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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:hepatopulmonary syndrome
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Accession:DOID:900 term browser browse the term
Definition:A syndrome characterized by the clinical triad of advanced chronic liver disease, pulmonary vascular dilatations, and reduced arterial oxygenation (HYPOXEMIA) in the absence of intrinsic cardiopulmonary disease. This syndrome is common in the patients with LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL).
Synonyms:exact_synonym: Hepato Pulmonary Syndrome;   Hepato-Pulmonary Syndromes;   Hepatopulmonary Syndromes
 primary_id: MESH:D020065
 alt_id: RDO:0007310
 xref: ICD10CM:K76.81;   ICD9CM:573.5
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
hepatopulmonary syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP protein:increased expression:lung, plasma RGD PMID:22659346 RGD:9491778 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 treatment IMP RGD PMID:22659346 RGD:9491778 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
JBrowse link
G Edn1 endothelin 1 IEP protein:increased secretion:liver, plasma (rat) RGD PMID:15185300 RGD:4144891 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednrb endothelin receptor type B IEP protein:increased expression:lung RGD PMID:17110505 RGD:4892290 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Hmox1 heme oxygenase 1 IEP mRNA, protein:increased expression:lung RGD PMID:21518603 RGD:10755724 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Nos3 nitric oxide synthase 3 IEP associated with Liver Cirrhosis;protein:increased expression:lung RGD PMID:18081228 RGD:2292110 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Tnf tumor necrosis factor treatment IMP RGD PMID:26236934 RGD:14696802 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A treatment IEP mRNA:increased expression:lung: RGD PMID:27029414, PMID:19109954 RGD:15003201, RGD:15036789 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16909
    syndrome 7568
      hepatopulmonary syndrome 8
Path 2
Term Annotations click to browse term
  disease 16909
    disease of anatomical entity 16281
      gastrointestinal system disease 4715
        hepatobiliary disease 2517
          liver disease 2423
            hepatopulmonary syndrome 8
paths to the root