increased expression, increased activity:spinal cord (rat) RGD PMID:22425718 RGD:10449098 NCBI chr 9:49,839,252...49,867,295
Ensembl chr 9:49,839,252...49,867,295
JBrowse link
G AMIGO3 adhesion molecule with Ig like domain 3 ISO mRNA, protein:increased expression:dorsal root ganglion (rat) RGD PMID:23613963 RGD:14390159 NCBI chr20:39,554,028...39,557,129
Ensembl chr20:39,554,629...39,556,155
JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO mRNA, protein:increased expression:liver, serum (rat)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:15135227 PMID:15855648 RGD:11526154 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CD163 CD163 molecule disease_progression ISO protein:increased expression:gray matter of spinal cord, white matter of spinal cord (rat) RGD PMID:23775900 RGD:149735576 NCBI chr27:37,669,757...37,700,746
Ensembl chr27:37,669,827...37,753,106
JBrowse link
G EGR1 early growth response 1 ISO protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:20675054 RGD:5131876 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
JBrowse link
G ELANE elastase, neutrophil expressed treatment ISO RGD PMID:9675307 RGD:10450552 NCBI chr20:57,789,044...57,790,932
Ensembl chr20:57,788,062...57,790,932
JBrowse link
G EPO erythropoietin ISO protein:increased expression:neuron, endothelium, glia: RGD PMID:15792521 RGD:11041719 NCBI chr 6:8,994,211...8,995,954
Ensembl chr 6:8,994,211...8,996,144
JBrowse link
G EPOR erythropoietin receptor ISO protein:increased expression:neuron, endothelium, glia: RGD PMID:15792521 RGD:11041719 NCBI chr20:49,945,777...49,950,856
Ensembl chr20:49,945,777...49,950,856
JBrowse link
G FAS Fas cell surface death receptor treatment ISO protein:increased expression:spinal cord:
human protein in a rat model
RGD PMID:16202410 PMID:16689665 PMID:21490053 RGD:12904017 RGD:1582444 RGD:8663485 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
JBrowse link
G FASLG Fas ligand treatment ISO protein:increased expression:spinal cord: RGD PMID:21490053 RGD:12904017 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224
JBrowse link
G FGF2 fibroblast growth factor 2 ISO protein:increased expression:spinal cord RGD PMID:17244329 RGD:8655633 NCBI chr19:17,403,288...17,463,143
Ensembl chr19:16,994,661...17,463,151
JBrowse link
G FIS1 fission, mitochondrial 1 treatment ISO RGD PMID:25595990 RGD:12437079 NCBI chr 6:8,642,014...8,645,812
Ensembl chr 6:8,642,039...8,648,851
JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO protein:decreased expression:spinal cord, thoracic vertebrae (rat) RGD PMID:20399821 RGD:2326108 NCBI chr 4:66,633,706...66,654,005
Ensembl chr 4:66,633,572...66,652,196
JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 ISO protein:increased expression:spinal cord (mouse) RGD PMID:21787762 RGD:6218959 NCBI chr11:21,290,603...21,363,701
Ensembl chr11:21,290,621...21,505,122
JBrowse link
G IL6 interleukin 6 ISO protein:increased expression:cerebrospinal fluid, serum RGD PMID:30327453 RGD:14975119 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
JBrowse link
G L1CAM L1 cell adhesion molecule ISO RGD PMID:21671795 RGD:6483029 NCBI chr  X:121,708,695...121,722,819
Ensembl chr  X:121,708,894...121,733,365
JBrowse link
G MT2A metallothionein 1H ISO mRNA:increased expression:spinal cord (mouse) RGD PMID:15592854 RGD:6483848 NCBI chr 2:59,607,926...59,608,825
Ensembl chr 2:59,607,927...59,626,727
JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO RGD PMID:29323048 RGD:13504709 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G PLAT plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12227717 NCBI chr16:23,469,590...23,496,013 JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15135227 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased expression:spinal cord (rat) RGD PMID:21224756 RGD:5130917 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO human protein in rat model
protein:increased expression:spinal cord (rat)
RGD PMID:21224756 RGD:5130917 NCBI chr 2:84,140,179...84,151,219
Ensembl chr 2:84,141,911...84,157,191
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13846
    Wounds and Injuries 838
      Spinal Cord Injuries 260
        Autonomic Dysreflexia 0
        Central Cord Syndrome 0
        Spinal Cord Compression 22
Path 2
Term Annotations click to browse term
  disease 13846
    disease of anatomical entity 13505
      nervous system disease 11197
        central nervous system disease 9796
          spinal cord disease 1580
            Spinal Cord Injuries 260
              Autonomic Dysreflexia 0
              Central Cord Syndrome 0
              Spinal Cord Compression 22
paths to the root