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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:vascular dementia
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Accession:DOID:8725 term browser browse the term
Definition:An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)
Synonyms:exact_synonym: Arteriosclerotic Dementia;   Arteriosclerotic Dementias;   Binswanger Disease;   Binswanger Encephalopathy;   Binswanger's Disease;   Binswanger's Encephalopathy;   Binswangers Disease;   Chronic Progressive Subcortical Encephalopathy;   Encephalopathy, Binswangers;   Multi Infarct Dementia;   Subcortical Arteriosclerotic Encephalopathies;   Subcortical Arteriosclerotic Encephalopathy;   Subcortical Leukoencephalopathies;   Subcortical Leukoencephalopathy;   Subcortical Vascular Dementia;   Subcortical Vascular Dementias;   acute onset vascular dementia;   multifocal dementia;   vascular dementias
 primary_id: MESH:D015140
 alt_id: RDO:0006843
 xref: ICD10CM:F01;   ICD9CM:290.4;   NCI:C34522;   NCI:C34525
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
vascular dementia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5f1a ATP synthase F1 subunit alpha ISO RGD PMID:24448401 RGD:14696801 NCBI chrNW_004936517:743,036...752,836 JBrowse link
G Bdnf brain derived neurotrophic factor treatment ISO RGD PMID:24622829 RGD:10059369 NCBI chrNW_004936540:5,530,081...5,582,765 JBrowse link
G Cdk5 cyclin dependent kinase 5 treatment ISO RGD PMID:27118553 RGD:13792766 NCBI chrNW_004936527:6,478,934...6,483,848 JBrowse link
G Eif4e eukaryotic translation initiation factor 4E ISO protein:decreased expression:hippocampus RGD PMID:23053837 RGD:10401142 NCBI chrNW_004936520:3,922,457...3,964,721 JBrowse link
G Epo erythropoietin ISO RGD PMID:17037738 RGD:10400891 NCBI chrNW_004936543:742,722...745,332 JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 treatment ISO RGD PMID:22500404 RGD:10402076 NCBI chrNW_004936710:1,760,365...1,815,269 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 treatment ISO RGD PMID:22500404 RGD:10402076 NCBI chrNW_004936472:23,442,946...23,617,523 JBrowse link
G Gclm glutamate-cysteine ligase modifier subunit susceptibility ISO associated with stroke;DNA:polymorphism:promoter:-588C>T(human) RGD PMID:17548779 RGD:10402374 NCBI chrNW_004936537:5,356,914...5,378,998 JBrowse link
G Gpx1 glutathione peroxidase 1 treatment ISO RGD PMID:24968700 RGD:11352822 NCBI chrNW_004936529:997,943...999,123 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO associated with Alzheimer's disease RGD PMID:25261450 RGD:13792687 NCBI chrNW_004936669:814,330...838,881 JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO RGD PMID:25261450 RGD:13792687 NCBI chrNW_004936530:8,286,101...8,612,183 JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B severity ISO RGD PMID:25261450 RGD:13792687 NCBI chrNW_004936587:3,406,055...3,806,956 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO RGD PMID:27118553 RGD:13792766 NCBI chrNW_004936536:6,730,070...6,893,818 JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO DNA:polymorphism: :-110A>C(human) RGD PMID:15832029 RGD:10402403 NCBI chrNW_004936727:1,732,323...1,735,128 JBrowse link
G Igf1 insulin like growth factor 1 severity ISO mRNA,protein:decreased expression:hippocampus: RGD PMID:16181175, PMID:22342912 RGD:10045864, RGD:1598446 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Igf1r insulin like growth factor 1 receptor ISO RGD PMID:16983186 RGD:10045873 NCBI chrNW_004936483:4,563,995...4,860,231 JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:plasma RGD PMID:16600299 RGD:1626633 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Mapt microtubule associated protein tau treatment ISO RGD PMID:27118553 RGD:13792766 NCBI chrNW_004936541:2,381,411...2,479,984 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:16385583 RGD:1582624 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO protein:decreased expression:hippocampus RGD PMID:23053837 RGD:10401142 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Pon2 paraoxonase 2 ISO DNA:missense mutation:cds:p.C311S (human) RGD PMID:11803456 RGD:1580219 NCBI chrNW_004936585:4,862,378...4,894,061 JBrowse link
G Rpgrip1l RPGRIP1 like susceptibility ISO DNA:SNPs:introns:rs16952362,rs17214955,rs17803830(human) RGD PMID:22425971 RGD:13204815 NCBI chrNW_004936475:6,219,187...6,321,612 JBrowse link
G Rps6 ribosomal protein S6 treatment ISO RGD PMID:25767501 RGD:11041644 NCBI chrNW_004936652:1,252,986...1,255,987 JBrowse link
G Sdhaf1 succinate dehydrogenase complex assembly factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19465911 NCBI chrNW_004936922:32,655...33,795 JBrowse link
G Snca synuclein alpha ISO protein:increased expression:cerebrospinal fluid RGD PMID:18577885 RGD:6478792 NCBI chrNW_004936685:2,077,017...2,175,298 JBrowse link
G Sncg synuclein gamma ISO protein:increased expression:cerebrospinal fluid RGD PMID:18577885 RGD:6478792 NCBI chrNW_004936804:16,869...21,684 JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO DNA:SNPs, haplotype: :24489C>T, 34995G>T, 68891C>T (human) RGD PMID:16082694 RGD:1581412 NCBI chrNW_004936492:115,923...174,614 JBrowse link
G Sst somatostatin ISO protein:decreased expression:brain RGD PMID:18925713 RGD:2303174 NCBI chrNW_004936578:2,464,310...2,465,673 JBrowse link
G Tnf tumor necrosis factor susceptibility ISO DNA:polymorphism:promoter:-850C>T(human) RGD PMID:11273064 RGD:13825254 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tp53 tumor protein p53 ISO protein:increased expression:brain RGD PMID:18083315 RGD:2290557 NCBI chrNW_004936595:919,807...935,367 JBrowse link
CADASIL term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra1 HtrA serine peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chrNW_004936486:11,271,130...11,317,271 JBrowse link
G Notch3 notch receptor 3 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Dementia, hereditary multi-infarct type
ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
CTD
ClinVar
PMID:9388399, PMID:10854111, PMID:11102981, PMID:11755616, PMID:12721871, PMID:15229130, PMID:15364702, PMID:16009764, PMID:16730748, PMID:20935329, PMID:25741868, PMID:26467025, PMID:26856460, PMID:28479817, PMID:29188607, PMID:29980472, PMID:30311386, PMID:30402942 NCBI chrNW_004936596:5,265,984...5,301,430 JBrowse link
CADASIL 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch3 notch receptor 3 ISO OMIM NCBI chrNW_004936596:5,265,984...5,301,430 JBrowse link
CADASIL 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra1 HtrA serine peptidase 1 ISO OMIM NCBI chrNW_004936486:11,271,130...11,317,271 JBrowse link
Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra1 HtrA serine peptidase 1 ISO OMIM NCBI chrNW_004936486:11,271,130...11,317,271 JBrowse link
Familial Vascular Leukoencephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Familial vascular leukoencephalopathy ClinVar PMID:9388399, PMID:10854111, PMID:11102981, PMID:11755616, PMID:12721871, PMID:15229130, PMID:15364702, PMID:16009764, PMID:16730748, PMID:20935329, PMID:26467025, PMID:26856460, PMID:28479817, PMID:29188607, PMID:29980472, PMID:30311386, PMID:30402942 NCBI chrNW_004936596:5,265,984...5,301,430 JBrowse link
Multi-Infarct Dementia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO protein:decreased expression:cerebrospinal fluid: RGD PMID:1677459 RGD:10054257 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:18938189 RGD:10054050 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:18938189 RGD:10054050 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment ISO RGD PMID:21279683 RGD:10449132 NCBI chrNW_004936809:1,269,900...1,285,853 JBrowse link
G Il2 interleukin 2 severity ISO protein:increased secretion:mononuclear cell: RGD PMID:8586980 RGD:10047081 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11942
    Diseases of the Aged 954
      dementia 602
        vascular dementia 37
          CADASIL + 2
          Multi-Infarct Dementia 5
Path 2
Term Annotations click to browse term
  disease 11942
    disease of anatomical entity 11503
      nervous system disease 9434
        central nervous system disease 7978
          brain disease 7383
            disease of mental health 5363
              cognitive disorder 1615
                dementia 602
                  vascular dementia 37
                    CADASIL + 2
                    Multi-Infarct Dementia 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.