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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:milker's nodule
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Accession:DOID:8729 term browser browse the term
Definition:A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy. (DO)
Synonyms:exact_synonym: Milker Nodes;   Milker's Node;   Milker's Nodes;   Milkers Nodes;   Poxviridae Infection;   Poxviridae Infections;   Poxvirus Infection;   Poxvirus Infections;   milker nodule;   milkers' node;   paravaccinia
 related_synonym: pseudocowpox
 primary_id: MESH:D011213
 xref: ICD10CM:B08.04;   ICD9CM:051.9
For additional species annotation, visit the Alliance of Genome Resources.



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milker's nodule term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prf1 perforin 1 ISO RGD PMID:22396645 RGD:6482788 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
JBrowse link
G Tlr3 toll-like receptor 3 severity ISO RGD PMID:18097050 RGD:5129216 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
Infectious Ectromelia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrk1 killer cell lectin like receptor K1 susceptibility ISO RGD PMID:18266471 RGD:38676489 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 exacerbates ISO RGD PMID:24673683 RGD:150340678 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: therapeutic CTD PMID:12235215 NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421
JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: therapeutic CTD PMID:12235215 NCBI chr 5:77,253,881...77,277,078
Ensembl chr 5:77,251,373...77,277,421
JBrowse link
molluscum contagiosum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr2 toll-like receptor 2 ISO protein:increased expression,altered expression:cytoplasm,membrane, nucleus: RGD PMID:24617037 RGD:8553046 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
smallpox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf1 interferon regulatory factor 1 treatment ISO DNA:SNPs,haplotype: :rs839, rs9282763(human) RGD PMID:18454680 RGD:42722608 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Mthfr methylenetetrahydrofolate reductase treatment ISO DNA:SNP:exon:rs1801133(human) RGD PMID:18454680 RGD:42722608 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
vaccinia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 susceptibility
severity
ISO RGD PMID:20943971 PMID:11967338 RGD:40902816, RGD:40902818 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Foxp3 forkhead box P3 ISO RGD PMID:20548030 RGD:36947870 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Mavs mitochondrial antiviral signaling protein treatment ISO RGD PMID:26849062 RGD:40903043 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 exacerbates ISO RGD PMID:19524513 RGD:127229939 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Rnasel ribonuclease L susceptibility
severity
ISO RGD PMID:20943971 PMID:11967338 RGD:40902816, RGD:40902818 NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704
JBrowse link
G Was WASP actin nucleation promoting factor severity ISO RGD PMID:15681416 RGD:38599240 NCBI chr  X:14,405,096...14,413,850
Ensembl chr  X:14,405,124...14,413,849
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18156
    disease by infectious agent 2134
      viral infectious disease 1672
        DNA Virus Infections 341
          milker's nodule 15
            Fowlpox 0
            Infectious Ectromelia 4
            Infectious Myxomatosis 0
            Lumpy Skin Disease 0
            contagious pustular dermatitis 0
            cowpox 0
            molluscum contagiosum 1
            monkeypox 0
            smallpox + 2
            vaccinia 6
paths to the root