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ONTOLOGY REPORT - ANNOTATIONS


Term:Crohn's disease
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Accession:DOID:8778 term browser browse the term
Definition:A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
Synonyms:exact_synonym: Crohn disease;   Crohn's disease of colon;   Crohn's disease of large bowel;   Crohn's enteritis;   Crohns disease;   Inflammatory Bowel Disease 1;   Pediatric Crohn's disease;   granulomatous colitis;   granulomatous enteritis;   regional enteritis;   regional ileitides;   regional ileitis;   terminal ileitis
 related_synonym: CROHN DISEASE, ASSOCIATION WITH;   INFLAMMATORY BOWEL DISEASE 1 (CROHN DISEASE), SUSCEPTIBILITY TO
 primary_id: MESH:D003424
 alt_id: OMIM:266600;   RDO:0001700
 xref: GARD:10232
For additional species annotation, visit the Alliance of Genome Resources.


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Crohn's disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:1598568
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 16 23,146,536 23,157,968 RGD:5686726
RGD:11554173
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) JBrowse link 8 124,556,587 124,569,706 RGD:8554872
G Alox12 arachidonate 12-lipoxygenase JBrowse link 11 70,241,457 70,255,380 RGD:5509621
G Alpi alkaline phosphatase, intestinal JBrowse link 1 87,098,002 87,101,606 RGD:14367879
G Apoa4 apolipoprotein A-IV JBrowse link 9 46,240,844 46,243,458 RGD:5685660
G Aqp7 aquaporin 7 JBrowse link 4 41,033,074 41,048,237 RGD:1626292
G Atg16l1 autophagy related 16-like 1 (S. cerevisiae) JBrowse link 1 87,756,007 87,792,428 RGD:11554173
G Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 JBrowse link 4 32,238,413 32,586,109 RGD:11554173
G Bglap bone gamma carboxyglutamate protein JBrowse link 3 88,383,495 88,384,466 RGD:6483321
RGD:6483546
G Bpi bactericidal permeablility increasing protein JBrowse link 2 158,258,063 158,284,533 RGD:1580079
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:11554173
G Ccny cyclin Y JBrowse link 18 9,312,304 9,450,154 RGD:11554173
G Cd40 CD40 antigen JBrowse link 2 165,055,614 165,071,654 RGD:5490590
RGD:5490971
G Cldn1 claudin 1 JBrowse link 16 26,356,645 26,371,839 RGD:11341809
G Crp C-reactive protein, pentraxin-related JBrowse link 1 172,698,056 172,699,966 RGD:6482309
RGD:11554173
G Dennd1b DENN/MADD domain containing 1B JBrowse link 1 138,963,709 139,176,043 RGD:11554173
G Dnmt3a DNA methyltransferase 3A JBrowse link 12 3,801,559 3,914,443 RGD:11554173
G Efs embryonal Fyn-associated substrate JBrowse link 14 54,916,543 54,926,788 RGD:13592920
G Esr2 estrogen receptor 2 (beta) JBrowse link 12 76,120,419 76,177,259 RGD:5508810
G F13a1 coagulation factor XIII, A1 subunit JBrowse link 13 36,867,178 37,050,244 RGD:10450739
G F2 coagulation factor II JBrowse link 2 91,612,397 91,636,457 RGD:5147754
G Fam92b family with sequence similarity 92, member B JBrowse link 8 120,166,397 120,177,486 RGD:11554173
G Fcgr3 Fc receptor, IgG, low affinity III JBrowse link 1 171,051,169 171,065,915 RGD:5147918
G Fcgr4 Fc receptor, IgG, low affinity IV JBrowse link 1 171,018,926 171,029,761 RGD:1304543
G Fga fibrinogen alpha chain JBrowse link 3 83,026,153 83,033,627 RGD:5688758
G Fn1 fibronectin 1 JBrowse link 1 71,585,473 71,653,280 RGD:11554173
G Fpr2 formyl peptide receptor 2 JBrowse link 17 17,887,824 17,893,952 RGD:11554173
G Fut2 fucosyltransferase 2 JBrowse link 7 45,648,591 45,666,394 RGD:11554173
G Gc vitamin D binding protein JBrowse link 5 89,417,511 89,457,898 RGD:5509866
G Gpbar1 G protein-coupled bile acid receptor 1 JBrowse link 1 74,278,600 74,279,589 RGD:11554173
G Gpx1 glutathione peroxidase 1 JBrowse link 9 108,339,080 108,340,342 RGD:11352754
G Gstm1 glutathione S-transferase, mu 1 JBrowse link 3 108,012,250 108,017,979 RGD:11538341
G Gstt1 glutathione S-transferase, theta 1 JBrowse link 10 75,783,813 75,798,584 RGD:5490554
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 JBrowse link 17 34,263,227 34,269,418 RGD:14974239
G H2-Eb1 histocompatibility 2, class II antigen E beta JBrowse link 17 34,305,867 34,316,674 RGD:11554173
G H2-Pa histocompatibility 2, P region alpha locus JBrowse link 17 34,084,613 34,085,852 RGD:6480648
G Hfe homeostatic iron regulator JBrowse link 13 23,702,034 23,710,854 RGD:14701051
G Hspa1l heat shock protein 1-like JBrowse link 17 34,972,703 34,979,228 RGD:8554872
G Icam1 intercellular adhesion molecule 1 JBrowse link 9 21,015,940 21,028,814 RGD:1625756
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:11554173
RGD:14974261
G Igf1 insulin-like growth factor 1 JBrowse link 10 87,858,265 87,937,047 RGD:11554173
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:11049181
RGD:14975133
RGD:11554173
G Il12b interleukin 12b JBrowse link 11 44,400,063 44,414,677 RGD:11554173
G Il21r interleukin 21 receptor JBrowse link 7 125,603,252 125,634,397 RGD:6482789
G Il23r interleukin 23 receptor JBrowse link 6 67,422,932 67,491,855 RGD:8549568
RGD:11554173
G Il2ra interleukin 2 receptor, alpha chain JBrowse link 2 11,642,792 11,693,194 RGD:11554173
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:11554173
RGD:7240710
G Irgm1 immunity-related GTPase family M member 1 JBrowse link 11 48,865,245 48,871,420 RGD:11554173
G Jak2 Janus kinase 2 JBrowse link 19 29,251,803 29,313,095 RGD:6483020
G Kdr kinase insert domain protein receptor JBrowse link 5 75,932,827 75,979,072 RGD:5684406
G Lep leptin JBrowse link 6 29,060,221 29,073,876 RGD:11554173
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 15 91,672,791 91,816,124 RGD:5508401
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 JBrowse link 10 79,664,559 79,668,542 RGD:2311550
G Mbl2 mannose-binding lectin (protein C) 2 JBrowse link 19 30,232,906 30,239,687 RGD:12910842
G Mki67 antigen identified by monoclonal antibody Ki 67 JBrowse link 7 135,689,784 135,716,450 RGD:6483536
G Mst1 macrophage stimulating 1 (hepatocyte growth factor-like) JBrowse link 9 108,080,409 108,085,027 RGD:11554173
G Mthfr methylenetetrahydrofolate reductase JBrowse link 4 148,039,077 148,059,562 RGD:11554173
G Ncf4 neutrophil cytosolic factor 4 JBrowse link 15 78,244,164 78,262,582 RGD:11554173
G Nkx2-3 NK2 homeobox 3 JBrowse link 19 43,612,325 43,615,892 RGD:11554173
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,955 RGD:11554173
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 8 88,647,315 88,688,474 RGD:1600778
RGD:8554872
RGD:7240710
RGD:11554173
RGD:5508730
RGD:5508719
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 10 89,454,234 89,533,645 RGD:11554173
G Ocln occludin JBrowse link 13 100,496,504 100,552,718 RGD:11341809
G Pgf placental growth factor JBrowse link 12 85,166,637 85,177,785 RGD:6483592
G Phox2b paired-like homeobox 2b JBrowse link 5 67,094,397 67,099,126 RGD:11554173
G Pikfyve phosphoinositide kinase, FYVE type zinc finger containing JBrowse link 1 65,186,640 65,278,696 RGD:13592920
G Plaur plasminogen activator, urokinase receptor JBrowse link 7 24,460,937 24,475,970 RGD:6483800
G Pon1 paraoxonase 1 JBrowse link 6 5,168,090 5,193,987 RGD:5509924
G Pon3 paraoxonase 3 JBrowse link 6 5,216,256 5,256,285 RGD:5509924
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 15 85,734,910 85,806,851 RGD:11554173
G Pparg peroxisome proliferator activated receptor gamma JBrowse link 6 115,360,879 115,490,404 RGD:11554173
G Prf1 perforin 1 (pore forming protein) JBrowse link 10 61,297,751 61,304,684 RGD:6482789
G Prkcq protein kinase C, theta JBrowse link 2 11,171,905 11,301,226 RGD:8554872
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:5508200
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 67,665,501 67,724,632 RGD:11554173
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) JBrowse link 3 103,856,575 103,912,252 RGD:6484668
G Sell selectin, lymphocyte JBrowse link 1 164,061,987 164,082,930 RGD:13464267
G Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 JBrowse link 1 74,375,014 74,386,057 RGD:5684938
RGD:11554173
RGD:5684968
RGD:5684956
RGD:5684952
RGD:5684942
RGD:5684941
RGD:5684939
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 JBrowse link 11 53,864,542 53,891,796 RGD:1580609
G Smad3 SMAD family member 3 JBrowse link 9 63,646,766 63,757,994 RGD:11554173
G Stat3 signal transducer and activator of transcription 3 JBrowse link 11 100,886,806 100,939,594 RGD:6483020
RGD:6483027
G Tagap T cell activation Rho GTPase activating protein JBrowse link 17 7,926,000 7,934,897 RGD:11554173
G Tcf7 transcription factor 7, T cell specific JBrowse link 11 52,246,527 52,283,383 RGD:11554173
G Thbd thrombomodulin JBrowse link 2 148,404,471 148,408,188 RGD:5685011
G Tlr4 toll-like receptor 4 JBrowse link 4 66,827,551 66,846,581 RGD:11554173
G Tlr9 toll-like receptor 9 JBrowse link 9 106,222,598 106,226,876 RGD:11554173
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:5130893
RGD:11554173
RGD:8661753
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a JBrowse link 6 125,349,723 125,362,483 RGD:5130893
RGD:8661753
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b JBrowse link 4 145,212,368 145,246,870 RGD:5130893
G Tyk2 tyrosine kinase 2 JBrowse link 9 21,104,068 21,131,393 RGD:11554173
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 JBrowse link 1 88,211,959 88,220,002 RGD:6482850
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor JBrowse link 15 97,854,427 97,908,296 RGD:1331525
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:5684406
G Vipr1 vasoactive intestinal peptide receptor 1 JBrowse link 9 121,642,716 121,672,954 RGD:5685618
G Vtn vitronectin JBrowse link 11 78,499,120 78,502,325 RGD:11554173
ileitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr2 chemokine (C-C motif) receptor 2 JBrowse link 9 124,101,918 124,109,140 RGD:8661712
G Ccr3 chemokine (C-C motif) receptor 3 JBrowse link 9 124,017,825 124,031,692 RGD:6892917
G Cd80 CD80 antigen JBrowse link 16 38,457,430 38,495,958 RGD:6902902
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:11554173
G Il17a interleukin 17A JBrowse link 1 20,730,905 20,734,496 RGD:4837793
G Itgam integrin alpha M JBrowse link 7 128,062,640 128,118,491 RGD:11554173
G Tlr2 toll-like receptor 2 JBrowse link 3 83,836,272 83,841,824 RGD:2312714
G Tlr4 toll-like receptor 4 JBrowse link 4 66,827,551 66,846,581 RGD:7241089
RGD:2312714
Pediatric Crohn's Disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F2 coagulation factor II JBrowse link 2 91,612,397 91,636,457 RGD:5147769
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:7394742

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12524
    disease of anatomical entity 12143
      gastrointestinal system disease 4030
        intestinal disease 1324
          inflammatory bowel disease 298
            Crohn's disease 102
              Crohn's colitis 0
              Pediatric Crohn's Disease 2
              gastroduodenal Crohn's disease 0
              ileitis + 8
              ileocolitis 0
              jejunoileitis 0
Path 2
Term Annotations click to browse term
  disease 12524
    disease of anatomical entity 12143
      Immune & Inflammatory Diseases 2704
        Inflammation 1805
          gastroenteritis 359
            inflammatory bowel disease 298
              Crohn's disease 102
                Crohn's colitis 0
                Pediatric Crohn's Disease 2
                gastroduodenal Crohn's disease 0
                ileitis + 8
                ileocolitis 0
                jejunoileitis 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.