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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:substance-induced psychosis
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Accession:DOID:8646 term browser browse the term
Definition:Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.
Synonyms:exact_synonym: Drug Psychoses;   Toxic Psychoses;   substance-induced psychoses
 primary_id: MESH:D011605;   RDO:0006434
 xref: ICD9CM:293.89
For additional species annotation, visit the Alliance of Genome Resources.


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substance-induced psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17196621 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20799992 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21041608 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II, beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17603807 NCBI chr11:5,969,629...6,066,357
Ensembl chr11:5,969,644...6,066,362
JBrowse link
G Esr1 estrogen receptor 1 (alpha) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19386276 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Grm2 glutamate receptor, metabotropic 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20211215 NCBI chr 9:106,644,534...106,656,109
Ensembl chr 9:106,643,095...106,656,082
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15729709 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19747927 NCBI chr13:105,443,693...105,448,133
Ensembl chr13:105,443,639...105,448,122
JBrowse link
G Htr6 5-hydroxytryptamine (serotonin) receptor 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20705401 NCBI chr 4:139,059,706...139,075,570
Ensembl chr 4:139,061,108...139,075,570
JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19566775 NCBI chr 8:66,697,149...66,706,800
Ensembl chr 8:66,697,192...66,706,792
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16402083 NCBI chr10:6,758,593...7,038,209
Ensembl chr10:6,758,506...7,038,198
JBrowse link
G Phb prohibitin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18504422 NCBI chr11:95,666,957...95,680,773
Ensembl chr11:95,666,957...95,680,773
JBrowse link
G Pick1 protein interacting with C kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17606663 NCBI chr15:79,229,140...79,249,466
Ensembl chr15:79,229,173...79,249,484
JBrowse link
G Rgs9 regulator of G-protein signaling 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17318883 NCBI chr11:109,225,348...109,298,181
Ensembl chr11:109,225,355...109,298,129
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12931138 NCBI chr13:73,536,128...73,578,672
Ensembl chr13:73,536,747...73,578,672
JBrowse link
G Snca synuclein, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15542733 NCBI chr 6:60,731,573...60,829,855
Ensembl chr 6:60,731,575...60,829,855
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:16807759 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
alcohol-induced mental disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:26711020 NCBI chr 5:121,566,027...121,593,824
Ensembl chr 5:121,566,027...121,593,824
JBrowse link
G Foxo4 forkhead box O4 ISO protein:increased phosphorylation:small intestine: RGD PMID:23292333 RGD:10402360 NCBI chr  X:101,254,261...101,260,873
Ensembl chr  X:101,254,528...101,260,873
JBrowse link
G Gsr glutathione reductase treatment ISO RGD PMID:24972622 RGD:10401897 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
drug psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 ISO RGD PMID:26174132 RGD:11534754 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
fetal alcohol spectrum disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3, epithelial ISO CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr10:69,533,486...70,027,436
Ensembl chr10:69,398,773...70,027,438
JBrowse link
G Apoe apolipoprotein E IMP RGD PMID:15007105 RGD:12904641 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G Bpifa1 BPI fold containing family A, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15513904 NCBI chr 2:154,142,880...154,149,217
Ensembl chr 2:154,142,880...154,149,219
JBrowse link
G Cat catalase ISO CTD Direct Evidence: therapeutic CTD PMID:26074427 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) treatment ISO RGD PMID:22037411, PMID:23763370 RGD:13210751, RGD:13432044 NCBI chr 6:135,713,221...136,173,615
Ensembl chr 6:135,713,233...136,173,511
JBrowse link
G Igf1 insulin-like growth factor 1 ISO mRNA:decreased expression:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Igf1r insulin-like growth factor I receptor ISO protein:decreased activity:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal ISO CTD Direct Evidence: marker/mechanism CTD PMID:25511929 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Pten phosphatase and tensin homolog ISO Protein:increased expression, increased activity:cerebellum (rat) RGD PMID:12700235 RGD:12801493 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr 4:133,847,290...133,887,797
Ensembl chr 4:133,847,290...133,887,797
JBrowse link
fetal alcohol syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhoa ras homolog family member A ISO protein:increased activation:neuron, cerebellum RGD PMID:17109064 RGD:2298867 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934
JBrowse link
Postoperative Cognitive Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a ISO RGD PMID:24814703 RGD:10047100 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Agtr1b angiotensin II receptor, type 1b ISO RGD PMID:24814703 RGD:10047100 NCBI chr 3:20,314,473...20,367,177
Ensembl chr 3:20,314,473...20,367,177
JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:22959208 RGD:7204702 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:23077050 RGD:8551854 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO protein:increased expression:hippocampus (rat) RGD PMID:23229539 RGD:12904023 NCBI chr 9:54,862,658...54,912,534
Ensembl chr 9:54,863,789...54,912,530
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13461
    Chemically-Induced Disorders 1136
      substance-related disorder 539
        substance-induced psychosis 37
          alcohol-induced mental disorder + 14
          alcoholic psychosis 0
          drug-induced mental disorder + 1
          subacute delirium + 5
Path 2
Term Annotations click to browse term
  disease 13461
    disease of anatomical entity 12946
      nervous system disease 10511
        central nervous system disease 8882
          brain disease 8224
            disease of mental health 6023
              cognitive disorder 1824
                psychotic disorder 1079
                  substance-induced psychosis 37
                    alcohol-induced mental disorder + 14
                    alcoholic psychosis 0
                    drug-induced mental disorder + 1
                    subacute delirium + 5
paths to the root