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ONTOLOGY REPORT - ANNOTATIONS


Term:degenerative disc disease
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Accession:DOID:90 term browser browse the term
Definition:Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
Synonyms:exact_synonym: Degenerative Intervertebral Disc;   Degenerative Intervertebral Discs;   Degenerative Intervertebral Disk;   Degenerative Intervertebral Disks;   Disc Degeneration;   Disc Degenerations;   Disc Degradation;   Disc Degradations;   Disk Degeneration;   Disk Degenerations;   Disk Degradation;   Disk Degradations;   Intervertebral Disc Degeneration;   Intervertebral Disc Degenerations;   Intervertebral Disk Degeneration;   Intervertebral Disk Degenerations;   cervical disc degenerative disease;   intervertebral disc degradation;   lumbar disc degeneration;   vertebral disc disease
 primary_id: MESH:D055959
 alt_id: RDO:0000697
 xref: NCI:C27156
For additional species annotation, visit the Alliance of Genome Resources.


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degenerative disc disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acan aggrecan JBrowse link 1 140,762,758 140,824,441 RGD:10043178
RGD:11570539
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 JBrowse link 13 89,622,996 89,632,485 RGD:10043115
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 JBrowse link 11 25,411,174 25,456,639 RGD:8661231
RGD:10043115
G Aspn asporin JBrowse link 17 14,655,958 14,681,355 RGD:9684961
RGD:9684970
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:11561942
G Col10a1 collagen type X alpha 1 chain JBrowse link 20 41,180,295 41,190,664 RGD:8661231
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:5688293
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:8661231
RGD:11570539
RGD:10043178
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:11568070
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:13207419
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:13792726
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:11561942
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:7207382
G Mmp13 matrix metallopeptidase 13 JBrowse link 8 5,522,739 5,533,018 RGD:8661231
RGD:10043178
RGD:2325859
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:2325859
RGD:8661231
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:5144150
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:5144150
G Pappa1 pappalysin 1 JBrowse link 5 80,919,932 81,153,904 RGD:10412724
G Postn periostin JBrowse link 2 143,656,820 143,688,087 RGD:10040995
G Sparc secreted protein acidic and cysteine rich JBrowse link 10 40,742,390 40,764,232 RGD:11554173
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11554173
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:10043178
Intervertebral Disc Disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aspn asporin JBrowse link 17 14,655,958 14,681,355 RGD:7240710
G Ccr2 C-C motif chemokine receptor 2 RGD:8661788
G Cilp cartilage intermediate layer protein JBrowse link 8 70,760,922 70,775,891 RGD:7240710
G Col11a1 collagen type XI alpha 1 chain JBrowse link 2 216,863,423 217,056,523 RGD:7240710
RGD:8554872
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:5688295
RGD:5688297
G Col9a3 collagen type IX alpha 3 chain JBrowse link 3 176,102,287 176,124,839 RGD:7240710
RGD:8554872
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:9068928
G Mir155 microRNA 155 JBrowse link 11 24,176,603 24,176,667 RGD:24922221
G Thbs2 thrombospondin 2 JBrowse link 1 56,653,929 56,683,571 RGD:7240710
RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16021
    disease of anatomical entity 15274
      musculoskeletal system disease 5541
        bone disease 3473
          spinal disease 1439
            degenerative disc disease 29
              Intervertebral Disc Disease + 9
Path 2
Term Annotations click to browse term
  disease 16021
    disease of anatomical entity 15274
      musculoskeletal system disease 5541
        connective tissue disease 4009
          bone disease 3473
            spinal disease 1439
              bone structure disease 82
                bone deterioration disease 29
                  degenerative disc disease 29
                    Intervertebral Disc Disease + 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.